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2017, volume 550, articles 7677

Non-union bone fracture: a quicker fix pp. S193-S193

David Holmes

Closing the gap pp. S194-S195

David Holmes

Cancer biology still needs physicists pp. 431-431

Robert Austin

Jupiter's stormy winds churn deep into the planet pp. 437-438

Alexandra Witze

Photons pair up like superconducting electrons pp. 438-439

Elizabeth Gibney

CRISPR hacks enable pinpoint repairs to genome pp. 439-440

Elie Dolgin

India gears up for second Moon mission pp. 440-440

T. V. Padma

Sleeping sickness can now be cured with pills pp. 441-441

Amy Maxmen

Efforts to save leading Hungarian university hit hurdle pp. 442-442

Alison Abbott

To stay young, kill zombie cells pp. 448-450

Megan Scudellari

The Human Cell Atlas: from vision to reality pp. 451-453

Orit Rozenblatt-Rosen, Michael J. T. Stubbington, Aviv Regev and Sarah A. Teichmann

History: Science and the Reformation pp. 454-455

David Wootton

Disaster preparedness: Risk, rout and ruination pp. 456-456

Anthony King

Public engagement: Young scientists welcome at IPBES pp. 457-457

Cosmas Kombat Lambini and Katja Heubach

Poaching: Is snow leopard tally underestimated? pp. 457-457

Achyut Aryal

Construction: limit China's sand mining pp. 457-457

Yushun Chen

Construction: use waste for building pp. 457-457

Nimisha Tripathi

Science writing: On what's neither clear nor obvious pp. 457-457

Eric G. Blackman

Nicolaas Bloembergen (1920–2017) pp. 458-458

Eli Yablonovitch

Memory beyond immunity pp. 460-461

Xing Dai and Ruslan Medzhitov

Atomistic views of deformation pp. 461-463

Neil K. Bourne

Cancer development: Origins in the oesophagus pp. 463-464

Lizhe Zhuang and Rebecca C. Fitzgerald

Origins in the oesophagus pp. 463-464

Lizhe Zhuang and Rebecca C. Fitzgerald

Fan-assisted insects pp. 464-464

Jennifer R. Gardiner

Rapid mass changes measured in cells pp. 465-466

David Alsteens and Yves F. Dufrêne

Twenty years of drying droplets pp. 466-467

Ronald G. Larson

How flowers get the blues to lure bees pp. 467-468

Dimitri D. Deheyn

Disorder in convergent floral nanostructures enhances signalling to bees pp. 469-474

Edwige Moyroud, Tobias Wenzel, Rox Middleton, Paula J. Rudall, Hannah Banks, Alison Reed, Greg Mellers, Patrick Killoran, M. Murphy Westwood, Ullrich Steiner, Silvia Vignolini and Beverley J. Glover

Inflammatory memory sensitizes skin epithelial stem cells to tissue damage pp. 475-480

Shruti Naik, Samantha B. Larsen, Nicholas C. Gomez, Kirill Alaverdyan, Ataman Sendoel, Shaopeng Yuan, Lisa Polak, Anita Kulukian, Sophia Chai and Elaine Fuchs

Molecular basis of USP7 inhibition by selective small-molecule inhibitors pp. 481-486

Andrew P. Turnbull, Stephanos Ioannidis, Wojciech W. Krajewski, Adan Pinto-Fernandez, Claire Heride, Agnes C. L. Martin, Louise M. Tonkin, Elizabeth C. Townsend, Shane M. Buker, David R. Lancia, Justin A. Caravella, Angela V. Toms, Thomas M. Charlton, Johanna Lahdenranta, Erik Wilker, Bruce C. Follows, Nicola J. Evans, Lucy Stead, Cristina Alli, Vladislav V. Zarayskiy, Adam C. Talbot, Alexandre J. Buckmelter, Minghua Wang, Crystal L. McKinnon, Fabienne Saab, Joanna F. McGouran, Hannah Century, Malte Gersch, Marc S. Pittman, C. Gary Marshall, Tony M. Raynham, Mary Simcox, Lorna M. D. Stewart, Sheila B. McLoughlin, Jaime A. Escobedo, Kenneth W. Bair, Christopher J. Dinsmore, Tim R. Hammonds, Sunkyu Kim, Sylvie Urbé, Michael J. Clague, Benedikt M. Kessler and David Komander

Structural phase transition in monolayer MoTe2 driven by electrostatic doping pp. 487-491

Ying Wang, Jun Xiao, Hanyu Zhu, Yao Li, Yousif Alsaid, King Yan Fong, Yao Zhou, Siqi Wang, Wu Shi, Yuan Wang, Alex Zettl, Evan J. Reed and Xiang Zhang

Probing the limits of metal plasticity with molecular dynamics simulations pp. 492-495

Luis A. Zepeda-Ruiz, Alexander Stukowski, Tomas Oppelstrup and Vasily V. Bulatov

In situ X-ray diffraction measurement of shock-wave-driven twinning and lattice dynamics pp. 496-499

C. E. Wehrenberg, D. McGonegle, C. Bolme, A. Higginbotham, A. Lazicki, H. J. Lee, B. Nagler, H.-S. Park, B. A. Remington, R. E. Rudd, M. Sliwa, M. Suggit, D. Swift, F. Tavella, L. Zepeda-Ruiz and J. S. Wark

Inertial picobalance reveals fast mass fluctuations in mammalian cells pp. 500-505

David Martínez-Martín, Gotthold Fläschner, Benjamin Gaub, Sascha Martin, Richard Newton, Corina Beerli, Jason Mercer, Christoph Gerber and Daniel J. Müller

