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2010, volume 464, articles 7293

Journal club pp. 1249-1249

Jean-Christophe Marine

Hasty switch for space magnet pp. 1252-1252

Edwin Cartlidge

Questions fly over ash-cloud models pp. 1253-1253

Katharine Sanderson

High stakes for science in UK election pp. 1254-1255

Geoff Brumfiel

Russia to boost university science pp. 1257-1257

Quirin Schiermeier

Clinical drug tests adapted for speed pp. 1258-1258

Heidi Ledford

Twin study surveys genome for cause of multiple sclerosis pp. 1259-1259

Alla Katsnelson

Cybersecurity: How safe are your data? pp. 1260-1261

Jeffrey Perkel

Hydrogen vehicles: Fuel of the future? pp. 1262-1264

Jeff Tollefson

French research also being stifled by autocracy pp. 1266-1266

Klaus Scherrer

Forensics: stronger scientific scrutiny needed in Britain pp. 1266-1266

Allan Jamieson

Forensics: experts disagree on statistics from DNA trawls pp. 1266-1267

Charles Taylor and Paul Colman

Statisticians and historians should help improve metrics pp. 1267-1267

Hanne Andersen

The making of an exceptional scientist pp. 1268-1270

Georgina Ferry

Forecasts needed for retreating forests pp. 1271-1271

Csaba Mátyás

Two views of our planet's future pp. 1273-1274

David Orr

Happiness breeds prosperity pp. 1275-1276

Felicia Huppert

Signatures of life on other worlds pp. 1276-1277

Debra Fischer

Education as a global commodity pp. 1277-1280

Adam R. Nelson

Why fairness pays pp. 1280-1280

Mike Mesterton-Gibbons

The omnipresent hubbub pp. 1281-1281

Jascha Hoffman

A hero with a butterfly net pp. 1282-1283

Robert Dunn

Under the skin of climate change pp. 1283-1283

Hans von Storch

Close encounters of the second type pp. 1285-1286

Gérard Eberl

A frosty finding pp. 1286-1287

Henry H. Hsieh

Host and microbes in a pickle pp. 1287-1288

Ping Li and Gökhan S. Hotamisligil

Atoms in chequerboard order pp. 1289-1290

Cheng Chin and Nathan Gemelke

Each synapse to its own pp. 1290-1291

Nicholas J. Priebe and David Ferster

The mystery of Don Juan Pond pp. 1290-1290

Andrew Mitchinson

James Black (1924–2010) pp. 1292-1292

Robin Ganellin and William Duncan

Genetics, pathogenesis and clinical interventions in type 1 diabetes pp. 1293-1300

Jeffrey A. Bluestone, Kevan Herold and George Eisenbarth

Dicke quantum phase transition with a superfluid gas in an optical cavity pp. 1301-1306

Kristian Baumann, Christine Guerlin, Ferdinand Brennecke and Tilman Esslinger

Dendritic organization of sensory input to cortical neurons in vivo pp. 1307-1312

Hongbo Jia, Nathalie L. Rochefort, Xiaowei Chen and Arthur Konnerth

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1 pp. 1313-1319

Masato Iwabu, Toshimasa Yamauchi, Miki Okada-Iwabu, Koji Sato, Tatsuro Nakagawa, Masaaki Funata, Mamiko Yamaguchi, Shigeyuki Namiki, Ryo Nakayama, Mitsuhisa Tabata, Hitomi Ogata, Naoto Kubota, Iseki Takamoto, Yukiko K. Hayashi, Naoko Yamauchi, Hironori Waki, Masashi Fukayama, Ichizo Nishino, Kumpei Tokuyama, Kohjiro Ueki, Yuichi Oike, Satoshi Ishii, Kenzo Hirose, Takao Shimizu, Kazushige Touhara and Takashi Kadowaki

Water ice and organics on the surface of the asteroid 24 Themis pp. 1320-1321

Humberto Campins, Kelsey Hargrove, Noemi Pinilla-Alonso, Ellen S. Howell, Michael S. Kelley, Javier Licandro, T. Mothé-Diniz, Y. Fernández and Julie Ziffer

Detection of ice and organics on an asteroidal surface pp. 1322-1323

Andrew S. Rivkin and Joshua P. Emery

Dipolar collisions of polar molecules in the quantum regime pp. 1324-1328

K.-K. Ni, S. Ospelkaus, D. Wang, G. Quéméner, B. Neyenhuis, M. H. G. de Miranda, J. L. Bohn, J. Ye and D. S. Jin

A molecular molybdenum-oxo catalyst for generating hydrogen from water pp. 1329-1333

Hemamala I. Karunadasa, Christopher J. Chang and Jeffrey R. Long

The central role of diminishing sea ice in recent Arctic temperature amplification pp. 1334-1337

James A. Screen and Ian Simmonds

Exceptional dinosaur fossils show ontogenetic development of early feathers pp. 1338-1341

Xing Xu, Xiaoting Zheng and Hailu You

Evolution of self-compatibility in Arabidopsis by a mutation in the male specificity gene pp. 1342-1346

Takashi Tsuchimatsu, Keita Suwabe, Rie Shimizu-Inatsugi, Sachiyo Isokawa, Pavlos Pavlidis, Thomas Städler, Go Suzuki, Seiji Takayama, Masao Watanabe and Kentaro K. Shimizu

A role for host–parasite interactions in the horizontal transfer of transposons across phyla pp. 1347-1350

Clément Gilbert, Sarah Schaack, John K. Pace, Paul J. Brindley and Cédric Feschotte

Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis pp. 1351-1356

Sergio E. Baranzini, Joann Mudge, Jennifer C. van Velkinburgh, Pouya Khankhanian, Irina Khrebtukova, Neil A. Miller, Lu Zhang, Andrew D. Farmer, Callum J. Bell, Ryan W. Kim, Gregory D. May, Jimmy E. Woodward, Stacy J. Caillier, Joseph P. McElroy, Refujia Gomez, Marcelo J. Pando, Leonda E. Clendenen, Elena E. Ganusova, Faye D. Schilkey, Thiruvarangan Ramaraj, Omar A. Khan, Jim J. Huntley, Shujun Luo, Pui-yan Kwok, Thomas D. Wu, Gary P. Schroth, Jorge R. Oksenberg, Stephen L. Hauser and Stephen F. Kingsmore

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals pp. 1357-1361

Peter Duewell, Hajime Kono, Katey J. Rayner, Cherilyn M. Sirois, Gregory Vladimer, Franz G. Bauernfeind, George S. Abela, Luigi Franchi, Gabriel Nuñez, Max Schnurr, Terje Espevik, Egil Lien, Katherine A. Fitzgerald, Kenneth L. Rock, Kathryn J. Moore, Samuel D. Wright, Veit Hornung and Eicke Latz

IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses pp. 1362-1366

Steven A. Saenz, Mark C. Siracusa, Jacqueline G. Perrigoue, Sean P. Spencer, Joseph F. Urban, Joel E. Tocker, Alison L. Budelsky, Melanie A. Kleinschek, Robert A. Kastelein, Taku Kambayashi, Avinash Bhandoola and David Artis

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity pp. 1367-1370

Daniel R. Neill, See Heng Wong, Agustin Bellosi, Robin J. Flynn, Maria Daly, Theresa K. A. Langford, Christine Bucks, Colleen M. Kane, Padraic G. Fallon, Richard Pannell, Helen E. Jolin and Andrew N. J. McKenzie

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology pp. 1371-1375

Sofia Buonocore, Philip P. Ahern, Holm H. Uhlig, Ivaylo I. Ivanov, Dan R. Littman, Kevin J. Maloy and Fiona Powrie

Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling pp. 1376-1380

Pietro Fazzari, Ana V. Paternain, Manuel Valiente, Ramón Pla, Rafael Luján, Kent Lloyd, Juan Lerma, Oscar Marín and Beatriz Rico

IκBζ regulates TH17 development by cooperating with ROR nuclear receptors pp. 1381-1385

Kazuo Okamoto, Yoshiko Iwai, Masatsugu Oh-hora, Masahiro Yamamoto, Tomohiro Morio, Kazuhiro Aoki, Keiichi Ohya, Anton M. Jetten, Shizuo Akira, Tatsushi Muta and Hiroshi Takayanagi

Tracking G-protein-coupled receptor activation using genetically encoded infrared probes pp. 1386-1389

Shixin Ye, Ekaterina Zaitseva, Gianluigi Caltabiano, Gebhard F. X. Schertler, Thomas P. Sakmar, Xavier Deupi and Reiner Vogel

Erratum: Enzyme-inhibitor-like tuning of Ca2+ channel connectivity with calmodulin pp. 1390-1390

Xiaodong Liu, Philemon S. Yang, Wanjun Yang and David T. Yue

Erratum: Lessons on longevity from budding yeast pp. 1390-1390

Matt Kaeberlein

Nadine Gassner pp. 1393-1393

Virginia Gewin

Getting better at biotech pp. 1394-1395

Paul Smaglik

Grandfather paradox pp. 1398-1398

Ian Stewart

2010, volume 464, articles 7292

Journal club pp. 1107-1107

Kevin Mitchell

A shot in the arm for cancer vaccines? pp. 1110-1111

Heidi Ledford

No gain from brain training pp. 1111-1111

Alla Katsnelson

Portrait of a year-old pandemic pp. 1112-1113

Declan Butler

Undersea project delivers data flood pp. 1115-1115

Nicola Jones

Crucial data on REACH not disclosed pp. 1116-1117

Natasha Gilbert

Environmental Science: New life for the Dead Sea? pp. 1118-1120

Josie Glausiusz

Toxicology: The big test for bisphenol A pp. 1122-1124

Brendan Borrell

Climate policy: role of scientists in public advocacy pp. 1125-1125

Stephen H. Schneider

Climate policy: dissent over moral as well as factual issues pp. 1125-1125

Gregor Betz

What users really want to know from university ratings pp. 1125-1125

Jimmy J. Zhuang, Annie X. Wang and Joyce Y. Zhang

African students value the results of studying in China pp. 1125-1125

Kenneth King

Actions speak louder than words to prevent language extinctions pp. 1125-1125

Yoshina Gautam and Aashish Jha

Copenhagen Accord pledges are paltry pp. 1126-1128

Joeri Rogelj, Julia Nabel, Claudine Chen, William Hare, Kathleen Markmann, Malte Meinshausen, Michiel Schaeffer, Kirsten Macey and Niklas Höhne

