Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

Masaki Imai, Tokiko Watanabe, Masato Hatta, Subash C. Das, Makoto Ozawa, Kyoko Shinya, Gongxun Zhong, Anthony Hanson, Hiroaki Katsura, Shinji Watanabe, Chengjun Li, Eiryo Kawakami, Shinya Yamada, Maki Kiso, Yasuo Suzuki, Eileen A. Maher, Gabriele Neumann and Yoshihiro Kawaoka ()
Additional contact information
Masaki Imai: University of Wisconsin-Madison
Tokiko Watanabe: University of Wisconsin-Madison
Masato Hatta: University of Wisconsin-Madison
Subash C. Das: University of Wisconsin-Madison
Makoto Ozawa: University of Wisconsin-Madison
Kyoko Shinya: Kobe University, Hyogo 650-0017, Japan
Gongxun Zhong: University of Wisconsin-Madison
Anthony Hanson: University of Wisconsin-Madison
Hiroaki Katsura: Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan
Shinji Watanabe: University of Wisconsin-Madison
Chengjun Li: University of Wisconsin-Madison
Eiryo Kawakami: ERATO Infection-Induced Host Responses Project, Saitama 332-0012, Japan
Shinya Yamada: Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan
Maki Kiso: Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan
Yasuo Suzuki: Health Science Hills, College of Life and Health Sciences, Chubu University, Kasugai, Aichi 487-8501, Japan
Eileen A. Maher: University of Wisconsin-Madison
Gabriele Neumann: University of Wisconsin-Madison
Yoshihiro Kawaoka: University of Wisconsin-Madison

Nature, 2012, vol. 486, issue 7403, 420-428

Abstract: Only four mutations in H5N1 HA are required to enable ferret-to-ferret transmission of a reassortant virus containing the H5 HA and the remaining seven gene segments from a human pandemic H1N1 influenza virus.

Date: 2012
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DOI: 10.1038/nature10831

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