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1997 - 2026

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2026, volume 649, articles 8097

Author Correction: Neuroimmune cardiovascular interfaces control atherosclerosis pp. E7-E7

Sarajo K. Mohanta, Li Peng, Yuanfang Li, Shu Lu, Ting Sun, Lorenzo Carnevale, Marialuisa Perrotta, Zhe Ma, Benjamin Förstera, Karen Stanic, Chuankai Zhang, Xi Zhang, Piotr Szczepaniak, Mariaelvy Bianchini, Borhan R. Saeed, Raimondo Carnevale, Desheng Hu, Ryszard Nosalski, Fabio Pallante, Michael Beer, Donato Santovito, Ali Ertürk, Thomas C. Mettenleiter, Barbara G. Klupp, Remco T. A. Megens, Sabine Steffens, Jaroslav Pelisek, Hans-Henning Eckstein, Robert Kleemann, Livia Habenicht, Ziad Mallat, Jean-Baptiste Michel, Jürgen Bernhagen, Martin Dichgans, Giuseppe D’Agostino, Tomasz J. Guzik, Peder S. Olofsson, Changjun Yin, Christian Weber, Giuseppe Lembo, Daniela Carnevale and Andreas J. R. Habenicht

Author Correction: Cryo-EM structure of a natural RNA nanocage pp. E8-E8

Xiaobin Ling, Dmitrij Golovenko, Jianhua Gan, Jinbiao Ma, Andrei A. Korostelev and Wenwen Fang

Publisher Correction: Covalent targeted radioligands potentiate radionuclide therapy pp. E9-E9

Xi-Yang Cui, Zhu Li, Ziren Kong, Yu Liu, Hao Meng, Zihao Wen, Changlun Wang, Junyi Chen, Mengxin Xu, Yiyan Li, Jingyue Gao, Wenjia Zhu, Zhixin Hao, Li Huo, Shaoyan Liu, Zhi Yang and Zhibo Liu

AI can spark creativity — if we ask it how, not what, to think pp. 529-529

Brian Uzzi

The academic community failed Wikipedia for 25 years — now it might fail us pp. 530-530

Dariusz Jemielniak

Will mpox go global again? Research shows it’s evolving in curious ways pp. 533-534

Max Kozlov

Chinese nuclear fusion reactor pushes plasma past crucial limit: what happens next pp. 534-535

Mohana Basu

AI models were given four weeks of therapy: the results worried researchers pp. 535-536

Elizabeth Gibney

Oldest known poison arrows show Stone Age humans’ technological talents pp. 536-537

Nicola Jones

Huge Chinese cell atlas reveals surprising immune variation among peoples pp. 537-538

Chris Simms

Jellyfish sleep like humans — even though they don’t have brains pp. 538-539

Lynne Peeples

NASA won’t bring Mars samples back to Earth: this is the science that will be lost pp. 539-540

Jenna Ahart

Octopus-inspired ‘synthetic skin’ changes colour and texture on demand pp. 540-540

Davide Castelvecchi

How did birds evolve? The answer is wilder than anyone thought pp. 542-545

Michael Marshall

The infection enigma: why some people die from typically harmless germs pp. 546-548

Diana Kwon

‘We’re humans — brilliant and a mess’: Wikipedia founder Jimmy Wales on trust and optimism pp. 549-551

Nicola Jones

To infinity and beyond Earth’s pale blue dot: Books in brief pp. 551-551

Andrew Robinson

Student mental health is in crisis — here’s how to help pp. 553-554

Lauro Miranda Demenech and Anne Duffy

AlphaFold can help African researchers to do cutting-edge structural biology pp. 555-555

Emmanuel Nji

Don’t assume that women’s low retraction rates reflect male ‘boldness’ pp. 555-555

Carrie J. McAdams, Kristine M. Erlandson, Sarah N. Cross and Katharine J. Liang

AI writing tools could lead scholars from low-income countries to erase their own voices pp. 555-555

Zhenning Li and Zhengbing He

No world-changing discoveries without biodiversity pp. 555-555

Kenneth D. Winkel and Brendan A. Wintle

Mysterious ‘little red dots’ could be black holes in disguise pp. 557-558

Rodrigo Nemmen

Systematic maps reveal how human chromosomes are organized pp. 558-560

Elzo de Wit

LLMs behaving badly: mistrained AI models quickly go off the rails pp. 560-561

Richard Ngo

Blood protein thwarts deadly fungal disease pp. 561-562

Katrina B. Mar and Tobias M. Hohl

Oldest known evidence of the controlled ignition of fire pp. 563-564

Ségolène Vandevelde

Enriching African genome representation through the AGenDA project pp. 565-573

M. Ramsay, H. Etheredge, F. Tluway, M. E. D’Amato, Z. Chikwambi, Y. Hamdi, I. Alhudiri, Y. Fakim, K. M. Ahmad, N. Belguith, D. Bentley, M. Boujemaa, N. Calumbuana, M. Chaouch, C. Charfeddine, G. Chinien, N. Dukuze, M. Eljilani, A. Elzagheid, N. Ferraz, A. Ghoorah, S. Goorah, M. Gribaa, S. Guidara, M. Guirat, S. Hazelhurst, M. Jallul, M. Kasu, N. Kharrat, U. Khumalo, Z. Kingsbury, I. Kisiangani, I. Lopes-Cendes, P. Lukusa, P. Makay, J. Makulo, G. Mubungu, C. Muhinda, D. M. Mukhongo, A. Murwira, A. Mustafa, J. Ndinkabandi, M. Ngole, Y. Nlandu, M. Nyathi, L. Pereira, I. Rejeb, L. L. Santos, D. Sengupta, A. Shebani, N. Smyth, A. Souissi, M. Trabelsi, A. Rebai, M. M. Chimpolo, A. Lumaka, C. Masimirembwa, S. F. Mohamed, N. Mulder, L. Mutesa, N. A. Hanchard and A. Choudhury

Little red dots as young supermassive black holes in dense ionized cocoons pp. 574-579

V. Rusakov, D. Watson, G. P. Nikopoulos, G. Brammer, R. Gottumukkala, T. Harvey, K. E. Heintz, R. Damgaard, S. A. Sim, A. Sneppen, A. P. Vijayan, N. Adams, D. Austin, C. J. Conselice, C. M. Goolsby, S. Toft and J. Witstok

Direct observation of the Migdal effect induced by neutron bombardment pp. 580-583

Difan Yi, Qian Liu, Shi Chen, Chunlai Dong, Huanbo Feng, Chaosong Gao, Wenqian Huang, Xinmei Jing, Lingquan Kong, Jin Li, Peirong Li, Enwei Liang, Ruiting Ma, Chenguang Su, Liangliang Su, Junwei Sun, Dong Wang, Junrun Wang, Zheng Wei, Zeen Yao, Yunlinchen Yu, Yu Zhang, Shiqiang Zhou, Zhuo Zhou, Bin Zhu, Jie Zuo, Hongbang Liu, Xiangming Sun, Lei Wu and Yangheng Zheng

