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2018, volume 559, articles 7715

Alzheimer’s disease pp. S1-S1

Richard Hodson

An age-old story of dementia pp. S2-S3

Liam Drew

The amyloid hypothesis on trial pp. S4-S7

Simon Makin

Drawing on the brain’s resilience to fight Alzheimer’s disease pp. S8-S9

Lauren Gravitz

Alzheimer’s disease is getting easier to spot pp. S10-S12

Elie Dolgin

Author Correction: EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma pp. E11-E11

Aparna Gorthi, July Carolina Romero, Eva Loranc, Lin Cao, Liesl A. Lawrence, Elicia Goodale, Amanda Balboni Iniguez, Xavier Bernard, V. Pragathi Masamsetti, Sydney Roston, Elizabeth R. Lawlor, Jeffrey A. Toretsky, Kimberly Stegmaier, Stephen L. Lessnick, Yidong Chen and Alexander J. R. Bishop

Author Correction: Discovery of stimulation-responsive immune enhancers with CRISPR activation pp. E13-E13

Dimitre R. Simeonov, Benjamin G. Gowen, Mandy Boontanrart, Theodore L. Roth, John D. Gagnon, Maxwell R. Mumbach, Ansuman T. Satpathy, Youjin Lee, Nicolas L. Bray, Alice Y. Chan, Dmytro S. Lituiev, Michelle L. Nguyen, Rachel E. Gate, Meena Subramaniam, Zhongmei Li, Jonathan M. Woo, Therese Mitros, Graham J. Ray, Gemma L. Curie, Nicki Naddaf, Julia S. Chu, Hong Ma, Eric Boyer, Frederic Gool, Hailiang Huang, Ruize Liu, Victoria R. Tobin, Kathrin Schumann, Mark J. Daly, Kyle K. Farh, K. Mark Ansel, Chun J. Ye, William J. Greenleaf, Mark S. Anderson, Jeffrey A. Bluestone, Howard Y. Chang, Jacob E. Corn and Alexander Marson

The search for better animal models of Alzheimer’s disease pp. S13-S15

Anthony King

Ways to stop the spread of Alzheimer’s disease pp. S16-S17

Moheb Costandi

How the evidence stacks up for preventing Alzheimer’s disease pp. S18-S20

Emily Sohn

Preprints could promote confusion and distortion pp. 445-445

Tom Sheldon

Ecologists try to speed up evolution to save Australian marsupial from toxic toads pp. 451-452

April Reese

Death-defying NASA mission will make humanity’s closest approach to the Sun pp. 452-453

Alexandra Witze

Philippines sweetens deal for scientists who return home pp. 453-454

Andrew Silver

Dutch publishing giant cuts off researchers in Germany and Sweden pp. 454-455

Holly Else

Big Bang telescope finale marks end of an era in cosmology pp. 455-456

Davide Castelvecchi

How to defuse malaria’s ticking time bomb pp. 458-465

Amy Maxmen

Ten years left to redesign lithium-ion batteries pp. 467-470

Kostiantyn Turcheniuk, Dmitry Bondarev, Vinod Singhal and Gleb Yushin

Pet genomics medicine runs wild pp. 470-472

Lisa Moses, Steve Niemi and Elinor Karlsson

Ancient dreams of intelligent machines: 3,000 years of robots pp. 473-475

Stephen Cave and Kanta Dihal

The souls of deserts, a gathering of visionary biologists, and an inside view on exoplanets: Books in brief pp. 475-475

Barbara Kiser

From literature search to vaccine candidate without a lab pp. 477-477

Reza Forough, Mohammad Mian, Anthony Klobas and Jeffrey Talada

The United States will lose money if it charges for Earth observation data pp. 477-477

Barbara J. Ryan

Don’t ignore health-care impacts of Internet shutdowns pp. 477-477

Okwen Mbah, Miriam Nkangu and Zak Rogoff

Modelling the trajectory of disease outbreaks works pp. 477-477

Caitlin M. Rivers and Samuel V. Scarpino

An early hominin arrival in Asia pp. 480-481

John Kappelman

Quantum optics without photons pp. 481-482

Alejandro González Tudela and J. Ignacio Cirac

Viruses cooperate to defeat bacteria pp. 482-484

Aude Bernheim and Rotem Sorek

Histidine metabolism boosts cancer therapy pp. 484-485

Christian Frezza

Neural circuit evolved to process pheromone differently in two species of fruit fly pp. 485-487

Nicolas Gompel and Benjamin Prud’homme

Ancient ice sheet had a growth spurt pp. 487-488

Pippa Whitehouse

Tropics pp. 489-489

Anna Armstrong, I-han Chou, Juliane Mossinger, Clare Thomas, Christina Tobin Kårlström and Michael White

Challenges and opportunities in controlling mosquito-borne infections pp. 490-497

Neil M. Ferguson

Challenges and recent progress in drug discovery for tropical diseases pp. 498-506

Manu Rycker, Beatriz Baragaña, Suzanne L. Duce and Ian H. Gilbert

Acting on non-communicable diseases in low- and middle-income tropical countries pp. 507-516

Majid Ezzati, Jonathan Pearson-Stuttard, James E. Bennett and Colin D. Mathers

The future of hyperdiverse tropical ecosystems pp. 517-526

Jos Barlow, Filipe França, Toby A. Gardner, Christina C. Hicks, Gareth D. Lennox, Erika Berenguer, Leandro Castello, Evan P. Economo, Joice Ferreira, Benoit Guénard, Cecília Gontijo Leal, Victoria Isaac, Alexander C. Lees, Catherine L. Parr, Shaun K. Wilson, Paul J. Young and Nicholas A. J. Graham

