Genetic induction and mechanochemical propagation of a morphogenetic wave

Anaïs Bailles, Claudio Collinet (), Jean-Marc Philippe, Pierre-François Lenne, Edwin Munro and Thomas Lecuit ()
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Anaïs Bailles: IBDM–UMR7288
Claudio Collinet: IBDM–UMR7288
Jean-Marc Philippe: IBDM–UMR7288
Pierre-François Lenne: IBDM–UMR7288
Edwin Munro: University of Chicago
Thomas Lecuit: IBDM–UMR7288

Nature, 2019, vol. 572, issue 7770, 467-473

Abstract: Abstract Tissue morphogenesis arises from coordinated changes in cell shape driven by actomyosin contractions. Patterns of gene expression regionalize cell behaviours by controlling actomyosin contractility. Here we report two modes of control over Rho1 and myosin II (MyoII) activation in the Drosophila endoderm. First, Rho1–MyoII are induced in a spatially restricted primordium via localized transcription of the G-protein-coupled receptor ligand Fog. Second, a tissue-scale wave of Rho1–MyoII activation and cell invagination progresses anteriorly away from the primordium. The wave does not require sustained gene transcription, and is not governed by regulated Fog delivery. Instead, MyoII inhibition blocks Rho1 activation and propagation, revealing a mechanical feedback driven by MyoII. We find that MyoII activation and invagination in each row of cells drives adhesion to the vitelline membrane mediated by integrins, apical spreading, MyoII activation and invagination in the next row. Endoderm morphogenesis thus emerges from local transcriptional initiation and a mechanically driven cycle of cell deformation.

Date: 2019
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DOI: 10.1038/s41586-019-1492-9

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