Training large language models on narrow tasks can lead to broad misalignment pp. 584-589

Jan Betley, Niels Warncke, Anna Sztyber-Betley, Daniel Tan, Xuchan Bao, Martín Soto, Megha Srivastava, Nathan Labenz and Owain Evans

Coherent nonlinear X-ray four-photon interaction with core-shell electrons pp. 590-596

Ana Sofia Morillo-Candas, Sven Augustin, Eduard Prat, Antoine Sarracini, Jonas Knurr, Serhane Zerdane, Zhibin Sun, Ningchen Yang, Marc Rebholz, Hankai Zhang, Yunpei Deng, Xinhua Xie, Elnaz Zyaee, David Rohrbach, Andrea Cannizzo, Andre Al-Haddad, Kirsten Schnorr, Christian Ott, Thomas Feurer, Christoph Bostedt, Thomas Pfeifer and Gregor Knopp

An electrically injected solid-state surface acoustic wave phonon laser pp. 597-603

Alexander Wendt, Matthew J. Storey, Michael Miller, Dalton Anderson, Eric Chatterjee, William Horrocks, Brandon Smith, Ping-Show Wong, Shawn Arterburn, Thomas A. Friedmann, Lisa Hackett and Matt Eichenfield

Exciplex-enabled high-efficiency, fully stretchable OLEDs pp. 604-611

Huanyu Zhou, Hyun-Wook Kim, Shin Jung Han, Danzhen Zhang, Woo Jin Jeong, Haomiao Yu, Youichi Tsuchiya, Bin Hu, June Huh, Teng Zhang, Seungyeon Cho, Joo Sung Kim, Dong-Hyeok Kim, Hyung Joong Yun, Jinwoo Park, Kyung Yeon Jang, Eojin Yoon, Amit Kumar Harit, Min-Jun Sung, Yooseong Ahn, Hao Chen, Qingsen Zeng, Chan-Yul Park, Kwan-Nyeong Kim, Landep Ayuningtias, Hoichang Yang, Jong Chan Kim, Yun-Hi Kim, Han Young Woo, Chihaya Adachi, Yury Gogotsi and Tae-Woo Lee

Mosaic lateral heterostructures in two-dimensional perovskite pp. 612-620

Shuchen Zhang, Yuan Lu, Linghai Zhang, Hongsheng Shi, Xiao Wang, Zhaoming Wang, Jiaxin Li, Zehua He, Kang Wang, Ke Ma, Hanjun Yang, Chenjian Lin, Yue Hu, Shangfeng Yang, Yi Yu and Letian Dou

The asymmetric synthesis of an acyclic N-stereogenic amine pp. 621-625

Chendan Zhu, Sayantani Das, Marie Sophie Sterling, Nobuya Tsuji, Spencer J. Léger, Frank Neese, Chandra Kanta De and Benjamin List

Climate change shifts the North Pacific storm track polewards pp. 626-630

Rei Chemke and Janni Yuval

Earliest evidence of making fire pp. 631-637

Rob Davis, Marcus Hatch, Sally Hoare, Simon G. Lewis, Claire Lucas, Simon A. Parfitt, Silvia M. Bello, Mark Lewis, Jordan Mansfield, Jens Najorka, Simon O’Connor, Sylvia Peglar, Andrew Sorensen, Chris Stringer and Nick Ashton

Convergent genome evolution shaped the emergence of terrestrial animals pp. 638-646

Jialin Wei, Davide Pisani, Philip C. J. Donoghue, Marta Álvarez-Presas and Jordi Paps

Eight millennia of continuity of a previously unknown lineage in Argentina pp. 647-656

Javier Maravall-López, Josefina M. B. Motti, Nicolás Pastor, María Pía Tavella, Mariana Fabra, Pilar Babot, Mariano Bonomo, Silvia E. Cornero, Guillermo N. Lamenza, Diego Catriel Leon, Paula C. Miranda de Zela, Gustavo G. Politis, Sofía C. Angeletti, G. Roxana Cattáneo, Mariana Dantas, Hilton Drube, Lucia G. Gonzalez Baroni, Salomón Hocsman, Andrés D. Izeta, Reinaldo A. Moralejo, Verónica Aldazabal, Diego M. Basso, Cristina Bayón, María Guillermina Couso, Ulises D’Andrea, Paula Del Río, Germán G. Figueroa, Romina Frontini, Mariela Edith Gonzalez, Andrés G. Laguens, Jorge G. Martínez, Pablo G. Messineo, Beatriz Nores, Daniel E. Olivera, Gisela M. Sario, Analía Sbattella, Clara Scabuzzo, Aldana M. Tavarone, Rodrigo Vecchi, Kim Callan, Ella Caughran, Oscar Estrada, Trudi Frost, Lora Iliev, Aisling Kearns, Jack Kellogg, Kim-Louise Krettek, Ann Marie Lawson, Matthew Mah, Nihal Manjila, Adam Micco, Iris Patterson, Lijun Qiu, Xavier Roca-Rada, Gregory Soos, Peter A. Webb, J. Noah Workman, Nadin Rohland, Nick Patterson, Iosif Lazaridis, Lars Fehren-Schmitz, Cosimo Posth, Bastien Llamas, Swapan Mallick, Darío A. Demarchi, Graciela S. Cabana, David Reich and Rodrigo Nores

Evolution of taste processing shifts dietary preference pp. 657-666

Enrico Bertolini, Daniel Münch, Justine Pascual, Noemi Sgammeglia, Matteo Bruzzone, Carlos Ribeiro and Thomas O. Auer

Repulsions instruct synaptic partner matching in an olfactory circuit pp. 667-676

Zhuoran Li, Cheng Lyu, Chuanyun Xu, Ying Hu, David J. Luginbuhl, Asaf B. Caspi-Lebovic, Jessica M. Priest, Engin Özkan and Liqun Luo

Rewiring an olfactory circuit by altering cell-surface combinatorial code pp. 677-684

Cheng Lyu, Zhuoran Li, Chuanyun Xu, Jordan Kalai and Liqun Luo

Ethylene modulates cell wall mechanics for root responses to compaction pp. 685-692

Jiao Zhang, Zengyu Liu, Edward J. Farrar, Minhao Li, Hui Lu, Zhuo Qu, Osvaldo Chara, Nobutaka Mitsuda, Shingo Sakamoto, Feiyang Xue, Qiji Shan, Ya Yu, Jingbin Li, Xiaobo Zhu, Mingyuan Zhu, Jin Shi, Lucas Peralta Ogorek, Augusto Borges, Malcolm J. Bennett, Wanqi Liang, Bipin K. Pandey, Dabing Zhang and Staffan Persson

Albumin orchestrates a natural host defence mechanism against mucormycosis pp. 693-702