The tropical forest carbon cycle and climate change pp. 527-534

Edward T. A. Mitchard

El Niño–Southern Oscillation complexity pp. 535-545

Axel Timmermann, Soon-Il An, Jong-Seong Kug, Fei-Fei Jin, Wenju Cai, Antonietta Capotondi, Kim M. Cobb, Matthieu Lengaigne, Michael J. McPhaden, Malte F. Stuecker, Karl Stein, Andrew T. Wittenberg, Kyung-Sook Yun, Tobias Bayr, Han-Ching Chen, Yoshimitsu Chikamoto, Boris Dewitte, Dietmar Dommenget, Pamela Grothe, Eric Guilyardi, Yoo-Geun Ham, Michiya Hayashi, Sarah Ineson, Daehyun Kang, Sunyong Kim, WonMoo Kim, June-Yi Lee, Tim Li, Jing-Jia Luo, Shayne McGregor, Yann Planton, Scott Power, Harun Rashid, Hong-Li Ren, Agus Santoso, Ken Takahashi, Alexander Todd, Guomin Wang, Guojian Wang, Ruihuang Xie, Woo-Hyun Yang, Sang-Wook Yeh, Jinho Yoon, Elke Zeller and Xuebin Zhang

Machine learning for molecular and materials science pp. 547-555

Keith T. Butler, Daniel W. Davies, Hugh Cartwright, Olexandr Isayev and Aron Walsh

Niobium tungsten oxides for high-rate lithium-ion energy storage pp. 556-563

Kent J. Griffith, Kamila M. Wiaderek, Giannantonio Cibin, Lauren E. Marbella and Clare P. Grey

Evolution of a central neural circuit underlies Drosophila mate preferences pp. 564-569

Laura F. Seeholzer, Max Seppo, David L. Stern and Vanessa Ruta

Cryo-EM structure of a fungal mitochondrial calcium uniporter pp. 570-574

Nam X. Nguyen, Jean-Paul Armache, Changkeun Lee, Yi Yang, Weizhong Zeng, Vamsi K. Mootha, Yifan Cheng, Xiao-chen Bai and Youxing Jiang

X-ray and cryo-EM structures of the mitochondrial calcium uniporter pp. 575-579

Chao Fan, Minrui Fan, Benjamin J. Orlando, Nathan M. Fastman, Jinru Zhang, Yan Xu, Melissa G. Chambers, Xiaofang Xu, Kay Perry, Maofu Liao and Liang Feng

Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters pp. 580-584

Rozbeh Baradaran, Chongyuan Wang, Andrew Francis Siliciano and Stephen Barstow Long

The formation of solar-neighbourhood stars in two generations separated by 5 billion years pp. 585-588

Masafumi Noguchi

Spontaneous emission of matter waves from a tunable open quantum system pp. 589-592

Ludwig Krinner, Michael Stewart, Arturo Pazmiño, Joonhyuk Kwon and Dominik Schneble

Complex silica composite nanomaterials templated with DNA origami pp. 593-598

Xiaoguo Liu, Fei Zhang, Xinxin Jing, Muchen Pan, Pi Liu, Wei Li, Bowen Zhu, Jiang Li, Hong Chen, Lihua Wang, Jianping Lin, Yan Liu, Dongyuan Zhao, Hao Yan and Chunhai Fan

Atmosphere–soil carbon transfer as a function of soil depth pp. 599-602

Jérôme Balesdent, Isabelle Basile-Doelsch, Joël Chadoeuf, Sophie Cornu, Delphine Derrien, Zuzana Fekiacova and Christine Hatté

Rapid glaciation and a two-step sea level plunge into the Last Glacial Maximum pp. 603-607

Yusuke Yokoyama, Tezer M. Esat, William G. Thompson, Alexander L. Thomas, Jody M. Webster, Yosuke Miyairi, Chikako Sawada, Takahiro Aze, Hiroyuki Matsuzaki, Jun’ichi Okuno, Stewart Fallon, Juan-Carlos Braga, Marc Humblet, Yasufumi Iryu, Donald C. Potts, Kazuhiko Fujita, Atsushi Suzuki and Hironobu Kan

Hominin occupation of the Chinese Loess Plateau since about 2.1 million years ago pp. 608-612

Zhaoyu Zhu, Robin Dennell, Weiwen Huang, Yi Wu, Shifan Qiu, Shixia Yang, Zhiguo Rao, Yamei Hou, Jiubing Xie, Jiangwei Han and Tingping Ouyang

Triple oxygen isotope evidence for limited mid-Proterozoic primary productivity pp. 613-616

Peter W. Crockford, Justin A. Hayles, Huiming Bao, Noah J. Planavsky, Andrey Bekker, Philip W. Fralick, Galen P. Halverson, Thi Hao Bui, Yongbo Peng and Boswell A. Wing

The outer membrane is an essential load-bearing element in Gram-negative bacteria pp. 617-621

Enrique R. Rojas, Gabriel Billings, Pascal D. Odermatt, George K. Auer, Lillian Zhu, Amanda Miguel, Fred Chang, Douglas B. Weibel, Julie A. Theriot and Kerwyn Casey Huang

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells pp. 622-626

Chamutal Bornstein, Shir Nevo, Amir Giladi, Noam Kadouri, Marie Pouzolles, François Gerbe, Eyal David, Alice Machado, Anna Chuprin, Beáta Tóth, Ori Goldberg, Shalev Itzkovitz, Naomi Taylor, Philippe Jay, Valérie S. Zimmermann, Jakub Abramson and Ido Amit

Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development pp. 627-631

Corey N. Miller, Irina Proekt, Jakob Moltke, Kristen L. Wells, Aparna R. Rajpurkar, Haiguang Wang, Kristin Rattay, Imran S. Khan, Todd C. Metzger, Joshua L. Pollack, Adam C. Fries, Wint W. Lwin, Eric J. Wigton, Audrey V. Parent, Bruno Kyewski, David J. Erle, Kristin A. Hogquist, Lars M. Steinmetz, Richard M. Locksley and Mark S. Anderson

Histidine catabolism is a major determinant of methotrexate sensitivity pp. 632-636

Naama Kanarek, Heather R. Keys, Jason R. Cantor, Caroline A. Lewis, Sze Ham Chan, Tenzin Kunchok, Monther Abu-Remaileh, Elizaveta Freinkman, Lawrence D. Schweitzer and David M. Sabatini

Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer pp. 637-641

Di Wu, Di Hu, Hao Chen, Guoming Shi, Irfete S. Fetahu, Feizhen Wu, Kimberlie Rabidou, Rui Fang, Li Tan, Shuyun Xu, Hang Liu, Christian Argueta, Lei Zhang, Fei Mao, Guoquan Yan, Jiajia Chen, Zhaoru Dong, Ruitu Lv, Yufei Xu, Mei Wang, Yong Ye, Shike Zhang, Danielle Duquette, Songmei Geng, Clark Yin, Christine Guo Lian, George F. Murphy, Gail K. Adler, Rajesh Garg, Lydia Lynch, Pengyuan Yang, Yiming Li, Fei Lan, Jia Fan, Yang Shi and Yujiang Geno Shi

The hackers teaching old DNA sequencers new tricks pp. 643-645

Jeffrey M. Perkel

How to deliver sound science in resource-poor regions pp. 647-649

Josie Glausiusz

Surrogate pp. 652-652

Griffin Ayaz Tyree

2018, volume 559, articles 7714

Publisher Correction: Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage pp. E8-E8

Nicole M. Gaudelli, Alexis C. Komor, Holly A. Rees, Michael S. Packer, Ahmed H. Badran, David I. Bryson and David R. Liu

Author Correction: Diffusible repression of cytokinin signalling produces endodermal symmetry and passage cells pp. E9-E9

Tonni Grube Andersen, Sadaf Naseer, Robertas Ursache, Brecht Wybouw, Wouter Smet, Bert Rybel, Joop E. M. Vermeer and Niko Geldner

Author Correction: The landscape of genomic alterations across childhood cancers pp. E10-E10

Susanne N. Gröbner, Barbara C. Worst, Joachim Weischenfeldt, Ivo Buchhalter, Kortine Kleinheinz, Vasilisa A. Rudneva, Pascal D. Johann, Gnana Prakash Balasubramanian, Maia Segura-Wang, Sebastian Brabetz, Sebastian Bender, Barbara Hutter, Dominik Sturm, Elke Pfaff, Daniel Hübschmann, Gideon Zipprich, Michael Heinold, Jürgen Eils, Christian Lawerenz, Serap Erkek, Sander Lambo, Sebastian Waszak, Claudia Blattmann, Arndt Borkhardt, Michaela Kuhlen, Angelika Eggert, Simone Fulda, Manfred Gessler, Jenny Wegert, Roland Kappler, Daniel Baumhoer, Stefan Burdach, Renate Kirschner-Schwabe, Udo Kontny, Andreas E. Kulozik, Dietmar Lohmann, Simone Hettmer, Cornelia Eckert, Stefan Bielack, Michaela Nathrath, Charlotte Niemeyer, Günther H. Richter, Johannes Schulte, Reiner Siebert, Frank Westermann, Jan J. Molenaar, Gilles Vassal, Hendrik Witt, Birgit Burkhardt, Christian P. Kratz, Olaf Witt, Cornelis M. Tilburg, Christof M. Kramm, Gudrun Fleischhack, Uta Dirksen, Stefan Rutkowski, Michael Frühwald, Katja Hoff, Stephan Wolf, Thomas Klingebiel, Ewa Koscielniak, Pablo Landgraf, Jan Koster, Adam C. Resnick, Jinghui Zhang, Yanling Liu, Xin Zhou, Angela J. Waanders, Danny A. Zwijnenburg, Pichai Raman, Benedikt Brors, Ursula D. Weber, Paul A. Northcott, Kristian W. Pajtler, Marcel Kool, Rosario M. Piro, Jan O. Korbel, Matthias Schlesner, Roland Eils, David T. W. Jones, Peter Lichter, Lukas Chavez, Marc Zapatka and Stefan M. Pfister

Why I testified in the Argentina abortion debate pp. 303-303

Alberto Kornblihtt

Single subatomic particle illuminates mysterious origins of cosmic rays pp. 309-310

Davide Castelvecchi

China expands surveillance of sewage to police illegal drug use pp. 310-311

David Cyranoski

Science journals end open-access trial with Gates Foundation pp. 311-312

Richard Van Noorden

Jupiter has 10 more moons we didn't know about — and they're weird pp. 312-313

Alexandra Witze

Gene therapy in mouse fetuses treats deadly disease pp. 313-314

Heidi Ledford

Science under siege: behind the scenes at Trump’s troubled environment agency pp. 316-319

