Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

Patricia T. Illing, Julian P. Vivian, Nadine L. Dudek, Lyudmila Kostenko, Zhenjun Chen, Mandvi Bharadwaj, John J. Miles, Lars Kjer-Nielsen, Stephanie Gras, Nicholas A. Williamson, Scott R. Burrows, Anthony W. Purcell (), Jamie Rossjohn () and James McCluskey ()
Additional contact information
Patricia T. Illing: University of Melbourne, Parkville, Victoria 3010, Australia
Julian P. Vivian: School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
Nadine L. Dudek: University of Melbourne, Parkville, Victoria 3010, Australia
Lyudmila Kostenko: University of Melbourne, Parkville, Victoria 3010, Australia
Zhenjun Chen: University of Melbourne, Parkville, Victoria 3010, Australia
Mandvi Bharadwaj: University of Melbourne, Parkville, Victoria 3010, Australia
John J. Miles: Queensland Institute of Medical Research and Australian Centre for Vaccine Development
Lars Kjer-Nielsen: University of Melbourne, Parkville, Victoria 3010, Australia
Stephanie Gras: School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
Nicholas A. Williamson: University of Melbourne, Parkville, Victoria 3010, Australia
Scott R. Burrows: Queensland Institute of Medical Research and Australian Centre for Vaccine Development
Anthony W. Purcell: University of Melbourne, Parkville, Victoria 3010, Australia
Jamie Rossjohn: School of Biomedical Sciences, Monash University, Clayton, Victoria 3800, Australia
James McCluskey: University of Melbourne, Parkville, Victoria 3010, Australia

Nature, 2012, vol. 486, issue 7404, 554-558

Abstract: The paper describes the mechanism by which small-molecule drugs such as abacavir affect antigen presentation and consequently T-cell response in immunologically based drug reactions such as abacavir hypersensitivity syndrome (AHS) and carbamazepine-induced Stevens–Johnson syndrome (SJS).

Date: 2012
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DOI: 10.1038/nature11147

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