Nature

1997 - 2026

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2026, volume 657, articles 8132

Use AI as a sparring partner, not an oracle pp. 575-575

Marc Schmitt

Ada Yonath obituary: Crystallographer who overcame ‘impossible’ challenge of mapping the ribosome pp. 595-595

Georgina Ferry

A call to celebrate your achievements — from dissertations to tenure pp. 845-846

Amanda Heidt

2026, volume 657, articles 8131

A good drug is useless if it misses its target pp. S1-S1

Richard Hodson

These six advances could change how drugs are delivered pp. S2-S3

Nic Fleming

Drug-delivering particles aim to breach the blood–brain barrier pp. S4-S7

Simon Makin

Nasal vaccines could stop pandemics before they begin pp. S8-S9

Anthony King

Addendum: Sea level much higher than assumed in most coastal hazard assessments pp. E8-E14

Katharina Seeger and Philip S. J. Minderhoud

Special delivery: bacterial couriers are smuggling drugs into cancers pp. S10-S12

Liam Drew

Medicines do no good if people don’t take them pp. S13-S13

Laura Vargas-Parada

Drug delivery gets subcellular pp. S14-S15

Katherine Bourzac

Dose once, treat forever: drugs are being engineered to last much longer pp. S16-S18

Ben Deighton

NASA’s Roman telescope holds promise far beyond mapping the invisible Universe pp. 321-321

Priyamvada Natarajan

‘Mother of Hubble’: how Nancy Grace Roman ushered in a new era of astronomy pp. 322-322

Robert W. Smith

Lift-off! NASA launches Roman Space Telescope to tackle dark-energy mysteries pp. 325-326

Davide Castelvecchi

‘Robot Olympics’ reveal humanoids’ rapid progress — and flaws pp. 327-328

Kaia Glickman

Satellite images before Nepal disaster showed warning signs pp. 328-329

Mohana Basu

Landmark pancreatic cancer drug shows potential against lung cancer too pp. 329-329

Heidi Ledford

Is this the first glimpse of dark matter? Data point excites physicists pp. 330-331

Davide Castelvecchi

Mutating every DNA letter of a genome shows surprising effects — and the limits of AI pp. 331-331

Ewen Callaway

Say hello to the next generation of lobsters — August’s best science images pp. 332-332

Dhruv Shenai

A data leak shut a top research biobank: lessons from the recovery pp. 334-336

Diana Kwon

The Einstein test: what happens when AI tries to rediscover relativity? pp. 338-340

Philip Ball

Isaac Newton’s remarkable year — and the plagiarism accusations that followed pp. 341-343

Andrew Robinson

Mysteries of the deep and AI friendship: Books in brief pp. 343-343

Andrew Robinson

Heisuke Hironaka obituary: mathematician who smoothed out geometry’s complexities pp. 344-344

Allyn Jackson

Why we need an International Panel on Inequality pp. 345-348

Joseph E. Stiglitz, Adriana E. Abdenur, Winnie Byanyima, Jayati Ghosh, Imraan Valodia and Wanga Zembe-Mkabile

How countries can grow without impoverishing future generations pp. 348-350

Eoin McLaughlin

Evolutionary mystery revealed by structures of a key enzyme in the synthesis of glycolipids pp. 351-352

Yaxin Dai and Chia-Hsueh Lee

Vaporization trick enables ‘tandem’ solar cells to be made at lower temperatures pp. 352-353

