The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

Pedro A. Pérez-Mancera, Alistair G. Rust, Louise van der Weyden, Glen Kristiansen, Allen Li, Aaron L. Sarver, Kevin A. T. Silverstein, Robert Grützmann, Daniela Aust, Petra Rümmele, Thomas Knösel, Colin Herd, Derek L. Stemple, Ross Kettleborough, Jacqueline A. Brosnan, Ang Li, Richard Morgan, Spencer Knight, Jun Yu, Shane Stegeman, Lara S. Collier, Jelle J. ten Hoeve, Jeroen de Ridder, Alison P. Klein, Michael Goggins, Ralph H. Hruban, David K. Chang, Andrew V. Biankin, Sean M. Grimmond, Lodewyk F. A. Wessels, Stephen A. Wood, Christine A. Iacobuzio-Donahue, Christian Pilarsky, David A. Largaespada, David J. Adams () and David A. Tuveson ()
Additional contact information
Pedro A. Pérez-Mancera: Li Ka Shing Centre, Cambridge Research Institute, Cancer Research UK, Robinson Way, Cambridge CB2 0RE, UK
Alistair G. Rust: Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
Louise van der Weyden: Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
Glen Kristiansen: Institute of Pathology, University Hospital of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany
Allen Li: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions
Aaron L. Sarver: Biostatistics and Bioinformatics Core, Masonic Cancer Center, University of Minnesota, 425 Delaware St SE MMC 806, Minneapolis, Minnesota 55455, USA
Kevin A. T. Silverstein: Biostatistics and Bioinformatics Core, Masonic Cancer Center, University of Minnesota, 425 Delaware St SE MMC 806, Minneapolis, Minnesota 55455, USA
Robert Grützmann: University Hospital Dresden, Fetscherstr. 74, 01307 Dresden, Germany
Daniela Aust: Institute of Pathology, University Hospital Dresden, Fetscherstr. 74, 01307 Dresden, Germany
Petra Rümmele: Institute of Pathology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany
Thomas Knösel: Institute of Pathology, University Hospital of Jena, Bachstraße 18, 07743 Jena, Germany
Colin Herd: Vertebrate Development and Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
Derek L. Stemple: Vertebrate Development and Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
Ross Kettleborough: Vertebrate Development and Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
Jacqueline A. Brosnan: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions
Ang Li: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions
Richard Morgan: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions
Spencer Knight: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions
Jun Yu: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions
Shane Stegeman: Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, Queensland 4111, Australia
Lara S. Collier: School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705, USA
Jelle J. ten Hoeve: Delft Bioinformatics Lab, Faculty of EEMCS, Delft University of Technology, 2628 CD Delft, The Netherlands
Jeroen de Ridder: Delft Bioinformatics Lab, Faculty of EEMCS, Delft University of Technology, 2628 CD Delft, The Netherlands
Alison P. Klein: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions
Michael Goggins: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions
Ralph H. Hruban: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions
David K. Chang: The Kinghorn Cancer Centre, Cancer Research Program, Garvan Institute of Medical Research, 372 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia
Andrew V. Biankin: The Kinghorn Cancer Centre, Cancer Research Program, Garvan Institute of Medical Research, 372 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia
Sean M. Grimmond: Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia
Lodewyk F. A. Wessels: Delft Bioinformatics Lab, Faculty of EEMCS, Delft University of Technology, 2628 CD Delft, The Netherlands
Stephen A. Wood: Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, Queensland 4111, Australia
Christine A. Iacobuzio-Donahue: The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions
Christian Pilarsky: University Hospital Dresden, Fetscherstr. 74, 01307 Dresden, Germany
David A. Largaespada: Masonic Cancer Center, University of Minnesota
David J. Adams: Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
David A. Tuveson: Li Ka Shing Centre, Cambridge Research Institute, Cancer Research UK, Robinson Way, Cambridge CB2 0RE, UK

Nature, 2012, vol. 486, issue 7402, 266-270

Abstract: An in vivo transposon screen in a pancreatic cancer model identifies frequent inactivation of Usp9x; deletion of Usp9x cooperates with KrasG12D to accelerate rapidly pancreatic tumorigenesis in mice, validating their genetic interaction.

Date: 2012
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DOI: 10.1038/nature11114

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