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2015, volume 520, articles 7549

Assessing science pp. S1-S1

Michelle Grayson

China's research & development spend pp. S8-S9

Xiaole Ni

Symposium overview: Raising standards pp. S10-S12

Michelle Grayson

Q&A: Kurt Wüthrich pp. S13-S13

Monya Baker

Evaluation: Moving away from metrics pp. S18-S20

Huang Kun

Q&A: David Sweeney pp. S21-S21

Nic Fleming

Q&A: Chen Xiangmei and Zeng Xuan pp. S26-S27

Piao Li

Research impact: A tale of two systems pp. S28-S30

Peng Tian

Q&A: Anthony Cheetham pp. S34-S35

Nic Fleming

Perspective: Give youth a chance pp. S36-S36

Chuan-Chao Wang

Q&A: Jin Dong-Yan pp. S37-S37

Felix Cheung

China’s scientific progress hinges on access to data pp. 587-587

Zheng Wan

Bar graphs criticized for misrepresenting data pp. 589-589

Chris Woolston

Embryo editing sparks epic debate pp. 593-594

David Cyranoski and Sara Reardon

Human-embryo editing poses challenges for journals pp. 594-594

Daniel Cressey and David Cyranoski

Canadian budget pushes applied research pp. 595-596

Margaret Munro

Vatican convenes major climate-change meeting pp. 596-597

Edwin Cartlidge

Consumer DNA firms get serious about drug development pp. 597-598

Erika Check Hayden

Bone DNA reveals humanity’s trek into South America pp. 598-599

Ewen Callaway

Collateral damage: How one misconduct case brought a biology institute to its knees pp. 600-603

David Cyranoski

Science in turmoil: After the Arab Spring pp. 604-607

Mohammed Yahia and Declan Butler

Personalized medicine: Time for one-person trials pp. 609-611

Nicholas J. Schork

Statistics: P values are just the tip of the iceberg pp. 612-612

Jeffrey T. Leek and Roger D. Peng

Climate economics: The high road pp. 614-615

Michael Grubb

Genetics: We are the 98% pp. 615-616

Nathaniel Comfort

New in paperback pp. 616-616

Emily Banham

Origins of life: An improbable journey pp. 617-618

Adrian Woolfson

Virology: Journal of the plague years pp. 618-619

Mark Dybul

Medical history: Pioneer of polio eradication pp. 620-621

Tilli Tansey

Physics: One hundred years of general relativity pp. 621-622

Pedro Ferreira

Germline edits: Heat does not help debate pp. 623-623

Mika Martikainen and Ole Pedersen

Germline edits: Trust ethics review process pp. 623-623

Julian Savulescu, Chris Gyngell and Tom Douglas

Lift sanctions now to save public health pp. 623-623

Mehdi Aloosh and Arash Aloosh

Double-blind peer review a double risk pp. 623-623

Thomas E. DeCoursey

Better policing for fishy catch data pp. 623-623

David W. Sims and Samantha J. Simpson

An essential passenger with p53 pp. 626-627

James E. Bradner

Stillbirth prevented by signal blockade pp. 627-628

Anna Bakardjiev

Malaria runs rings round artemisinin pp. 628-630

Jeremy Burrows

Northern push for the bipolar see-saw pp. 630-631

Tas van Ommen

Semiconductors grown large and thin pp. 631-632

Tobin J. Marks and Mark C. Hersam

A multilevel multimodal circuit enhances action selection in Drosophila pp. 633-639

Tomoko Ohyama, Casey M. Schneider-Mizell, Richard D. Fetter, Javier Valdes Aleman, Romain Franconville, Marta Rivera-Alba, Brett D. Mensh, Kristin M. Branson, Julie H. Simpson, James W. Truman, Albert Cardona and Marta Zlatic

Structure of the human 80S ribosome pp. 640-645

Heena Khatter, Alexander G. Myasnikov, S. Kundhavai Natchiar and Bruno P. Klaholz

Extended hard-X-ray emission in the inner few parsecs of the Galaxy pp. 646-649

Kerstin Perez, Charles J. Hailey, Franz E. Bauer, Roman A. Krivonos, Kaya Mori, Frederick K. Baganoff, Nicolas M. Barrière, Steven E. Boggs, Finn E. Christensen, William W. Craig, Brian W. Grefenstette, Jonathan E. Grindlay, Fiona A. Harrison, Jaesub Hong, Kristin K. Madsen, Melania Nynka, Daniel Stern, John A. Tomsick, Daniel R. Wik, Shuo Zhang, William W. Zhang and Andreas Zoglauer

Topological valley transport at bilayer graphene domain walls pp. 650-655

Long Ju, Zhiwen Shi, Nityan Nair, Yinchuan Lv, Chenhao Jin, Jairo Velasco, Claudia Ojeda-Aristizabal, Hans A. Bechtel, Michael C. Martin, Alex Zettl, James Analytis and Feng Wang

High-mobility three-atom-thick semiconducting films with wafer-scale homogeneity pp. 656-660

Kibum Kang, Saien Xie, Lujie Huang, Yimo Han, Pinshane Y. Huang, Kin Fai Mak, Cheol-Joo Kim, David Muller and Jiwoong Park

Isotopic evidence for biological nitrogen fixation by molybdenum-nitrogenase from 3.2 Gyr pp. 666-669

Eva E. Stüeken, Roger Buick, Bradley M. Guy and Matthew C. Koehler

An epigenome-wide association study of total serum immunoglobulin E concentration pp. 670-674

Liming Liang, Saffron A. G. Willis-Owen, Catherine Laprise, Kenny C. C. Wong, Gwyneth A. Davies, Thomas J. Hudson, Aristea Binia, Julian M. Hopkin, Ivana V. Yang, Elin Grundberg, Stephan Busche, Marie Hudson, Lars Rönnblom, Tomi M. Pastinen, David A. Schwartz, G. Mark Lathrop, Miriam F. Moffatt and William O. C. M. Cookson

A circuit mechanism for differentiating positive and negative associations pp. 675-678

Praneeth Namburi, Anna Beyeler, Suzuko Yorozu, Gwendolyn G. Calhoon, Sarah A. Halbert, Romy Wichmann, Stephanie S. Holden, Kim L. Mertens, Melodi Anahtar, Ada C. Felix-Ortiz, Ian R. Wickersham, Jesse M. Gray and Kay M. Tye

NIK1-mediated translation suppression functions as a plant antiviral immunity mechanism pp. 679-682

Cristiane Zorzatto, João Paulo B. Machado, Kênia V. G. Lopes, Kelly J. T. Nascimento, Welison A. Pereira, Otávio J. B. Brustolini, Pedro A. B. Reis, Iara P. Calil, Michihito Deguchi, Gilberto Sachetto-Martins, Bianca C. Gouveia, Virgílio A. P. Loriato, Marcos A. C. Silva, Fabyano F. Silva, Anésia A. Santos, Joanne Chory and Elizabeth P. B. Fontes