Evidence of marine ice-cliff instability in Pine Island Bay from iceberg-keel plough marks pp. 506-510

Matthew G. Wise, Julian A. Dowdeswell, Martin Jakobsson and Robert D. Larter

Indirect effects drive coevolution in mutualistic networks pp. 511-514

Paulo R. Guimarães, Mathias M. Pires, Pedro Jordano, Jordi Bascompte and John N. Thompson

The prevalence of Plasmodium falciparum in sub-Saharan Africa since 1900 pp. 515-518

Robert W. Snow, Benn Sartorius, David Kyalo, Joseph Maina, Punam Amratia, Clara W. Mundia, Philip Bejon and Abdisalan M. Noor

Network control principles predict neuron function in the Caenorhabditis elegans connectome pp. 519-523

Gang Yan, Petra E. Vértes, Emma K. Towlson, Yee Lian Chew, Denise S. Walker, William R. Schafer and Albert-László Barabási

Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets pp. 524-528

Thiet M. Vu, Ayako-Nakamura Ishizu, Juat Chin Foo, Xiu Ru Toh, Fangyu Zhang, Ding Ming Whee, Federico Torta, Amaury Cazenave-Gassiot, Takayoshi Matsumura, Sangho Kim, Sue-Anne E. S. Toh, Toshio Suda, David L. Silver, Markus R. Wenk and Long N. Nguyen

Transitional basal cells at the squamous–columnar junction generate Barrett’s oesophagus pp. 529-533

Ming Jiang, Haiyan Li, Yongchun Zhang, Ying Yang, Rong Lu, Kuancan Liu, Sijie Lin, Xiaopeng Lan, Haikun Wang, Han Wu, Jian Zhu, Zhongren Zhou, Jianming Xu, Dong-Kee Lee, Lanjing Zhang, Yuan-Cho Lee, Jingsong Yuan, Julian A. Abrams, Timothy C. Wang, Antonia R. Sepulveda, Qi Wu, Huaiyong Chen, Xin Sun, Junjun She, Xiaoxin Chen and Jianwen Que

USP7 small-molecule inhibitors interfere with ubiquitin binding pp. 534-538

Lorna Kategaya, Paola Di Lello, Lionel Rougé, Richard Pastor, Kevin R. Clark, Jason Drummond, Tracy Kleinheinz, Eva Lin, John-Paul Upton, Sumit Prakash, Johanna Heideker, Mark McCleland, Maria Stella Ritorto, Dario R. Alessi, Matthias Trost, Travis W. Bainbridge, Michael C. M. Kwok, Taylur P. Ma, Zachary Stiffler, Bradley Brasher, Yinyan Tang, Priyadarshini Jaishankar, Brian R. Hearn, Adam R. Renslo, Michelle R. Arkin, Frederick Cohen, Kebing Yu, Frank Peale, Florian Gnad, Matthew T. Chang, Christiaan Klijn, Elizabeth Blackwood, Scott E. Martin, William F. Forrest, James A. Ernst, Chudi Ndubaku, Xiaojing Wang, Maureen H. Beresini, Vickie Tsui, Carsten Schwerdtfeger, Robert A. Blake, Jeremy Murray, Till Maurer and Ingrid E. Wertz

Nucleosome–Chd1 structure and implications for chromatin remodelling pp. 539-542

Lucas Farnung, Seychelle M. Vos, Christoph Wigge and Patrick Cramer

Single-molecule imaging reveals receptor–G protein interactions at cell surface hot spots pp. 543-547

Titiwat Sungkaworn, Marie-Lise Jobin, Krzysztof Burnecki, Aleksander Weron, Martin J. Lohse and Davide Calebiro

Correction: Corrigendum: Whole-genome landscape of pancreatic neuroendocrine tumours pp. 548-548

Aldo Scarpa, David K. Chang, Katia Nones, Vincenzo Corbo, Ann-Marie Patch, Peter Bailey, Rita T. Lawlor, Amber L. Johns, David K. Miller, Andrea Mafficini, Borislav Rusev, Maria Scardoni, Davide Antonello, Stefano Barbi, Katarzyna O. Sikora, Sara Cingarlini, Caterina Vicentini, Skye McKay, Michael C. J. Quinn, Timothy J. C. Bruxner, Angelika N. Christ, Ivon Harliwong, Senel Idrisoglu, Suzanne McLean, Craig Nourse, Ehsan Nourbakhsh, Peter J. Wilson, Matthew J. Anderson, J. Lynn Fink, Felicity Newell, Nick Waddell, Oliver Holmes, Stephen H. Kazakoff, Conrad Leonard, Scott Wood, Qinying Xu, Shivashankar Hiriyur Nagaraj, Eliana Amato, Irene Dalai, Samantha Bersani, Ivana Cataldo, Angelo P. Dei Tos, Paola Capelli, Maria Vittoria Davì, Luca Landoni, Anna Malpaga, Marco Miotto, Vicki L. J. Whitehall, Barbara A. Leggett, Janelle L. Harris, Jonathan Harris, Marc D. Jones, Jeremy Humphris, Lorraine A. Chantrill, Venessa Chin, Adnan M. Nagrial, Marina Pajic, Christopher J. Scarlett, Andreia Pinho, Ilse Rooman, Christopher Toon, Jianmin Wu, Mark Pinese, Mark Cowley, Andrew Barbour, Amanda Mawson, Emily S. Humphrey, Emily K. Colvin, Angela Chou, Jessica A. Lovell, Nigel B. Jamieson, Fraser Duthie, Marie-Claude Gingras, William E. Fisher, Rebecca A. Dagg, Loretta M. S. Lau, Michael Lee, Hilda A. Pickett, Roger R. Reddel, Jaswinder S. Samra, James G. Kench, Neil D. Merrett, Krishna Epari, Nam Q. Nguyen, Nikolajs Zeps, Massimo Falconi, Michele Simbolo, Giovanni Butturini, George Van Buren, Stefano Partelli, Matteo Fassan, Kum Kum Khanna, Anthony J. Gill, David A. Wheeler, Richard A. Gibbs, Elizabeth A. Musgrove, Claudio Bassi, Giampaolo Tortora, Paolo Pederzoli, John V. Pearson, Nicola Waddell, Andrew V. Biankin and Sean M. Grimmond

