Plant cell-surface GIPC sphingolipids sense salt to trigger Ca2+ influx

Zhonghao Jiang, Xiaoping Zhou, Ming Tao, Fang Yuan, Lulu Liu, Feihua Wu, Xiaomei Wu, Yun Xiang, Yue Niu, Feng Liu, Chijun Li, Rui Ye, Benjamin Byeon, Yan Xue, Hongyan Zhao, Hsin-Neng Wang, Bridget M. Crawford, Douglas M. Johnson, Chanxing Hu, Christopher Pei, Wenming Zhou, Gary B. Swift, Han Zhang, Tuan Vo-Dinh, Zhangli Hu (), James N. Siedow and Zhen-Ming Pei ()
Additional contact information
Zhonghao Jiang: Longhua Innovation Institute for Biotechnology, Shenzhen University
Xiaoping Zhou: Hangzhou Normal University
Ming Tao: Longhua Innovation Institute for Biotechnology, Shenzhen University
Fang Yuan: Duke University
Lulu Liu: Duke University
Feihua Wu: Longhua Innovation Institute for Biotechnology, Shenzhen University
Xiaomei Wu: Hangzhou Normal University
Yun Xiang: Duke University
Yue Niu: Duke University
Feng Liu: Duke University
Chijun Li: Duke University
Rui Ye: Duke University
Benjamin Byeon: Duke University
Yan Xue: Duke University
Hongyan Zhao: Hangzhou Normal University
Hsin-Neng Wang: Duke University
Bridget M. Crawford: Duke University
Douglas M. Johnson: Duke University
Chanxing Hu: Duke University
Christopher Pei: Duke University
Wenming Zhou: Longhua Innovation Institute for Biotechnology, Shenzhen University
Gary B. Swift: Duke University
Han Zhang: Shenzhen University
Tuan Vo-Dinh: Duke University
Zhangli Hu: Longhua Innovation Institute for Biotechnology, Shenzhen University
James N. Siedow: Duke University
Zhen-Ming Pei: Duke University

Nature, 2019, vol. 572, issue 7769, 341-346

Abstract: Abstract Salinity is detrimental to plant growth, crop production and food security worldwide. Excess salt triggers increases in cytosolic Ca2+ concentration, which activate Ca2+-binding proteins and upregulate the Na+/H+ antiporter in order to remove Na+. Salt-induced increases in Ca2+ have long been thought to be involved in the detection of salt stress, but the molecular components of the sensing machinery remain unknown. Here, using Ca2+-imaging-based forward genetic screens, we isolated the Arabidopsis thaliana mutant monocation-induced [Ca2+]i increases 1 (moca1), and identified MOCA1 as a glucuronosyltransferase for glycosyl inositol phosphorylceramide (GIPC) sphingolipids in the plasma membrane. MOCA1 is required for salt-induced depolarization of the cell-surface potential, Ca2+ spikes and waves, Na+/H+ antiporter activation, and regulation of growth. Na+ binds to GIPCs to gate Ca2+ influx channels. This salt-sensing mechanism might imply that plasma-membrane lipids are involved in adaption to various environmental salt levels, and could be used to improve salt resistance in crops.

Date: 2019
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41586-019-1449-z Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:572:y:2019:i:7769:d:10.1038_s41586-019-1449-z

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/s41586-019-1449-z

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().