Building life from the bottom up pp. 1129-1130

Michael A. Goldman

Why twins age differently pp. 1130-1131

Michael Sargent

Where the wilderness line blurs pp. 1131-1131

Emma Marris

Extreme makeover of pancreatic α-cells pp. 1132-1133

Kenneth S. Zaret and Morris F. White

A condensate's main squeeze pp. 1133-1134

Charles A. Sackett

Signals far and away pp. 1134-1136

Dirk Feldmeyer

Not just any old anion pp. 1136-1137

Kyoko Nozaki

A cloak of liquidity pp. 1137-1138

A. Lindsay Greer

Listeria does it again pp. 1138-1139

Julian I. Rood

Magnetic-field perception pp. 1140-1142

Kenneth J. Lohmann

Generation of a novel wing colour pattern by the Wingless morphogen pp. 1143-1148

Thomas Werner, Shigeyuki Koshikawa, Thomas M. Williams and Sean B. Carroll

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss pp. 1149-1154

Fabrizio Thorel, Virginie Népote, Isabelle Avril, Kenji Kohno, Renaud Desgraz, Simona Chera and Pedro L. Herrera

Lateral competition for cortical space by layer-specific horizontal circuits pp. 1155-1160

Hillel Adesnik and Massimo Scanziani

Possible thermochemical disequilibrium in the atmosphere of the exoplanet GJ 436b pp. 1161-1164

Kevin B. Stevenson, Joseph Harrington, Sarah Nymeyer, Nikku Madhusudhan, Sara Seager, William C. Bowman, Ryan A. Hardy, Drake Deming, Emily Rauscher and Nate B. Lust

Nonlinear atom interferometer surpasses classical precision limit pp. 1165-1169

C. Gross, T. Zibold, E. Nicklas, J. Estève and M. K. Oberthaler

Atom-chip-based generation of entanglement for quantum metrology pp. 1170-1173

Max F. Riedel, Pascal Böhi, Yun Li, Theodor W. Hänsch, Alice Sinatra and Philipp Treutlein

Substrate-enhanced supercooling in AuSi eutectic droplets pp. 1174-1177

T. U. Schülli, R. Daudin, G. Renaud, A. Vaysset, O. Geaymond and A. Pasturel

Stoichiometric control of organic carbon–nitrate relationships from soils to the sea pp. 1178-1181

Philip G. Taylor and Alan R. Townsend

Learning-related fine-scale specificity imaged in motor cortex circuits of behaving mice pp. 1182-1186

Takaki Komiyama, Takashi R. Sato, Daniel H. O’Connor, Ying-Xin Zhang, Daniel Huber, Bryan M. Hooks, Mariano Gabitto and Karel Svoboda

Genetic analysis of variation in transcription factor binding in yeast pp. 1187-1191

Wei Zheng, Hongyu Zhao, Eugenio Mancera, Lars M. Steinmetz and Michael Snyder

Listeria monocytogenes impairs SUMOylation for efficient infection pp. 1192-1195

David Ribet, Mélanie Hamon, Edith Gouin, Marie-Anne Nahori, Francis Impens, Hélène Neyret-Kahn, Kris Gevaert, Joël Vandekerckhove, Anne Dejean and Pascale Cossart

MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis pp. 1196-1200

Stefania Nicoli, Clive Standley, Paul Walker, Adam Hurlstone, Kevin E. Fogarty and Nathan D. Lawson

Caspase activation precedes and leads to tangles pp. 1201-1204

Alix de Calignon, Leora M. Fox, Rose Pitstick, George A. Carlson, Brian J. Bacskai, Tara L. Spires-Jones and Bradley T. Hyman

Crystal structure of the FTO protein reveals basis for its substrate specificity pp. 1205-1209

Zhifu Han, Tianhui Niu, Junbiao Chang, Xiaoguang Lei, Mingyan Zhao, Qiang Wang, Wei Cheng, Jinjing Wang, Yi Feng and Jijie Chai

Isolation of the elusive supercomplex that drives cyclic electron flow in photosynthesis pp. 1210-1213

Masakazu Iwai, Kenji Takizawa, Ryutaro Tokutsu, Akira Okamuro, Yuichiro Takahashi and Jun Minagawa

Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends pp. 1214-1217

Steven A. Roberts, Natasha Strande, Martin D. Burkhalter, Christina Strom, Jody M. Havener, Paul Hasty and Dale A. Ramsden

Super-resolution biomolecular crystallography with low-resolution data pp. 1218-1222

Gunnar F. Schröder, Michael Levitt and Axel T. Brunger

Homing in on delivery pp. 1225-1227

Monya Baker

Science outreach scheme ramps up pp. 1233-1233

Karen Kaplan

The junior senior supervisor pp. 1233-1233

Fabio Paglieri

Making a switch pp. 1234-1235

Bryn Nelson

Corrective action pp. 1238-1238

John Gilbey

2010, volume 464, articles 7291

Journal club pp. 961-961

Xing Xu

Lab-animal battle reaches truce pp. 964-964

Alison Abbott

US nuclear policy could boost basic research pp. 965-965

Jeff Tollefson

Japan rolls out elite science funds pp. 966-967

David Cyranoski

Stem-cell funding in sight pp. 967-967

Meredith Wadman

What it will take to feed the world pp. 969-969

Declan Butler

Pentagon turns to 'softer' sciences pp. 970-970

Sharon Weinberger

Panel to take broad view of bioethics pp. 971-971

Brendan Borrell

Big science: The cancer genome challenge pp. 972-974

Heidi Ledford

World view: Moment of reckoning pp. 975-975

Colin Macilwain

Questioning how different societies respond to crises pp. 977-977

Patricia A. McAnany and Norman Yoffee

Students caught up in legal impasse at Mexican institute pp. 977-977

Aarón Morelos Gómez, Eduardo Gracia Espino and Juan Carlos García Gallegos

Weighing up the case for telescope site on La Palma pp. 977-977

Francisco Sanchez

Let parents decide pp. 978-979

Alan Handyside

Beyond the image of the tragic genius pp. 980-980

Jascha Hoffman

Calibrating the scales of suffering pp. 981-981

Clive Wynne

Books in brief pp. 982-982

Joanne Baker

Artificial reefs to buffer New York pp. 982-983

Josie Glausiusz

Q&A: John Sims on mathematical art pp. 983-983

Jascha Hoffman

The fragility of interdependency pp. 984-985

Alessandro Vespignani

Lessons in complexity from yeast pp. 985-986

David B. Goldstein and Mohamed A. F. Noor

A ribosome in action pp. 987-988

Susanne Brakmann

Guaranteed randomness pp. 988-989

Valerio Scarani

Genomics of metastasis pp. 989-990

Joe Gray

Ways to raise tadpoles pp. 990-991

Hanna Kokko and Michael Jennions

Fisheye views pp. 990-990

Tim Lincoln

Leena Peltonen-Palotie (1952–2010) pp. 992-992

Gertjan van Ommen

Genome remodelling in a basal-like breast cancer metastasis and xenograft pp. 999-1005

Li Ding, Matthew J. Ellis, Shunqiang Li, David E. Larson, Ken Chen, John W. Wallis, Christopher C. Harris, Michael D. McLellan, Robert S. Fulton, Lucinda L. Fulton, Rachel M. Abbott, Jeremy Hoog, David J. Dooling, Daniel C. Koboldt, Heather Schmidt, Joelle Kalicki, Qunyuan Zhang, Lei Chen, Ling Lin, Michael C. Wendl, Joshua F. McMichael, Vincent J. Magrini, Lisa Cook, Sean D. McGrath, Tammi L. Vickery, Elizabeth Appelbaum, Katherine DeSchryver, Sherri Davies, Therese Guintoli, Li Lin, Robert Crowder, Yu Tao, Jacqueline E. Snider, Scott M. Smith, Adam F. Dukes, Gabriel E. Sanderson, Craig S. Pohl, Kim D. Delehaunty, Catrina C. Fronick, Kimberley A. Pape, Jerry S. Reed, Jody S. Robinson, Jennifer S. Hodges, William Schierding, Nathan D. Dees, Dong Shen, Devin P. Locke, Madeline E. Wiechert, James M. Eldred, Josh B. Peck, Benjamin J. Oberkfell, Justin T. Lolofie, Feiyu Du, Amy E. Hawkins, Michelle D. O’Laughlin, Kelly E. Bernard, Mark Cunningham, Glendoria Elliott, Mark D. Mason, Dominic M. Thompson, Jennifer L. Ivanovich, Paul J. Goodfellow, Charles M. Perou, George M. Weinstock, Rebecca Aft, Mark Watson, Timothy J. Ley, Richard K. Wilson and Elaine R. Mardis

Molecular basis of infrared detection by snakes pp. 1006-1011

Elena O. Gracheva, Nicholas T. Ingolia, Yvonne M. Kelly, Julio F. Cordero-Morales, Gunther Hollopeter, Alexander T. Chesler, Elda E. Sánchez, John C. Perez, Jonathan S. Weissman and David Julius

Real-time tRNA transit on single translating ribosomes at codon resolution pp. 1012-1017

Sotaro Uemura, Colin Echeverría Aitken, Jonas Korlach, Benjamin A. Flusberg, Stephen W. Turner and Joseph D. Puglisi

An image of an exoplanet separated by two diffraction beamwidths from a star pp. 1018-1020

E. Serabyn, D. Mawet and R. Burruss

Random numbers certified by Bell’s theorem pp. 1021-1024

S. Pironio, A. Acín, S. Massar, A. Boyer de la Giroday, D. N. Matsukevich, P. Maunz, S. Olmschenk, D. Hayes, L. Luo, T. A. Manning and C. Monroe