Correction: Corrigendum: Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep pp. 548-548

Kai Liu, Juhyun Kim, Dong Won Kim, Yi Stephanie Zhang, Hechen Bao, Myrto Denaxa, Szu-Aun Lim, Eileen Kim, Chang Liu, Ian R. Wickersham, Vassilis Pachnis, Samer Hattar, Juan Song, Solange P. Brown and Seth Blackshaw

Addendum: Editorial Expression of Concern: Asia’s glaciers are a regionally important buffer against drought pp. 548-548

Hamish D. Pritchard

Graduate survey: A love–hurt relationship pp. 549-552

Chris Woolston

The Everywhere Bus pp. 554-554

Jonathan L. Howard

2017, volume 550, articles 7676

Amyotrophic lateral sclerosis pp. S105-S105

Brian Owens

The hexanucleotide hex pp. S106-S108

Elie Dolgin

Non-Familial ALS: A tangled web pp. S109-S111

Carolyn Brown

Perspective: Don't keep it in the family pp. S112-S112

Ammar Al-Chalabi

Fundraising: The Ice Bucket Challenge delivers pp. S113-S114

Emily Sohn

Calculating disease pp. S115-S117

Neil Savage

On the treatment trail for ALS pp. S120-S121

Andrew Scott

Perspective: Untangling the ALS X-Files pp. S122-S122

Richard Bedlack

Metropolis of minds pp. S157-S157

Smriti Mallapaty

Steeped in science pp. S164-S166

Anna Petherick

On the biotech block pp. S168-S171

Alexandra Ossola

Comment: Where the streets are paved with ideas pp. S172-S172

Richard Florida

Destination Daejeon pp. S176-S179

Mark Zastrow

Spain's science rivalry pp. S180-S183

Monica G. Salomone

A league of their own pp. S186-S187

Hepeng Jia

Neighbours in knowledge pp. S188-S191

Hepeng Jia

Give researchers a lifetime word limit pp. 303-303

Brian C. Martinson

Colliding stars spark rush to solve cosmic mysteries pp. 309-310

Davide Castelvecchi

Japanese research leaders warn about national science decline pp. 310-311

Nicky Phillips

Trump EPA begins push to overturn Obama-era climate regulation pp. 311-311

Jeff Tollefson

New definitions of scientific units are on the horizon pp. 312-313

Elizabeth Gibney

FDA advisers back gene therapy for rare form of blindness pp. 314-314

Heidi Ledford

The shape of work to come pp. 316-319

Emily Anthes

Lessons from history for the future of work pp. 321-324

Robert Allen

Reboot for the AI revolution pp. 324-327

Yuval Noah Harari

The second Renaissance pp. 327-329

Ian Goldin

Archaeology: The wonder of the pyramids pp. 330-331

Andrew Robinson

Books in brief pp. 331-331

Barbara Kiser

History: Five millennia of Indian science pp. 332-332

James Poskett

Stifled by budgets, not irrelevance pp. 333-333

Thomas O. Baldwin

Danish dairy farmer delivers data coup pp. 333-333

Tony Fox and Henning Heldbjerg

Spot data glitches before publication pp. 333-333

Noah F. Greenwald, Pratiti Bandopadhayay and Rameen Beroukhim

PhD students: living wage key to diversity pp. 333-333

Larissa K. Barber, Nicholas A. Barber and Holly P. Jones

PhD students: side jobs are no solution pp. 333-333

Therice Morris

Learning to play Go from scratch pp. 336-337

Satinder Singh, Andy Okun and Andrew Jackson

Bacterial snack attack deactivates a drug pp. 337-339

Christian Jobin

Data analysis meets quantum physics pp. 339-340

Steven Schramm

Genome jail-break triggers lockdown pp. 340-341

Neil T. Umbreit and David Pellman

Complex assistance for DNA invasion pp. 342-343

Petr Cejka

Domains to the rescue for Rett syndrome pp. 343-344

Anne E. West

DNA sequencing at 40: past, present and future pp. 345-353

Jay Shendure, Shankar Balasubramanian, George M. Church, Walter Gilbert, Jane Rogers, Jeffery A. Schloss and Robert H. Waterston

Mastering the game of Go without human knowledge pp. 354-359

David Silver, Julian Schrittwieser, Karen Simonyan, Ioannis Antonoglou, Aja Huang, Arthur Guez, Thomas Hubert, Lucas Baker, Matthew Lai, Adrian Bolton, Yutian Chen, Timothy Lillicrap, Fan Hui, Laurent Sifre, George van den Driessche, Thore Graepel and Demis Hassabis

BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing pp. 360-365

Weixing Zhao, Justin B. Steinfeld, Fengshan Liang, Xiaoyong Chen, David G. Maranon, Chu Jian Ma, Youngho Kwon, Timsi Rao, Weibin Wang, Chen Sheng, Xuemei Song, Yanhong Deng, Judit Jimenez-Sainz, Lucy Lu, Ryan B. Jensen, Yong Xiong, Gary M. Kupfer, Claudia Wiese, Eric C. Greene and Patrick Sung

