Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

Sandra Misale, Rona Yaeger, Sebastijan Hobor, Elisa Scala, Manickam Janakiraman, David Liska, Emanuele Valtorta, Roberta Schiavo, Michela Buscarino, Giulia Siravegna, Katia Bencardino, Andrea Cercek, Chin-Tung Chen, Silvio Veronese, Carlo Zanon, Andrea Sartore-Bianchi, Marcello Gambacorta, Margherita Gallicchio, Efsevia Vakiani, Valentina Boscaro, Enzo Medico, Martin Weiser, Salvatore Siena, Federica Di Nicolantonio, David Solit () and Alberto Bardelli ()
Additional contact information
Sandra Misale: Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo (Torino), Italy
Rona Yaeger: Memorial Sloan-Kettering Cancer Center
Sebastijan Hobor: Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo (Torino), Italy
Elisa Scala: Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo (Torino), Italy
Manickam Janakiraman: Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
David Liska: Memorial Sloan-Kettering Cancer Center
Emanuele Valtorta: Ospedale Niguarda Ca’ Granda, 20162 Milano, Italy
Roberta Schiavo: Ospedale Niguarda Ca’ Granda, 20162 Milano, Italy
Michela Buscarino: Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo (Torino), Italy
Giulia Siravegna: Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo (Torino), Italy
Katia Bencardino: Ospedale Niguarda Ca’ Granda, 20162 Milano, Italy
Andrea Cercek: Memorial Sloan-Kettering Cancer Center
Chin-Tung Chen: Memorial Sloan-Kettering Cancer Center
Silvio Veronese: Ospedale Niguarda Ca’ Granda, 20162 Milano, Italy
Carlo Zanon: Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo (Torino), Italy
Andrea Sartore-Bianchi: Ospedale Niguarda Ca’ Granda, 20162 Milano, Italy
Marcello Gambacorta: Ospedale Niguarda Ca’ Granda, 20162 Milano, Italy
Margherita Gallicchio: University of Torino, 10125 Torino, Italy
Efsevia Vakiani: Memorial Sloan-Kettering Cancer Center
Valentina Boscaro: University of Torino, 10125 Torino, Italy
Enzo Medico: University of Torino Medical School, 10060 Candiolo (Torino), Italy
Martin Weiser: Memorial Sloan-Kettering Cancer Center
Salvatore Siena: Ospedale Niguarda Ca’ Granda, 20162 Milano, Italy
Federica Di Nicolantonio: Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo (Torino), Italy
David Solit: Memorial Sloan-Kettering Cancer Center
Alberto Bardelli: Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment (IRCC), 10060 Candiolo (Torino), Italy

Nature, 2012, vol. 486, issue 7404, 532-536

Abstract: Molecular alterations in KRAS are associated with acquired resistance to anti-epidermal growth factor receptor (EGFR) treatment in colorectal cancer; resistant mutations can be identified in the blood of patients, months before clinical evidence of disease progression.

Date: 2012
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature11156 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:486:y:2012:i:7404:d:10.1038_nature11156

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature11156

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().