Catastrophic cascade of failures in interdependent networks pp. 1025-1028

Sergey V. Buldyrev, Roni Parshani, Gerald Paul, H. Eugene Stanley and Shlomo Havlin

Phosphate oxygen isotopic evidence for a temperate and biologically active Archaean ocean pp. 1029-1032

Ruth E. Blake, Sae Jung Chang and Aivo Lepland

Périgord black truffle genome uncovers evolutionary origins and mechanisms of symbiosis pp. 1033-1038

Francis Martin, Annegret Kohler, Claude Murat, Raffaella Balestrini, Pedro M. Coutinho, Olivier Jaillon, Barbara Montanini, Emmanuelle Morin, Benjamin Noel, Riccardo Percudani, Bettina Porcel, Andrea Rubini, Antonella Amicucci, Joelle Amselem, Véronique Anthouard, Sergio Arcioni, François Artiguenave, Jean-Marc Aury, Paola Ballario, Angelo Bolchi, Andrea Brenna, Annick Brun, Marc Buée, Brandi Cantarel, Gérard Chevalier, Arnaud Couloux, Corinne Da Silva, France Denoeud, Sébastien Duplessis, Stefano Ghignone, Benoît Hilselberger, Mirco Iotti, Benoît Marçais, Antonietta Mello, Michele Miranda, Giovanni Pacioni, Hadi Quesneville, Claudia Riccioni, Roberta Ruotolo, Richard Splivallo, Vilberto Stocchi, Emilie Tisserant, Arturo Roberto Viscomi, Alessandra Zambonelli, Elisa Zampieri, Bernard Henrissat, Marc-Henri Lebrun, Francesco Paolocci, Paola Bonfante, Simone Ottonello and Patrick Wincker

Dissection of genetically complex traits with extremely large pools of yeast segregants pp. 1039-1042

Ian M. Ehrenreich, Noorossadat Torabi, Yue Jia, Jonathan Kent, Stephen Martis, Joshua A. Shapiro, David Gresham, Amy A. Caudy and Leonid Kruglyak

APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex pp. 1043-1047

Yutaka Shimomura, Dritan Agalliu, Alin Vonica, Victor Luria, Muhammad Wajid, Alessandra Baumer, Serena Belli, Lynn Petukhova, Albert Schinzel, Ali H. Brivanlou, Ben A. Barres and Angela M. Christiano

Functional genomic screen for modulators of ciliogenesis and cilium length pp. 1048-1051

Joon Kim, Ji Eun Lee, Susanne Heynen-Genel, Eigo Suyama, Keiichiro Ono, KiYoung Lee, Trey Ideker, Pedro Aza-Blanc and Joseph G. Gleeson

Therapeutic antibody targeting of individual Notch receptors pp. 1052-1057

Yan Wu, Carol Cain-Hom, Lisa Choy, Thijs J. Hagenbeek, Gladys P. de Leon, Yongmei Chen, David Finkle, Rayna Venook, Xiumin Wu, John Ridgway, Dorreyah Schahin-Reed, Graham J. Dow, Amy Shelton, Scott Stawicki, Ryan J. Watts, Jeff Zhang, Robert Choy, Peter Howard, Lisa Kadyk, Minhong Yan, Jiping Zha, Christopher A. Callahan, Sarah G. Hymowitz and Christian W. Siebel

Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis pp. 1058-1061

Ling Zhang, Xiaoyang Ren, Eckhard Alt, Xiaowen Bai, Shaoyi Huang, Zhengming Xu, Patrick M. Lynch, Mary P. Moyer, Xian-Feng Wen and Xiangwei Wu

Migrastatin analogues target fascin to block tumour metastasis pp. 1062-1066

Lin Chen, Shengyu Yang, Jean Jakoncic, J. Jillian Zhang and Xin-Yun Huang

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles pp. 1067-1070

Mark E. Davis, Jonathan E. Zuckerman, Chung Hang J. Choi, David Seligson, Anthony Tolcher, Christopher A. Alabi, Yun Yen, Jeremy D. Heidel and Antoni Ribas

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis pp. 1071-1076

Rajnish A. Gupta, Nilay Shah, Kevin C. Wang, Jeewon Kim, Hugo M. Horlings, David J. Wong, Miao-Chih Tsai, Tiffany Hung, Pedram Argani, John L. Rinn, Yulei Wang, Pius Brzoska, Benjamin Kong, Rui Li, Robert B. West, Marc J. van de Vijver, Saraswati Sukumar and Howard Y. Chang

Fructose 1,6-bisphosphate aldolase/phosphatase may be an ancestral gluconeogenic enzyme pp. 1077-1081

Rafael F. Say and Georg Fuchs

CpG islands influence chromatin structure via the CpG-binding protein Cfp1 pp. 1082-1086

John P. Thomson, Peter J. Skene, Jim Selfridge, Thomas Clouaire, Jacky Guy, Shaun Webb, Alastair R. W. Kerr, Aimée Deaton, Rob Andrews, Keith D. James, Daniel J. Turner, Robert Illingworth and Adrian Bird

Harmit Malik pp. 1089-1089

Virginia Gewin

A systems approach pp. 1090-1091

Kelly Rae Chi

The frozen hive of her mind pp. 1094-1094

Deborah Walker

2010, volume 464, articles 7290

Fight or flight? pp. 1-1

Fabio Paglieri

Journal club pp. 817-817

C. Oliver Kappe

Telescope arrays give fine view of stars pp. 820-821

Eric Hand

Charities warm to climate pp. 821-821

Laura Thompson Osuri

US seeks to make science free for all pp. 822-823

Declan Butler

What's in a name? Fly world is abuzz pp. 825-825

Rex Dalton

Animals thrive without oxygen at sea bottom pp. 825-825

Janet Fang

Archaeology: Hidden treasure pp. 826-827

Matt Ford

Protein folding: The dark side of proteins pp. 828-829

Jim Schnabel

PhD: routine technical work of sequencing is no substitute pp. 831-831

Yijun Chen

PhD: still necessary for independent research leaders pp. 831-831

Yonghong Li

PhD: time and effort invested foster scientific maturity pp. 831-831

Biswa Prasun Chatterji

Food security requires genetic advances to increase farm yields pp. 831-831

Richard C. Leegood, John R. Evans and Robert T. Furbank

How is the Global Green New Deal going? pp. 832-833

Edward Barbier

Why music moves us pp. 834-835

Daniel J. Levitin

Once more into the animal mind pp. 835-835

Nicky Clayton

Smithsonian on human origins pp. 836-836

Janet Fang

Books in brief pp. 836-836

Joanne Baker

Genetic pot luck pp. 837-838

Justin L. Sonnenburg

Stranger from Siberia pp. 838-839

Terence A. Brown

Exploiting elephants in the room pp. 839-840

Robert C. R. Wootton and Andrew J. deMello

A flourishing of fish forms pp. 840-842

Michael Alfaro and Francesco Santini

Shrouded in a dusty disk pp. 842-843

Edward Guinan

Grazing and nitrous oxide pp. 843-844

Stephen J. Del Grosso

Drug-tolerant insurgents pp. 844-845

Paul Workman and Jon Travers

Quantum spin liquid emerging in two-dimensional correlated Dirac fermions pp. 847-851

Z. Y. Meng, T. C. Lang, S. Wessel, F. F. Assaad and A. Muramatsu

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia pp. 852-857

Marc H. G. P. Raaijmakers, Siddhartha Mukherjee, Shangqin Guo, Siyi Zhang, Tatsuya Kobayashi, Jesse A. Schoonmaker, Benjamin L. Ebert, Fatima Al-Shahrour, Robert P. Hasserjian, Edward O. Scadden, Zinmar Aung, Marc Matza, Matthias Merkenschlager, Charles Lin, Johanna M. Rommens and David. T. Scadden

Zscan4 regulates telomere elongation and genomic stability in ES cells pp. 858-863

Michal Zalzman, Geppino Falco, Lioudmila V. Sharova, Akira Nishiyama, Marshall Thomas, Sung-Lim Lee, Carole A. Stagg, Hien G. Hoang, Hsih-Te Yang, Fred E. Indig, Robert P. Wersto and Minoru S. H. Ko

Molecular mechanism of multivesicular body biogenesis by ESCRT complexes pp. 864-869

Thomas Wollert and James H. Hurley

Infrared images of the transiting disk in the ε Aurigae system pp. 870-872

Brian Kloppenborg, Robert Stencel, John D. Monnier, Gail Schaefer, Ming Zhao, Fabien Baron, Hal McAlister, Theo ten Brummelaar, Xiao Che, Chris Farrington, Ettore Pedretti, P. J. Sallave-Goldfinger, Judit Sturmann, Laszlo Sturmann, Nathalie Thureau, Nils Turner and Sean M. Carroll

‘Memristive’ switches enable ‘stateful’ logic operations via material implication pp. 873-876

Julien Borghetti, Gregory S. Snider, Philip J. Kuekes, J. Joshua Yang, Duncan R. Stewart and R. Stanley Williams

Dislocation nucleation governed softening and maximum strength in nano-twinned metals pp. 877-880

Xiaoyan Li, Yujie Wei, Lei Lu, Ke Lu and Huajian Gao

Grazing-induced reduction of natural nitrous oxide release from continental steppe pp. 881-884

Benjamin Wolf, Xunhua Zheng, Nicolas Brüggemann, Weiwei Chen, Michael Dannenmann, Xingguo Han, Mark A. Sutton, Honghui Wu, Zhisheng Yao and Klaus Butterbach-Bahl

Seismic evidence for widespread western-US deep-crustal deformation caused by extension pp. 885-889

M. P. Moschetti, M. H. Ritzwoller, F. Lin and Y. Yang

Hierarchical group dynamics in pigeon flocks pp. 890-893

Máté Nagy, Zsuzsa Ákos, Dora Biro and Tamás Vicsek

The complete mitochondrial DNA genome of an unknown hominin from southern Siberia pp. 894-897

Johannes Krause, Qiaomei Fu, Jeffrey M. Good, Bence Viola, Michael V. Shunkov, Anatoli P. Derevianko and Svante Pääbo

Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication pp. 898-902

Bridgett M. vonHoldt, John P. Pollinger, Kirk E. Lohmueller, Eunjung Han, Heidi G. Parker, Pascale Quignon, Jeremiah D. Degenhardt, Adam R. Boyko, Dent A. Earl, Adam Auton, Andy Reynolds, Kasia Bryc, Abra Brisbin, James C. Knowles, Dana S. Mosher, Tyrone C. Spady, Abdel Elkahloun, Eli Geffen, Malgorzata Pilot, Wlodzimierz Jedrzejewski, Claudia Greco, Ettore Randi, Danika Bannasch, Alan Wilton, Jeremy Shearman, Marco Musiani, Michelle Cargill, Paul G. Jones, Zuwei Qian, Wei Huang, Zhao-Li Ding, Ya-ping Zhang, Carlos D. Bustamante, Elaine A. Ostrander, John Novembre and Robert K. Wayne

Human memory strength is predicted by theta-frequency phase-locking of single neurons pp. 903-907

Ueli Rutishauser, Ian B. Ross, Adam N. Mamelak and Erin M. Schuman

Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota pp. 908-912

Jan-Hendrik Hehemann, Gaëlle Correc, Tristan Barbeyron, William Helbert, Mirjam Czjzek and Gurvan Michel

MONOPTEROS controls embryonic root initiation by regulating a mobile transcription factor pp. 913-916

Alexandra Schlereth, Barbara Möller, Weilin Liu, Marika Kientz, Jacky Flipse, Eike H. Rademacher, Markus Schmid, Gerd Jürgens and Dolf Weijers

Vascular endothelial growth factor B controls endothelial fatty acid uptake pp. 917-921

Carolina E. Hagberg, Annelie Falkevall, Xun Wang, Erik Larsson, Jenni Huusko, Ingrid Nilsson, Laurens A. van Meeteren, Erik Samen, Li Lu, Maarten Vanwildemeersch, Joakim Klar, Guillem Genove, Kristian Pietras, Sharon Stone-Elander, Lena Claesson-Welsh, Seppo Ylä-Herttuala, Per Lindahl and Ulf Eriksson

Chromatin signature of embryonic pluripotency is established during genome activation pp. 922-926

Nadine L. Vastenhouw, Yong Zhang, Ian G. Woods, Farhad Imam, Aviv Regev, X. Shirley Liu, John Rinn and Alexander F. Schier

Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET pp. 927-931

Toshiyuki Matsui, Danny Leung, Hiroki Miyashita, Irina A. Maksakova, Hitoshi Miyachi, Hiroshi Kimura, Makoto Tachibana, Matthew C. Lorincz and Yoichi Shinkai

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness pp. 932-936

Jun Huang, Veronika I. Zarnitsyna, Baoyu Liu, Lindsay J. Edwards, Ning Jiang, Brian D. Evavold and Cheng Zhu

Double Holliday junctions are intermediates of DNA break repair pp. 937-941

Malgorzata Bzymek, Nathaniel H. Thayer, Steve D. Oh, Nancy Kleckner and Neil Hunter

Erratum: Homotypic fusion of ER membranes requires the dynamin-like GTPase Atlastin pp. 942-942

Genny Orso, Diana Pendin, Song Liu, Jessica Tosetto, Tyler J. Moss, Joseph E. Faust, Massimo Micaroni, Anastasia Egorova, Andrea Martinuzzi, James A. McNew and Andrea Daga

Erratum: A canine distemper virus epidemic in Serengeti lions (Panthera leo) pp. 942-942

Melody E. Roelke-Parker, Linda Munson, Craig Packer, Richard Kock, Sarah Cleaveland, Margaret Carpenter, Stephen J. O’Brien, Andreas Pospischil, Regina Hofmann-Lehmann, Hans Lutz, George L. M. Mwamengele, M. N. Mgasa, G. A. Machange, Brian A. Summers and Max J. G. Appel

Retraction Note: Transient FTY720 treatment promotes immune-mediated clearance of a chronic viral infection pp. 942-942

Mary Premenko-Lanier, Nelson B. Moseley, Sarah T. Pruett, Pablo A. Romagnoli and John D. Altman

Maharashtra by the numbers pp. 944-944

K. S. Jayaraman

Sanjay Singh pp. 944-944

K. S. Jayaraman

The path less travelled pp. 945-945

Andrea Schweitzer

Memory sticks pp. 948-948

Steve Longworth

2010, volume 464, articles 7289

FTO effect on energy demand versus food intake pp. E1-E1

John R. Speakman

Fischer et al. reply pp. E2-E2

Julia Fischer, Linda Koch, Christian Emmerling, Jeanette Vierkotten, Thomas Peters, Jens C. Brüning and Ulrich Rüther

Journal club pp. 653-653

Leonid Padyukov

Geoengineers get the fear pp. 656-656

Jeff Tollefson

River reveals chilling tracks of ancient flood pp. 657-657

Quirin Schiermeier

Space probe set to size up polar ice pp. 658-658

Quirin Schiermeier

Synching Europe's big science facilities pp. 659-659

Cristina Jiménez

Japan plans nuclear power expansion pp. 661-661

David Cyranoski

Rule poses threat to museum bones pp. 662-662

Rex Dalton

Gene flaw found in induced stem cells pp. 663-663

Elie Dolgin

Human genome at ten: Life is complicated pp. 664-667

Erika Check Hayden

Human genome at ten: The human race pp. 668-669

Alison Abbott

World view: Missing weapons pp. 672-672

Daniel Sarewitz

Sceptics and deniers of climate change not to be confused pp. 673-673

Jeremy Kemp, Richard Milne and Dave S. Reay

Fishermen contribute to protection of marine reserves pp. 673-673

Joachim Claudet and Paolo Guidetti

Public database for HIV drug resistance in southern Africa pp. 673-673

Tulio de Oliveira, Robert W. Shafer and Christopher Seebregts

Has the revolution arrived? pp. 674-675

Francis Collins

Multiple personal genomes await pp. 676-677

J. Craig Venter

Point: Hypotheses first pp. 678-678

Robert Weinberg

Counterpoint: Data first pp. 679-679

Todd Golub

A reality check for personalized medicine pp. 680-680

Muin J. Khoury, James Evans and Wylie Burke

Lost curve hits a nerve pp. 681-682

Alison Abbott

How ocean stirring affects climate pp. 681-681

Stefan Rahmstorf

Books in brief pp. 682-682

Joanne Baker

Genome-wide view of mitosis pp. 684-685

Jason R. Swedlow, Cecilia Cotta-Ramusino and Stephen J. Elledge

The surf is up pp. 685-686

Markus Aspelmeyer

Skin regeneration and repair pp. 686-687

Cédric Blanpain

Faint young Sun redux pp. 687-689

James F. Kasting

Fat-free proteins kill parasites pp. 689-690

George A. M. Cross

There is no single p pp. 691-693

Craig R. White

Another dimension for anyons pp. 693-694

Chetan Nayak

Cosmic acceleration confirmed pp. 694-694

Ana Lopes

Joanne Simpson (1923–2010) pp. 696-696

Robert A. Houze

Quantum ground state and single-phonon control of a mechanical resonator pp. 697-703

A. D. O’Connell, M. Hofheinz, M. Ansmann, Radoslaw C. Bialczak, M. Lenander, Erik Lucero, M. Neeley, D. Sank, H. Wang, M. Weides, J. Wenner, John M. Martinis and A. N. Cleland

Origins and functional impact of copy number variation in the human genome pp. 704-712

Donald F. Conrad, Dalila Pinto, Richard Redon, Lars Feuk, Omer Gokcumen, Yujun Zhang, Jan Aerts, T. Daniel Andrews, Chris Barnes, Peter Campbell, Tomas Fitzgerald, Min Hu, Chun Hwa Ihm, Kati Kristiansson, Daniel G. MacArthur, Jeffrey R. MacDonald, Ifejinelo Onyiah, Andy Wing Chun Pang, Sam Robson, Kathy Stirrups, Armand Valsesia, Klaudia Walter, John Wei, Chris Tyler-Smith, Nigel P. Carter, Charles Lee, Stephen W. Scherer and Matthew E. Hurles

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes pp. 721-727

Beate Neumann, Thomas Walter, Jean-Karim Hériché, Jutta Bulkescher, Holger Erfle, Christian Conrad, Phill Rogers, Ina Poser, Michael Held, Urban Liebel, Cihan Cetin, Frank Sieckmann, Gregoire Pau, Rolf Kabbe, Annelie Wünsche, Venkata Satagopam, Michael H. A. Schmitz, Catherine Chapuis, Daniel W. Gerlich, Reinhard Schneider, Roland Eils, Wolfgang Huber, Jan-Michael Peters, Anthony A. Hyman, Richard Durbin, Rainer Pepperkok and Jan Ellenberg

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness pp. 728-732

Julie A. Frearson, Stephen Brand, Stuart P. McElroy, Laura A. T. Cleghorn, Ondrej Smid, Laste Stojanovski, Helen P. Price, M. Lucia S. Guther, Leah S. Torrie, David A. Robinson, Irene Hallyburton, Chidochangu P. Mpamhanga, James A. Brannigan, Anthony J. Wilkinson, Michael Hodgkinson, Raymond Hui, Wei Qiu, Olawale G. Raimi, Daan M. F. van Aalten, Ruth Brenk, Ian H. Gilbert, Kevin D. Read, Alan H. Fairlamb, Michael A. J. Ferguson, Deborah F. Smith and Paul G. Wyatt

Intense star formation within resolved compact regions in a galaxy at z = 2.3 pp. 733-736

A. M. Swinbank, I. Smail, S. Longmore, A. I. Harris, A. J. Baker, C. De Breuck, J. Richard, A. C. Edge, R. J. Ivison, R. Blundell, K. E. K. Coppin, P. Cox, M. Gurwell, L. J. Hainline, M. Krips, A. Lundgren, R. Neri, B. Siana, G. Siringo, D. P. Stark, D. Wilner and J. D. Younger

