Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

Deepak A. Rao (), Michael F. Gurish, Jennifer L. Marshall, Kamil Slowikowski, Chamith Y. Fonseka, Yanyan Liu, Laura T. Donlin, Lauren A. Henderson, Kevin Wei, Fumitaka Mizoguchi, Nikola C. Teslovich, Michael E. Weinblatt, Elena M. Massarotti, Jonathan S. Coblyn, Simon M. Helfgott, Yvonne C. Lee, Derrick J. Todd, Vivian P. Bykerk, Susan M. Goodman, Alessandra B. Pernis, Lionel B. Ivashkiv, Elizabeth W. Karlson, Peter A. Nigrovic, Andrew Filer, Christopher D. Buckley, James A. Lederer, Soumya Raychaudhuri and Michael B. Brenner ()
Additional contact information
Deepak A. Rao: Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
Michael F. Gurish: Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
Jennifer L. Marshall: Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Queen Elizabeth Hospital
Kamil Slowikowski: Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
Chamith Y. Fonseka: Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
Yanyan Liu: Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
Laura T. Donlin: Arthritis and Tissue Degeneration Program, Hospital for Special Surgery
Lauren A. Henderson: Boston Children’s Hospital
Kevin Wei: Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
Fumitaka Mizoguchi: Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
Nikola C. Teslovich: Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
Michael E. Weinblatt: Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
Elena M. Massarotti: Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
Jonathan S. Coblyn: Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
Simon M. Helfgott: Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
Yvonne C. Lee: Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
Derrick J. Todd: Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
Vivian P. Bykerk: Hospital for Special Surgery
Susan M. Goodman: Hospital for Special Surgery
Alessandra B. Pernis: David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery
Lionel B. Ivashkiv: Arthritis and Tissue Degeneration Program, Hospital for Special Surgery
Elizabeth W. Karlson: Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
Peter A. Nigrovic: Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
Andrew Filer: Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Queen Elizabeth Hospital
Christopher D. Buckley: Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Queen Elizabeth Hospital
James A. Lederer: Brigham and Women’s Hospital
Soumya Raychaudhuri: Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School
Michael B. Brenner: Immunology, and Allergy, Brigham and Women’s Hospital and Harvard Medical School

Nature, 2017, vol. 542, issue 7639, 110-114

Abstract: The authors identify in patients with rheumatoid arthritis a pathogenic subset of CD4+ T cells that augments B cell responses within inflamed tissues.

Date: 2017
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DOI: 10.1038/nature20810

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