C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress

Ilija Melentijevic, Marton L. Toth, Meghan L. Arnold, Ryan J. Guasp, Girish Harinath, Ken C. Nguyen, Daniel Taub, J. Alex Parker, Christian Neri, Christopher V. Gabel, David H. Hall and Monica Driscoll ()
Additional contact information
Ilija Melentijevic: Nelson Biological Laboratories, Rutgers, The State University of New Jersey
Marton L. Toth: Nelson Biological Laboratories, Rutgers, The State University of New Jersey
Meghan L. Arnold: Nelson Biological Laboratories, Rutgers, The State University of New Jersey
Ryan J. Guasp: Nelson Biological Laboratories, Rutgers, The State University of New Jersey
Girish Harinath: Nelson Biological Laboratories, Rutgers, The State University of New Jersey
Ken C. Nguyen: Albert Einstein College of Medicine
Daniel Taub: Boston University School of Medicine
J. Alex Parker: Université de Montréal CRCHUM
Christian Neri: CNRS, UMR 8256, Brain-C team, Paris, France, and Sorbonnes Universités, University Pierre and Marie Curie (UPMC) Univ Paris 06
Christopher V. Gabel: Boston University School of Medicine
David H. Hall: Albert Einstein College of Medicine
Monica Driscoll: Nelson Biological Laboratories, Rutgers, The State University of New Jersey

Nature, 2017, vol. 542, issue 7641, 367-371

Abstract: Adult neurons from Caenorhabditis elegans can extrude large membrane-surrounded vesicles, known as exophers, containing protein aggregates and dysfunctional organelles that threaten neuronal homeostasis.

Date: 2017
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DOI: 10.1038/nature21362

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