Jeff Tollefson

Beat protectionism and emissions at a stroke pp. 321-324

Michael A. Mehling, Harro van Asselt, Kasturi Das and Susanne Droege

AI can be sexist and racist — it’s time to make it fair pp. 324-326

James Zou and Londa Schiebinger

Summer reads: Darwin’s dilemma on sexual selection, ecology versus empire, and the dark side of the greater good pp. 328-330

Andrew Jaffe, Fatimah Jackson, Elizabeth Yale, Adam Rome, Jennifer Rohn, Tim Radford, Alex Haslam and Diane Coyle

Iran’s scientists uncrushed by decades of sanctions pp. 331-331

Shahin Akhondzadeh

Learn from industry to build a healthy lab pp. 331-331

Z. Hugh Fan

Evaluation woes: professors should have fought harder pp. 331-331

Andrew Beattie

Evaluation woes: define metrics from the off pp. 331-331

Paola Zaratin and Marco Salvetti

Evaluation woes: Metrics can help beat bias pp. 331-331

Li Tang and Guangyuan Hu

A record-breaking microscope pp. 334-335

John Rodenburg

Coronary artery development, one cell at a time pp. 335-336

Arndt F. Siekmann

High-quality genomes reveal new differences between the great apes pp. 336-338

Aylwyn Scally

Resistance to prostate-cancer treatment is driven by immune cells pp. 338-339

Matthew D. Galsky

Sluggish Atlantic circulation could cause global temperatures to surge pp. 340-341

Gerard D. McCarthy and Peter W. Thorne

Speciation far from the madding crowd pp. 341-342

Arne O. Mooers and Dan A. Greenberg

Electron ptychography of 2D materials to deep sub-ångström resolution pp. 343-349

Yi Jiang, Zhen Chen, Yimo Han, Pratiti Deb, Hui Gao, Saien Xie, Prafull Purohit, Mark W. Tate, Jiwoong Park, Sol M. Gruner, Veit Elser and David A. Muller

Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations pp. 350-355

Po-Ru Loh, Giulio Genovese, Robert E. Handsaker, Hilary K. Finucane, Yakir A. Reshef, Pier Francesco Palamara, Brenda M. Birmann, Michael E. Talkowski, Samuel F. Bakhoum, Steven A. McCarroll and Alkes L. Price

Single-cell analysis of early progenitor cells that build coronary arteries pp. 356-362

Tianying Su, Geoff Stanley, Rahul Sinha, Gaetano D’Amato, Soumya Das, Siyeon Rhee, Andrew H. Chang, Aruna Poduri, Brian Raftrey, Thanh Theresa Dinh, Walter A. Roper, Guang Li, Kelsey E. Quinn, Kathleen M. Caron, Sean Wu, Lucile Miquerol, Eugene C. Butcher, Irving Weissman, Stephen Quake and Kristy Red-Horse

IL-23 secreted by myeloid cells drives castration-resistant prostate cancer pp. 363-369

Arianna Calcinotto, Clarissa Spataro, Elena Zagato, Diletta Di Mitri, Veronica Gil, Mateus Crespo, Gaston De Bernardis, Marco Losa, Michela Mirenda, Emiliano Pasquini, Andrea Rinaldi, Semini Sumanasuriya, Maryou B. Lambros, Antje Neeb, Roberta Lucianò, Carlo A. Bravi, Daniel Nava-Rodrigues, David Dolling, Tommaso Prayer-Galetti, Ana Ferreira, Alberto Briganti, Antonio Esposito, Simon Barry, Wei Yuan, Adam Sharp, Johann de Bono and Andrea Alimonti

Scaling up molecular pattern recognition with DNA-based winner-take-all neural networks pp. 370-376

Kevin M. Cherry and Lulu Qian

Controlling an organic synthesis robot with machine learning to search for new reactivity pp. 377-381

Jarosław M. Granda, Liva Donina, Vincenza Dragone, Long De-Liang and Leroy Cronin

Synchronous tropical and polar temperature evolution in the Eocene pp. 382-386

Marlow J. Cramwinckel, Matthew Huber, Ilja J. Kocken, Claudia Agnini, Peter K. Bijl, Steven M. Bohaty, Joost Frieling, Aaron Goldner, Frederik J. Hilgen, Elizabeth L. Kip, Francien Peterse, Robin Ploeg, Ursula Röhl, Stefan Schouten and Appy Sluijs

Global surface warming enhanced by weak Atlantic overturning circulation pp. 387-391

Xianyao Chen and Ka-Kit Tung

An inverse latitudinal gradient in speciation rate for marine fishes pp. 392-395

Daniel L. Rabosky, Jonathan Chang, Pascal O. Title, Peter F. Cowman, Lauren Sallan, Matt Friedman, Kristin Kaschner, Cristina Garilao, Thomas J. Near, Marta Coll and Michael E. Alfaro