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria pp. 683-687

Alassane Mbengue, Souvik Bhattacharjee, Trupti Pandharkar, Haining Liu, Guillermina Estiu, Robert V. Stahelin, Shahir S. Rizk, Dieudonne L. Njimoh, Yana Ryan, Kesinee Chotivanich, Chea Nguon, Mehdi Ghorbal, Jose-Juan Lopez-Rubio, Michael Pfrender, Scott Emrich, Narla Mohandas, Arjen M. Dondorp, Olaf Wiest and Kasturi Haldar

Single-dose attenuated Vesiculovax vaccines protect primates against Ebola Makona virus pp. 688-691

Chad E. Mire, Demetrius Matassov, Joan B. Geisbert, Theresa E. Latham, Krystle N. Agans, Rong Xu, Ayuko Ota-Setlik, Michael A. Egan, Karla A. Fenton, David K. Clarke, John H. Eldridge and Thomas W. Geisbert

Mutant MHC class II epitopes drive therapeutic immune responses to cancer pp. 692-696

Sebastian Kreiter, Mathias Vormehr, Niels van de Roemer, Mustafa Diken, Martin Löwer, Jan Diekmann, Sebastian Boegel, Barbara Schrörs, Fulvia Vascotto, John C. Castle, Arbel D. Tadmor, Stephen P. Schoenberger, Christoph Huber, Özlem Türeci and Ugur Sahin

TP53 loss creates therapeutic vulnerability in colorectal cancer pp. 697-701

Yunhua Liu, Xinna Zhang, Cecil Han, Guohui Wan, Xingxu Huang, Cristina Ivan, Dahai Jiang, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Pulivarthi H. Rao, Dipen M. Maru, Andreas Pahl, Xiaoming He, Anil K. Sood, Lee M. Ellis, Jan Anderl and Xiongbin Lu

Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9 pp. 702-705

Umeharu Ohto, Takuma Shibata, Hiromi Tanji, Hanako Ishida, Elena Krayukhina, Susumu Uchiyama, Kensuke Miyake and Toshiyuki Shimizu

The octahaem MccA is a haem c–copper sulfite reductase pp. 706-709

Bianca Hermann, Melanie Kern, Luigi La Pietra, Jörg Simon and Oliver Einsle

Correction: Corrigendum: Deterministic direct reprogramming of somatic cells to pluripotency pp. 710-710

Yoach Rais, Asaf Zviran, Shay Geula, Ohad Gafni, Elad Chomsky, Sergey Viukov, Abed AlFatah Mansour, Inbal Caspi, Vladislav Krupalnik, Mirie Zerbib, Itay Maza, Nofar Mor, Dror Baran, Leehee Weinberger, Diego A. Jaitin, David Lara-Astiaso, Ronnie Blecher-Gonen, Zohar Shipony, Zohar Mukamel, Tzachi Hagai, Shlomit Gilad, Daniela Amann-Zalcenstein, Amos Tanay, Ido Amit, Noa Novershtern and Jacob H. Hanna

Correction: Corrigendum: Derivation of novel human ground state naive pluripotent stem cells pp. 710-710

Ohad Gafni, Leehee Weinberger, Abed AlFatah Mansour, Yair S. Manor, Elad Chomsky, Dalit Ben-Yosef, Yael Kalma, Sergey Viukov, Itay Maza, Asaf Zviran, Yoach Rais, Zohar Shipony, Zohar Mukamel, Vladislav Krupalnik, Mirie Zerbib, Shay Geula, Inbal Caspi, Dan Schneir, Tamar Shwartz, Shlomit Gilad, Daniela Amann-Zalcenstein, Sima Benjamin, Ido Amit, Amos Tanay, Rada Massarwa, Noa Novershtern and Jacob H. Hanna

Public health: Behind a vaccine pp. 711-713

Bryn Nelson

Workplace climate: Metrics for ethics pp. 713-713

Monya Baker

The archive personality protocol pp. 716-716

Brian Trent

2015, volume 520, articles 7548

Why I teach evolution to Muslim students pp. 409-409

Rana Dajani

Wolf decline threatens iconic island study pp. 415-415

Emma Marris

Bee studies stir up pesticide debate pp. 416-416

Daniel Cressey

Drug that boosts nerve signals offers hope for multiple sclerosis pp. 417-417

Heidi Ledford

Race to unravel Oklahoma’s artificial quakes pp. 418-419

Alexandra Witze

Climate scientists join search for alien Earths pp. 420-420

Jeff Tollefson

Oldest stone tools raise questions about their creators pp. 421-421

Ewen Callaway

Forensic science: The soil sleuth pp. 422-424

Chelsea Wald

Chemistry: Degrees of separation pp. 426-427

XiaoZhi Lim

Bibliometrics: The Leiden Manifesto for research metrics pp. 429-431

Diana Hicks, Paul Wouters, Ludo Waltman, Sarah de Rijcke and Ismael Rafols

Policy: Five priorities for the UN Sustainable Development Goals pp. 432-433

Yonglong Lu, Nebojsa Nakicenovic, Martin Visbeck and Anne-Sophie Stevance

Environmental economics: Pricing the planet pp. 434-435

Nick Hanley

Library science: The word on our archival future pp. 435-435

Michael Lesk

Music inspired Newton's rainbow pp. 436-436

Len Fisher

Disputed start dates for Anthropocene pp. 436-436

Jan Zalasiewicz

Act to staunch loss of research data pp. 436-436

Andrew Gonzalez and Pedro R. Peres-Neto

China needs more monitoring apps pp. 436-436

Jian Zhang and Xiaolei Huang

Illuminating the past pp. 438-439

Richard G. Roberts and Olav B. Lian

Pain-sensing TRPA1 channel resolved pp. 439-441

David E. Clapham

Listening to quantum grains of sound pp. 441-442

Ivan Favero

Landscape inversion by stream piracy pp. 442-443

Jérôme Lavé

The yin and yang of cortical oxytocin pp. 444-445

Robert C. Liu

Neuregulin 1 makes heart muscle pp. 445-446

Katherine E. Yutzey

Shared ancestry predicts disease levels pp. 446-447

Helen M. Alexander

Origin and evolution of vertebrates pp. 449-449

Henry Gee

Scenarios for the making of vertebrates pp. 450-455

Nicholas D. Holland, Linda Z. Holland and Peter W. H. Holland

The deuterostome context of chordate origins pp. 456-465

Christopher J. Lowe, D. Nathaniel Clarke, Daniel M. Medeiros, Daniel S. Rokhsar and John Gerhart

A new heart for a new head in vertebrate cardiopharyngeal evolution pp. 466-473

Rui Diogo, Robert G. Kelly, Lionel Christiaen, Michael Levine, Janine M. Ziermann, Julia L. Molnar, Drew M. Noden and Eldad Tzahor

Evolution of vertebrates as viewed from the crest pp. 474-482

Stephen A. Green, Marcos Simoes-Costa and Marianne E. Bronner

Facts and fancies about early fossil chordates and vertebrates pp. 483-489

Philippe Janvier

The origin and early phylogenetic history of jawed vertebrates pp. 490-497

Martin D. Brazeau and Matt Friedman

Oxytocin enables maternal behaviour by balancing cortical inhibition pp. 499-504

Bianca J. Marlin, Mariela Mitre, James A. D’amour, Moses V. Chao and Robert C. Froemke