Human TRPML1 channel structures in open and closed conformations pp. 366-370

Philip Schmiege, Michael Fine, Günter Blobel and Xiaochun Li

A parts-per-billion measurement of the antiproton magnetic moment pp. 371-374

C. Smorra, S. Sellner, M. J. Borchert, J. A. Harrington, T. Higuchi, H. Nagahama, T. Tanaka, A. Mooser, G. Schneider, M. Bohman, K. Blaum, Y. Matsuda, C. Ospelkaus, W. Quint, J. Walz, Y. Yamazaki and S. Ulmer

Solving a Higgs optimization problem with quantum annealing for machine learning pp. 375-379

Alex Mott, Joshua Job, Jean-Roch Vlimant, Daniel Lidar and Maria Spiropulu

Ion sieving in graphene oxide membranes via cationic control of interlayer spacing pp. 380-383

Liang Chen, Guosheng Shi, Jie Shen, Bingquan Peng, Bowu Zhang, Yuzhu Wang, Fenggang Bian, Jiajun Wang, Deyuan Li, Zhe Qian, Gang Xu, Gongping Liu, Jianrong Zeng, Lijuan Zhang, Yizhou Yang, Guoquan Zhou, Minghong Wu, Wanqin Jin, Jingye Li and Haiping Fang

Organic long persistent luminescence pp. 384-387

Ryota Kabe and Chihaya Adachi

Social behaviour shapes hypothalamic neural ensemble representations of conspecific sex pp. 388-392

Ryan Remedios, Ann Kennedy, Moriel Zelikowsky, Benjamin F. Grewe, Mark J. Schnitzer and David J. Anderson

Establishment of mouse expanded potential stem cells pp. 393-397

Jian Yang, David J. Ryan, Wei Wang, Jason Cheuk-Ho Tsang, Guocheng Lan, Hideki Masaki, Xuefei Gao, Liliana Antunes, Yong Yu, Zhexin Zhu, Juexuan Wang, Aleksandra A. Kolodziejczyk, Lia S. Campos, Cui Wang, Fengtang Yang, Zhen Zhong, Beiyuan Fu, Melanie A. Eckersley-Maslin, Michael Woods, Yosuke Tanaka, Xi Chen, Adam C. Wilkinson, James Bussell, Jacqui White, Ramiro Ramirez-Solis, Wolf Reik, Berthold Göttgens, Sarah A. Teichmann, Patrick P. L. Tam, Hiromitsu Nakauchi, Xiangang Zou, Liming Lu and Pentao Liu

Radically truncated MeCP2 rescues Rett syndrome-like neurological defects pp. 398-401

Rebekah Tillotson, Jim Selfridge, Martha V. Koerner, Kamal K. E. Gadalla, Jacky Guy, Dina De Sousa, Ralph D. Hector, Stuart R. Cobb and Adrian Bird

Cytoplasmic chromatin triggers inflammation in senescence and cancer pp. 402-406

Zhixun Dou, Kanad Ghosh, Maria Grazia Vizioli, Jiajun Zhu, Payel Sen, Kirk J. Wangensteen, Johayra Simithy, Yemin Lan, Yanping Lin, Zhuo Zhou, Brian C. Capell, Caiyue Xu, Mingang Xu, Julia E. Kieckhaefer, Tianying Jiang, Michal Shoshkes-Carmel, K. M. Ahasan Al Tanim, Glen N. Barber, John T. Seykora, Sarah E. Millar, Klaus H. Kaestner, Benjamin A. Garcia, Peter D. Adams and Shelley L. Berger

Enhanced proofreading governs CRISPR–Cas9 targeting accuracy pp. 407-410

Janice S. Chen, Yavuz S. Dagdas, Benjamin P. Kleinstiver, Moira M. Welch, Alexander A. Sousa, Lucas B. Harrington, Samuel H. Sternberg, J. Keith Joung, Ahmet Yildiz and Jennifer A. Doudna

Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3 pp. 411-414

Marscha Hirschi, Mark A. Herzik, Jinhong Wie, Yang Suo, William F. Borschel, Dejian Ren, Gabriel C. Lander and Seok-Yong Lee

Structure of mammalian endolysosomal TRPML1 channel in nanodiscs pp. 415-418

Qingfeng Chen, Ji She, Weizhong Zeng, Jiangtao Guo, Haoxing Xu, Xiao-chen Bai and Youxing Jiang

Flexible working: Science in the gig economy pp. 419-421

Roberta Kwok

Trade talk: Habitat helper pp. 421-421

Sarah Boon

Breaking and entering pp. 424-424

Hall Jameson

2017, volume 550, articles 7675

Climate change pp. S53-S53

Richard Hodson

Sea change pp. S54-S58

Sarah DeWeerdt

Getting political pp. S59-S61

Peter Fairley

The real climate debate pp. S62-S64

Peter Agre, Mario Molina and Steven Chu

We have the technology pp. S66-S69

Katherine Bourzac

Fatty liver disease: turning the tide pp. S101-S101

Liam Drew

Fighting the fatty liver pp. S102-S103

Liam Drew

Developing nations need more than just money pp. 159-159

Rana Dajani

Navajo Nation reconsiders ban on genetic research pp. 165-166

Sara Reardon

Scientists plead with Brazilian government to restore funding pp. 166-167

Claudio Angelo

Cryo-electron microscopy wins chemistry Nobel pp. 167-167

Daniel Cressey and Ewen Callaway

The ambitious effort to document California’s changing deserts pp. 168-169

Amy Maxmen

Gene-expression study raises thorny ethical issues pp. 169-170

Ewen Callaway

How the United States plans to trap its biggest stash of nuclear-weapons waste in glass pp. 172-173

