The clonal and mutational evolution spectrum of primary triple-negative breast cancers

Sohrab P. Shah (), Andrew Roth, Rodrigo Goya, Arusha Oloumi, Gavin Ha, Yongjun Zhao, Gulisa Turashvili, Jiarui Ding, Kane Tse, Gholamreza Haffari, Ali Bashashati, Leah M. Prentice, Jaswinder Khattra, Angela Burleigh, Damian Yap, Virginie Bernard, Andrew McPherson, Karey Shumansky, Anamaria Crisan, Ryan Giuliany, Alireza Heravi-Moussavi, Jamie Rosner, Daniel Lai, Inanc Birol, Richard Varhol, Angela Tam, Noreen Dhalla, Thomas Zeng, Kevin Ma, Simon K. Chan, Malachi Griffith, Annie Moradian, S.-W. Grace Cheng, Gregg B. Morin, Peter Watson, Karen Gelmon, Stephen Chia, Suet-Feung Chin, Christina Curtis, Oscar M. Rueda, Paul D. Pharoah, Sambasivarao Damaraju, John Mackey, Kelly Hoon, Timothy Harkins, Vasisht Tadigotla, Mahvash Sigaroudinia, Philippe Gascard, Thea Tlsty, Joseph F. Costello, Irmtraud M. Meyer, Connie J. Eaves, Wyeth W. Wasserman, Steven Jones, David Huntsman, Martin Hirst, Carlos Caldas (), Marco A. Marra () and Samuel Aparicio ()
Additional contact information
Sohrab P. Shah: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Andrew Roth: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Rodrigo Goya: Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
Arusha Oloumi: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Gavin Ha: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Yongjun Zhao: Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
Gulisa Turashvili: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Jiarui Ding: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Kane Tse: Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
Gholamreza Haffari: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Ali Bashashati: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Leah M. Prentice: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Jaswinder Khattra: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Angela Burleigh: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Damian Yap: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Virginie Bernard: Centre for Molecular Medicine and Therapeutics, 950 West 28th Avenue, Vancouver, British Columbia V5Z 4H4, Canada
Andrew McPherson: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Karey Shumansky: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Anamaria Crisan: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Ryan Giuliany: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Alireza Heravi-Moussavi: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Jamie Rosner: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Daniel Lai: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Inanc Birol: Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
Richard Varhol: Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
Angela Tam: Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
Noreen Dhalla: Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
Thomas Zeng: Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
Kevin Ma: Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
Simon K. Chan: Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
Malachi Griffith: Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
Annie Moradian: Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
S.-W. Grace Cheng: Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
Gregg B. Morin: Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
Peter Watson: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Karen Gelmon: British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada
Stephen Chia: British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia V5Z 4E6, Canada
Suet-Feung Chin: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Christina Curtis: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Oscar M. Rueda: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Paul D. Pharoah: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Sambasivarao Damaraju: University of Alberta, 11560 University Avenue, Cross Cancer Institute, Edmonton, Alberta T6G 1Z2, Canada
John Mackey: University of Alberta, 11560 University Avenue, Cross Cancer Institute, Edmonton, Alberta T6G 1Z2, Canada
Kelly Hoon: Life Technologies, 101 Lincoln Centre Dr.
Timothy Harkins: Life Technologies, 101 Lincoln Centre Dr.
Vasisht Tadigotla: Life Technologies, 101 Lincoln Centre Dr.
Mahvash Sigaroudinia: University of California
Philippe Gascard: University of California
Thea Tlsty: University of California
Joseph F. Costello: Brain Tumor Research Center, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
Irmtraud M. Meyer: University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
Connie J. Eaves: Terry Fox Laboratory, BC Cancer Agency, 675 W 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Wyeth W. Wasserman: Centre for Molecular Medicine and Therapeutics, 950 West 28th Avenue, Vancouver, British Columbia V5Z 4H4, Canada
Steven Jones: Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
David Huntsman: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Martin Hirst: Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
Carlos Caldas: Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
Marco A. Marra: Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia V5Z 1L3, Canada
Samuel Aparicio: University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada

Nature, 2012, vol. 486, issue 7403, 395-399

Abstract: Primary triple-negative breast cancers are shown to vary widely and continuously in the degree of clonal evolution and mutational content at the time of diagnosis, with implications for future studies of the disease.

Date: 2012
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DOI: 10.1038/nature10933

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