Sterile protection against human malaria by chemoattenuated PfSPZ vaccine

Benjamin Mordmüller, Güzin Surat, Heimo Lagler, Sumana Chakravarty, Andrew S. Ishizuka, Albert Lalremruata, Markus Gmeiner, Joseph J. Campo, Meral Esen, Adam J. Ruben, Jana Held, Carlos Lamsfus Calle, Juliana B. Mengue, Tamirat Gebru, Javier Ibáñez, Mihály Sulyok, Eric R. James, Peter F. Billingsley, Natasha Kc, Anita Manoj, Tooba Murshedkar, Anusha Gunasekera, Abraham G. Eappen, Tao Li, Richard E. Stafford, Minglin Li, Phil L. Felgner, Robert A. Seder, Thomas L. Richie, B. Kim Lee Sim, Stephen L. Hoffman () and Peter G. Kremsner
Additional contact information
Benjamin Mordmüller: Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen
Güzin Surat: Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen
Heimo Lagler: Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen
Sumana Chakravarty: Sanaria Inc.
Andrew S. Ishizuka: Vaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH)
Albert Lalremruata: Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen
Markus Gmeiner: Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen
Joseph J. Campo: Antigen Discovery Inc.
Meral Esen: Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen
Adam J. Ruben: Sanaria Inc.
Jana Held: Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen
Carlos Lamsfus Calle: Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen
Juliana B. Mengue: Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen
Tamirat Gebru: Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen
Javier Ibáñez: Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen
Mihály Sulyok: Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen
Eric R. James: Sanaria Inc.
Peter F. Billingsley: Sanaria Inc.
Natasha Kc: Sanaria Inc.
Anita Manoj: Sanaria Inc.
Tooba Murshedkar: Sanaria Inc.
Anusha Gunasekera: Sanaria Inc.
Abraham G. Eappen: Sanaria Inc.
Tao Li: Sanaria Inc.
Richard E. Stafford: Sanaria Inc.
Minglin Li: Sanaria Inc.
Phil L. Felgner: University of California Irvine
Robert A. Seder: Vaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH)
Thomas L. Richie: Sanaria Inc.
B. Kim Lee Sim: Sanaria Inc.
Stephen L. Hoffman: Sanaria Inc.
Peter G. Kremsner: Institute of Tropical Medicine, University of Tübingen and German Center for Infection Research, partner site Tübingen

Nature, 2017, vol. 542, issue 7642, 445-449

Abstract: Immunization with Plasmodium falciparum sporozoites under chemoprophylaxis can protect against controlled human malaria infection with the same strain for at least 10 weeks, and protection correlates with polyfunctional T-cell memory.

Date: 2017
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DOI: 10.1038/nature21060

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