Hot streaks in artistic, cultural, and scientific careers pp. 396-399

Lu Liu, Yang Wang, Roberta Sinatra, C. Lee Giles, Chaoming Song and Dashun Wang

Prediction of acute myeloid leukaemia risk in healthy individuals pp. 400-404

Sagi Abelson, Grace Collord, Stanley W. K. Ng, Omer Weissbrod, Netta Mendelson Cohen, Elisabeth Niemeyer, Noam Barda, Philip C. Zuzarte, Lawrence Heisler, Yogi Sundaravadanam, Robert Luben, Shabina Hayat, Ting Ting Wang, Zhen Zhao, Iulia Cirlan, Trevor J. Pugh, David Soave, Karen Ng, Calli Latimer, Claire Hardy, Keiran Raine, David Jones, Diana Hoult, Abigail Britten, John D. McPherson, Mattias Johansson, Faridah Mbabaali, Jenna Eagles, Jessica K. Miller, Danielle Pasternack, Lee Timms, Paul Krzyzanowski, Philip Awadalla, Rui Costa, Eran Segal, Scott V. Bratman, Philip Beer, Sam Behjati, Inigo Martincorena, Jean C. Y. Wang, Kristian M. Bowles, J. Ramón Quirós, Anna Karakatsani, Carlo Vecchia, Antonia Trichopoulou, Elena Salamanca-Fernández, José M. Huerta, Aurelio Barricarte, Ruth C. Travis, Rosario Tumino, Giovanna Masala, Heiner Boeing, Salvatore Panico, Rudolf Kaaks, Alwin Krämer, Sabina Sieri, Elio Riboli, Paolo Vineis, Matthieu Foll, James McKay, Silvia Polidoro, Núria Sala, Kay-Tee Khaw, Roel Vermeulen, Peter J. Campbell, Elli Papaemmanuil, Mark D. Minden, Amos Tanay, Ran D. Balicer, Nicholas J. Wareham, Moritz Gerstung, John E. Dick, Paul Brennan, George S. Vassiliou and Liran I. Shlush

Reprogramming human T cell function and specificity with non-viral genome targeting pp. 405-409

Theodore L. Roth, Cristina Puig-Saus, Ruby Yu, Eric Shifrut, Julia Carnevale, P. Jonathan Li, Joseph Hiatt, Justin Saco, Paige Krystofinski, Han Li, Victoria Tobin, David N. Nguyen, Michael R. Lee, Amy L. Putnam, Andrea L. Ferris, Jeff W. Chen, Jean-Nicolas Schickel, Laurence Pellerin, David Carmody, Gorka Alkorta-Aranburu, Daniela del Gaudio, Hiroyuki Matsumoto, Montse Morell, Ying Mao, Min Cho, Rolen M. Quadros, Channabasavaiah B. Gurumurthy, Baz Smith, Michael Haugwitz, Stephen H. Hughes, Jonathan S. Weissman, Kathrin Schumann, Jonathan H. Esensten, Andrew P. May, Alan Ashworth, Gary M. Kupfer, Siri Atma W. Greeley, Rosa Bacchetta, Eric Meffre, Maria Grazia Roncarolo, Neil Romberg, Kevan C. Herold, Antoni Ribas, Manuel D. Leonetti and Alexander Marson

Mechanism of parkin activation by PINK1 pp. 410-414

Christina Gladkova, Sarah L. Maslen, J. Mark Skehel and David Komander

Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action pp. 415-418

Yan Yan, Qikun Liu, Xin Zang, Shuguang Yuan, Undramaa Bat-Erdene, Calvin Nguyen, Jianhua Gan, Jiahai Zhou, Steven E. Jacobsen and Yi Tang

Prespliceosome structure provides insights into spliceosome assembly and regulation pp. 419-422

Clemens Plaschka, Pei-Chun Lin, Clément Charenton and Kiyoshi Nagai

PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling pp. 423-427

Hsin-Yung Yen, Kin Kuan Hoi, Idlir Liko, George Hedger, Michael R. Horrell, Wanling Song, Di Wu, Philipp Heine, Tony Warne, Yang Lee, Byron Carpenter, Andreas Plückthun, Christopher G. Tate, Mark S. P. Sansom and Carol V. Robinson

How retirement can give your career a new lease of life pp. 429-431

Amber Dance

Why organizing a scientific conference can produce huge benefits pp. 431-431

Francesco Sciortino

Papa Bear pp. 434-434

Kurt Pankau

2018, volume 559, articles 7713

Publisher Correction: Pervasive phosphorus limitation of tree species but not communities in tropical forests pp. E4-E4

Benjamin L. Turner, Tania Brenes-Arguedas and Richard Condit

Author Correction: A series of energetic metal pentazolate hydrates pp. E5-E5

Yuangang Xu, Qian Wang, Cheng Shen, Qiuhan Lin, Pengcheng Wang and Ming Lu

Author Correction: Roads towards fault-tolerant universal quantum computation pp. E6-E6

Earl T. Campbell, Barbara M. Terhal and Christophe Vuillot

Publisher Correction: A TRP channel trio mediates acute noxious heat sensing pp. E7-E7

Ine Vandewauw, Katrien Clercq, Marie Mulier, Katharina Held, Silvia Pinto, Nele Ranst, Andrei Segal, Thierry Voet, Rudi Vennekens, Katharina Zimmermann, Joris Vriens and Thomas Voets

Lab heads should learn to talk about racism pp. 153-153

Devang Mehta

Max Planck astrophysicist at centre of bullying allegations speaks up pp. 159-160

Alison Abbott

Foreign-researcher figures stress need for immigration reform before Brexit pp. 160-161

Elizabeth Gibney

Coming soon to a lab near you? Genetically modified cannabis pp. 162-162

Amy Maxmen

Software beats animal tests at predicting toxicity of chemicals pp. 163-163

Richard Van Noorden

Controversial CRISPR ‘gene drives’ tested in mammals for the first time pp. 164-164

Ewen Callaway

100 bats and a long, dark tunnel: one neuroscientist’s quest to unlock the secrets of 3D navigation pp. 165-168

Alison Abbott

Grand challenges in humanitarian aid pp. 169-173

Abdallah S. Daar, Trillium Chang, Angela Salomon and Peter A. Singer

Cape Town’s drought: don’t blame climate change pp. 174-176

Mike Muller

The imperial roots of climate science pp. 178-179

Mott Greene

A guidebook to cancer, slavery to stupid machines, and the buzz about bees: Books in brief pp. 179-179