Generation of electron beams carrying orbital angular momentum pp. 737-739

Masaya Uchida and Akira Tonomura

Identification of Younger Dryas outburst flood path from Lake Agassiz to the Arctic Ocean pp. 740-743

Julian B. Murton, Mark D. Bateman, Scott R. Dallimore, James T. Teller and Zhirong Yang

No climate paradox under the faint early Sun pp. 744-747

Minik T. Rosing, Dennis K. Bird, Norman H. Sleep and Christian J. Bjerrum

Hominins on Flores, Indonesia, by one million years ago pp. 748-752

Adam Brumm, Gitte M. Jensen, Gert D. van den Bergh, Michael J. Morwood, Iwan Kurniawan, Fachroel Aziz and Michael Storey

Curvature in metabolic scaling pp. 753-756

Tom Kolokotrones, Savage Van, Eric J. Deeds and Walter Fontana

The genome of a songbird pp. 757-762

Wesley C. Warren, David F. Clayton, Hans Ellegren, Arthur P. Arnold, LaDeana W. Hillier, Axel Künstner, Steve Searle, Simon White, Albert J. Vilella, Susan Fairley, Andreas Heger, Lesheng Kong, Chris P. Ponting, Erich D. Jarvis, Claudio V. Mello, Pat Minx, Peter Lovell, Tarciso A. F. Velho, Margaret Ferris, Christopher N. Balakrishnan, Saurabh Sinha, Charles Blatti, Sarah E. London, Yun Li, Ya-Chi Lin, Julia George, Jonathan Sweedler, Bruce Southey, Preethi Gunaratne, Michael Watson, Kiwoong Nam, Niclas Backström, Linnea Smeds, Benoit Nabholz, Yuichiro Itoh, Osceola Whitney, Andreas R. Pfenning, Jason Howard, Martin Völker, Bejamin M. Skinner, Darren K. Griffin, Liang Ye, William M. McLaren, Paul Flicek, Victor Quesada, Gloria Velasco, Carlos Lopez-Otin, Xose S. Puente, Tsviya Olender, Doron Lancet, Arian F. A. Smit, Robert Hubley, Miriam K. Konkel, Jerilyn A. Walker, Mark A. Batzer, Wanjun Gu, David D. Pollock, Lin Chen, Ze Cheng, Evan E. Eichler, Jessica Stapley, Jon Slate, Robert Ekblom, Tim Birkhead, Terry Burke, David Burt, Constance Scharff, Iris Adam, Hugues Richard, Marc Sultan, Alexey Soldatov, Hans Lehrach, Scott V. Edwards, Shiaw-Pyng Yang, XiaoChing Li, Tina Graves, Lucinda Fulton, Joanne Nelson, Asif Chinwalla, Shunfeng Hou, Elaine R. Mardis and Richard K. Wilson

Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia pp. 763-767

Torfi Sigurdsson, Kimberly L. Stark, Maria Karayiorgou, Joseph A. Gogos and Joshua A. Gordon

Understanding mechanisms underlying human gene expression variation with RNA sequencing pp. 768-772

Joseph K. Pickrell, John C. Marioni, Athma A. Pai, Jacob F. Degner, Barbara E. Engelhardt, Everlyne Nkadori, Jean-Baptiste Veyrieras, Matthew Stephens, Yoav Gilad and Jonathan K. Pritchard

Transcriptome genetics using second generation sequencing in a Caucasian population pp. 773-777

Stephen B. Montgomery, Micha Sammeth, Maria Gutierrez-Arcelus, Radoslaw P. Lach, Catherine Ingle, James Nisbett, Roderic Guigo and Emmanouil T. Dermitzakis

Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells pp. 778-782

Jason M. Kinchen and Kodi S. Ravichandran

Spatial control of EGF receptor activation by reversible dimerization on living cells pp. 783-787

Inhee Chung, Robert Akita, Richard Vandlen, Derek Toomre, Joseph Schlessinger and Ira Mellman

NINJA connects the co-repressor TOPLESS to jasmonate signalling pp. 788-791

Laurens Pauwels, Gemma Fernández Barbero, Jan Geerinck, Sofie Tilleman, Wim Grunewald, Amparo Cuéllar Pérez, José Manuel Chico, Robin Vanden Bossche, Jared Sewell, Eduardo Gil, Gloria García-Casado, Erwin Witters, Dirk Inzé, Jeff A. Long, Geert De Jaeger, Roberto Solano and Alain Goossens

Phosphorylation of histone H3T6 by PKCβI controls demethylation at histone H3K4 pp. 792-796

Eric Metzger, Axel Imhof, Dharmeshkumar Patel, Philip Kahl, Katrin Hoffmeyer, Nicolaus Friedrichs, Judith M. Müller, Holger Greschik, Jutta Kirfel, Sujuan Ji, Natalia Kunowska, Christian Beisenherz-Huss, Thomas Günther, Reinhard Buettner and Roland Schüle

Keystone takes minority views on board pp. 799-799

Kendall Powell

The method and madness of publishing pp. 799-799

Marwan Azar

Gatekeeper's burden pp. 800-801

Kendall Powell

The balance scale pp. 804-804

Shelly Li

2010, volume 464, articles 7288

Journal club pp. 469-469

Michael Brockhurst

Fossil finger points to new human species pp. 472-472

Rex Dalton

Teams set for first taste of Antarctic lakes pp. 472-473

Quirin Schiermeier

Fixing a grant system in crisis pp. 474-475

Richard Van Noorden and Geoff Brumfiel

China boosts African research links pp. 477-477

David Cyranoski

Turkish law could cripple bioscience pp. 478-478

Alison Abbott

US health bill promises changes for biomedical researchers pp. 479-479

Meredith Wadman

Ageing: Much ado about ageing pp. 480-481

Heidi Ledford

Physics: The Large Human Collider pp. 482-484

Zeeya Merali

Industry in academia: ethical frameworks would clarify links pp. 486-486

Annalee Yassi, Shafik Dharamsi and Jerry Spiegel

Industry in academia: transparency alone is not enough pp. 486-486

Theodore Lawry

Structural changes to aid science in developing countries pp. 486-486

Mauricio Terrones

European routes to reinventing Internet technology pp. 486-486

Jon Crowcroft and Eiko Yoneki

Issues raised by use of ethnic-group names in genome study pp. 487-487

Carina Schlebusch

Questions over the scientific basis of epigenome project pp. 487-487

Mark Ptashne, Oliver Hobert and Eric Davidson

Let's make science metrics more scientific pp. 488-489

Julia Lane

How do morals change? pp. 490-490

Paul Bloom

Exposing the longevity business pp. 491-492

S. Jay Olshansky

Learning from history's trials pp. 492-492

Jon Christensen

Matisse's methods revealed pp. 493-494

Josie Glausiusz

Evidence for RNA origins pp. 494-494

Tim Harris

Books in brief pp. 494-494

Joanne Baker

The hidden cost of transpiration pp. 495-496

David J. Beerling and Peter J. Franks

Reconfigurable colloids pp. 496-497

Michael J. Solomon

Liquid marbles pp. 497-497

Andrew Mitchinson

Plumbing the heart pp. 498-499

Paul Riley

A warm response by soils pp. 499-500

Pete Smith and Changming Fang

NO connection with methane pp. 500-501

Ronald S. Oremland

William E. Gordon (1918–2010) pp. 502-502

Donald T. Farley

Ageing pp. 503-503

Marie-Thérèse Heemels

The genetics of ageing pp. 504-512

Cynthia J. Kenyon

Lessons on longevity from budding yeast pp. 513-519

Matt Kaeberlein

Linking functional decline of telomeres, mitochondria and stem cells during ageing pp. 520-528

Ergün Sahin and Ronald A. DePinho

Neural mechanisms of ageing and cognitive decline pp. 529-535

Nicholas A. Bishop, Tao Lu and Bruce A. Yankner

Biodemography of human ageing pp. 536-542

James W. Vaupel

Nitrite-driven anaerobic methane oxidation by oxygenic bacteria pp. 543-548

Katharina F. Ettwig, Margaret K. Butler, Denis Le Paslier, Eric Pelletier, Sophie Mangenot, Marcel M. M. Kuypers, Frank Schreiber, Bas E. Dutilh, Johannes Zedelius, Dirk de Beer, Jolein Gloerich, Hans J. C. T. Wessels, Theo van Alen, Francisca Luesken, Ming L. Wu, Katinka T. van de Pas-Schoonen, Huub J. M. Op den Camp, Eva M. Janssen-Megens, Kees-Jan Francoijs, Henk Stunnenberg, Jean Weissenbach, Mike S. M. Jetten and Marc Strous

Coronary arteries form by developmental reprogramming of venous cells pp. 549-553

Kristy Red-Horse, Hiroo Ueno, Irving L. Weissman and Mark A. Krasnow

Neurogenic radial glia in the outer subventricular zone of human neocortex pp. 554-561

David V. Hansen, Jan H. Lui, Philip R. L. Parker and Arnold R. Kriegstein

Escape of about five per cent of Lyman-α photons from high-redshift star-forming galaxies pp. 562-565

Matthew Hayes, Göran Östlin, Daniel Schaerer, J. Miguel Mas-Hesse, Claus Leitherer, Hakim Atek, Daniel Kunth, Anne Verhamme, Stéphane de Barros and Jens Melinder

Anomalous structure in the single particle spectrum of the fractional quantum Hall effect pp. 566-570

O. E. Dial, R. C. Ashoori, L. N. Pfeiffer and K. W. West

Atom-by-atom structural and chemical analysis by annular dark-field electron microscopy pp. 571-574

Ondrej L. Krivanek, Matthew F. Chisholm, Valeria Nicolosi, Timothy J. Pennycook, George J. Corbin, Niklas Dellby, Matthew F. Murfitt, Christopher S. Own, Zoltan S. Szilagyi, Mark P. Oxley, Sokrates T. Pantelides and Stephen J. Pennycook

Lock and key colloids pp. 575-578

S. Sacanna, W. T. M. Irvine, P. M. Chaikin and D. J. Pine

Temperature-associated increases in the global soil respiration record pp. 579-582