Jeff Tollefson

The rise and fall and rise again of 23andMe pp. 174-177

Erika Check Hayden

The future of DNA sequencing pp. 179-181

Eric D. Green, Edward M. Rubin and Maynard V. Olson

Build on the outer space treaty pp. 182-184

Joan Johnson-Freese

Physics: A classical toolkit pp. 185-186

Malcolm Longair

Chemistry: Explosive moments in the laboratory pp. 186-187

Mark Peplow

Books in brief pp. 187-187

Barbara Kiser

Tap latent source of frugal cancer ideas pp. 188-188

Gauthier Bouche

Risk assessments face legal scrutiny pp. 188-188

Richard Bretton and Willy Aspinall

Avoid glib terms of development status pp. 188-188

Khaled Moustafa

Does the brain control foraging? pp. 188-188

Per Södersten

Research that isn't read doesn't exist pp. 188-188

Stephen K. Donovan

Cracking the regulatory code pp. 190-191

Michelle C. Ward and Yoav Gilad

A pariah finds a home pp. 191-192

Terry Gannon

Tumours addicted to drugs are vulnerable pp. 192-193

Rebecca J. Lee and Richard Marais

Liquid metal pumped at a record temperature pp. 194-195

Konstantina Lambrinou

Receptors identified for a weight regulator pp. 195-197

Mart Saarma and Adrian Goldman

Ring detected around a dwarf planet pp. 197-198

Amanda A. Sickafoose

Pumping liquid metal at high temperatures up to 1,673 kelvin pp. 199-203

C. Amy, D. Budenstein, M. Bagepalli, D. England, F. DeAngelis, G. Wilk, C. Jarrett, C. Kelsall, J. Hirschey, H. Wen, A. Chavan, B. Gilleland, C. Yuan, W. C. Chueh, K. H. Sandhage, Y. Kawajiri and A. Henry

The transcription fidelity factor GreA impedes DNA break repair pp. 214-218

Priya Sivaramakrishnan, Leonardo A. Sepúlveda, Jennifer A. Halliday, Jingjing Liu, María Angélica Bravo Núñez, Ido Golding, Susan M. Rosenberg and Christophe Herman

The size, shape, density and ring of the dwarf planet Haumea from a stellar occultation pp. 219-223

J. L. Ortiz, P. Santos-Sanz, B. Sicardy, G. Benedetti-Rossi, D. Bérard, N. Morales, R. Duffard, F. Braga-Ribas, U. Hopp, C. Ries, V. Nascimbeni, F. Marzari, V. Granata, A. Pál, C. Kiss, T. Pribulla, R. Komžík, K. Hornoch, P. Pravec, P. Bacci, M. Maestripieri, L. Nerli, L. Mazzei, M. Bachini, F. Martinelli, G. Succi, F. Ciabattari, H. Mikuz, A. Carbognani, B. Gaehrken, S. Mottola, S. Hellmich, F. L. Rommel, E. Fernández-Valenzuela, A. Campo Bagatin, S. Cikota, A. Cikota, J. Lecacheux, R. Vieira-Martins, J. I. B. Camargo, M. Assafin, F. Colas, R. Behrend, J. Desmars, E. Meza, A. Alvarez-Candal, W. Beisker, A. R. Gomes-Junior, B. E. Morgado, F. Roques, F. Vachier, J. Berthier, T. G. Mueller, J. M. Madiedo, O. Unsalan, E. Sonbas, N. Karaman, O. Erece, D. T. Koseoglu, T. Ozisik, S. Kalkan, Y. Guney, M. S. Niaei, O. Satir, C. Yesilyaprak, C. Puskullu, A. Kabas, O. Demircan, J. Alikakos, V. Charmandaris, G. Leto, J. Ohlert, J. M. Christille, R. Szakáts, A. Takácsné Farkas, E. Varga-Verebélyi, G. Marton, A. Marciniak, P. Bartczak, T. Santana-Ros, M. Butkiewicz-Bąk, G. Dudziński, V. Alí-Lagoa, K. Gazeas, L. Tzouganatos, N. Paschalis, V. Tsamis, A. Sánchez-Lavega, S. Pérez-Hoyos, R. Hueso, J. C. Guirado, V. Peris and R. Iglesias-Marzoa

Light-field-driven currents in graphene pp. 224-228

Takuya Higuchi, Christian Heide, Konrad Ullmann, Heiko B. Weber and Peter Hommelhoff

Layer-by-layer assembly of two-dimensional materials into wafer-scale heterostructures pp. 229-233

Kibum Kang, Kan-Heng Lee, Yimo Han, Hui Gao, Saien Xie, David A. Muller and Jiwoong Park

Patchy particles made by colloidal fusion pp. 234-238

Zhe Gong, Theodore Hueckel, Gi-Ra Yi and Stefano Sacanna

The impact of rare variation on gene expression across tissues pp. 239-243

Xin Li, Yungil Kim, Emily K. Tsang, Joe R. Davis, Farhan N. Damani, Colby Chiang, Gaelen T. Hess, Zachary Zappala, Benjamin J. Strober, Alexandra J. Scott, Amy Li, Andrea Ganna, Michael C. Bassik, Jason D. Merker, Ira M. Hall, Alexis Battle and Stephen B. Montgomery