CRISPR adaptation biases explain preference for acquisition of foreign DNA pp. 505-510

Asaf Levy, Moran G. Goren, Ido Yosef, Oren Auster, Miriam Manor, Gil Amitai, Rotem Edgar, Udi Qimron and Rotem Sorek

Structure of the TRPA1 ion channel suggests regulatory mechanisms pp. 511-517

Candice E. Paulsen, Jean-Paul Armache, Yuan Gao, Yifan Cheng and David Julius

Self-similar fragmentation regulated by magnetic fields in a region forming massive stars pp. 518-521

Hua-bai Li, Ka Ho Yuen, Frank Otto, Po Kin Leung, T. K. Sridharan, Qizhou Zhang, Hauyu Liu, Ya-Wen Tang and Keping Qiu

Phonon counting and intensity interferometry of a nanomechanical resonator pp. 522-525

Justin D. Cohen, Seán M. Meenehan, Gregory S. MacCabe, Simon Gröblacher, Amir H. Safavi-Naeini, Francesco Marsili, Matthew D. Shaw and Oskar Painter

In situ low-relief landscape formation as a result of river network disruption pp. 526-529

Rong Yang, Sean D. Willett and Liran Goren

Tungsten isotopic evidence for disproportional late accretion to the Earth and Moon pp. 530-533

Mathieu Touboul, Igor S. Puchtel and Richard J. Walker

Lunar tungsten isotopic evidence for the late veneer pp. 534-537

Thomas S. Kruijer, Thorsten Kleine, Mario Fischer-Gödde and Peter Sprung

Eocene primates of South America and the African origins of New World monkeys pp. 538-541

Mariano Bond, Marcelo F. Tejedor, Kenneth E. Campbell, Laura Chornogubsky, Nelson Novo and Francisco Goin

Phylogenetic structure and host abundance drive disease pressure in communities pp. 542-544

Ingrid M. Parker, Megan Saunders, Megan Bontrager, Andrew P. Weitz, Rebecca Hendricks, Roger Magarey, Karl Suiter and Gregory S. Gilbert

Agrochemical control of plant water use using engineered abscisic acid receptors pp. 545-548

Sang-Youl Park, Francis C. Peterson, Assaf Mosquna, Jin Yao, Brian F. Volkman and Sean R. Cutler

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells pp. 549-552

Dagmar Walter, Amelie Lier, Anja Geiselhart, Frederic B. Thalheimer, Sina Huntscha, Mirko C. Sobotta, Bettina Moehrle, David Brocks, Irem Bayindir, Paul Kaschutnig, Katja Muedder, Corinna Klein, Anna Jauch, Timm Schroeder, Hartmut Geiger, Tobias P. Dick, Tim Holland-Letz, Peter Schmezer, Steven W. Lane, Michael A. Rieger, Marieke A. G. Essers, David A. Williams, Andreas Trumpp and Michael D. Milsom

Mitochondrial DNA stress primes the antiviral innate immune response pp. 553-557

A. Phillip West, William Khoury-Hanold, Matthew Staron, Michal C. Tal, Cristiana M. Pineda, Sabine M. Lang, Megan Bestwick, Brett A. Duguay, Nuno Raimundo, Donna A. MacDuff, Susan M. Kaech, James R. Smiley, Robert E. Means, Akiko Iwasaki and Gerald S. Shadel

Super-enhancers delineate disease-associated regulatory nodes in T cells pp. 558-562

Golnaz Vahedi, Yuka Kanno, Yasuko Furumoto, Kan Jiang, Stephen C. J. Parker, Michael R. Erdos, Sean R. Davis, Rahul Roychoudhuri, Nicholas P. Restifo, Massimo Gadina, Zhonghui Tang, Yijun Ruan, Francis S. Collins, Vittorio Sartorelli and John J. O’Shea

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes pp. 563-566

Jiajie Diao, Rong Liu, Yueguang Rong, Minglei Zhao, Jing Zhang, Ying Lai, Qiangjun Zhou, Livia M. Wilz, Jianxu Li, Sandro Vivona, Richard A. Pfuetzner, Axel T. Brunger and Qing Zhong

Structure of the E. coli ribosome–EF-Tu complex at pp. 567-570

Niels Fischer, Piotr Neumann, Andrey L. Konevega, Lars V. Bock, Ralf Ficner, Marina V. Rodnina and Holger Stark

Hydrogens detected by subatomic resolution protein crystallography in a [NiFe] hydrogenase pp. 571-574

Hideaki Ogata, Koji Nishikawa and Wolfgang Lubitz

Respect the report pp. 575-576

Ingrid Eisenstadter

Transference pp. 578-578

Jennifer Campbell-Hicks

2015, volume 520, articles 7547

MAGI3–AKT3 fusion in breast cancer amended pp. E11-E12

Juan-Miguel Mosquera, Sonal Varma, Chantal Pauli, Theresa Y. MacDonald, Jossie J. Yashinskie, Zsuzsanna Varga, Andrea Sboner, Holger Moch, Mark A. Rubin and Sandra J. Shin

Pugh et al. reply pp. E12-E14

Trevor J. Pugh, Shantanu Banerji and Matthew Meyerson

Scientists must speak up on fossil-fuel divestment pp. 265-265

Alan Rusbridger

Scientists share inspiration on Twitter with #IAmAScientistBecause and #BeyondMarieCurie pp. 267-267

Chris Woolston

UK funders demand strong statistics for animal studies pp. 271-272

Daniel Cressey

Canadians baulk at reforms to health-research agency pp. 272-273

Sara Reardon

The printed organs coming to a body near you pp. 273-273

Heidi Ledford

Iran nuclear deal raises hopes for science pp. 274-275

Declan Butler

Leading scientists favour women in tenure-track hiring test pp. 275-276

Boer Deng

Rule rewrite aims to clean up scientific software pp. 276-277

Erika Check Hayden

Cancer: The Ras renaissance pp. 278-280

Heidi Ledford

How the Hubble Telescope cheated death pp. 282-286

Alexandra Witze

Astronomy: Hubble's legacy pp. 287-289

Mario Livio

Health: Make precision medicine work for cancer care pp. 290-291

Mark A. Rubin

Data visualization: Mapping the topical space pp. 292-293

Rikke Schmidt Kjærgaard

Books in brief pp. 293-293

Barbara Kiser

Q&A: Geological historian pp. 294-294

Alexandra Witze

Is a mega-project the ELI in the room? pp. 295-295

Radu Silaghi-Dumitrescu

Antibodies: validate recombinants once pp. 295-295

Andrew M. Bradbury and Andreas Plückthun

Inform public on GM, don't cheerlead pp. 295-295

Yongbo Liu, Junsheng Li and C. Neal Stewart

Zero net emissions from Venter facility pp. 295-295

J. Craig Venter and Robert M. Friedman

Bury botany's outdated image pp. 295-295

Isabel Marques

The complex seeds of metastasis pp. 298-299

Michael M. Shen

A new recipe for Earth formation pp. 299-300

Richard W. Carlson

An extravascular route for tumour cells pp. 300-302

Mary J. C. Hendrix

Streamlining drug synthesis pp. 302-303

Joel M. Hawkins

A weighty mass difference pp. 303-304

Frank Wilczek

Recovering the potential of coral reefs pp. 304-305

Nicholas K. Dulvy and Holly K. Kindsvater

A resource for cell line authentication, annotation and quality control pp. 307-311

