Metabolic gatekeeper function of B-lymphoid transcription factors

Lai N. Chan, Zhengshan Chen, Daniel Braas, Jae-Woong Lee, Gang Xiao, Huimin Geng, Kadriye Nehir Cosgun, Christian Hurtz, Seyedmehdi Shojaee, Valeria Cazzaniga, Hilde Schjerven, Thomas Ernst, Andreas Hochhaus, Steven M. Kornblau, Marina Konopleva, Miles A. Pufall, Giovanni Cazzaniga, Grace J. Liu, Thomas A. Milne, H. Phillip Koeffler, Theodora S. Ross, Isidro Sánchez-García, Arndt Borkhardt, Keith R. Yamamoto, Ross A. Dickins, Thomas G. Graeber and Markus Müschen ()
Additional contact information
Lai N. Chan: Beckman Research Institute and City of Hope National Medical Center
Zhengshan Chen: Beckman Research Institute and City of Hope National Medical Center
Daniel Braas: UCLA Metabolomics Center and Crump Institute for Molecular Imaging, University of California Los Angeles
Jae-Woong Lee: Beckman Research Institute and City of Hope National Medical Center
Gang Xiao: Beckman Research Institute and City of Hope National Medical Center
Huimin Geng: University of California San Francisco
Kadriye Nehir Cosgun: Beckman Research Institute and City of Hope National Medical Center
Christian Hurtz: University of California San Francisco
Seyedmehdi Shojaee: University of California San Francisco
Valeria Cazzaniga: University of California San Francisco
Hilde Schjerven: University of California San Francisco
Thomas Ernst: Hämatologie/Onkologie, Klinik für Innere Medizin II, Universitätsklinikum Jena
Andreas Hochhaus: Hämatologie/Onkologie, Klinik für Innere Medizin II, Universitätsklinikum Jena
Steven M. Kornblau: The University of Texas M.D. Anderson Cancer Center
Marina Konopleva: The University of Texas M.D. Anderson Cancer Center
Miles A. Pufall: University of Iowa
Giovanni Cazzaniga: Centro Ricerca Tettamanti, Clinica Pediatrica, Università di Milano-Bicocca, Ospedale S. Gerardo
Grace J. Liu: Australian Centre for Blood Diseases, Monash University
Thomas A. Milne: MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford
H. Phillip Koeffler: Cancer Science Institute of Singapore, National University of Singapore
Theodora S. Ross: University of Texas Southwestern Medical Center
Isidro Sánchez-García: Experimental Therapeutics and Translational Oncology Program, Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de Salamanca and Institute of Biomedical Research of Salamanca (IBSAL)
Arndt Borkhardt: Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich Heine University
Keith R. Yamamoto: University of California San Francisco
Ross A. Dickins: Australian Centre for Blood Diseases, Monash University
Thomas G. Graeber: UCLA Metabolomics Center and Crump Institute for Molecular Imaging, University of California Los Angeles
Markus Müschen: Beckman Research Institute and City of Hope National Medical Center

Nature, 2017, vol. 542, issue 7642, 479-483

Abstract: The B-lymphoid transcription factors PAX5 and IKZF1 restrict the supply of glucose and energy to B cells to levels that are not enough to fuel a driver-oncogene, thereby acting as tumour suppressors and sensitizing acute lymphoblastic leukaemia B cells to glucocorticoid therapy.

Date: 2017
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DOI: 10.1038/nature21076

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