Landscape of X chromosome inactivation across human tissues pp. 244-248

Taru Tukiainen, Alexandra-Chloé Villani, Angela Yen, Manuel A. Rivas, Jamie L. Marshall, Rahul Satija, Matt Aguirre, Laura Gauthier, Mark Fleharty, Andrew Kirby, Beryl B. Cummings, Stephane E. Castel, Konrad J. Karczewski, François Aguet, Andrea Byrnes, Tuuli Lappalainen, Aviv Regev, Kristin G. Ardlie, Nir Hacohen and Daniel G. MacArthur

Dynamic landscape and regulation of RNA editing in mammals pp. 249-254

Meng How Tan, Qin Li, Raghuvaran Shanmugam, Robert Piskol, Jennefer Kohler, Amy N. Young, Kaiwen Ivy Liu, Rui Zhang, Gokul Ramaswami, Kentaro Ariyoshi, Ankita Gupte, Liam P. Keegan, Cyril X. George, Avinash Ramu, Ni Huang, Elizabeth A. Pollina, Dena S. Leeman, Alessandra Rustighi, Y. P. Sharon Goh, Ajay Chawla, Giannino Del Sal, Gary Peltz, Anne Brunet, Donald F. Conrad, Charles E. Samuel, Mary A. O’Connell, Carl R. Walkley, Kazuko Nishikura and Jin Billy Li

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15 pp. 255-259

Jer-Yuan Hsu, Suzanne Crawley, Michael Chen, Dina A. Ayupova, Darrin A. Lindhout, Jared Higbee, Alan Kutach, William Joo, Zhengyu Gao, Diana Fu, Carmen To, Kalyani Mondal, Betty Li, Avantika Kekatpure, Marilyn Wang, Teresa Laird, Geoffrey Horner, Jackie Chan, Michele McEntee, Manuel Lopez, Damodharan Lakshminarasimhan, Andre White, Sheng-Ping Wang, Jun Yao, Junming Yie, Hugo Matern, Mark Solloway, Raj Haldankar, Thomas Parsons, Jie Tang, Wenyan D. Shen, Yu Alice Chen, Hui Tian and Bernard B. Allan

Hippo pathway deficiency reverses systolic heart failure after infarction pp. 260-264

John P. Leach, Todd Heallen, Min Zhang, Mahdis Rahmani, Yuka Morikawa, Matthew C. Hill, Ana Segura, James T. Willerson and James F. Martin

TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity pp. 265-269

Manoël Prouteau, Ambroise Desfosses, Christian Sieben, Clélia Bourgoint, Nour Lydia Mozaffari, Davide Demurtas, Alok K. Mitra, Paul Guichard, Suliana Manley and Robbie Loewith

Cancer drug addiction is relayed by an ERK2-dependent phenotype switch pp. 270-274

Xiangjun Kong, Thomas Kuilman, Aida Shahrabi, Julia Boshuizen, Kristel Kemper, Ji-Ying Song, Hans W. M. Niessen, Elisa A. Rozeman, Marnix H. Geukes Foppen, Christian U. Blank and Daniel S. Peeper

A viral Sm-class RNA base-pairs with mRNAs and recruits microRNAs to inhibit apoptosis pp. 275-279

Carlos Gorbea, Tim Mosbruger and Demián Cazalla

RNA targeting with CRISPR–Cas13 pp. 280-284

Omar O. Abudayyeh, Jonathan S. Gootenberg, Patrick Essletzbichler, Shuo Han, Julia Joung, Joseph J. Belanto, Vanessa Verdine, David B. T. Cox, Max J. Kellner, Aviv Regev, Eric S. Lander, Daniel F. Voytas, Alice Y. Ting and Feng Zhang

An ace in the hole for DNA sequencing pp. 285-288

Michael Eisenstein

Career change: It's never too late to switch pp. 289-291

Amber Dance

Writing takes work pp. 291-291

Eli Lazarus

Runes transcribed from Dig Site 401A in Ladysmith, Wisconsin pp. 294-294

Rachael K. Jones

2017, volume 550, articles 7674

Women's health pp. S1-S1

Michelle Grayson

Sex matters pp. S2-S3

Anna Petherick

Women's invisible power pp. S4-S5

Linda Nordling

Sex and the single cell pp. S6-S8

Claire Ainsworth

Make plans to eliminate cholera outbreaks pp. 9-9

Anita Zaidi

Perspective: A heartfelt plea pp. S9-S9

Nanette Wenger

Early starters pp. S10-S11

Jessa Gamble

Detecting diversity pp. S12-S14

Courtney Humphries

Staying strong pp. S15-S17

Carolyn Brown

Chinese scientists fix genetic disorder in cloned human embryos pp. 15-16

David Cyranoski

Ethics of Internet research trigger scrutiny pp. 16-17

Elizabeth Gibney

How the latest US travel ban could affect science pp. 17-17

Sara Reardon

Inequality in medicine pp. S18-S19

Anna Nowogrodzki

Medicine Nobel awarded for work on circadian clocks pp. 18-18

Ewen Callaway and Heidi Ledford

Gravitational wave detection wins physics Nobel pp. 19-19

Davide Castelvecchi

The United States is failing its mothers pp. S20-S23

Lauren Gravitz

Controversial Thirty Meter Telescope gets go-ahead to build in Hawaii pp. 20-20

Alexandra Witze

Why fake islands might be a real boon for science pp. 22-24

Emma Marris

How fracking is upending the chemical industry pp. 26-28

Mark Peplow

Scientists have most impact when they're free to move pp. 29-31

Cassidy R. Sugimoto, Nicolas Robinson-Garcia, Dakota S. Murray, Alfredo Yegros-Yegros, Rodrigo Costas and Vincent Larivière