Ben Bond-Lamberty and Allison Thomson

A computational model of teeth and the developmental origins of morphological variation pp. 583-586

Isaac Salazar-Ciudad and Jukka Jernvall

Whole-genome resequencing reveals loci under selection during chicken domestication pp. 587-591

Carl-Johan Rubin, Michael C. Zody, Jonas Eriksson, Jennifer R. S. Meadows, Ellen Sherwood, Matthew T. Webster, Lin Jiang, Max Ingman, Ted Sharpe, Sojeong Ka, Finn Hallböök, Francois Besnier, Örjan Carlborg, Bertrand Bed’hom, Michèle Tixier-Boichard, Per Jensen, Paul Siegel, Kerstin Lindblad-Toh and Leif Andersson

The dynamic genome of Hydra pp. 592-596

Jarrod A. Chapman, Ewen F. Kirkness, Oleg Simakov, Steven E. Hampson, Therese Mitros, Thomas Weinmaier, Thomas Rattei, Prakash G. Balasubramanian, Jon Borman, Dana Busam, Kathryn Disbennett, Cynthia Pfannkoch, Nadezhda Sumin, Granger G. Sutton, Lakshmi Devi Viswanathan, Brian Walenz, David M. Goodstein, Uffe Hellsten, Takeshi Kawashima, Simon E. Prochnik, Nicholas H. Putnam, Shengquiang Shu, Bruce Blumberg, Catherine E. Dana, Lydia Gee, Dennis F. Kibler, Lee Law, Dirk Lindgens, Daniel E. Martinez, Jisong Peng, Philip A. Wigge, Bianca Bertulat, Corina Guder, Yukio Nakamura, Suat Ozbek, Hiroshi Watanabe, Konstantin Khalturin, Georg Hemmrich, André Franke, René Augustin, Sebastian Fraune, Eisuke Hayakawa, Shiho Hayakawa, Mamiko Hirose, Jung Shan Hwang, Kazuho Ikeo, Chiemi Nishimiya-Fujisawa, Atshushi Ogura, Toshio Takahashi, Patrick R. H. Steinmetz, Xiaoming Zhang, Roland Aufschnaiter, Marie-Kristin Eder, Anne-Kathrin Gorny, Willi Salvenmoser, Alysha M. Heimberg, Benjamin M. Wheeler, Kevin J. Peterson, Angelika Böttger, Patrick Tischler, Alexander Wolf, Takashi Gojobori, Karin A. Remington, Robert L. Strausberg, J. Craig Venter, Ulrich Technau, Bert Hobmayer, Thomas C. G. Bosch, Thomas W. Holstein, Toshitaka Fujisawa, Hans R. Bode, Charles N. David, Daniel S. Rokhsar and Robert E. Steele

Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception pp. 597-600

Kyeongjin Kang, Stefan R. Pulver, Vincent C. Panzano, Elaine C. Chang, Leslie C. Griffith, Douglas L. Theobald and Paul A. Garrity

Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes pp. 601-605

Kazu Kikuchi, Jennifer E. Holdway, Andreas A. Werdich, Ryan M. Anderson, Yi Fang, Gregory F. Egnaczyk, Todd Evans, Calum A. MacRae, Didier Y. R. Stainier and Kenneth D. Poss

Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation pp. 606-609

Chris Jopling, Eduard Sleep, Marina Raya, Mercè Martí, Angel Raya and Juan Carlos Izpisúa Belmonte

Heteroplasmic mitochondrial DNA mutations in normal and tumour cells pp. 610-614

Yiping He, Jian Wu, Devin C. Dressman, Christine Iacobuzio-Donahue, Sanford D. Markowitz, Victor E. Velculescu, Luis A. Diaz, Kenneth W. Kinzler, Bert Vogelstein and Nickolas Papadopoulos

Haploid plants produced by centromere-mediated genome elimination pp. 615-618

Maruthachalam Ravi and Simon W. L. Chan

Transcriptional control of preadipocyte determination by Zfp423 pp. 619-623

Rana K. Gupta, Zoltan Arany, Patrick Seale, Rina J. Mepani, Li Ye, Heather M. Conroe, Yang A. Roby, Heather Kulaga, Randall R. Reed and Bruce M. Spiegelman

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses pp. 624-627

Delin Chen, Jing Shan, Wei-Guo Zhu, Jun Qin and Wei Gu

Control of female gamete formation by a small RNA pathway in Arabidopsis pp. 628-632

Vianey Olmedo-Monfil, Noé Durán-Figueroa, Mario Arteaga-Vázquez, Edgar Demesa-Arévalo, Daphné Autran, Daniel Grimanelli, R. Keith Slotkin, Robert A. Martienssen and Jean-Philippe Vielle-Calzada

Cheng-An Lin pp. 635-635

Virginia Gewin

Golden opportunity pp. 636-637

Karen Kaplan

The drained world pp. 640-640

Ian Watson

2010, volume 464, articles 7287

Journal club pp. 329-329

Eran Segal

Sex bias blights drug studies pp. 332-333

Erika Check Hayden

Wildlife service plans for a warmer world pp. 332-332

Janet Fang

Hunt for the sterile neutrino heats up pp. 334-335

Eric Hand

Hobbit origins pushed back pp. 335-335

Rex Dalton

China debates university reform pp. 336-337

David Cyranoski

Cash crisis looms for vaccine drive pp. 338-338

Declan Butler

Science in court: Head case pp. 340-342

Virginia Hughes

Science in court: The fine print pp. 344-346

Laura Spinney

Science in court: DNA's identity crisis pp. 347-348

Natasha Gilbert

World view: What can little Europe do? pp. 349-349

Colin Macilwain

Tsunami: unexpected blow foils flawless warning system pp. 350-350

Dale Dominey-Howes and James Goff

Tsunami: time for models to be tested in warning centres pp. 350-350

Delilah H. A. Al Khudhairy and Alessandro Annunziato

Researchers' petition aims to simplify European funding pp. 350-350

Olivier Küttel and Sabine Herlitschka

Smoking out the big tobacco-users — and they're not in China pp. 350-350

Jie-Yu Chuang

Waterfall is the clue to a case of mistaken identity pp. 350-350

William R. Dickinson

Making forensic science more scientific pp. 351-351

Peter Neufeld and Barry Scheck

Tales from the climate-change crossroads pp. 352-353

Roger Pielke

A misguided attack on evolution pp. 353-354

Massimo Pigliucci

A macromolecular history pp. 354-354

Richard Jones

Q&A: Hervé This on flavour and perception pp. 355-355

Michael White

Expanding versatility pp. 357-357

Martin Moskovits

Inhibitors that activate pp. 358-359

Karen Cichowski and Pasi A. Jänne

First generation of quasars pp. 359-360

Giulia Stratta

Closing in on an oral treatment pp. 360-361

Roland Martin

Golden ratio seen in a magnet pp. 362-363

Ian Affleck

A lower bar for senescence pp. 363-364

Manuel Serrano

Pregnant fathers in charge pp. 364-365

Anders Berglund

Actin filaments up against a wall pp. 365-366

Cécile Sykes and Julie Plastino

Pores off the peg pp. 366-366

Neil Withers

Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium pp. 367-373

Li-Jun Ma, H. Charlotte van der Does, Katherine A. Borkovich, Jeffrey J. Coleman, Marie-Josée Daboussi, Antonio Di Pietro, Marie Dufresne, Michael Freitag, Manfred Grabherr, Bernard Henrissat, Petra M. Houterman, Seogchan Kang, Won-Bo Shim, Charles Woloshuk, Xiaohui Xie, Jin-Rong Xu, John Antoniw, Scott E. Baker, Burton H. Bluhm, Andrew Breakspear, Daren W. Brown, Robert A. E. Butchko, Sinead Chapman, Richard Coulson, Pedro M. Coutinho, Etienne G. J. Danchin, Andrew Diener, Liane R. Gale, Donald M. Gardiner, Stephen Goff, Kim E. Hammond-Kosack, Karen Hilburn, Aurélie Hua- Van, Wilfried Jonkers, Kemal Kazan, Chinnappa D. Kodira, Michael Koehrsen, Lokesh Kumar, Yong-Hwan Lee, Liande Li, John M. Manners, Diego Miranda-Saavedra, Mala Mukherjee, Gyungsoon Park, Jongsun Park, Sook-Young Park, Robert H. Proctor, Aviv Regev, M. Carmen Ruiz-Roldan, Divya Sain, Sharadha Sakthikumar, Sean Sykes, David C. Schwartz, B. Gillian Turgeon, Ilan Wapinski, Olen Yoder, Sarah Young, Qiandong Zeng, Shiguo Zhou, James Galagan, Christina A. Cuomo, H. Corby Kistler and Martijn Rep

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence pp. 374-379

Hui-Kuan Lin, Zhenbang Chen, Guocan Wang, Caterina Nardella, Szu-Wei Lee, Chan-Hsin Chan, Wei-Lei Yang, Jing Wang, Ainara Egia, Keiichi I. Nakayama, Carlos Cordon-Cardo, Julie Teruya-Feldstein and Pier Paolo Pandolfi

Dust-free quasars in the early Universe pp. 380-383

Linhua Jiang, Xiaohui Fan, W. N. Brandt, Chris L. Carilli, Eiichi Egami, Dean C. Hines, Jaron D. Kurk, Gordon T. Richards, Yue Shen, Michael A. Strauss, Marianne Vestergaard and Fabian Walter