Mamie Yu, Suresh K. Selvaraj, May M. Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker and Richard M. Neve

Crystal structures of the human adiponectin receptors pp. 312-316

Hiroaki Tanabe, Yoshifumi Fujii, Miki Okada-Iwabu, Masato Iwabu, Yoshihiro Nakamura, Toshiaki Hosaka, Kanna Motoyama, Mariko Ikeda, Motoaki Wakiyama, Takaho Terada, Noboru Ohsawa, Masakatsu Hato, Satoshi Ogasawara, Tomoya Hino, Takeshi Murata, So Iwata, Kunio Hirata, Yoshiaki Kawano, Masaki Yamamoto, Tomomi Kimura-Someya, Mikako Shirouzu, Toshimasa Yamauchi, Takashi Kadowaki and Shigeyuki Yokoyama

Two disparate ligand-binding sites in the human P2Y1 receptor pp. 317-321

Dandan Zhang, Zhan-Guo Gao, Kaihua Zhang, Evgeny Kiselev, Steven Crane, Jiang Wang, Silvia Paoletta, Cuiying Yi, Limin Ma, Wenru Zhang, Gye Won Han, Hong Liu, Vadim Cherezov, Vsevolod Katritch, Hualiang Jiang, Raymond C. Stevens, Kenneth A. Jacobson, Qiang Zhao and Beili Wu

Nuclear ashes and outflow in the eruptive star Nova Vul 1670 pp. 322-324

Tomasz Kamiński, Karl M. Menten, Romuald Tylenda, Marcin Hajduk, Nimesh A. Patel and Alexander Kraus

An ultrafast rechargeable aluminium-ion battery pp. 324-328

Meng-Chang Lin, Ming Gong, Bingan Lu, Yingpeng Wu, Di-Yan Wang, Mingyun Guan, Michael Angell, Changxin Chen, Jiang Yang, Bing-Joe Hwang and Hongjie Dai

Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts pp. 329-332

Tetsu Tsubogo, Hidekazu Oyamada and Shū Kobayashi

Icebergs not the trigger for North Atlantic cold events pp. 333-336

Stephen Barker, James Chen, Xun Gong, Lukas Jonkers, Gregor Knorr and David Thornalley

A Mercury-like component of early Earth yields uranium in the core and high mantle 142Nd pp. 337-340

Anke Wohlers and Bernard J. Wood

Recovery potential of the world's coral reef fishes pp. 341-344

M. Aaron MacNeil, Nicholas A. J. Graham, Joshua E. Cinner, Shaun K. Wilson, Ivor D. Williams, Joseph Maina, Steven Newman, Alan M. Friedlander, Stacy Jupiter, Nicholas V. C. Polunin and Tim R. McClanahan

Emotional learning selectively and retroactively strengthens memories for related events pp. 345-348

Joseph E. Dunsmoor, Vishnu P. Murty, Lila Davachi and Elizabeth A. Phelps

Thirst driving and suppressing signals encoded by distinct neural populations in the brain pp. 349-352

Yuki Oka, Mingyu Ye and Charles S. Zuker

The evolutionary history of lethal metastatic prostate cancer pp. 353-357

Gunes Gundem, Peter Van Loo, Barbara Kremeyer, Ludmil B. Alexandrov, Jose M. C. Tubio, Elli Papaemmanuil, Daniel S. Brewer, Heini M. L. Kallio, Gunilla Högnäs, Matti Annala, Kati Kivinummi, Victoria Goody, Calli Latimer, Sarah O'Meara, Kevin J. Dawson, William Isaacs, Michael R. Emmert-Buck, Matti Nykter, Christopher Foster, Zsofia Kote-Jarai, Douglas Easton, Hayley C. Whitaker, David E. Neal, Colin S. Cooper, Rosalind A. Eeles, Tapio Visakorpi, Peter J. Campbell, Ultan McDermott, David C. Wedge and G. Steven Bova

A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis pp. 358-362

Elvin Wagenblast, Mar Soto, Sara Gutiérrez-Ángel, Christina A. Hartl, Annika L. Gable, Ashley R. Maceli, Nicolas Erard, Alissa M. Williams, Sun Y. Kim, Steffen Dickopf, J. Chuck Harrell, Andrew D. Smith, Charles M. Perou, John E. Wilkinson, Gregory J. Hannon and Simon R. V. Knott

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance pp. 363-367

Dohoon Kim, Brian P. Fiske, Kivanc Birsoy, Elizaveta Freinkman, Kenjiro Kami, Richard L. Possemato, Yakov Chudnovsky, Michael E. Pacold, Walter W. Chen, Jason R. Cantor, Laura M. Shelton, Dan Y. Gui, Manjae Kwon, Shakti H. Ramkissoon, Keith L. Ligon, Seong Woo Kang, Matija Snuderl, Matthew G. Vander Heiden and David M. Sabatini

Therapy-induced tumour secretomes promote resistance and tumour progression pp. 368-372

Anna C. Obenauf, Yilong Zou, Andrew L. Ji, Sakari Vanharanta, Weiping Shu, Hubing Shi, Xiangju Kong, Marcus C. Bosenberg, Thomas Wiesner, Neal Rosen, Roger S. Lo and Joan Massagué

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer pp. 373-377

Christina Twyman-Saint Victor, Andrew J. Rech, Amit Maity, Ramesh Rengan, Kristen E. Pauken, Erietta Stelekati, Joseph L. Benci, Bihui Xu, Hannah Dada, Pamela M. Odorizzi, Ramin S. Herati, Kathleen D. Mansfield, Dana Patsch, Ravi K. Amaravadi, Lynn M. Schuchter, Hemant Ishwaran, Rosemarie Mick, Daniel A. Pryma, Xiaowei Xu, Michael D. Feldman, Tara C. Gangadhar, Stephen M. Hahn, E. John Wherry, Robert H. Vonderheide and Andy J. Minn

Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation pp. 378-382

J. Marsolier, M. Perichon, J. D. DeBarry, B. O. Villoutreix, J. Chluba, T. Lopez, C. Garrido, X. Z. Zhou, K. P. Lu, L. Fritsch, S. Ait-Si-Ali, M. Mhadhbi, S. Medjkane and J. B. Weitzman

β-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis pp. 383-387

Nicole M. Gaudelli, Darcie H. Long and Craig A. Townsend

Erratum: A new antibiotic kills pathogens without detectable resistance pp. 388-388