Barbara Kiser

The Flint water crisis: how citizen scientists exposed poisonous politics pp. 180-180

Mark Peplow

Local diagnostics kits for Africa being developed in Ghana pp. 181-181

Aniweh Yaw, Kanyong Prosper, Francis Krampa and Gordon A. Awandare

Two centuries since discovery of dawn-of-life molecule pp. 181-181

Willem H. Koppenol and Helmut Sies

EPA is open to scrutiny pp. 181-181

Charles Herrick

Now India is electrified, bring on the renewables pp. 181-181

Shekhar Chandra and Lawrence E. Susskind

Justification for the EPA’s transparency rule pp. 181-181

Peter Wood

Self-organizing multicellular structures designed using synthetic biology pp. 184-185

Jesse Tordoff and Ron Weiss

A fresh take on ancient climate change in the North Pacific pp. 185-186

Kaustubh Thirumalai

Superfast DNA replication causes damage in cancer cells pp. 186-187

Annabel Quinet and Alessandro Vindigni

Estimate suggests many infant deaths in sub-Saharan Africa attributable to air pollution pp. 188-189

Lance A. Waller

The heat is on for Majorana fermions pp. 189-190

Kirill Shtengel

How rats wreak havoc on coral reefs pp. 190-191

Nancy Knowlton

China’s response to a national land-system sustainability emergency pp. 193-204

Brett A. Bryan, Lei Gao, Yanqiong Ye, Xiufeng Sun, Jeffery D. Connor, Neville D. Crossman, Mark Stafford-Smith, Jianguo Wu, Chunyang He, Deyong Yu, Zhifeng Liu, Ang Li, Qingxu Huang, Hai Ren, Xiangzheng Deng, Hua Zheng, Jianming Niu, Guodong Han and Xiangyang Hou

Observation of half-integer thermal Hall conductance pp. 205-210

Mitali Banerjee, Moty Heiblum, Vladimir Umansky, Dima E. Feldman, Yuval Oreg and Ady Stern

Kinase-controlled phase transition of membraneless organelles in mitosis pp. 211-216

Arpan Kumar Rai, Jia-Xuan Chen, Matthias Selbach and Lucas Pelkmans

Structure of the origin recognition complex bound to DNA replication origin pp. 217-222

Ningning Li, Wai Hei Lam, Yuanliang Zhai, Jiaxuan Cheng, Erchao Cheng, Yongqian Zhao, Ning Gao and Bik-Kwoon Tye

Non-gravitational acceleration in the trajectory of 1I/2017 U1 (‘Oumuamua) pp. 223-226

Marco Micheli, Davide Farnocchia, Karen J. Meech, Marc W. Buie, Olivier R. Hainaut, Dina Prialnik, Norbert Schörghofer, Harold A. Weaver, Paul W. Chodas, Jan T. Kleyna, Robert Weryk, Richard J. Wainscoat, Harald Ebeling, Jacqueline V. Keane, Kenneth C. Chambers, Detlef Koschny and Anastassios E. Petropoulos

Majorana quantization and half-integer thermal quantum Hall effect in a Kitaev spin liquid pp. 227-231

Y. Kasahara, T. Ohnishi, Y. Mizukami, O. Tanaka, Sixiao Ma, K. Sugii, N. Kurita, H. Tanaka, J. Nasu, Y. Motome, T. Shibauchi and Y. Matsuda

Metallic nanoparticle contacts for high-yield, ambient-stable molecular-monolayer devices pp. 232-235

Gabriel Puebla-Hellmann, Koushik Venkatesan, Marcel Mayor and Emanuel Lörtscher

Electrically controlled water permeation through graphene oxide membranes pp. 236-240

K.-G. Zhou, K. S. Vasu, C. T. Cherian, M. Neek-Amal, J. C. Zhang, H. Ghorbanfekr-Kalashami, K. Huang, O. P. Marshall, V. G. Kravets, J. Abraham, Y. Su, A. N. Grigorenko, A. Pratt, A. K. Geim, F. M. Peeters, K. S. Novoselov and R. R. Nair

North Pacific freshwater events linked to changes in glacial ocean circulation pp. 241-245

E. Maier, X. Zhang, A. Abelmann, R. Gersonde, S. Mulitza, M. Werner, M. Méheust, J. Ren, B. Chapligin, H. Meyer, R. Stein, R. Tiedemann and G. Lohmann

Evolution of cooperation in stochastic games pp. 246-249

Christian Hilbe, Štěpán Šimsa, Krishnendu Chatterjee and Martin A. Nowak

Seabirds enhance coral reef productivity and functioning in the absence of invasive rats pp. 250-253

Nicholas A. J. Graham, Shaun K. Wilson, Peter Carr, Andrew S. Hoey, Simon Jennings and M. Aaron MacNeil

Robust relationship between air quality and infant mortality in Africa pp. 254-258

Sam Heft-Neal, Jennifer Burney, Eran Bendavid and Marshall Burke

Species-specific activity of antibacterial drug combinations pp. 259-263

Ana Rita Brochado, Anja Telzerow, Jacob Bobonis, Manuel Banzhaf, André Mateus, Joel Selkrig, Emily Huth, Stefan Bassler, Jordi Zamarreño Beas, Matylda Zietek, Natalie Ng, Sunniva Foerster, Benjamin Ezraty, Béatrice Py, Frédéric Barras, Mikhail M. Savitski, Peer Bork, Stephan Göttig and Athanasios Typas

