PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos

Toshinobu Nakamura (), Yu-Jung Liu, Hiroyuki Nakashima, Hiroki Umehara, Kimiko Inoue, Shogo Matoba, Makoto Tachibana, Atsuo Ogura, Yoichi Shinkai and Toru Nakano ()
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Toshinobu Nakamura: Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan
Yu-Jung Liu: Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan
Hiroyuki Nakashima: Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan
Hiroki Umehara: Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan
Kimiko Inoue: RIKEN BioResouce Center, Tsukuba, Ibaraki 305-0074, Japan
Shogo Matoba: RIKEN BioResouce Center, Tsukuba, Ibaraki 305-0074, Japan
Makoto Tachibana: Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan
Atsuo Ogura: RIKEN BioResouce Center, Tsukuba, Ibaraki 305-0074, Japan
Yoichi Shinkai: Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan
Toru Nakano: Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan

Nature, 2012, vol. 486, issue 7403, 415-419

Abstract: The binding of PGC7 to maternal chromatin, which is important for methylation maintenance during embryogenesis, is shown to be dependent on a particular histone modification, H3K9me2.

Date: 2012
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DOI: 10.1038/nature11093

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