Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

Hyejung Won, Hye-Ryeon Lee, Heon Yung Gee, Won Mah, Jae-Ick Kim, Jiseok Lee, Seungmin Ha, Changuk Chung, Eun Suk Jung, Yi Sul Cho, Sae-Geun Park, Jung-Soo Lee, Kyungmin Lee, Daesoo Kim, Yong Chul Bae, Bong-Kiun Kaang (), Min Goo Lee () and Eunjoon Kim ()
Additional contact information
Hyejung Won: Department of Biological Sciences
Hye-Ryeon Lee: National Creative Research Initiative Center for Memory, College of Natural Sciences, Seoul National University, Gwanangno 599, Gwanak-gu, Seoul 151-747, Korea
Heon Yung Gee: Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine
Won Mah: Department of Biological Sciences
Jae-Ick Kim: National Creative Research Initiative Center for Memory, College of Natural Sciences, Seoul National University, Gwanangno 599, Gwanak-gu, Seoul 151-747, Korea
Jiseok Lee: Department of Biological Sciences
Seungmin Ha: Department of Biological Sciences
Changuk Chung: Department of Biological Sciences
Eun Suk Jung: Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine
Yi Sul Cho: School of Dentistry, Kyungpook National University
Sae-Geun Park: Department of Biological Sciences
Jung-Soo Lee: Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine
Kyungmin Lee: School of Medicine, Brain Science & Engineering Institute, Kyungpook National University
Daesoo Kim: Department of Biological Sciences
Yong Chul Bae: School of Dentistry, Kyungpook National University
Bong-Kiun Kaang: National Creative Research Initiative Center for Memory, College of Natural Sciences, Seoul National University, Gwanangno 599, Gwanak-gu, Seoul 151-747, Korea
Min Goo Lee: Brain Korea 21 Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine
Eunjoon Kim: Department of Biological Sciences

Nature, 2012, vol. 486, issue 7402, 261-265

Abstract: Mutations in SHANK2 have been associated with autism spectrum disorders in humans; here, Shank2 mutant mice are shown to exhibit autistic-like behaviours that can be improved by restoring decreased NMDA receptor function.

Date: 2012
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DOI: 10.1038/nature11208

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