Growth factor rattled out of its cage

Taekjip Ha ()
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Taekjip Ha: Biomedical Engineering and Biophysics and Biochemistry, Johns Hopkins University, Howard Hughes Medical Institute, Baltimore, Maryland 21205, USA.

Nature, 2017, vol. 542, issue 7639, 40-41

Abstract: The growth factor TGF-ß1 is located inside a protein cage, and is thought to be released by force applied through integrin proteins. A structure of TGF-ß1 in complex with integrin αVß6 sheds light on the uncaging process. See Article p.55

Date: 2017
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DOI: 10.1038/nature21119

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