Losee L. Ling, Tanja Schneider, Aaron J. Peoples, Amy L. Spoering, Ina Engels, Brian P. Conlon, Anna Mueller, Till F. Schäberle, Dallas E. Hughes, Slava Epstein, Michael Jones, Linos Lazarides, Victoria A. Steadman, Douglas R. Cohen, Cintia R. Felix, K. Ashley Fetterman, William P. Millett, Anthony G. Nitti, Ashley M. Zullo, Chao Chen and Kim Lewis

Correction: Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer pp. 388-388

Jae Myoung Suh, Johan W. Jonker, Maryam Ahmadian, Regina Goetz, Denise Lackey, Olivia Osborn, Zhifeng Huang, Weilin Liu, Eiji Yoshihara, Theo H. van Dijk, Rick Havinga, Weiwei Fan, Yun-Qiang Yin, Ruth T. Yu, Christopher Liddle, Annette R. Atkins, Jerrold M. Olefsky, Moosa Mohammadi, Michael Downes and Ronald M. Evans

Correction: Corrigendum: Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism pp. 388-388

Fiona Cuskin, Elisabeth C. Lowe, Max J. Temple, Yanping Zhu, Elizabeth A. Cameron, Nicholas A. Pudlo, Nathan T. Porter, Karthik Urs, Andrew J. Thompson, Alan Cartmell, Artur Rogowski, Brian S. Hamilton, Rui Chen, Thomas J. Tolbert, Kathleen Piens, Debby Bracke, Wouter Vervecken, Zalihe Hakki, Gaetano Speciale, Jose L. Munōz-Munōz, Andrew Day, Maria J. Peña, Richard McLean, Michael D. Suits, Alisdair B. Boraston, Todd Atherly, Cherie J. Ziemer, Spencer J. Williams, Gideon J. Davies, D. Wade Abbott, Eric C. Martens and Harry J. Gilbert

A most exceptional response pp. 389-393

Vivien Marx

Glaciology: Climatology on thin ice pp. 395-397

Neil Savage

Turning point: Arun Shukla pp. 397-397

Virginia Gewin

The buyout pp. 400-400

Ananyo Bhattacharya

2015, volume 520, articles 7546

Test the effects of ash on jet engines pp. 133-133

Matthew Watson

Petition calls for lay summaries in ecology journals pp. 135-135

Chris Woolston

Race to stamp out animal plague begins pp. 139-140

Ewen Callaway

Climatologists to physicists: your planet needs you pp. 140-141

Quirin Schiermeier

Synthetic biologists seek standards for nascent field pp. 141-142

Erika Check Hayden

African hub set up to boost research autonomy pp. 142-143

Linda Nordling

The future of the postdoc pp. 144-147

Kendall Powell

Materials science: The hole story pp. 148-150

Mark Peplow

Core services: Reward bioinformaticians pp. 151-152

Jeffrey Chang

History: Women at the edge of science pp. 154-155

Jennifer Rampling

Books in brief pp. 155-155

Barbara Kiser

Scientific instrumentation: The aided eye pp. 156-156

Philip Ball

Academies review insecticide harm pp. 157-157

Peter Neumann

Sanctions in Iran disrupt cancer care pp. 157-157

Shohreh Shahabi

No case for Japan to kill minke whales pp. 157-157

Andrew S. Brierley

One scientist's data as another's noise pp. 157-157

Christine Borgman

Another two-body trick before Dawn pp. 157-157

John D. Rummel

Zofia Kielan-Jaworowska (1925–2015) pp. 158-158

Richard L. Cifelli

Race for healthy hearts pp. 160-161

Marc-Phillip Hitz and Gregor Andelfinger

Prebiotic chemistry on the rocks pp. 161-162

Geoffrey A. Blake and Edwin A. Bergin

RNA interference hangs by a thread pp. 162-164

Mikel Zaratiegui

Unique wrinkles as identity tags pp. 164-165

Jie Yin and Mary C. Boyce

Growth in the fat lane pp. 165-166

Robert A. Egnatchik and Ralph J. DeBerardinis

Lawrencium bridges a knowledge gap pp. 166-167

Andreas Türler

Binge drinking and brain stress systems pp. 168-169

Richard M. O'Connor and Paul J. Kenny

An incredible likeness of being pp. 169-170

Robin M. Canup

Climate change and the permafrost carbon feedback pp. 171-179

E. A. G. Schuur, A. D. McGuire, C. Schädel, G. Grosse, J. W. Harden, D. J. Hayes, G. Hugelius, C. D. Koven, P. Kuhry, D. M. Lawrence, S. M. Natali, D. Olefeldt, V. E. Romanovsky, K. Schaefer, M. R. Turetsky, C. C. Treat and J. E. Vonk

Branch-specific dendritic Ca2+ spikes cause persistent synaptic plasticity pp. 180-185

Joseph Cichon and Wen-Biao Gan

In vivo genome editing using Staphylococcus aureus Cas9 pp. 186-191

F. Ann Ran, Le Cong, Winston X. Yan, David A. Scott, Jonathan S. Gootenberg, Andrea J. Kriz, Bernd Zetsche, Ophir Shalem, Xuebing Wu, Kira S. Makarova, Eugene V. Koonin, Phillip A. Sharp and Feng Zhang

Fatty acid carbon is essential for dNTP synthesis in endothelial cells pp. 192-197

Sandra Schoors, Ulrike Bruning, Rindert Missiaen, Karla C. S. Queiroz, Gitte Borgers, Ilaria Elia, Annalisa Zecchin, Anna Rita Cantelmo, Stefan Christen, Jermaine Goveia, Ward Heggermont, Lucica Goddé, Stefan Vinckier, Paul P. Van Veldhoven, Guy Eelen, Luc Schoonjans, Holger Gerhardt, Mieke Dewerchin, Myriam Baes, Katrien De Bock, Bart Ghesquière, Sophia Y. Lunt, Sarah-Maria Fendt and Peter Carmeliet

The comet-like composition of a protoplanetary disk as revealed by complex cyanides pp. 198-201

Karin I. Öberg, Viviana V. Guzmán, Kenji Furuya, Chunhua Qi, Yuri Aikawa, Sean M. Andrews, Ryan Loomis and David J. Wilner

Saturn’s fast spin determined from its gravitational field and oblateness pp. 202-204

Ravit Helled, Eli Galanti and Yohai Kaspi

Four-wave mixing experiments with extreme ultraviolet transient gratings pp. 205-208

F. Bencivenga, R. Cucini, F. Capotondi, A. Battistoni, R. Mincigrucci, E. Giangrisostomi, A. Gessini, M. Manfredda, I. P. Nikolov, E. Pedersoli, E. Principi, C. Svetina, P. Parisse, F. Casolari, M. B. Danailov, M. Kiskinova and C. Masciovecchio

Measurement of the first ionization potential of lawrencium, element 103 pp. 209-211

T. K. Sato, M. Asai, A. Borschevsky, T. Stora, N. Sato, Y. Kaneya, K. Tsukada, Ch. E. Düllmann, K. Eberhardt, E. Eliav, S. Ichikawa, U. Kaldor, J. V. Kratz, S. Miyashita, Y. Nagame, K. Ooe, A. Osa, D. Renisch, J. Runke, M. Schädel, P. Thörle-Pospiech, A. Toyoshima and N. Trautmann