Antonis Pikoulas, Ioannis Morianos, Vassilis Nidris, Rania Hamdy, Evangelia Intze, Ángeles López-López, Maria Moran-Garrido, Valliappan Muthu, Maria Halabalaki, Varvara Papaioanou, Maria Papadovasilaki, Irene Kyrmizi, Yiyou Gu, Sandra Camunas-Alberca, Robina Aerts, Toine Mercier, Yuri Vanbiervliet, Sung-Yeon Cho, Amy Spallone, Ying Jiang, Dimitrios Samonakis, Efstathios Kastritis, Carlos Lax, Maria Tzardi, Aristides Eliopoulos, Konstantina Georgila, Agostinho Carvalho, Oliver Kurzai, Shivaprakash Mandya Rudramurthy, Caroline Elie, Fanny Lanternier, Kyriakos Petratos, Victoriano Garre, Elias Drakos, Johan Maertens, Vincent M. Bruno, Dimitrios P. Kontoyiannis, Coral Barbas, Sameh S. M. Soliman, Ashraf S. Ibrahim and Georgios Chamilos

Spatial fibroblast niches define Crohn’s fistulae pp. 703-712

Colleen McGregor, Xiao Qin, Marta Jagielowicz, Tarun Gupta, Zinan Yin, Verena Lentsch, David Fawkner-Corbett, Vy Wien Lai, Paula Gomez Castro, Esther Bridges, Chloe Hyun-Jung Lee, Huei-Wen Chuang, Lei Deng, Anna Aulicino, Renuka Teague, Sorayya Moradi, Jun Sung Park, Jeongmin Woo, Kexin Xu, Ruchi Tandon, Nicole Cianci, Jan Bornschein, Ling-Pei Ho, Paulina Siejka-Zielinska, Zoe Christoforidou, Sarah Hill, Johannes Lehmann, Rhea Kujawa, Paola Vargas Gutierrez, Carol Cheng, Maria Greco, Katherine Baker, Mark Bignell, Bruce George, Eve Fryer, Michael Vieth, Agne Antanaviciute and Alison Simmons

Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency pp. 713-720

Joshua D. Meisel, Pallavi R. Joshi, Amy N. Spelbring, Hong Wang, Sandra M. Wellner, Presli P. Wiesenthal, Maria Miranda, Jason G. McCoy, David P. Barondeau, Gary Ruvkun and Vamsi K. Mootha

Cross-regulation of [2Fe–2S] cluster synthesis by ferredoxin-2 and frataxin pp. 721-728

Kristian Want, Hubert Gorny, Ema Turki, Magali Noiray, Beata Monfort, Rémi Mor-Gautier, Thibault Tubiana, Estelle Jullian, Véronique Monnier and Benoit D’Autréaux

Decay of driver mutations shapes the landscape of intestinal transformation pp. 729-738

Filipe C. Lourenço, Iannish D. Sadien, Kim Wong, Sam Adler, Ashley Sawle, Leonor Schubert Santana, Lee Hazelwood, Giada Giavara, Anna M. Nicholson, Matthew D. Eldridge, Noori Maka, Gerard Lynch, Stephen T. McSorley, Joanne Edwards, Richard Kemp, David J. Adams and Douglas J. Winton

Hepatic zonation determines tumorigenic potential of mutant β-catenin pp. 739-748

Alexander Raven, Kathryn Gilroy, Hu Jin, Joseph A. Waldron, Holly Leslie, June Munro, Holly Hall, Rachel A. Ridgway, Catriona A. Ford, Doga C. Gulhan, Nikola Vlahov, Megan L. Mills, Andrew Hartley, Eve Anderson, Sheila Bryson, Nathalie Sphyris, Miryam Müller, Stephanie May, Barbara Cadden, Colin Nixon, Scott H. Waddell, Rachel Guest, Luke Boulter, Nick Barker, Hans Clevers, Hao Zhu, Johanna Ivaska, Douglas Strathdee, Crispin J. Miller, Nigel B. Jamieson, Martin Bushell, Peter J. Park, Thomas G. Bird and Owen J. Sansom

Semantic design of functional de novo genes from a genomic language model pp. 749-758

Aditi T. Merchant, Samuel H. King, Eric Nguyen and Brian L. Hie

An integrated view of the structure and function of the human 4D nucleome pp. 759-776

Job Dekker, Betul Akgol Oksuz, Yang Zhang, Ye Wang, Miriam K. Minsk, Shuzhen Kuang, Liyan Yang, Johan H. Gibcus, Nils Krietenstein, Oliver J. Rando, Jie Xu, Derek H. Janssens, Steven Henikoff, Alexander Kukalev, Willemin Andréa, Warren Winick-Ng, Rieke Kempfer, Ana Pombo, Miao Yu, Pradeep Kumar, Liguo Zhang, Andrew S. Belmont, Takayo Sasaki, Tom van Schaik, Laura Brueckner, Daan Peric-Hupkes, Bas van Steensel, Ping Wang, Haoxi Chai, Minji Kim, Yijun Ruan, Ran Zhang, Sofia A. Quinodoz, Prashant Bhat, Mitchell Guttman, Wenxin Zhao, Shu Chien, Yuan Liu, Sergey V. Venev, Dariusz Plewczynski, Ibai Irastorza Azcarate, Dominik Szabó, Christoph J. Thieme, Teresa Szczepińska, Mateusz Chiliński, Kaustav Sengupta, Mattia Conte, Andrea Esposito, Alex Abraham, Ruochi Zhang, Yuchuan Wang, Xingzhao Wen, Qiuyang Wu, Yang Yang, Jie Liu, Lorenzo Boninsegna, Asli Yildirim, Yuxiang Zhan, Andrea Maria Chiariello, Simona Bianco, Lindsay Lee, Ming Hu, Yun Li, R. Jordan Barnett, Ashley L. Cook, Daniel J. Emerson, Claire Marchal, Peiyao Zhao, Peter J. Park, Burak H. Alver, Andrew J. Schroeder, Rahi Navelkar, Clara Bakker, William Ronchetti, Shannon Ehmsen, Alexander D. Veit, Nils Gehlenborg, Ting Wang, Daofeng Li, Xiaotao Wang, Mario Nicodemi, Bing Ren, Sheng Zhong, Jennifer E. Phillips-Cremins, David M. Gilbert, Katherine S. Pollard, Frank Alber, Jian Ma, William S. Noble and Feng Yue

Structural basis of regulated N-glycosylation at the secretory translocon pp. 777-784

Melvin Yamsek, Mengxiao Ma, Roshan Jha, Yu Wan, Qianru Li, Frank Zhong, Katherine DeLong, Zhe Ji, Rajat Rohatgi and Robert J. Keenan

Fresh starts: how to thrive when you leave academia pp. 785-787

Josie Glausiusz

Six steps to protect researchers’ digital security pp. 788-790

Virginia Gewin

Developing super-tortillas to address malnutrition in Latin America pp. 792-792

Rachael Pells

2026, volume 649, articles 8096

Author Correction: Unravelling cysteine-deficiency-associated rapid weight loss pp. E1-E1