Open countries have strong science pp. 32-33

Caroline S. Wagner and Koen Jonkers

Neuroscience: The mother lode of invention pp. 34-35

Dan Jones

Health: The war on germs pp. 36-37

Tilli Tansey

Sustainability: China's path to ecotopia pp. 37-38

Xuemei Bai

Ornithology: All eyes on the 10,000 species pp. 38-39

Stuart Pimm

Theoretical physics: When the doer met the dreamer pp. 40-41

Graham Farmelo

Technology: Into cyberia pp. 41-42

Li Gong

Heed local impact of coal mining pp. 43-43

Samuel Spiegel and Benjamin Brown

Hurricanes: rescue natural defences pp. 43-43

Virginie K. E. Duvat and Alexandre K. Magnan

Hurricanes: enlist nature's protection pp. 43-43

Timon McPhearson

UNESCO honour for Polish mining facility pp. 43-43

Ryszard Chybiorz and Bogumiła A. Piwowar

Blockchain could boost food security pp. 43-43

Selena Ahmed and Noah ten Broek

Zapping viral RNAs pp. 46-47

Stephen P. Goff

Material change for X-ray detectors pp. 47-48

John A. Rowlands

A global plan for nature conservation pp. 48-49

James E. M. Watson and Oscar Venter

Big science in a small country pp. S49-S51

Nic Fleming

Computational design hits record resolution pp. 50-51

Matthijs Langelaar

A matter of time for tropical diversity pp. 51-52

Gary G. Mittelbach

Expanding and reprogramming the genetic code pp. 53-60

Jason W. Chin

Strains, functions and dynamics in the expanded Human Microbiome Project pp. 61-66

Jason Lloyd-Price, Anup Mahurkar, Gholamali Rahnavard, Jonathan Crabtree, Joshua Orvis, A. Brantley Hall, Arthur Brady, Heather H. Creasy, Carrie McCracken, Michelle G. Giglio, Daniel McDonald, Eric A. Franzosa, Rob Knight, Owen White and Curtis Huttenhower

Genome editing reveals a role for OCT4 in human embryogenesis pp. 67-73

Norah M. E. Fogarty, Afshan McCarthy, Kirsten E. Snijders, Benjamin E. Powell, Nada Kubikova, Paul Blakeley, Rebecca Lea, Kay Elder, Sissy E. Wamaitha, Daesik Kim, Valdone Maciulyte, Jens Kleinjung, Jin-Soo Kim, Dagan Wells, Ludovic Vallier, Alessandro Bertero, James M. A. Turner and Kathy K. Niakan

Massively parallel de novo protein design for targeted therapeutics pp. 74-79

Aaron Chevalier, Daniel-Adriano Silva, Gabriel J. Rocklin, Derrick R. Hicks, Renan Vergara, Patience Murapa, Steffen M. Bernard, Lu Zhang, Kwok-Ho Lam, Guorui Yao, Christopher D. Bahl, Shin-Ichiro Miyashita, Inna Goreshnik, James T. Fuller, Merika T. Koday, Cody M. Jenkins, Tom Colvin, Lauren Carter, Alan Bohn, Cassie M. Bryan, D. Alejandro Fernández-Velasco, Lance Stewart, Min Dong, Xuhui Huang, Rongsheng Jin, Ian A. Wilson, Deborah H. Fuller and David Baker

A hybrid type Ia supernova with an early flash triggered by helium-shell detonation pp. 80-83

Ji-an Jiang, Mamoru Doi, Keiichi Maeda, Toshikazu Shigeyama, Ken’ichi Nomoto, Naoki Yasuda, Saurabh W. Jha, Masaomi Tanaka, Tomoki Morokuma, Nozomu Tominaga, Željko Ivezić, Pilar Ruiz-Lapuente, Maximilian D. Stritzinger, Paolo A. Mazzali, Christopher Ashall, Jeremy Mould, Dietrich Baade, Nao Suzuki, Andrew J. Connolly, Ferdinando Patat, Lifan Wang, Peter Yoachim, David Jones, Hisanori Furusawa and Satoshi Miyazaki

Giga-voxel computational morphogenesis for structural design pp. 84-86

Niels Aage, Erik Andreassen, Boyan S. Lazarov and Ole Sigmund

Printable organometallic perovskite enables large-area, low-dose X-ray imaging pp. 87-91

Yong Churl Kim, Kwang Hee Kim, Dae-Yong Son, Dong-Nyuk Jeong, Ja-Young Seo, Yeong Suk Choi, In Taek Han, Sang Yoon Lee and Nam-Gyu Park

A solvent- and vacuum-free route to large-area perovskite films for efficient solar modules pp. 92-95

Han Chen, Fei Ye, Wentao Tang, Jinjin He, Maoshu Yin, Yanbo Wang, Fengxian Xie, Enbing Bi, Xudong Yang, Michael Grätzel and Liyuan Han

A spin transition mechanism for cooperative adsorption in metal–organic frameworks pp. 96-100

Douglas A. Reed, Benjamin K. Keitz, Julia Oktawiec, Jarad A. Mason, Tomče Runčevski, Dianne J. Xiao, Lucy E. Darago, Valentina Crocellà, Silvia Bordiga and Jeffrey R. Long

Delta progradation in Greenland driven by increasing glacial mass loss pp. 101-104

Mette Bendixen, Lars Lønsmann Iversen, Anders Anker Bjørk, Bo Elberling, Andreas Westergaard-Nielsen, Irina Overeem, Katy R. Barnhart, Shfaqat Abbas Khan, Jason E. Box, Jakob Abermann, Kirsty Langley and Aart Kroon

Temporal coexistence mechanisms contribute to the latitudinal gradient in forest diversity pp. 105-108