A transiting giant planet with a temperature between 250 K and 430 K pp. 384-387

H. J. Deeg, C. Moutou, A. Erikson, Sz. Csizmadia, B. Tingley, P. Barge, H. Bruntt, M. Havel, S. Aigrain, J. M. Almenara, R. Alonso, M. Auvergne, A. Baglin, M. Barbieri, W. Benz, A. S. Bonomo, P. Bordé, F. Bouchy, J. Cabrera, L. Carone, S. Carpano, D. Ciardi, M. Deleuil, R. Dvorak, S. Ferraz-Mello, M. Fridlund, D. Gandolfi, J.-C. Gazzano, M. Gillon, P. Gondoin, E. Guenther, T. Guillot, R. den Hartog, A. Hatzes, M. Hidas, G. Hébrard, L. Jorda, P. Kabath, H. Lammer, A. Léger, T. Lister, A. Llebaria, C. Lovis, M. Mayor, T. Mazeh, M. Ollivier, M. Pätzold, F. Pepe, F. Pont, D. Queloz, M. Rabus, H. Rauer, D. Rouan, B. Samuel, J. Schneider, A. Shporer, B. Stecklum, R. Street, S. Udry, J. Weingrill and G. Wuchterl

A trapped single ion inside a Bose–Einstein condensate pp. 388-391

Christoph Zipkes, Stefan Palzer, Carlo Sias and Michael Köhl

Shell-isolated nanoparticle-enhanced Raman spectroscopy pp. 392-395

Jian Feng Li, Yi Fan Huang, Yong Ding, Zhi Lin Yang, Song Bo Li, Xiao Shun Zhou, Feng Ru Fan, Wei Zhang, Zhi You Zhou, Wu De Yin, Bin Ren, Zhong Lin Wang and Zhong Qun Tian

Isotope fractionation in silicate melts by thermal diffusion pp. 396-400

F. Huang, P. Chakraborty, C. C. Lundstrom, C. Holmden, J. J. G. Glessner, S. W. Kieffer and C. E. Lesher

Post-copulatory sexual selection and sexual conflict in the evolution of male pregnancy pp. 401-404

Kimberly A. Paczolt and Adam G. Jones

ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C pp. 405-408

Jacques Fellay, Alexander J. Thompson, Dongliang Ge, Curtis E. Gumbs, Thomas J. Urban, Kevin V. Shianna, Latasha D. Little, Ping Qiu, Arthur H. Bertelsen, Mark Watson, Amelia Warner, Andrew J. Muir, Clifford Brass, Janice Albrecht, Mark Sulkowski, John G. McHutchison and David B. Goldstein

Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice pp. 409-412

Axel Visel, Yiwen Zhu, Dalit May, Veena Afzal, Elaine Gong, Catia Attanasio, Matthew J. Blow, Jonathan C. Cohen, Edward M. Rubin and Len A. Pennacchio

An intrinsic vasopressin system in the olfactory bulb is involved in social recognition pp. 413-417

Vicky A. Tobin, Hirofumi Hashimoto, Douglas W. Wacker, Yuki Takayanagi, Kristina Langnaese, Celine Caquineau, Julia Noack, Rainer Landgraf, Tatsushi Onaka, Gareth Leng, Simone L. Meddle, Mario Engelmann and Mike Ludwig

Differential innate immune signalling via Ca2+ sensor protein kinases pp. 418-422

Marie Boudsocq, Matthew R. Willmann, Matthew McCormack, Horim Lee, Libo Shan, Ping He, Jenifer Bush, Shu-Hua Cheng and Jen Sheen

Control of Arabidopsis apical–basal embryo polarity by antagonistic transcription factors pp. 423-426

Zachery R. Smith and Jeff A. Long

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF pp. 427-430

Poulikos I. Poulikakos, Chao Zhang, Gideon Bollag, Kevan M. Shokat and Neal Rosen

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth pp. 431-435

Georgia Hatzivassiliou, Kyung Song, Ivana Yen, Barbara J. Brandhuber, Daniel J. Anderson, Ryan Alvarado, Mary J. C. Ludlam, David Stokoe, Susan L. Gloor, Guy Vigers, Tony Morales, Ignacio Aliagas, Bonnie Liu, Steve Sideris, Klaus P. Hoeflich, Bijay S. Jaiswal, Somasekar Seshagiri, Hartmut Koeppen, Marcia Belvin, Lori S. Friedman and Shiva Malek

Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal pp. 436-440

Rocio Sotillo, Juan-Manuel Schvartzman, Nicholas D. Socci and Robert Benezra

Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome pp. 441-444

Heinz Neumann, Kaihang Wang, Lloyd Davis, Maria Garcia-Alai and Jason W. Chin

Structural basis for receptor recognition of vitamin-B12–intrinsic factor complexes pp. 445-448

Christian Brix Folsted Andersen, Mette Madsen, Tina Storm, Søren K. Moestrup and Gregers R. Andersen

Mara Mather pp. 451-451

Virginia Gewin

Beauty contest pp. 452-453

Alaina Levine

Expectancy theory pp. 456-456

Ananyo Bhattacharya

2010, volume 464, articles 7286

Journal club pp. 145-145

Markus Reichstein

Outcry over scientists' dismissal pp. 148-149

Rex Dalton

Climate e-mail rerun pp. 149-149

Jeff Tollefson

Old rocks drown dry Moon theory pp. 150-151

Eric Hand

Biology thinks big to stay cuts pp. 151-151

Alison Abbott

Science survives Canadian budget pp. 153-153

Nicola Jones

Plant biologists fear for cress project pp. 154-154

Heidi Ledford

Securing UK science pp. 155-155

Richard Van Noorden

A rescue plan for UK physics funding pp. 155-155

Geoff Brumfiel

Nuclear weapons physics: Welcome to the Atomic Weapons Establishment pp. 156-157

Geoff Brumfiel

Bioengineering: What to make with DNA origami pp. 158-159

Katharine Sanderson

Science and Mexico are the losers in institute politics pp. 160-160

Harold W. Kroto, Pulikel M. Ajayan, Anthony K. Cheetham, Mildred S. Dresselhaus, Morinobu Endo, Alan L. Mackay and Ljubisa R. Radovic

Colour-coded targets would help clarify biodiversity priorities pp. 160-160

Anne Larigauderie, Georgina M. Mace and Harold A. Mooney

Barriers to carbon capture and storage may not be obvious pp. 160-160

Frances Bowen

Accelerating HIV vaccine development pp. 161-162

Wayne C. Koff

Evolution of the motor car pp. 163-163

Daniel Sperling

Space to contemplate pp. 164-165

Joanne Baker

Genius who shuns the limelight pp. 165-165

George Szpiro

Q&A: Peter Hessler on urbanization in China pp. 166-166

Jane Qiu

When four become one pp. 167-168

Robert Craigie

Wider role for airborne chlorine pp. 168-169

Roland von Glasow

Sticking to sugars pp. 169-170

Anthony P. Davis

An avian sexual revolution pp. 171-172

Lindsey A. Barske and Blanche Capel

Grass and the X factor pp. 172-172

Tim Lincoln

Gravity tested on cosmic scales pp. 172-173

J. Anthony Tyson

Exotic matter pp. 175-175

Dan Csontos

The enigma of supersolidity pp. 176-182

Sebastien Balibar

Superconductivity gets an iron boost pp. 183-186

Igor I. Mazin

Non-Abelian states of matter pp. 187-193

Ady Stern

The birth of topological insulators pp. 194-198

Joel E. Moore

Spin liquids in frustrated magnets pp. 199-208

Leon Balents

Electron liquids and solids in one dimension pp. 209-216

Vikram V. Deshpande, Marc Bockrath, Leonid I. Glazman and Amir Yacoby

Targeting early infection to prevent HIV-1 mucosal transmission pp. 217-223

Ashley T. Haase

Immunology and the elusive AIDS vaccine pp. 224-231

Herbert W. Virgin and Bruce D. Walker

Retroviral intasome assembly and inhibition of DNA strand transfer pp. 232-236

Stephen Hare, Saumya Shree Gupta, Eugene Valkov, Alan Engelman and Peter Cherepanov

Somatic sex identity is cell autonomous in the chicken pp. 237-242

D. Zhao, D. McBride, S. Nandi, H. A. McQueen, M. J. McGrew, P. M. Hocking, P. D. Lewis, H. M. Sang and M. Clinton

Systems survey of endocytosis by multiparametric image analysis pp. 243-249

Claudio Collinet, Martin Stöter, Charles R. Bradshaw, Nikolay Samusik, Jochen C. Rink, Denise Kenski, Bianca Habermann, Frank Buchholz, Robert Henschel, Matthias S. Mueller, Wolfgang E. Nagel, Eugenio Fava, Yannis Kalaidzidis and Marino Zerial

The primary transcriptome of the major human pathogen Helicobacter pylori pp. 250-255

Cynthia M. Sharma, Steve Hoffmann, Fabien Darfeuille, Jérémy Reignier, Sven Findeiß, Alexandra Sittka, Sandrine Chabas, Kristin Reiche, Jörg Hackermüller, Richard Reinhardt, Peter F. Stadler and Jörg Vogel

Confirmation of general relativity on large scales from weak lensing and galaxy velocities pp. 256-258

Reinabelle Reyes, Rachel Mandelbaum, Uros Seljak, Tobias Baldauf, James E. Gunn, Lucas Lombriser and Robert E. Smith

Deviations from a uniform period spacing of gravity modes in a massive star pp. 259-261

Pieter Degroote, Conny Aerts, Annie Baglin, Andrea Miglio, Maryline Briquet, Arlette Noels, Ewa Niemczura, Josefina Montalban, Steven Bloemen, Raquel Oreiro, Maja Vučković, Kristof Smolders, Michel Auvergne, Frederic Baudin, Claude Catala and Eric Michel

Transmission of electrical signals by spin-wave interconversion in a magnetic insulator pp. 262-266

Y. Kajiwara, K. Harii, S. Takahashi, J. Ohe, K. Uchida, M. Mizuguchi, H. Umezawa, H. Kawai, K. Ando, K. Takanashi, S. Maekawa and E. Saitoh

Tunable polymer multi-shape memory effect pp. 267-270

Tao Xie

A large atomic chlorine source inferred from mid-continental reactive nitrogen chemistry pp. 271-274

Joel A. Thornton, James P. Kercher, Theran P. Riedel, Nicholas L. Wagner, Julie Cozic, John S. Holloway, William P. Dubé, Glenn M. Wolfe, Patricia K. Quinn, Ann M. Middlebrook, Becky Alexander and Steven S. Brown