A primordial origin for the compositional similarity between the Earth and the Moon pp. 212-215

Alessandra Mastrobuono-Battisti, Hagai B. Perets and Sean N. Raymond

Levantine cranium from Manot Cave (Israel) foreshadows the first European modern humans pp. 216-219

Israel Hershkovitz, Ofer Marder, Avner Ayalon, Miryam Bar-Matthews, Gal Yasur, Elisabetta Boaretto, Valentina Caracuta, Bridget Alex, Amos Frumkin, Mae Goder-Goldberger, Philipp Gunz, Ralph L. Holloway, Bruce Latimer, Ron Lavi, Alan Matthews, Viviane Slon, Daniella Bar-Yosef Mayer, Francesco Berna, Guy Bar-Oz, Reuven Yeshurun, Hila May, Mark G. Hans, Gerhard W. Weber and Omry Barzilai

Distinct relationships of parietal and prefrontal cortices to evidence accumulation pp. 220-223

Timothy D. Hanks, Charles D. Kopec, Bingni W. Brunton, Chunyu A. Duan, Jeffrey C. Erlich and Carlos D. Brody

Common genetic variants influence human subcortical brain structures pp. 224-229

Derrek P. Hibar, Jason L. Stein, Miguel E. Renteria, Alejandro Arias-Vasquez, Sylvane Desrivières, Neda Jahanshad, Roberto Toro, Katharina Wittfeld, Lucija Abramovic, Micael Andersson, Benjamin S. Aribisala, Nicola J. Armstrong, Manon Bernard, Marc M. Bohlken, Marco P. Boks, Janita Bralten, Andrew A. Brown, M. Mallar Chakravarty, Qiang Chen, Christopher R. K. Ching, Gabriel Cuellar-Partida, Anouk den Braber, Sudheer Giddaluru, Aaron L. Goldman, Oliver Grimm, Tulio Guadalupe, Johanna Hass, Girma Woldehawariat, Avram J. Holmes, Martine Hoogman, Deborah Janowitz, Tianye Jia, Sungeun Kim, Marieke Klein, Bernd Kraemer, Phil H. Lee, Loes M. Olde Loohuis, Michelle Luciano, Christine Macare, Karen A. Mather, Manuel Mattheisen, Yuri Milaneschi, Kwangsik Nho, Martina Papmeyer, Adaikalavan Ramasamy, Shannon L. Risacher, Roberto Roiz-Santiañez, Emma J. Rose, Alireza Salami, Philipp G. Sämann, Lianne Schmaal, Andrew J. Schork, Jean Shin, Lachlan T. Strike, Alexander Teumer, Marjolein M. J. van Donkelaar, Kristel R. van Eijk, Raymond K. Walters, Lars T. Westlye, Christopher D. Whelan, Anderson M. Winkler, Marcel P. Zwiers, Saud Alhusaini, Lavinia Athanasiu, Stefan Ehrlich, Marina M. H. Hakobjan, Cecilie B. Hartberg, Unn K. Haukvik, Angelien J. G. A. M. Heister, David Hoehn, Dalia Kasperaviciute, David C. M. Liewald, Lorna M. Lopez, Remco R. R. Makkinje, Mar Matarin, Marlies A. M. Naber, D. Reese McKay, Margaret Needham, Allison C. Nugent, Benno Pütz, Natalie A. Royle, Li Shen, Emma Sprooten, Daniah Trabzuni, Saskia S. L. van der Marel, Kimm J. E. van Hulzen, Esther Walton, Christiane Wolf, Laura Almasy, David Ames, Sampath Arepalli, Amelia A. Assareh, Mark E. Bastin, Henry Brodaty, Kazima B. Bulayeva, Melanie A. Carless, Sven Cichon, Aiden Corvin, Joanne E. Curran, Michael Czisch, Greig I. de Zubicaray, Allissa Dillman, Ravi Duggirala, Thomas D. Dyer, Susanne Erk, Iryna O. Fedko, Luigi Ferrucci, Tatiana M. Foroud, Peter T. Fox, Masaki Fukunaga, J. Raphael Gibbs, Harald H. H. Göring, Robert C. Green, Sebastian Guelfi, Narelle K. Hansell, Catharina A. Hartman, Katrin Hegenscheid, Andreas Heinz, Dena G. Hernandez, Dirk J. Heslenfeld, Pieter J. Hoekstra, Florian Holsboer, Georg Homuth, Jouke-Jan Hottenga, Masashi Ikeda, Clifford R. Jack, Mark Jenkinson, Robert Johnson, Ryota Kanai, Maria Keil, Jack W. Kent, Peter Kochunov, John B. Kwok, Stephen M. Lawrie, Xinmin Liu, Dan L. Longo, Katie L. McMahon, Eva Meisenzahl, Ingrid Melle, Sebastian Mohnke, Grant W. Montgomery, Jeanette C. Mostert, Thomas W. Mühleisen, Michael A. Nalls, Thomas E. Nichols, Lars G. Nilsson, Markus M. Nöthen, Kazutaka Ohi, Rene L. Olvera, Rocio Perez-Iglesias, G. Bruce Pike, Steven G. Potkin, Ivar Reinvang, Simone Reppermund, Marcella Rietschel, Nina Romanczuk-Seiferth, Glenn D. Rosen, Dan Rujescu, Knut Schnell, Peter R. Schofield, Colin Smith, Vidar M. Steen, Jessika E. Sussmann, Anbupalam Thalamuthu, Arthur W. Toga, Bryan J. Traynor, Juan Troncoso, Jessica A. Turner, Maria C. Valdés Hernández, Dennis van 't Ent, Marcel van der Brug, Nic J. A. van der Wee, Marie-Jose van Tol, Dick J. Veltman, Thomas H. Wassink, Eric Westman, Ronald H. Zielke, Alan B. Zonderman, David G. Ashbrook, Reinmar Hager, Lu Lu, Francis J. McMahon, Derek W. Morris, Robert W. Williams, Han G. Brunner, Randy L. Buckner, Jan K. Buitelaar, Wiepke Cahn, Vince D. Calhoun, Gianpiero L. Cavalleri, Benedicto Crespo-Facorro, Anders M. Dale, Gareth E. Davies, Norman Delanty, Chantal Depondt, Srdjan Djurovic, Wayne C. Drevets, Thomas Espeseth, Randy L. Gollub, Beng-Choon Ho, Wolfgang Hoffmann, Norbert Hosten, René S. Kahn, Stephanie Le Hellard, Andreas Meyer-Lindenberg, Bertram Müller-Myhsok, Matthias Nauck, Lars Nyberg, Massimo Pandolfo, Brenda W. J. H. Penninx, Joshua L. Roffman, Sanjay M. Sisodiya, Jordan W. Smoller, Hans van Bokhoven, Neeltje E. M. van Haren, Henry Völzke, Henrik Walter, Michael W. Weiner, Wei Wen, Tonya White, Ingrid Agartz, Ole A. Andreassen, John Blangero, Dorret I. Boomsma, Rachel M. Brouwer, Dara M. Cannon, Mark R. Cookson, Eco J. C. de Geus, Ian J. Deary, Gary Donohoe, Guillén Fernández, Simon E. Fisher, Clyde Francks, David C. Glahn, Hans J. Grabe, Oliver Gruber, John Hardy, Ryota Hashimoto, Hilleke E. Hulshoff Pol, Erik G. Jönsson, Iwona Kloszewska, Simon Lovestone, Venkata S. Mattay, Patrizia Mecocci, Colm McDonald, Andrew M. McIntosh, Roel A. Ophoff, Tomas Paus, Zdenka Pausova, Mina Ryten, Perminder S. Sachdev, Andrew J. Saykin, Andy Simmons, Andrew Singleton, Hilkka Soininen, Joanna M. Wardlaw, Michael E. Weale, Daniel R. Weinberger, Hieab H. H. Adams, Lenore J. Launer, Stephan Seiler, Reinhold Schmidt, Ganesh Chauhan, Claudia L. Satizabal, James T. Becker, Lisa Yanek, Sven J. van der Lee, Maritza Ebling, Bruce Fischl, W. T. Longstreth, Douglas Greve, Helena Schmidt, Paul Nyquist, Louis N. Vinke, Cornelia M. van Duijn, Luting Xue, Bernard Mazoyer, Joshua C. Bis, Vilmundur Gudnason, Sudha Seshadri, M. Arfan Ikram, Nicholas G. Martin, Margaret J. Wright, Gunter Schumann, Barbara Franke, Paul M. Thompson and Sarah E. Medland

