Incompatible and sterile insect techniques combined eliminate mosquitoes

Xiaoying Zheng, Dongjing Zhang, Yongjun Li, Cui Yang, Yu Wu, Xiao Liang, Yongkang Liang, Xiaoling Pan, Linchao Hu, Qiang Sun, Xiaohua Wang, Yingyang Wei, Jian Zhu, Wei Qian, Ziqiang Yan, Andrew G. Parker, Jeremie R. L. Gilles, Kostas Bourtzis, Jérémy Bouyer, Moxun Tang, Bo Zheng, Jianshe Yu, Julian Liu, Jiajia Zhuang, Zhigang Hu, Meichun Zhang, Jun-Tao Gong, Xiao-Yue Hong, Zhoubing Zhang, Lifeng Lin, Qiyong Liu, Zhiyong Hu, Zhongdao Wu, Luke Anthony Baton, Ary A. Hoffmann and Zhiyong Xi ()
Additional contact information
Xiaoying Zheng: Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University
Dongjing Zhang: Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University
Yongjun Li: Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University
Cui Yang: Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University
Yu Wu: Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University
Xiao Liang: Michigan State University
Yongkang Liang: Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University
Xiaoling Pan: Michigan State University
Linchao Hu: Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University
Qiang Sun: Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University
Xiaohua Wang: Guangzhou Wolbaki Biotech Co., Ltd
Yingyang Wei: Guangzhou Wolbaki Biotech Co., Ltd
Jian Zhu: Guangzhou Wolbaki Biotech Co., Ltd
Wei Qian: Guangzhou Wolbaki Biotech Co., Ltd
Ziqiang Yan: Guangzhou Center for Disease Control and Prevention
Andrew G. Parker: Vienna International Centre
Jeremie R. L. Gilles: Vienna International Centre
Kostas Bourtzis: Vienna International Centre
Jérémy Bouyer: Vienna International Centre
Moxun Tang: Michigan State University
Bo Zheng: Guangzhou University
Jianshe Yu: Guangzhou University
Julian Liu: Guangzhou Wolbaki Biotech Co., Ltd
Jiajia Zhuang: Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University
Zhigang Hu: Guangzhou Center for Disease Control and Prevention
Meichun Zhang: Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University
Jun-Tao Gong: Nanjing Agricultural University
Xiao-Yue Hong: Nanjing Agricultural University
Zhoubing Zhang: Guangzhou Center for Disease Control and Prevention
Lifeng Lin: Guangdong Provincial Center for Disease Control and Prevention
Qiyong Liu: National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention
Zhiyong Hu: Guangzhou University
Zhongdao Wu: Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University
Luke Anthony Baton: Michigan State University
Ary A. Hoffmann: University of Melbourne
Zhiyong Xi: Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University

Nature, 2019, vol. 572, issue 7767, 56-61

Abstract: Abstract The radiation-based sterile insect technique (SIT) has successfully suppressed field populations of several insect pest species, but its effect on mosquito vector control has been limited. The related incompatible insect technique (IIT)—which uses sterilization caused by the maternally inherited endosymbiotic bacteria Wolbachia—is a promising alternative, but can be undermined by accidental release of females infected with the same Wolbachia strain as the released males. Here we show that combining incompatible and sterile insect techniques (IIT–SIT) enables near elimination of field populations of the world’s most invasive mosquito species, Aedes albopictus. Millions of factory-reared adult males with an artificial triple-Wolbachia infection were released, with prior pupal irradiation of the released mosquitoes to prevent unintentionally released triply infected females from successfully reproducing in the field. This successful field trial demonstrates the feasibility of area-wide application of combined IIT–SIT for mosquito vector control.

Date: 2019
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DOI: 10.1038/s41586-019-1407-9

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