The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells pp. 264-268

Henrique Borges da Silva, Lalit K. Beura, Haiguang Wang, Eric A. Hanse, Reshma Gore, Milcah C. Scott, Daniel A. Walsh, Katharine E. Block, Raissa Fonseca, Yan Yan, Keli L. Hippen, Bruce R. Blazar, David Masopust, Ameeta Kelekar, Lucy Vulchanova, Kristin A. Hogquist and Stephen C. Jameson

Targeting STING with covalent small-molecule inhibitors pp. 269-273

Simone M. Haag, Muhammet F. Gulen, Luc Reymond, Antoine Gibelin, Laurence Abrami, Alexiane Decout, Michael Heymann, F. Gisou van der Goot, Gerardo Turcatti, Rayk Behrendt and Andrea Ablasser

Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13 pp. 274-278

Claudio Alfieri, Leifu Chang and David Barford

High speed of fork progression induces DNA replication stress and genomic instability pp. 279-284

Apolinar Maya-Mendoza, Pavel Moudry, Joanna Maria Merchut-Maya, MyungHee Lee, Robert Strauss and Jiri Bartek

CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions pp. 285-289

Michal Zimmermann, Olga Murina, Martin A. M. Reijns, Angelo Agathanggelou, Rachel Challis, Žygimantė Tarnauskaitė, Morwenna Muir, Adeline Fluteau, Michael Aregger, Andrea McEwan, Wei Yuan, Matthew Clarke, Maryou B. Lambros, Shankara Paneesha, Paul Moss, Megha Chandrashekhar, Stephane Angers, Jason Moffat, Valerie G. Brunton, Traver Hart, Johann Bono, Tatjana Stankovic, Andrew P. Jackson and Daniel Durocher

How to start a lab when funds are tight pp. 291-293

Elie Dolgin

Your face pp. 296-296

Grace Tang

2018, volume 559, articles 7712

Publisher Correction: Adolescence and the next generation pp. E1-E1

George C. Patton, Craig A. Olsson, Vegard Skirbekk, Richard Saffery, Mary E. Wlodek, Peter S. Azzopardi, Marcin Stonawski, Bruce Rasmussen, Elizabeth Spry, Kate Francis, Zulfiqar A. Bhutta, Nicholas J. Kassebaum, Ali H. Mokdad, Christopher J. L. Murray, Andrew M. Prentice, Nicola Reavley, Peter Sheehan, Kim Sweeny, Russell M. Viner and Susan M. Sawyer

Author Correction: The axolotl genome and the evolution of key tissue formation regulators pp. E2-E2

Sergej Nowoshilow, Siegfried Schloissnig, Ji-Feng Fei, Andreas Dahl, Andy W. C. Pang, Martin Pippel, Sylke Winkler, Alex R. Hastie, George Young, Juliana G. Roscito, Francisco Falcon, Dunja Knapp, Sean Powell, Alfredo Cruz, Han Cao, Bianca Habermann, Michael Hiller, Elly M. Tanaka and Eugene W. Myers

Addendum: Copper-catalysed enantioselective stereodivergent synthesis of amino alcohols pp. E3-E3

Shi-Liang Shi, Zackary L. Wong and Stephen L. Buchwald

A welcome from the new Nature editor pp. 6-6

Magdalena Skipper

Advance the ecosystem approach in cities pp. 7-7

Xuemei Bai

Gigantic study of Chinese babies yields slew of health data pp. 13-14

David Cyranoski

There’s no limit to longevity, says study that revives human lifespan debate pp. 14-15

Elie Dolgin

Cyprus asserts itself as regional hub for climate-change research pp. 15-16

Anita Makri

Delays mount for NASA’s $8-billion Hubble successor pp. 16-17

Alexandra Witze

Europe’s biggest research fund cracks down on ‘ethics dumping’ pp. 17-18

Linda Nordling

The labs growing human embryos for longer than ever before pp. 19-22

Helen Shen

A better measure of research from the global south pp. 23-26

Jean Lebel and Robert McLean

LGBTQ scientists are still left out pp. 27-28

Jon Freeman

UNESCO’s troubled drive for peace through science and culture pp. 29-30

Andrew Robinson

The backbone begins: a spine-tingling story pp. 31-31

Chris Lowe

Evaluation woes: we’re on it, responds DORA pp. 32-32

Anna Hatch and Stephen Curry

Personalized medicine should not be restricted to the wealthy pp. 32-32

Colum P. Dunne and Suzanne S. Dunne

Italy is squeezing out wet biology research pp. 32-32

Davide Zannoni

University came to the rescue of accused researcher pp. 32-32

Roberto Caminiti

Doubt cast on how the pace of global glacial erosion responds to climate cooling pp. 34-35

Eric Kirby

Actin proteins assemble to protect the genome pp. 35-37

Vassilis Roukos

Key receptor involved in neuronal signalling visualized pp. 37-38

Erwin Sigel

A molecular signature for social isolation identified in the brain pp. 38-40

Noga Zilkha and Tali Kimchi

General relativity verified by a triple-star system pp. 40-41

Clifford M. Will

Unexpected cell population gives fat a brake pp. 41-42

David A. Guertin

Taking bioengineered heart valves from faulty to functional pp. 42-43

Craig A. Simmons

Structural insights into G-protein-coupled receptor allostery pp. 45-53

David M. Thal, Alisa Glukhova, Patrick M. Sexton and Arthur Christopoulos

Nuclear F-actin and myosins drive relocalization of heterochromatic breaks pp. 54-60