Alan Varghese, Ivan Gusarov, Begoña Gamallo-Lana, Daria Dolgonos, Yatin Mankan, Ilya Shamovsky, Mydia Phan, Rebecca Jones, Maria Gomez-Jenkins, Eileen White, Rui Wang, Drew R. Jones, Thales Papagiannakopoulos, Michael E. Pacold, Adam C. Mar, Dan R. Littman and Evgeny Nudler

Author Correction: Distinct fibroblast subsets drive inflammation and damage in arthritis pp. E2-E2

Adam P. Croft, Joana Campos, Kathrin Jansen, Jason D. Turner, Jennifer Marshall, Moustafa Attar, Loriane Savary, Corinna Wehmeyer, Amy J. Naylor, Samuel Kemble, Jenefa Begum, Kerstin Dürholz, Harris Perlman, Francesca Barone, Helen M. McGettrick, Douglas T. Fearon, Kevin Wei, Soumya Raychaudhuri, Ilya Korsunsky, Michael B. Brenner, Mark Coles, Stephen N. Sansom, Andrew Filer and Christopher D. Buckley

Author Correction: Cancer SLC43A2 alters T cell methionine metabolism and histone methylation pp. E3-E3

Yingjie Bian, Wei Li, Daniel M. Kremer, Peter Sajjakulnukit, Shasha Li, Joel Crespo, Zeribe C. Nwosu, Li Zhang, Arkadiusz Czerwonka, Anna Pawłowska, Houjun Xia, Jing Li, Peng Liao, Jiali Yu, Linda Vatan, Wojciech Szeliga, Shuang Wei, Sara Grove, J. Rebecca Liu, Karen McLean, Marcin Cieslik, Arul M. Chinnaiyan, Witold Zgodziński, Grzegorz Wallner, Iwona Wertel, Karolina Okła, Ilona Kryczek, Costas A. Lyssiotis and Weiping Zou

Author Correction: Conservation and alteration of mammalian striatal interneurons pp. E4-E4

Emily K. Corrigan, Michael DeBerardine, Aunoy Poddar, Miguel Turrero García, Sean de la O, Siting He, Harsha Sen, Mariana Duhne, Shanti Lindberg, Mengyi Song, Matthew T. Schmitz, Karen E. Sears, Ricardo Mallarino, Joshua D. Berke, Corey C. Harwell, Mercedes F. Paredes, Fenna M. Krienen and Alex A. Pollen

AI and quantum science take centre stage under Trump — but with little new proposed funding pp. 271-272

Jenna Ahart

AI is saving time and money in research — but at what cost? pp. 272-273

Rachel Fieldhouse

More than half of researchers now use AI for peer review — often against guidance pp. 273-274

Miryam Naddaf

Scientists skip key US meetings — and seize on smaller alternatives pp. 274-275

Alexandra Witze

NSF softens grant-review rules to cope with backlog pp. 275-276

Dan Garisto

Restoring youth to old immune cells: mRNA therapy turns back the clock pp. 276-276

Heidi Ledford

‘I rarely get outside’: scientists ditch fieldwork in the age of AI pp. 278-281

Aisling Irwin

Why cancer can come back years later — and how to stop it pp. 282-284

Amanda Heidt

These women helped to shape quantum mechanics — it’s time to recognize them pp. 286-288

Indianara Lima Silva

Living water and whispering rocks: Books in brief pp. 288-288

Andrew Robinson

Help small-scale gold miners to transition away from mercury use pp. 289-289

Shabbir Ahmad and Saleem H. Ali

To improve resilience to climate change, track what endures pp. 289-289

Stacy-ann Robinson

Rethink how we build AI to enable effective climate-change mitigation pp. 289-289

Carlos Rodriguez-Pardo and Massimo Tavoni

Retire ‘seminal’ from the scientific vocabulary pp. 289-289

Nicole D. Sintov and Christine Sprunger

Land-use changes threaten the safety net for birds pp. 291-292

Carlos P. Carmona

Ultra-low-density exoplanets observed around a young star pp. 292-293

Valerio Nascimbeni

SOS: RNA-processing mechanism rescues genes from invasive DNA pp. 294-295

René F. Ketting

Shared genetic risk in psychiatric disorders pp. 295-296

Abdel Abdellaoui

Artificial skin mimics the octopus’s art of disguise pp. 297-298

Benjamin Renz and Na Liu

Shape-shifting electrodes tune optical-frequency converter pp. 298-300

Kartik Srinivasan

A framework for addressing racial and related inequities in conservation pp. 301-309

Moreangels M. Mbizah, Tanesha Allen, Shorna Allred, Julius G. Bright Ross, Andrea Dávalos, Amy Dickman, Michael Dunaway, Ritwick Ghosh, Maxwell Gomera, Niall L. Hammond, Darragh Hare, Thembela Kepe, Merlyn Nomusa Nkomo, Meera Anna Oommen, Kumar Paudel, Anouska Perram, Dilys Roe, Lauren F. Rudd, Kartik Shanker, Tarsh Thekaekara and Duan Biggs

A young progenitor for the most common planetary systems in the Galaxy pp. 310-314

John H. Livingston, Erik A. Petigura, Trevor J. David, Kento Masuda, James Owen, David Nesvorný, Konstantin Batygin, Jerome de Leon, Mayuko Mori, Kai Ikuta, Akihiko Fukui, Noriharu Watanabe, Jaume Orell Miquel, Felipe Murgas, Hannu Parviainen, Judith Korth, Florence Libotte, Néstor Abreu García, Pedro Pablo Meni Gallardo, Norio Narita, Enric Pallé, Motohide Tamura, Atsunori Yonehara, Andrew Ridden-Harper, Allyson Bieryla, Alessandro A. Trani, Eric E. Mamajek, David R. Ciardi, Varoujan Gorjian, Lynne A. Hillenbrand, Luisa M. Rebull, Elisabeth R. Newton, Andrew W. Mann, Andrew Vanderburg, Guðmundur Stefánsson, Suvrath Mahadevan, Caleb Cañas, Joe Ninan, Jesus Higuera, Kamen Todorov, Jean-Michel Désert and Lorenzo Pino

Surface optimization governs the local design of physical networks pp. 315-322

Xiangyi Meng, Benjamin Piazza, Csaba Both, Baruch Barzel and Albert-László Barabási

Aharonov–Bohm interference in even-denominator fractional quantum Hall states pp. 323-329

Jehyun Kim, Himanshu Dev, Amit Shaer, Ravi Kumar, Alexey Ilin, André Haug, Shelly Iskoz, Kenji Watanabe, Takashi Taniguchi, David F. Mross, Ady Stern and Yuval Ronen

Programmable on-chip nonlinear photonics pp. 330-337

Ryotatsu Yanagimoto, Benjamin A. Ash, Mandar M. Sohoni, Martin M. Stein, Yiqi Zhao, Federico Presutti, Marc Jankowski, Logan G. Wright, Tatsuhiro Onodera and Peter L. McMahon

