Autoregulation of microRNA biogenesis by let-7 and Argonaute

Dimitrios G. Zisoulis, Zoya S. Kai, Roger K. Chang and Amy E. Pasquinelli ()
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Dimitrios G. Zisoulis: University of California, San Diego, La Jolla, California 92093-0349, USA
Zoya S. Kai: University of California, San Diego, La Jolla, California 92093-0349, USA
Roger K. Chang: University of California, San Diego, La Jolla, California 92093-0349, USA
Amy E. Pasquinelli: University of California, San Diego, La Jolla, California 92093-0349, USA

Nature, 2012, vol. 486, issue 7404, 541-544

Abstract: MicroRNA in worms is shown to target non-coding primary microRNA transcripts through interaction with the Argonaute protein, promoting the production of further microRNA and thus generating a positive-feedback loop.

Date: 2012
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DOI: 10.1038/nature11134

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