The maternal-age-associated risk of congenital heart disease is modifiable pp. 230-233

Claire E. Schulkey, Suk D. Regmi, Rachel A. Magnan, Megan T. Danzo, Herman Luther, Alayna K. Hutchinson, Adam A. Panzer, Mary M. Grady, David B. Wilson and Patrick Y. Jay

Repeated ER–endosome contacts promote endosome translocation and neurite outgrowth pp. 234-238

Camilla Raiborg, Eva M. Wenzel, Nina M. Pedersen, Hallvard Olsvik, Kay O. Schink, Sebastian W. Schultz, Marina Vietri, Veronica Nisi, Cecilia Bucci, Andreas Brech, Terje Johansen and Harald Stenmark

EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors pp. 239-242

Christine M. Fillmore, Chunxiao Xu, Pooja T. Desai, Joanne M. Berry, Samuel P. Rowbotham, Yi-Jang Lin, Haikuo Zhang, Victor E. Marquez, Peter S. Hammerman, Kwok-Kin Wong and Carla F. Kim

Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation pp. 243-247

Tuncay Baubec, Daniele F. Colombo, Christiane Wirbelauer, Juliane Schmidt, Lukas Burger, Arnaud R. Krebs, Altuna Akalin and Dirk Schübeler

The Paf1 complex represses small-RNA-mediated epigenetic gene silencing pp. 248-252

Katarzyna Maria Kowalik, Yukiko Shimada, Valentin Flury, Michael Beda Stadler, Julia Batki and Marc Bühler

Data science: Industry allure pp. 253-255

Monya Baker

Bread of life pp. 258-258

Beth Cato

2015, volume 520, articles 7545

PLD3 and sporadic Alzheimer's disease risk pp. E1-E1

Jean-Charles Lambert, Benjamin Grenier-Boley, Céline Bellenguez, Florence Pasquier, Dominique Campion, Jean-Francois Dartigues, Claudine Berr, Christophe Tzourio and Philippe Amouyel

PLD3 variants in population studies pp. E2-E3

Sven J. van der Lee, Henne Holstege, Tsz Hang Wong, Johanna Jakobsdottir, Joshua C. Bis, Vincent Chouraki, Jeroen G. J. van Rooij, Megan L. Grove, Albert V. Smith, Najaf Amin, Seung-Hoan Choi, Alexa S. Beiser, Melissa E. Garcia, Wilfred F. J. van IJcken, Yolande A. L. Pijnenburg, Eva Louwersheimer, Rutger W. W. Brouwer, Mirjam C. G. N. van den Hout, Edwin Oole, Gudny Eirkisdottir, Daniel Levy, Jerome I. Rotter, Valur Emilsson, Christopher J. O'Donnell, Thor Aspelund, Andre G. Uitterlinden, Lenore J. Launer, Albert Hofman, Eric Boerwinkle, Bruce M. Psaty, Anita L. DeStefano, Philip Scheltens, Sudha Seshadri, John C. van Swieten, Vilmundur Gudnason, Wiesje M. van der Flier, M. Arfan Ikram and Cornelia M. van Duijn

PLD3 in non-familial Alzheimer's disease pp. E3-E5

Stefanie Heilmann, Dmitriy Drichel, Jordi Clarimon, Victoria Fernández, André Lacour, Holger Wagner, Mathias Thelen, Isabel Hernández, Juan Fortea, Montserrat Alegret, Rafael Blesa, Ana Mauleón, Maitée Rosende Roca, Johannes Kornhuber, Oliver Peters, Reinhard Heun, Lutz Frölich, Michael Hüll, Michael T. Heneka, Eckart Rüther, Steffi Riedel-Heller, Martin Scherer, Jens Wiltfang, Frank Jessen, Tim Becker, Lluís Tárraga, Mercè Boada, Wolfgang Maier, Alberto Lleó, Agustin Ruiz, Markus M. Nöthen and Alfredo Ramirez

Cruchaga & Goate reply pp. E5-E6

Carlos Cruchaga and Alison M. Goate

Change the cancer conversation pp. 7-7

Colin Macilwain

PLD3 gene variants and Alzheimer's disease pp. E7-E8

Basavaraj V. Hooli, Christina M. Lill, Kristina Mullin, Dandi Qiao, Christoph Lange, Lars Bertram and Rudolph E. Tanzi