Towards fibre-like loss for photonic integration from violet to near-infrared pp. 338-344

Hao-Jing Chen, Kellan Colburn, Peng Liu, Hongrui Yan, Hanfei Hou, Jinhao Ge, Jin-Yu Liu, Phineas Lehan, Qing-Xin Ji, Zhiquan Yuan, Dirk Bouwmeester, Christopher Holmes, James Gates, Henry Blauvelt and Kerry Vahala

Soft photonic skins with dynamic texture and colour control pp. 345-352

Siddharth Doshi, Nicholas A. Güsken, Gerwin Dijk, Johan Carlström, Jennifer E. Ortiz-Cárdenas, Peter Suzuki, Bohan Li, Polly M. Fordyce, Alberto Salleo, Nicholas A. Melosh and Mark L. Brongersma

High-voltage anode-free sodium–sulfur batteries pp. 353-359

Shitao Geng, Bin Yuan, Xiaoju Zhao, Qiuchen Xu, Yan Wang, Zhaofeng Ouyang, Shanshan Tang, Shuo Wang, Chengxiao Zhang, Qianyun Chen, Meng Liao, Bingjie Wang, Chen Zhao, Weihua Jin, Zichuang Li, Tian-Nan Ye, Xueqing Gong, Huisheng Peng and Hao Sun

Pulse heating and slip enhance charging of phase-change thermal batteries pp. 360-365

Zi-Rui Li, Nan Hu, Zhen-Bo Wang, Guo-Tao Fu, Yang-Yan Lai, Yue-Fei Wu, Jia-Jie Jiang, Xiao-Rong Wang, Shuang-Shuang Ni, Yu-Min Ye, Zi-Tao Yu, Xiang Gao, Howard A. Stone and Li-Wu Fan

Soft biodegradable implants for long-distance and wide-angle sensing pp. 366-374

Yuqun Lan, Shuang Li, Haitao Guo, Qinyuan Liu, Tairan Wang, Lianqiao Zhou, Jiahuiyu Fang, Yang Zhao, Zanxin Zhou, Qi Wang, Jing Li, Yiping Zhu, Rongfang Su, Xinyi Wen, Xinkai Xu, Yuhong Wu, Zixuan Wang, Bo Liu, Jiaqi Li, Hui Li, Hanfei Gao, Yuchen Wu, Qi Gu, Xi-Qiao Feng, Xinge Yu and Yewang Su

Small persistent humid forest clearings drive tropical forest biomass losses pp. 375-380

Yidi Xu, Philippe Ciais, Maurizio Santoro, Clément Bourgoin, François Ritter, Agnès Pellissier-Tanon, Yu Feng, Chuanlong Zhou, Guojin He, Viola Heinrich, Simon Besnard, Nathaniel Robinson, Susan C. Cook-Patton, Jérôme Chave, Luiz E. O. C. Aragao, Jean P. Ometto, Simon P. K. Bowring, Ibrahim Fayad, Lei Zhu, Yang Su, Jean-Pierre Wigneron and Wei Li

Land-use change undermines the stability of avian functional diversity pp. 381-387

Thomas L. Weeks, Patrick A. Walkden, David P. Edwards, Alexander C. Lees, Alexander L. Pigot, Andy Purvis and Joseph A. Tobias

Rare microbial relict sheds light on an ancient eukaryotic supergroup pp. 388-395

Marek Valt, Tomáš Pánek, Seda Mirzoyan, Alexander K. Tice, Robert E. Jones, Vít Dohnálek, Pavel Doležal, Jiří Mikšátko, Johana Rotterová, Pavla Hrubá, Matthew W. Brown and Ivan Čepička

Plug-in strategy for resistance engineering inspired by potato NLRome pp. 396-405

Luyao Wang, Hongbo Li, Yuhang Ke, Ping Zhu, Yuying Li, Pei Wang, Haohao Liu, Yajie Li, Jingqi Chen, Shaoqun Zhou, Li Wan, Savithramma P. Dinesh-Kumar, Suomeng Dong and Sanwen Huang

Mapping the genetic landscape across 14 psychiatric disorders pp. 406-415

Andrew D. Grotzinger, Josefin Werme, Wouter J. Peyrot, Oleksandr Frei, Christiaan de Leeuw, Lucy K. Bicks, Qiuyu Guo, Michael P. Margolis, Brandon J. Coombes, Anthony Batzler, Vanessa Pazdernik, Joanna M. Biernacka, Ole A. Andreassen, Verneri Anttila, Anders D. Børglum, Gerome Breen, Na Cai, Ditte Demontis, Howard J. Edenberg, Stephen V. Faraone, Barbara Franke, Michael J. Gandal, Joel Gelernter, Alexander S. Hatoum, John M. Hettema, Emma C. Johnson, Katherine G. Jonas, James A. Knowles, Karestan C. Koenen, Adam X. Maihofer, Travis T. Mallard, Manuel Mattheisen, Karen S. Mitchell, Benjamin M. Neale, Caroline M. Nievergelt, John I. Nurnberger, Kevin S. O’Connell, Roseann E. Peterson, Elise B. Robinson, Sandra S. Sanchez-Roige, Susan L. Santangelo, Jeremiah M. Scharf, Hreinn Stefansson, Kari Stefansson, Murray B. Stein, Nora I. Strom, Laura M. Thornton, Elliot M. Tucker-Drob, Brad Verhulst, Irwin D. Waldman, G. Bragi Walters, Naomi R. Wray, Dongmei Yu, Phil H. Lee, Kenneth S. Kendler and Jordan W. Smoller

Connectivity underlying motor cortex activity during goal-directed behaviour pp. 416-422

Arseny Finkelstein, Kayvon Daie, Márton Rózsa, Ran Darshan and Karel Svoboda

Adenosine signalling drives antidepressant actions of ketamine and ECT pp. 423-431

Chenyu Yue, Na Wang, Haojiang Zhai, Zhengwei Yuan, Yuting Cui, Jing Quan, Yu Zhou, Xiaofeng Fan, Hongshuang Wang, Zhaofa Wu, Huijie Mi, Wooping Ge, Yulong Li, Xiaohui Wang and Minmin Luo

Ecology and spread of the North American H5N1 epizootic pp. 432-441

Lambodhar Damodaran, Anna S. Jaeger and Louise H. Moncla

Gene-drive-capable mosquitoes suppress patient-derived malaria in Tanzania pp. 442-448

Tibebu Habtewold, Dickson Wilson Lwetoijera, Astrid Hoermann, Rajabu Mashauri, Fatuma Matwewe, Rehema Mwanga, Prisca Kweyamba, Gilbert Maganga, Beatrice Philip Magani, Rachel Mtama, Moze Ally Mahonje, Mgeni Mohamed Tambwe, Felista Tarimo, Pratima R. Chennuri, Julia A. Cai, Giuseppe Del Corsano, Paolo Capriotti, Peter Sasse, Jason Moore, Douglas Hudson, Alphaxard Manjurano, Brian Tarimo, Dina Vlachou, Sarah Moore, Nikolai Windbichler and George K. Christophides

