Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer

Di Zhao, Xin Lu, Guocan Wang, Zhengdao Lan, Wenting Liao, Jun Li, Xin Liang, Jasper Robin Chen, Sagar Shah, Xiaoying Shang, Ming Tang, Pingna Deng, Prasenjit Dey, Deepavali Chakravarti, Peiwen Chen, Denise J. Spring, Nora M. Navone, Patricia Troncoso, Jianhua Zhang, Y. Alan Wang () and Ronald A. DePinho ()
Additional contact information
Di Zhao: The University of Texas MD Anderson Cancer Center
Xin Lu: The University of Texas MD Anderson Cancer Center
Guocan Wang: The University of Texas MD Anderson Cancer Center
Zhengdao Lan: The University of Texas MD Anderson Cancer Center
Wenting Liao: The University of Texas MD Anderson Cancer Center
Jun Li: The University of Texas MD Anderson Cancer Center
Xin Liang: The University of Texas MD Anderson Cancer Center
Jasper Robin Chen: The University of Texas MD Anderson Cancer Center
Sagar Shah: The University of Texas MD Anderson Cancer Center
Xiaoying Shang: The University of Texas MD Anderson Cancer Center
Ming Tang: The University of Texas MD Anderson Cancer Center
Pingna Deng: The University of Texas MD Anderson Cancer Center
Prasenjit Dey: The University of Texas MD Anderson Cancer Center
Deepavali Chakravarti: The University of Texas MD Anderson Cancer Center
Peiwen Chen: The University of Texas MD Anderson Cancer Center
Denise J. Spring: The University of Texas MD Anderson Cancer Center
Nora M. Navone: The University of Texas MD Anderson Cancer Center
Patricia Troncoso: The University of Texas MD Anderson Cancer Center
Jianhua Zhang: The University of Texas MD Anderson Cancer Center
Y. Alan Wang: The University of Texas MD Anderson Cancer Center
Ronald A. DePinho: The University of Texas MD Anderson Cancer Center

Nature, 2017, vol. 542, issue 7642, 484-488

Abstract: The gene CHD1 is synthetic essential in PTEN-deficient prostate and breast cancers.

Date: 2017
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DOI: 10.1038/nature21357

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