Website recruits people to share health data for studies pp. 9-9

Chris Woolston

Cruchaga & Goate reply pp. E10-E10

Carlos Cruchaga and Alison M. Goate

Neuron encyclopaedia fires up to reveal brain secrets pp. 13-14

Helen Shen

Global-warming limit of 2 °C hangs in the balance pp. 14-15

Jeff Tollefson

UK election: Upstart parties set out science plans pp. 16-17

Elizabeth Gibney and Daniel Cressey

Mini enzyme moves gene editing closer to the clinic pp. 18-18

Heidi Ledford

Stopping deforestation: Battle for the Amazon pp. 20-23

Jeff Tollefson

Evidence-based medicine: Save blood, save lives pp. 24-26

Emily Anthes

Climate change: Embed the social sciences in climate policy pp. 27-29

David Victor

History of science: Revelations of a wild continent pp. 30-31

Linda Lear

Books in brief pp. 31-31

Daniel Cressey

Neuroscience: Total recall, welcome oblivion pp. 32-32

Alison Abbott

Aboriginal myth meets DNA analysis pp. 33-33

David M. J. S. Bowman, Jason Gibson and Toshiaki Kondo

US Congress replies on NSF scrutiny pp. 33-33

Lamar Smith

Evaluate risks of coating reservoirs pp. 33-33

Guohe Huang and Yao Yao

Laboratory work is 'like falling in love' pp. 33-33

Oliver Sacks

Two-atom bunching pp. 36-37

Lindsay J. LeBlanc

A piece of the p53 puzzle pp. 37-38

Kathryn T. Bieging and Laura D. Attardi

Land use matters pp. 38-39

Brian McGill

Preventing stars from eating their young pp. 40-41

Martin J. Duncan

Coding in non-coding RNAs pp. 41-42

Peter M. Waterhouse and Roger P. Hellens

Here be dragons pp. 42-43

Andrew J. Hamilton, Robert M. May and Edward K. Waters

Global effects of land use on local terrestrial biodiversity pp. 45-50

Tim Newbold, Lawrence N. Hudson, Samantha L. L. Hill, Sara Contu, Igor Lysenko, Rebecca A. Senior, Luca Börger, Dominic J. Bennett, Argyrios Choimes, Ben Collen, Julie Day, Adriana De Palma, Sandra Díaz, Susy Echeverria-Londoño, Melanie J. Edgar, Anat Feldman, Morgan Garon, Michelle L. K. Harrison, Tamera Alhusseini, Daniel J. Ingram, Yuval Itescu, Jens Kattge, Victoria Kemp, Lucinda Kirkpatrick, Michael Kleyer, David Laginha Pinto Correia, Callum D. Martin, Shai Meiri, Maria Novosolov, Yuan Pan, Helen R. P. Phillips, Drew W. Purves, Alexandra Robinson, Jake Simpson, Sean L. Tuck, Evan Weiher, Hannah J. White, Robert M. Ewers, Georgina M. Mace, Jörn P. W. Scharlemann and Andy Purvis

Loss of δ-catenin function in severe autism pp. 51-56

Tychele N. Turner, Kamal Sharma, Edwin C. Oh, Yangfan P. Liu, Ryan L. Collins, Maria X. Sosa, Dallas R. Auer, Harrison Brand, Stephan J. Sanders, Daniel Moreno- De-Luca, Vasyl Pihur, Teri Plona, Kristen Pike, Daniel R. Soppet, Michael W. Smith, Sau Wai Cheung, Christa Lese Martin, Matthew W. State, Michael E. Talkowski, Edwin Cook, Richard Huganir, Nicholas Katsanis and Aravinda Chakravarti

Ferroptosis as a p53-mediated activity during tumour suppression pp. 57-62

Le Jiang, Ning Kon, Tongyuan Li, Shang-Jui Wang, Tao Su, Hanina Hibshoosh, Richard Baer and Wei Gu

Planet heating prevents inward migration of planetary cores pp. 63-65

Pablo Benítez-Llambay, Frédéric Masset, Gloria Koenigsberger and Judit Szulágyi

Atomic Hong–Ou–Mandel experiment pp. 66-68

R. Lopes, A. Imanaliev, A. Aspect, M. Cheneau, D. Boiron and C. I. Westbrook

Monolayer semiconductor nanocavity lasers with ultralow thresholds pp. 69-72

Sanfeng Wu, Sonia Buckley, John R. Schaibley, Liefeng Feng, Jiaqiang Yan, David G. Mandrus, Fariba Hatami, Wang Yao, Jelena Vučković, Arka Majumdar and Xiaodong Xu

Shape-changing magnetic assemblies as high-sensitivity NMR-readable nanoprobes pp. 73-77

G. Zabow, S. J. Dodd and A. P. Koretsky

Orbital-specific mapping of the ligand exchange dynamics of Fe(CO)5 in solution pp. 78-81

Ph. Wernet, K. Kunnus, I. Josefsson, I. Rajkovic, W. Quevedo, M. Beye, S. Schreck, S. Grübel, M. Scholz, D. Nordlund, W. Zhang, R. W. Hartsock, W. F. Schlotter, J. J. Turner, B. Kennedy, F. Hennies, F. M. F. de Groot, K. J. Gaffney, S. Techert, M. Odelius and A. Föhlisch

Osteichthyan-like cranial conditions in an Early Devonian stem gnathostome pp. 82-85

Sam Giles, Matt Friedman and Martin D. Brazeau

Evolution of the snake body form reveals homoplasy in amniote Hox gene function pp. 86-89

Jason J. Head and P. David Polly

Primary transcripts of microRNAs encode regulatory peptides pp. 90-93

Dominique Lauressergues, Jean-Malo Couzigou, Hélène San Clemente, Yves Martinez, Christophe Dunand, Guillaume Bécard and Jean-Philippe Combier

G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons pp. 94-98

Masoud Ghamari-Langroudi, Gregory J. Digby, Julien A. Sebag, Glenn L. Millhauser, Rafael Palomino, Robert Matthews, Taneisha Gillyard, Brandon L. Panaro, Iain R. Tough, Helen M. Cox, Jerod S. Denton and Roger D. Cone

Growth and host interaction of mouse segmented filamentous bacteria in vitro pp. 99-103

Pamela Schnupf, Valérie Gaboriau-Routhiau, Marine Gros, Robin Friedman, Maryse Moya-Nilges, Giulia Nigro, Nadine Cerf-Bensussan and Philippe J. Sansonetti

Commensal–dendritic-cell interaction specifies a unique protective skin immune signature pp. 104-108

Shruti Naik, Nicolas Bouladoux, Jonathan L. Linehan, Seong-Ji Han, Oliver J. Harrison, Christoph Wilhelm, Sean Conlan, Sarah Himmelfarb, Allyson L. Byrd, Clayton Deming, Mariam Quinones, Jason M. Brenchley, Heidi H. Kong, Roxanne Tussiwand, Kenneth M. Murphy, Miriam Merad, Julia A. Segre and Yasmine Belkaid

Recognition determinants of broadly neutralizing human antibodies against dengue viruses pp. 109-113

Alexander Rouvinski, Pablo Guardado-Calvo, Giovanna Barba-Spaeth, Stéphane Duquerroy, Marie-Christine Vaney, Carlos M. Kikuti, M. Erika Navarro Sanchez, Wanwisa Dejnirattisai, Wiyada Wongwiwat, Ahmed Haouz, Christine Girard-Blanc, Stéphane Petres, William E. Shepard, Philippe Desprès, Fernando Arenzana-Seisdedos, Philippe Dussart, Juthathip Mongkolsapaya, Gavin R. Screaton and Félix A. Rey

Tel1ATM-mediated interference suppresses clustered meiotic double-strand-break formation pp. 114-118

Valerie Garcia, Stephen Gray, Rachal M. Allison, Tim J. Cooper and Matthew J. Neale

Rate that journal pp. 119-120

Jeffrey M. Perkel

Authorship: Dynamic duos pp. 121-123

Roberta Kwok

Turning point: Danielle Edwards pp. 123-123

Virginia Gewin

Mort's laws pp. 126-126

Jacey Bedford