Jacob Usinowicz, Chia-Hao Chang-Yang, Yu-Yun Chen, James S. Clark, Christine Fletcher, Nancy C. Garwood, Zhanqing Hao, Jill Johnstone, Yiching Lin, Margaret R. Metz, Takashi Masaki, Tohru Nakashizuka, I-Fang Sun, Renato Valencia, Yunyun Wang, Jess K. Zimmerman, Anthony R. Ives and S. Joseph Wright

Retrograde semaphorin–plexin signalling drives homeostatic synaptic plasticity pp. 109-113

Brian O. Orr, Richard D. Fetter and Graeme W. Davis

A reversible haploid mouse embryonic stem cell biobank resource for functional genomics pp. 114-118

Ulrich Elling, Reiner A. Wimmer, Andreas Leibbrandt, Thomas Burkard, Georg Michlits, Alexandra Leopoldi, Thomas Micheler, Dana Abdeen, Sergei Zhuk, Irene M. Aspalter, Cornelia Handl, Julia Liebergesell, Maria Hubmann, Anna-Maria Husa, Manuela Kinzer, Nicole Schuller, Ellen Wetzel, Nina van de Loo, Jorge Arturo Zepeda Martinez, David Estoppey, Ralph Riedl, Fengtang Yang, Beiyuan Fu, Thomas Dechat, Zoltán Ivics, Chukwuma A. Agu, Oliver Bell, Dieter Blaas, Holger Gerhardt, Dominic Hoepfner, Alexander Stark and Josef M. Penninger

Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing pp. 119-123

Christina D. Camell, Jil Sander, Olga Spadaro, Aileen Lee, Kim Y. Nguyen, Allison Wing, Emily L. Goldberg, Yun-Hee Youm, Chester W. Brown, John Elsworth, Matthew S. Rodeheffer, Joachim L. Schultze and Vishwa Deep Dixit

CG dinucleotide suppression enables antiviral defence targeting non-self RNA pp. 124-127

Matthew A. Takata, Daniel Gonçalves-Carneiro, Trinity M. Zang, Steven J. Soll, Ashley York, Daniel Blanco-Melo and Paul D. Bieniasz

Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours pp. 128-132

Loren M. Lasko, Clarissa G. Jakob, Rohinton P. Edalji, Wei Qiu, Debra Montgomery, Enrico L. Digiammarino, T. Matt Hansen, Roberto M. Risi, Robin Frey, Vlasios Manaves, Bailin Shaw, Mikkel Algire, Paul Hessler, Lloyd T. Lam, Tamar Uziel, Emily Faivre, Debra Ferguson, Fritz G. Buchanan, Ruth L. Martin, Maricel Torrent, Gary G. Chiang, Kannan Karukurichi, J. William Langston, Brian T. Weinert, Chunaram Choudhary, Peter de Vries, Arthur F. Kluge, Michael A. Patane, John H. Van Drie, Ce Wang, David McElligott, Ed Kesicki, Ronen Marmorstein, Chaohong Sun, Philip A. Cole, Saul H. Rosenberg, Michael R. Michaelides, Albert Lai and Kenneth D. Bromberg

PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas pp. 133-136

Hezhe Lu, Shujing Liu, Gao Zhang, Bin Wu, Yueyao Zhu, Dennie T. Frederick, Yi Hu, Wenqun Zhong, Sergio Randell, Norah Sadek, Wei Zhang, Gang Chen, Chaoran Cheng, Jingwen Zeng, Lawrence W. Wu, Jie Zhang, Xiaoming Liu, Wei Xu, Clemens Krepler, Katrin Sproesser, Min Xiao, Benchun Miao, Jianglan Liu, Claire D. Song, Jephrey Y. Liu, Giorgos C. Karakousis, Lynn M. Schuchter, Yiling Lu, Gordon Mills, Yusheng Cong, Jonathan Chernoff, Jun Guo, Genevieve M. Boland, Ryan J. Sullivan, Zhi Wei, Jeffrey Field, Ravi K. Amaravadi, Keith T. Flaherty, Meenhard Herlyn, Xiaowei Xu and Wei Guo

How type II CRISPR–Cas establish immunity through Cas1–Cas2-mediated spacer integration pp. 137-141

Yibei Xiao, Sherwin Ng, Ki Hyun Nam and Ailong Ke

Correction: Corrigendum: Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation pp. 142-142

Weiwei Yang, Yan Xia, Haitao Ji, Yanhua Zheng, Ji Liang, Wenhua Huang, Xiang Gao, Kenneth Aldape and Zhimin Lu

Correction: Corrigendum: Stability and function of regulatory T cells expressing the transcription factor T-bet pp. 142-142

Andrew G. Levine, Alejandra Mendoza, Saskia Hemmers, Bruno Moltedo, Rachel E. Niec, Michail Schizas, Beatrice E. Hoyos, Ekaterina V. Putintseva, Ashutosh Chaudhry, Stanislav Dikiy, Sho Fujisawa, Dmitriy M. Chudakov, Piper M. Treuting and Alexander Y. Rudensky

Correction: Corrigendum: High-temperature crystallization of nanocrystals into three-dimensional superlattices pp. 142-142

Liheng Wu, Joshua J. Willis, Ian Salmon McKay, Benjamin T. Diroll, Jian Qin, Matteo Cargnello and Christopher J. Tassone

Collaborative software development made easy pp. 143-144

Andrew Silver

The secrets of a standout seminar pp. 145-147

Amber Dance

Societies reconsider conference plans pp. 147-147

Chris Woolston

The daughter you've always wanted pp. 150-150

Steve Pantazis