Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

Xu Zhang, Wenlin Ren, Paul DeCaen, Chuangye Yan, Xiao Tao, Lin Tang, Jingjing Wang, Kazuya Hasegawa, Takashi Kumasaka, Jianhua He, Jiawei Wang, David E. Clapham and Nieng Yan ()
Additional contact information
Xu Zhang: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Wenlin Ren: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Paul DeCaen: Howard Hughes Medical Institute, Children’s Hospital Boston
Chuangye Yan: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Xiao Tao: Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10065, USA
Lin Tang: Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 239 Zhangheng Road, Shanghai 201204, China
Jingjing Wang: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Kazuya Hasegawa: Japan Synchrotron Radiation Research Institute (SPring-8), 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan
Takashi Kumasaka: Japan Synchrotron Radiation Research Institute (SPring-8), 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5198, Japan
Jianhua He: Shanghai Institute of Applied Physics, Chinese Academy of Sciences, 239 Zhangheng Road, Shanghai 201204, China
Jiawei Wang: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
David E. Clapham: Howard Hughes Medical Institute, Children’s Hospital Boston
Nieng Yan: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University

Nature, 2012, vol. 486, issue 7401, 130-134

Abstract: The crystal structure of NavRh, a NaChBac orthologue from the marine Rickettsiales sp. HIMB114, defines an ion binding site within the selectivity filter, and reveals several conformational rearrangements that may underlie the electromechanical coupling mechanism.

Date: 2012
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DOI: 10.1038/nature11054

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