The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition

Masatoshi Yamamoto, Shizue Ohsawa, Kei Kunimasa and Tatsushi Igaki ()
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Masatoshi Yamamoto: Laboratory of Genetics, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe-cho
Shizue Ohsawa: Laboratory of Genetics, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe-cho
Kei Kunimasa: Laboratory of Genetics, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe-cho
Tatsushi Igaki: Laboratory of Genetics, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe-cho

Nature, 2017, vol. 542, issue 7640, 246-250

Abstract: Wild-type Drosophila epithelial cells outcompete proto-oncogenic cells through translocation of the ligand Sas to the wild-type–tumour cell interface, where it binds the PTP10D receptor of the tumour cell, initiating pro-apoptotic signalling.

Date: 2017
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DOI: 10.1038/nature21033

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