Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2

Michael J. Schmeisser, Elodie Ey, Stephanie Wegener, Juergen Bockmann, A. Vanessa Stempel, Angelika Kuebler, Anna-Lena Janssen, Patrick T. Udvardi, Ehab Shiban, Christina Spilker, Detlef Balschun, Boris V. Skryabin, Susanne tom Dieck, Karl-Heinz Smalla, Dirk Montag, Claire S. Leblond, Philippe Faure, Nicolas Torquet, Anne-Marie Le Sourd, Roberto Toro, Andreas M. Grabrucker, Sarah A. Shoichet, Dietmar Schmitz, Michael R. Kreutz, Thomas Bourgeron, Eckart D. Gundelfinger and Tobias M. Boeckers ()
Additional contact information
Michael J. Schmeisser: Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
Elodie Ey: Human Genetics and Cognitive Functions, Institut Pasteur, 75724 Paris CEDEX 15, France
Stephanie Wegener: Neuroscience Research Center, Cluster of Excellence NeuroCure, Charité, 10117 Berlin, Germany
Juergen Bockmann: Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
A. Vanessa Stempel: Neuroscience Research Center, Cluster of Excellence NeuroCure, Charité, 10117 Berlin, Germany
Angelika Kuebler: Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
Anna-Lena Janssen: Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
Patrick T. Udvardi: Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
Ehab Shiban: Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
Christina Spilker: PG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
Detlef Balschun: Laboratory of Biological Psychology, Catholic University of Leuven, 3000 Leuven, Belgium
Boris V. Skryabin: Institute of Experimental Pathology (ZMBE), University of Muenster, 48149 Muenster, Germany
Susanne tom Dieck: Max Planck Institute for Brain Research, 60528 Frankfurt, Germany
Karl-Heinz Smalla: Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
Dirk Montag: Neurogenetics Special Laboratory, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
Claire S. Leblond: Human Genetics and Cognitive Functions, Institut Pasteur, 75724 Paris CEDEX 15, France
Philippe Faure: University Paris 06, CNRS, UMR 7102, 75005 Paris, France
Nicolas Torquet: Human Genetics and Cognitive Functions, Institut Pasteur, 75724 Paris CEDEX 15, France
Anne-Marie Le Sourd: Human Genetics and Cognitive Functions, Institut Pasteur, 75724 Paris CEDEX 15, France
Roberto Toro: Human Genetics and Cognitive Functions, Institut Pasteur, 75724 Paris CEDEX 15, France
Andreas M. Grabrucker: Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
Sarah A. Shoichet: Neuroscience Research Center, Cluster of Excellence NeuroCure, Charité, 10117 Berlin, Germany
Dietmar Schmitz: Neuroscience Research Center, Cluster of Excellence NeuroCure, Charité, 10117 Berlin, Germany
Michael R. Kreutz: PG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
Thomas Bourgeron: Human Genetics and Cognitive Functions, Institut Pasteur, 75724 Paris CEDEX 15, France
Eckart D. Gundelfinger: Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany
Tobias M. Boeckers: Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany

Nature, 2012, vol. 486, issue 7402, 256-260

Abstract: Altered glutamatergic neurotransmission can lead to the core symptoms of autism, and ProSAP1/Shank2 and ProSAP2/Shank3 proteins seem to serve different interrelated functions at excitatory synapses, especially in glutamate receptor targeting/assembly.

Date: 2012
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DOI: 10.1038/nature11015

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