Parity and lactation induce T-cell-mediated breast cancer protection pp. 449-459

Balaji Virassamy, Franco Caramia, Peter Savas, Michael A. Harris, Jia-Wern Pan, Jianan Wang, Emmaline Brown, Megan M. R. O’Malley, Courtney T. van Geelen, Michael Hun, Thomas N. Burn, Sneha Sant, Jamieson D. Ballan, Jasmine Kay, Luis E. Lara Gonzalez, Kylie Clarke, Han Xian Aw Yeang, Rejhan Idrizi, Metta Jana, Damon J. Challice, Roberto Salgado, Heather Thorne, Cathie Poliness, Sophie Nightingale, Soo-Hwang Teo, Terence P. Speed, Jane Visvader, Paul J. Neeson, Phillip K. Darcy, Laura K. Mackay and Sherene Loi

SIGLEC12 mediates plasma membrane rupture during necroptotic cell death pp. 460-466

Hyunjin Noh, Zeena Hashem, Elena Boms and Ayaz Najafov

Tumour-reactive heterotypic CD8 T cell clusters from clinical samples pp. 467-476

Sofía Ibáñez-Molero, Johanna Veldman, Juan Simon Nieto, Joleen J. H. Traets, Austin George, Kelly Hoefakker, Anita Karomi, Rolf Harkes, Bram van den Broek, Su Min Pack, Liselotte Tas, Nils L. Visser, Susan E. van Hal-van Veen, Paula Alóndiga-Mérida, Maartje Alkemade, Iris M. Seignette, Renaud Tissier, Marja Nieuwland, Martijn van Baalen, Joanna Poźniak, Erik Mul, Simon Tol, Sofia Stenqvist, Lisa M. Nilsson, Jonas A. Nilsson, John B. A. G. Haanen, Winan J. van Houdt and Daniel S. Peeper

Lymph node environment drives FSP1 targetability in metastasizing melanoma pp. 477-486

Mario Palma, Milena Chaufan, Cort B. Breuer, Sebastian Müller, Marie Sabatier, Cameron S. Fraser, Krystina J. Szylo, Mahsa Yavari, Alanis Carmona, Mayher Kaur, Luiza Martins Nascentes Melo, Feyza Cansiz, June Monge-Lorenzo, Midori Flores, Eikan Mishima, Toshitaka Nakamura, Bettina Proneth, Marcos Labrado, Yanshan Liang, Nicole Cayting, Lan Zheng, Tatiana Cañeque, Ludovic Colombeau, Adam Wahida, José Pedro Friedmann Angeli, Alpaslan Tasdogan, Sheng Hui, Raphaël Rodriguez, Marcus Conrad, Nathan E. Reticker-Flynn and Jessalyn M. Ubellacker

Targeting FSP1 triggers ferroptosis in lung cancer pp. 487-495

Katherine Wu, Alec J. Vaughan, Jozef P. Bossowski, Yuan Hao, Aikaterini Ziogou, Seon Min Kim, Tae Ha Kim, Mari N. Nakamura, Ray Pillai, Mariana Mancini, Sahith Rajalingam, Mingqi Han, Toshitaka Nakamura, Lidong Wang, Suckwoo Chung, Diane Simeone, David Shackelford, Yun Pyo Kang, Marcus Conrad and Thales Papagiannakopoulos

An RNA splicing system that excises DNA transposons from animal mRNAs pp. 496-504

Long-Wen Zhao, Christopher Nardone, Cindy Chang, Joao A. Paulo, Stephen J. Elledge and Scott Kennedy

iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion pp. 505-514

Fengxiang Wang, Cuiji Sun, Tianshu William Wu, Yuting Fu, Yujing Fan, Shuchang Zhao, Kaiyin Huang, Zijian Pan, Yang Lu, Jingrong Regina Han, Shikai Jia, Lizhou Zeng, Sheng Zhang, Ting Chen, Shaowei An, Shuang Susie Meng, Xun Guo, Weizhe Li, Heyuan Lian, Xiaoting Sun, Jin Hu, Chuanzhen Yang, Shan Feng, Pengfei Li, Liyuan Du, Xiaodong Liu, Kiryl D. Piatkevich and Yilong Zou

Pandemic PhDs: graduates anxious, but optimistic, about the future pp. 515-517

Amanda Heidt

I see Mozambique’s baboons as windows into hominid evolution pp. 520-520

Patricia Maia Noronha

2026, volume 649, articles 8095

Author Correction: Activity of caspase-8 determines plasticity between cell death pathways pp. E1-E1

Kim Newton, Katherine E. Wickliffe, Allie Maltzman, Debra L. Dugger, Rohit Reja, Yue Zhang, Merone Roose-Girma, Zora Modrusan, Meredith S. Sagolla, Joshua D. Webster and Vishva M. Dixit

Publisher Correction: CRISPR activation for SCN2A-related neurodevelopmental disorders pp. E2-E2

Serena Tamura, Andrew D. Nelson, Perry W. E. Spratt, Elizabeth C. Hamada, Xujia Zhou, Henry Kyoung, Zizheng Li, Coline Arnould, Vladyslav Barskyi, Beniamin Krupkin, Kiana Young, Jingjing Zhao, Stephanie S. Holden, Atehsa Sahagun, Caroline M. Keeshen, Congyi Lu, Roy Ben-Shalom, Sunrae E. Taloma, Selin Schamiloglu, Ying C. Li, Lia Min, Paul M. Jenkins, Jen Q. Pan, Jeanne T. Paz, Stephan J. Sanders, Navneet Matharu, Nadav Ahituv and Kevin J. Bender

Put pressure on publishers to follow best practice — external regulation is the answer pp. 8-8

Jennifer A. Byrne

US–Africa bilateral health deals won’t help against diseases that ignore borders pp. 9-9

Paul Adepoju

Science in 2026: the events to watch for in the coming year pp. 11-13

Miryam Naddaf

China leads research in 90% of crucial technologies — a dramatic shift this century pp. 13-14

Xiaoying You

How common is Alzheimer’s? Blood-test study holds surprises pp. 14-14

Asher Mullard

Quantum computing ‘KPIs’ could distinguish true breakthroughs from spurious claims pp. 15-16

Elizabeth Gibney

Giant 3D map shows almost every building in the world pp. 16-16

Mohana Basu

Science in 2050: the future breakthroughs that will shape our world — and beyond pp. 18-20

David Adam

Some of your cells are not genetically yours — what can they tell us about life and death? pp. 21-22

Sing Sing Way

Mummies give up their secrets — but not their mystery pp. 23-25

Laura Spinney

These are a few of my favourite sounds: Books in brief pp. 25-25

Andrew Robinson

Why academics should do more consulting — and how to make it work pp. 27-29

Louise J. Slater, Weston B. Struwe, Christopher R. Vogel, Emma Walker and Regent Lee