Christopher P. Caridi, Carla D’Agostino, Taehyun Ryu, Grzegorz Zapotoczny, Laetitia Delabaere, Xiao Li, Varandt Y. Khodaverdian, Nuno Amaral, Emily Lin, Alesandra R. Rau and Irene Chiolo

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair pp. 61-66

Benjamin R. Schrank, Tomas Aparicio, Yinyin Li, Wakam Chang, Brian T. Chait, Gregg G. Gundersen, Max E. Gottesman and Jean Gautier

Structure of a human synaptic GABAA receptor pp. 67-72

Shaotong Zhu, Colleen M. Noviello, Jinfeng Teng, Richard M. Walsh, Jeong Joo Kim and Ryan E. Hibbs

Universality of free fall from the orbital motion of a pulsar in a stellar triple system pp. 73-76

Anne M. Archibald, Nina V. Gusinskaia, Jason W. T. Hessels, Adam T. Deller, David L. Kaplan, Duncan R. Lorimer, Ryan S. Lynch, Scott M. Ransom and Ingrid H. Stairs

Multifunctional ferrofluid-infused surfaces with reconfigurable multiscale topography pp. 77-82

Wendong Wang, Jaakko V. I. Timonen, Andreas Carlson, Dirk-Michael Drotlef, Cathy T. Zhang, Stefan Kolle, Alison Grinthal, Tak-Sing Wong, Benjamin Hatton, Sung Hoon Kang, Stephen Kennedy, Joshua Chi, Robert Thomas Blough, Metin Sitti, L. Mahadevan and Joanna Aizenberg

Decarboxylative sp3 C–N coupling via dual copper and photoredox catalysis pp. 83-88

Yufan Liang, Xiaheng Zhang and David W. C. MacMillan

Spatial correlation bias in late-Cenozoic erosion histories derived from thermochronology pp. 89-93

Taylor F. Schildgen, Pieter A. Beek, Hugh D. Sinclair and Rasmus C. Thiede

Low-temperature crystallization of granites and the implications for crustal magmatism pp. 94-97

Michael R. Ackerson, B. O. Mysen, N. D. Tailby and E. B. Watson

Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus pp. 98-102

Christoph Anacker, Victor M. Luna, Gregory S. Stevens, Amira Millette, Ryan Shores, Jessica C. Jimenez, Briana Chen and René Hen

A stromal cell population that inhibits adipogenesis in mammalian fat depots pp. 103-108

Petra C. Schwalie, Hua Dong, Magda Zachara, Julie Russeil, Daniel Alpern, Nassila Akchiche, Christian Caprara, Wenfei Sun, Kai-Uwe Schlaudraff, Gianni Soldati, Christian Wolfrum and Bart Deplancke

Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche pp. 109-113

Ysbrand M. Nusse, Adam K. Savage, Pauline Marangoni, Axel K. M. Rosendahl-Huber, Tyler A. Landman, Frederic J. Sauvage, Richard M. Locksley and Ophir D. Klein

Induction of innate immune memory via microRNA targeting of chromatin remodelling factors pp. 114-119

John J. Seeley, Rebecca G. Baker, Ghait Mohamed, Tony Bruns, Matthew S. Hayden, Sachin D. Deshmukh, Daniel E. Freedberg and Sankar Ghosh

OTULIN limits cell death and inflammation by deubiquitinating LUBAC pp. 120-124

Klaus Heger, Katherine E. Wickliffe, Ada Ndoja, Juan Zhang, Aditya Murthy, Debra L. Dugger, Allie Maltzman, Felipe de Sousa e Melo, Jeffrey Hung, Yi Zeng, Erik Verschueren, Donald S. Kirkpatrick, Domagoj Vucic, Wyne P. Lee, Merone Roose-Girma, Robert J. Newman, Søren Warming, Yi-Chun Hsiao, László G. Kőműves, Joshua D. Webster, Kim Newton and Vishva M. Dixit

Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations pp. 125-129

Andrew M. Intlekofer, Alan H. Shih, Bo Wang, Abbas Nazir, Ariën S. Rustenburg, Steven K. Albanese, Minal Patel, Christopher Famulare, Fabian M. Correa, Naofumi Takemoto, Vidushi Durani, Hui Liu, Justin Taylor, Noushin Farnoud, Elli Papaemmanuil, Justin R. Cross, Martin S. Tallman, Maria E. Arcila, Mikhail Roshal, Gregory A. Petsko, Bin Wu, Sung Choe, Zenon D. Konteatis, Scott A. Biller, John D. Chodera, Craig B. Thompson, Ross L. Levine and Eytan M. Stein

The helicase Ded1p controls use of near-cognate translation initiation codons in 5′ UTRs pp. 130-134

Ulf-Peter Guenther, David E. Weinberg, Meghan M. Zubradt, Frank A. Tedeschi, Brittany N. Stawicki, Leah L. Zagore, Gloria A. Brar, Donny D. Licatalosi, David P. Bartel, Jonathan S. Weissman and Eckhard Jankowsky

Cryo-EM structure of an essential Plasmodium vivax invasion complex pp. 135-139

Jakub Gruszczyk, Rick K. Huang, Li-Jin Chan, Sébastien Menant, Chuan Hong, James M. Murphy, Yee-Foong Mok, Michael D. W. Griffin, Richard D. Pearson, Wilson Wong, Alan F. Cowman, Zhiheng Yu and Wai-Hong Tham

Speaking in code: how to program by voice pp. 141-142

Julian Nowogrodzki

Harness the power of groups to beat the ‘PhD blues’ pp. 143-144

Karra Harrington

Ded-Mek pp. 146-146

Matt Thompson