Antagonistic coevolution accelerates molecular evolution pp. 275-278

Steve Paterson, Tom Vogwill, Angus Buckling, Rebecca Benmayor, Andrew J. Spiers, Nicholas R. Thomson, Mike Quail, Frances Smith, Danielle Walker, Ben Libberton, Andrew Fenton, Neil Hall and Michael A. Brockhurst

Compensatory evolution in mitochondrial tRNAs navigates valleys of low fitness pp. 279-282

Margarita V. Meer, Alexey S. Kondrashov, Yael Artzy-Randrup and Fyodor A. Kondrashov

Sister chromosome pairing maintains heterozygosity in parthenogenetic lizards pp. 283-286

Aracely A. Lutes, William B. Neaves, Diana P. Baumann, Winfried Wiegraebe and Peter Baumann

Systematic genetic analysis of muscle morphogenesis and function in Drosophila pp. 287-291

Frank Schnorrer, Cornelia Schönbauer, Christoph C. H. Langer, Georg Dietzl, Maria Novatchkova, Katharina Schernhuber, Michaela Fellner, Anna Azaryan, Martin Radolf, Alexander Stark, Krystyna Keleman and Barry J. Dickson

Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients pp. 292-296

Suneet Agarwal, Yuin-Han Loh, Erin M. McLoughlin, Junjiu Huang, In-Hyun Park, Justine D. Miller, Hongguang Huo, Maja Okuka, Rosana Maria dos Reis, Sabine Loewer, Huck-Hui Ng, David L. Keefe, Frederick D. Goldman, Aloysius J. Klingelhutz, Lin Liu and George Q. Daley

The cells and peripheral representation of sodium taste in mice pp. 297-301

Jayaram Chandrashekar, Christina Kuhn, Yuki Oka, David A. Yarmolinsky, Edith Hummler, Nicholas J. P. Ryba and Charles S. Zuker

B-cell-derived lymphotoxin promotes castration-resistant prostate cancer pp. 302-305

Massimo Ammirante, Jun-Li Luo, Sergei Grivennikov, Sergei Nedospasov and Michael Karin

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells pp. 306-310

Diego Pasini, Paul A. C. Cloos, Julian Walfridsson, Linda Olsson, John-Paul Bukowski, Jens V. Johansen, Mads Bak, Niels Tommerup, Juri Rappsilber and Kristian Helin

Speak up pp. 312-312

Peter Fiske

Lidia Brito pp. 313-313

Virginia Gewin

The Omniplus Ultra pp. 316-316

Paul Di Filippo

2010, volume 464, articles 7285

Journal club pp. 11-11

Robert Lucas

Model response to Chile quake? pp. 14-14

Quirin Schiermeier

Unmanned planes take wing for science pp. 14-15

Jeff Tollefson

University rankings smarten up pp. 16-17

Declan Butler

Fat rats skew research results pp. 19-19

Daniel Cressey

The labours of Fotis Kafatos pp. 20-20

Natasha Gilbert

Weapons labs to thrive as Obama trims nukes pp. 21-21

Jeff Tollefson

Chinese bioscience: The sequence factory pp. 22-24

David Cyranoski

Non-proliferation: Borderline detection pp. 26-27

Sharon Weinberger

World view: Curing climate backlash pp. 28-28

Daniel Sarewitz

South Africa: telescopes raise the nation's sights pp. 30-30

Patricia Whitelock

South Africa: aiming to be premier global astronomy hub pp. 30-30

Rob Adam

South Africa: big science should stay on the agenda pp. 30-30

Steven L. Chown

Myth-busting about first mass-produced human cell line pp. 30-30

Leonard Hayflick

Spring awakening planned for Mars rover Spirit pp. 31-31

Steve Squyres

Esaki diode is still a radio star, half a century on pp. 31-31

Leo Esaki, Yasuhiko Arakawa and Masatoshi Kitamura

Foundations could allocate money more productively pp. 31-31

Ingrid Eisenstadter

Stop laser uranium enrichment pp. 32-33

Francis Slakey and Linda R. Cohen

Is there anybody out there? pp. 34-34

Chris McKay

Why you shouldn't always follow the crowd pp. 35-35

Mark Buchanan

Autism and animal insight pp. 35-35

Wes Jamison and Clive Wynne

Q&A: Joanna Cole on writing science books for kids pp. 36-36

Nicola Jones

The treacherous scent of a human pp. 37-38

Walter S. Leal

When mica and water meet pp. 38-39

Joost W. M. Frenken and Tjerk H. Oosterkamp

Hydrocarbon superconductors pp. 39-41

Matthew J. Rosseinsky and Kosmas Prassides

Culprits with evolutionary ties pp. 41-42

Carolyn S. Calfee and Michael A. Matthay

Mind the helical crack pp. 42-43

Markus J. Buehler and Zhiping Xu

Time for teeth pp. 43-43

Sadaf Shadan

Marshall Nirenberg (1927–2010) pp. 44-44

C. Thomas Caskey

Quantum computers pp. 45-53

T. D. Ladd, F. Jelezko, R. Laflamme, Y. Nakamura, C. Monroe and J. L. O’Brien

Remarkably ancient balanced polymorphisms in a multi-locus gene network pp. 54-58

Chris Todd Hittinger, Paula Gonçalves, José Paulo Sampaio, Jim Dover, Mark Johnston and Antonis Rokas

A human gut microbial gene catalogue established by metagenomic sequencing pp. 59-65

Junjie Qin, Ruiqiang Li, Jeroen Raes, Manimozhiyan Arumugam, Kristoffer Solvsten Burgdorf, Chaysavanh Manichanh, Trine Nielsen, Nicolas Pons, Florence Levenez, Takuji Yamada, Daniel R. Mende, Junhua Li, Junming Xu, Shaochuan Li, Dongfang Li, Jianjun Cao, Bo Wang, Huiqing Liang, Huisong Zheng, Yinlong Xie, Julien Tap, Patricia Lepage, Marcelo Bertalan, Jean-Michel Batto, Torben Hansen, Denis Le Paslier, Allan Linneberg, H. Bjørn Nielsen, Eric Pelletier, Pierre Renault, Thomas Sicheritz-Ponten, Keith Turner, Hongmei Zhu, Chang Yu, Shengting Li, Min Jian, Yan Zhou, Yingrui Li, Xiuqing Zhang, Songgang Li, Nan Qin, Huanming Yang, Jian Wang, Søren Brunak, Joel Doré, Francisco Guarner, Karsten Kristiansen, Oluf Pedersen, Julian Parkhill, Jean Weissenbach, Peer Bork, S. Dusko Ehrlich and Jun Wang

Odorant reception in the malaria mosquito Anopheles gambiae pp. 66-71

Allison F. Carey, Guirong Wang, Chih-Ying Su, Laurence J. Zwiebel and John R. Carlson

Linking dwarf galaxies to halo building blocks with the most metal-poor star in Sculptor pp. 72-75

Anna Frebel, Evan N. Kirby and Joshua D. Simon

Superconductivity in alkali-metal-doped picene pp. 76-79

Ryoji Mitsuhashi, Yuta Suzuki, Yusuke Yamanari, Hiroki Mitamura, Takashi Kambe, Naoshi Ikeda, Hideki Okamoto, Akihiko Fujiwara, Minoru Yamaji, Naoko Kawasaki, Yutaka Maniwa and Yoshihiro Kubozono

Reinventing germanium avalanche photodetector for nanophotonic on-chip optical interconnects pp. 80-84

Solomon Assefa, Fengnian Xia and Yurii A. Vlasov

Helical crack-front instability in mixed-mode fracture pp. 85-89

Antonio J. Pons and Alain Karma

Metabolic streamlining in an open-ocean nitrogen-fixing cyanobacterium pp. 90-94

H. James Tripp, Shellie R. Bench, Kendra A. Turk, Rachel A. Foster, Brian A. Desany, Faheem Niazi, Jason P. Affourtit and Jonathan P. Zehr

Ecologically distinct dinosaurian sister group shows early diversification of Ornithodira pp. 95-98

Sterling J. Nesbitt, Christian A. Sidor, Randall B. Irmis, Kenneth D. Angielczyk, Roger M. H. Smith and Linda A. Tsuji

Changes in Hox genes’ structure and function during the evolution of the squamate body plan pp. 99-103

Nicolas Di-Poï, Juan I. Montoya-Burgos, Hilary Miller, Olivier Pourquié, Michel C. Milinkovitch and Denis Duboule

Circulating mitochondrial DAMPs cause inflammatory responses to injury pp. 104-107

Qin Zhang, Mustafa Raoof, Yu Chen, Yuka Sumi, Tolga Sursal, Wolfgang Junger, Karim Brohi, Kiyoshi Itagaki and Carl J. Hauser

Haematopoietic stem cells derive directly from aortic endothelium during development pp. 108-111

Julien Y. Bertrand, Neil C. Chi, Buyung Santoso, Shutian Teng, Didier Y. R. Stainier and David Traver

Blood stem cells emerge from aortic endothelium by a novel type of cell transition pp. 112-115

Karima Kissa and Philippe Herbomel

Clinical judgement pp. 115-115

Marwan Azar

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium pp. 116-120

Jean-Charles Boisset, Wiggert van Cappellen, Charlotte Andrieu-Soler, Niels Galjart, Elaine Dzierzak and Catherine Robin

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation pp. 121-125

Matthew D. Hirschey, Tadahiro Shimazu, Eric Goetzman, Enxuan Jing, Bjoern Schwer, David B. Lombard, Carrie A. Grueter, Charles Harris, Sudha Biddinger, Olga R. Ilkayeva, Robert D. Stevens, Yu Li, Asish K. Saha, Neil B. Ruderman, James R. Bain, Christopher B. Newgard, Robert V. Farese, Frederick W. Alt, C. Ronald Kahn and Eric Verdin

Erratum: Opposing microRNA families regulate self-renewal in mouse embryonic stem cells pp. 126-126

Collin Melton, Robert L. Judson and Robert Blelloch

Cultivating new talent pp. 128-130

Virginia Gewin

Transitions pp. 132-132

Dan Erlanson