How to reduce the environmental impact of wearable health-care devices pp. 31-32

Callie Babbitt

Revised estimates of CO2 sources and sinks improve global carbon accounting pp. 32-33

Galen A. McKinley

Primate embryo model leaps across developmental boundaries pp. 34-35

Xiangyu Kong and Thorold W. Theunissen

What changing energy flows reveal about Africa’s ecosystems pp. 35-37

Wendy Foden

Circular DNA has a ticket to ride chromosomes pp. 37-38

Noah A. Dusseau and Eunhee Yi

A fault-tolerant neutral-atom architecture for universal quantum computation pp. 39-46

Dolev Bluvstein, Alexandra A. Geim, Sophie H. Li, Simon J. Evered, J. Pablo Bonilla Ataides, Gefen Baranes, Andi Gu, Tom Manovitz, Muqing Xu, Marcin Kalinowski, Shayan Majidy, Christian Kokail, Nishad Maskara, Elias C. Trapp, Luke M. Stewart, Simon Hollerith, Hengyun Zhou, Michael J. Gullans, Susanne F. Yelin, Markus Greiner, Vladan Vuletić, Madelyn Cain and Mikhail D. Lukin

A chiral fermionic valve driven by quantum geometry pp. 47-52

Anvesh Dixit, Pranava K. Sivakumar, Kaustuv Manna, Claudia Felser and Stuart S. P. Parkin

High-performance tandem perovskite LEDs through interlayer photon recycling pp. 53-58

You Ke, Wei Zhu, Chao Ma, Kuankuan Xiong, Wang Liu, Zhiyuan Kuang, Jianhong Wu, Dongmin Qian, Mengmeng Li, Saixue Wang, Jinpei Wang, Xiangru Tao, Shuang Xu, Lin Zhu, Qiming Peng, Nana Wang, Wei Huang and Jianpu Wang

Flexible perovskite/silicon tandem solar cells with 33.6% efficiency pp. 59-64

Shibo Wang, Wenhao Li, Cao Yu, Wei Shi, Qian Kang, Fengxian Cao, Kun Gao, Liu Yang, Bowen Yang, Jian Zhou, Shaofei Yang, Qi Wang, Qin Fei, Xi Chen, Gaoyuan Chen, Pengxu Chen, Zijia Li, Wei-Chih Hsu, Zhongliang Yan, Yang Bai, Wenzhu Liu, Stefaan De Wolf, Xinbo Yang and Xiaohong Zhang

Flexible perovskite/silicon tandem solar cell with a dual-buffer layer pp. 65-72

Zheng Fang, Lei Ding, Ying Yang, Xiaobing Gu, Haiyue Li, Hao Chen, Yue Yin, Wei Wang, Xiaoyong Wu, Zhijie Rao, Linyu Ning, Dongsheng Yang, Huimin Zhang, Yongdeng Long, Wei Li, Fu Zhang, Simeng Xia, Lingbo Jia, Chi Liu, Bochao Li, Bo Liu, Shijie Ju, Wei Du, Hua Zhang, Yuan Qin, Xiaoning Ru, Yongyuan Xu, Yue Lu, Yongcai He, Zhenguo Li, Xixiang Xu, Minghao Qu, Bo He, Jiang Liu and Xiaohong Zhang

Quantifying the global eco-footprint of wearable healthcare electronics pp. 73-82

Chuanwang Yang, Bingzheng Wang, Ji Wan, Ananth Kamath, Fengqi You and Bozhi Tian

Random heteropolymers as enzyme mimics pp. 83-90

Hao Yu, Marco Eres, Shayna L. Hilburg, Philjun Kang, Tianyi Jin, Alexandra Grigoropoulos, Zhixia Li, Daniel M. Loh, Ivan Jayapurna, Zhiyuan Ruan, Wen Fu, Feipeng Yang, Priya Ganesh, Kali Toste, Shuni Li, Jinghua Guo, Haiyan Huang, F. Dean Toste, R. David Britt, Y Z, Alfredo Alexander-Katz and Ting Xu

Myriad aryne derivatives from carboxylic acids pp. 91-97

Chris M. Seong, Sallu S. Kargbo, Chia-Ling Yu, Daniel Gibney, Jan-Niklas Boyn and Courtney C. Roberts

Emerging climate impact on carbon sinks in a consolidated carbon budget pp. 98-103

Pierre Friedlingstein, Corinne Le Quéré, Michael O’Sullivan, Judith Hauck, Peter Landschützer, Ingrid T. Luijkx, Hongmei Li, Auke van der Woude, Clemens Schwingshackl, Julia Pongratz, Pierre Regnier, Robbie M. Andrew, Dorothee C. E. Bakker, Josep G. Canadell, Philippe Ciais, Thomas Gasser, Matthew W. Jones, Xin Lan, Eric Morgan, Are Olsen, Glen P. Peters, Wouter Peters, Stephen Sitch and Hanqin Tian

Energy flows reveal declining ecosystem functions by animals across Africa pp. 104-112

Ty Loft, Imma Oliveras Menor, Nicola Stevens, Robert Beyer, Hayley S. Clements, Luca Santini, Seth Thomas, Joseph A. Tobias and Yadvinder Malhi

A place-based assessment of biodiversity intactness in sub-Saharan Africa pp. 113-121

Hayley S. Clements, Reinette Biggs, Alta De Vos, Emmanuel Do Linh San, Gareth P. Hempson, Birthe Linden, Bryan Maritz, Ara Monadjem, Chevonne Reynolds, Frances Siebert, Nicola Stevens, Matthew Child, Enrico Di Minin, Karen J. Esler, Maike Hamann, Ty Loft, Belinda Reyers, Odirilwe Selomane, Geethen Singh and Andrew L. Skowno

Neuroendocrine control of calcium mobilization in the fruit fly pp. 122-130

Naoki Okamoto, Yosuke Mizuno, Akira Watanabe, Hiroshi Kohsaka and Ryusuke Niwa

A pangenome and pantranscriptome of hexaploid oat pp. 131-139

Raz Avni, Nadia Kamal, Lidija Bitz, Eric N. Jellen, Wubishet A. Bekele, Tefera T. Angessa, Petri Auvinen, Oliver Bitz, Brian Boyle, Francisco J. Canales, Craig H. Carlson, Brett Chapman, Harmeet Singh Chawla, Yutang Chen, Dario Copetti, Samara Correia de Lemos, Viet Dang, Steven R. Eichten, Kathy Esvelt Klos, Amit M. Fenn, Anne Fiebig, Yong-Bi Fu, Heidrun Gundlach, Rajeev Gupta, Georg Haberer, Tianhua He, Matthias H. Herrmann, Axel Himmelbach, Catherine J. Howarth, Haifei Hu, Julio Isidro y Sánchez, Asuka Itaya, Jean-Luc Jannink, Yong Jia, Rajvinder Kaur, Manuela Knauft, Tim Langdon, Thomas Lux, Sofia Marmon, Vanda Marosi, Klaus F. X. Mayer, Steve Michel, Raja Sekhar Nandety, Kirby T. Nilsen, Edyta Paczos-Grzęda, Asher Pasha, Elena Prats, Nicholas J. Provart, Adriana Ravagnani, Robert W. Reid, Jessica A. Schlueter, Alan H. Schulman, Taner Z. Sen, Jaswinder Singh, Mehtab Singh, Nick Sirijovski, Nils Stein, Bruno Studer, Sirja Viitala, Shauna Vronces, Sean Walkowiak, Penghao Wang, Amanda J. Waters, Charlene P. Wight, Weikai Yan, Eric Yao, Xiao-Qi Zhang, Gaofeng Zhou, Zhou Zhou, Nicholas A. Tinker, Jason D. Fiedler, Chengdao Li, Peter J. Maughan, Manuel Spannagl and Martin Mascher

Shared and language-specific phonological processing in the human temporal lobe pp. 140-151

Ilina Bhaya-Grossman, Matthew K. Leonard, Yizhen Zhang, Laura Gwilliams, Keith Johnson, Junfeng Lu and Edward F. Chang

Genetic elements promote retention of extrachromosomal DNA in cancer cells pp. 152-160

Venkat Sankar, King L. Hung, Aditi Gnanasekar, Ivy Tsz-Lo Wong, Quanming Shi, Katerina Kraft, Matthew G. Jones, Britney Jiayu He, Xiaowei Yan, Julia A. Belk, Kevin J. Liu, Sangya Agarwal, Sean K. Wang, Anton G. Henssen, Paul S. Mischel and Howard Y. Chang

Modelling late gastrulation in stem cell-derived monkey embryo models pp. 161-172

Jie Li, Jie Li, Jing Cao, ShenShen Shang, Liansheng Zhang, Fei Gao, Jiqiang Fu, Hongyu Chen, Guizhong Cui, Haoyuan Wu, Xiaolong Wang, Alfonso Martinez-Arias, Qiang Sun and Zhen Liu

Multiple LDLR family members act as entry receptors for yellow fever virus pp. 173-182

Zhenlu Chong, Sean Hui, Xueer Qiu, Sathvik Palakurty, Alan Sariol, Tomasz Kaszuba, Michael N. Nguyen, Pengfei Li, Saravanan Raju, Paige D. Hall, Christopher A. Nelson, Israel Baltazar-Perez, David A. Price, Paul W. Rothlauf, James E. Crowe, Sean P. J. Whelan, Daisy W. Leung, Gaya K. Amarasinghe, Adam L. Bailey, Daved H. Fremont and Michael S. Diamond

Atomically accurate de novo design of antibodies with RFdiffusion pp. 183-193

Nathaniel R. Bennett, Joseph L. Watson, Robert J. Ragotte, Andrew J. Borst, DéJenaé L. See, Connor Weidle, Riti Biswas, Yutong Yu, Ellen L. Shrock, Russell Ault, Philip J. Y. Leung, Buwei Huang, Inna Goreshnik, John Tam, Kenneth D. Carr, Benedikt Singer, Cameron Criswell, Basile I. M. Wicky, Dionne Vafeados, Mariana Garcia Sanchez, Ho Min Kim, Susana Vázquez Torres, Sidney Chan, Shirley M. Sun, Timothy T. Spear, Yi Sun, Keelan O’Reilly, John M. Maris, Nikolaos G. Sgourakis, Roman A. Melnyk, Chang C. Liu and David Baker

Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells pp. 194-204

Jyh Liang Hor, Edward C. Schrom, Abigail Wong-Rolle, Luke Vistain, Wanjing Shang, Qiang Dong, Chen Zhao, Chengcheng Jin and Ronald N. Germain

NSD2 inhibitors rewire chromatin to treat lung and pancreatic cancers pp. 205-215

Jinho Jeong, Simone Hausmann, Hanyang Dong, Kacper Szczepski, Natasha M. Flores, Andy Garcia Gonzalez, Liyang Shi, Xiaoyin Lu, Joanna Lempiäinen, Moritz Jakab, Liyong Zeng, Tourkian Chasan, Eric Bareke, Rui Dong, Emma Carlson, Reinnier Padilla, Dylan Husmann, Julia Thompson, Gerry A. Shipman, Emily Zahn, Courtney A. Barnes, Laiba F. Khan, Liz Marie Albertorio-Sáez, Eva Brill, Vishnu Udayakumar Sunita Kumary, Matthew R. Marunde, Danielle N. Maryanski, Cheryl C. Szany, Bryan J. Venters, Carolina Lin Windham, Michal Eligiusz Nowakowski, Iwona Czaban, Mariusz Jaremko, Michael-Christopher Keogh, Kang Le, Michael J. Soth, Benjamin A. Garcia, Łukasz Jaremko, Jacek Majewski, Pawel K. Mazur and Or Gozani

NSD2 targeting reverses plasticity and drug resistance in prostate cancer pp. 216-226

Jia J. Li, Alessandro Vasciaveo, Dimitris Karagiannis, Zhen Sun, Kristjan H. Gretarsson, Xiao Chen, Ouathek Ouerfelli, Fabio Socciarelli, Ziv Frankenstein, Hanyang Dong, Min Zou, Wei Yuan, Guangli Yang, Gabriel M. Aizenman, Tania Pannellini, Xinjing Xu, Himisha Beltran, Yu Chen, Kevin Gardner, Brian D. Robinson, Johann de Bono, Or Gozani, Cory Abate-Shen, Mark A. Rubin, Massimo Loda, Charles L. Sawyers, Andrea Califano, Chao Lu and Michael M. Shen

Secretome translation shaped by lysosomes and lunapark-marked ER junctions pp. 227-236

Heejun Choi, Ya-Cheng Liao, Young J. Yoon, Jonathan Grimm, Nan Wang, Luke D. Lavis, Robert H. Singer and Jennifer Lippincott-Schwartz

Computational enzyme design by catalytic motif scaffolding pp. 237-245

Markus Braun, Adrian Tripp, Morakot Chakatok, Sigrid Kaltenbrunner, Celina Fischer, David Stoll, Aleksandar Bijelic, Wael Elaily, Massimo G. Totaro, Melanie Moser, Shlomo Y. Hoch, Horst Lechner, Federico Rossi, Matteo Aleotti, Mélanie Hall and Gustav Oberdorfer

Computational design of metallohydrolases pp. 246-253

Donghyo Kim, Seth M. Woodbury, Woody Ahern, Doug Tischer, Alex Kang, Emily Joyce, Asim K. Bera, Nikita Hanikel, Saman Salike, Rohith Krishna, Jason Yim, Samuel J. Pellock, Anna Lauko, Indrek Kalvet, Donald Hilvert and David Baker

Nine books to help shape your science career in 2026 pp. 255-257

Anne Gulland

Probing pollutants: how I use penguin faeces to measure contaminants in Antarctica pp. 260-260

Rachael Pells