Ulrich W. Paetzold and Paul Fassl

Weight-loss drug slows ageing in female mice pp. 354-355

Maria Emilia Fernandez and Rafael de Cabo

Computational ‘gym’ trains AI models to control turbulence pp. 355-356

Clara M. Velte

The secret life of a cell-cycle gatekeeper of breast cancer pp. 357-358

Cristina Guarducci and Luca Malorni

Discovery of a star sensitive to the spin of Sagittarius A* pp. 359-363

K. Abd El Dayem, R. Abuter, N. Aimar, P. Amaro-Seoane, A. Berdeu, J.-P. Berger, G. Bourdarot, W. Brandner, A. Burkert, D. Caldéron, C. Correia, J. Cuadra, R. Davies, D. Defrère, L. Delit, A. Drescher, F. Eisenhauer, L. Esteras Otal, M. Fabricius, H. Feuchtgruber, S. Flesch, N. M. Förster Schreiber, A. Foschi, Q. Fournier, P. Garcia, R. Garcia Lopez, A. Generozov, R. Genzel, S. Gillessen, F. Gonté, X. Haubois, S. F. Hönig, M. Houllé, S. Joharle, A. Kaufer, J. Kammerer, P. Kervella, J. Kolb, L. Kreidberg, L. Labadie, S. Lacour, O. Lai, R. Laugier, J.-B. Le Bouquin, J. Leftley, R. Li, B. Lopez, D. Lutz, F. Mang, A. Mérand, F. Millour, M. Montargès, N. Morujão, H. Nowacki, M. Nowak, S. Oberti, J. Osorno, T. Ott, T. Paumard, C. Paladini, S. Pappert, H. B. Perets, K. Perraut, G. Perrin, R. Petrov, P. O. Petrucci, T. Piran, N. Pourré, S. Rabien, D. C. Ribeiro, S. Robbe-Dubois, M. Sadun Bordoni, J. Sanchez-Bermudez, D. Santos, R. Sari, J. Sauter, S. Scheithauer, J. Scigliuto, J. Shangguan, T. T. Shimizu, F. Soulez, J. Stadler, C. Straubmeier, E. Sturm, M. Subroweit, C. Sykes, L. J. Tacconi, P. Thévenet, I. Urso, F. Vincent, J. Woillez, G. Zins and Collaboration Gravity+

Infrared absorption spectroscopy of a single polyatomic molecular ion pp. 364-368

Zhenlin Wu, Tim Duka, Mariano Isaza-Monsalve, Miriam Kautzky, Vojtěch Švarc, Andrea Turci, René Nardi, Marcin Gronowski, Michał Tomza, Brandon J. Furey and Philipp Schindler

The HydroGym reinforcement learning platform for fluid dynamics pp. 369-376

Christian Lagemann, Sajeda Mokbel, Miro Gondrum, Mario Rüttgers, Yuning Wang, Pol Suárez, Ludger Paehler, Deniz A. Bezgin, Aaron B. Buhendwa, Jared L. Callaham, Samuel Ahnert, Nicholas Zolman, Xiao Shao, Jean-Christophe Loiseau, Nikolaus A. Adams, Matthias Meinke, Wolfgang Schröder, Kai Lagemann, Esther Lagemann, Ricardo Vinuesa and Steven L. Brunton

Degree-of-polarization modulation for high-dimensional optical computing pp. 377-384

Alessandro Petrini, Claudio Conti and Davide Pierangeli

Thermally evaporated perovskite/silicon tandems via formamidinium eutectic pp. 385-392

Chao Luo, Rui He, Ran Luo, Jingcong Hu, Yuduan Wang, Yu Shi, Yi Mo, Cheng Yan, Yuxin Yao, Zihao Zhu, Chenxia Kan, Xinyi Du, Ling Kai Lee, Qilin Zhou, Nengxu Li, Xiuxiu Niu, Fengtao Pei, Ming Lin, Xi Wang, Jinxi Chen, Zhenrong Jia, Tao Wang, Zijing Dong, Xiao Guo, Xin Meng, Xinyu Zhang, Yuhui Jiang, Peng Gao, Keli Wang, Yabin Ma, Zhen Guan, Jing Wei, Sai Bai, Yu Chen, Wan-Jian Yin, Qing Zhao, Zhigang Xie, Xueling Zhang, Yifeng Chen, Jifan Gao and Yi Hou

Spontaneously charged water drops induce corrosion pp. 393-399

Zhongyuan Ni, Xiaomei Li, Aaron D. Ratschow, Lin Jian, Xiaoteng Zhou, Pravash Bista, Diego Cortes, Gunnar Glasser, Haojian Luo, Shuai Chen, Jiyao Yu, Yongkang Wang, Katrin Amann-Winkel, Kaloian Koynov, Rüdiger Berger and Hans-Jürgen Butt

Entangled dual-site migration through boracycle rearrangement pp. 400-408

Zheng Zhu, Peiqi Zhang, Bin Gao, Kit San Ly, Hongyi Tao, Yiyi Fu, Zhenyang Lin and Yangjian Quan

A global atmospheric methane record from a tropical ice core pp. 409-413

Kara A. Lamantia, Lonnie G. Thompson, Mary E. Davis, Ben Riddell-Young, Ivo Strawson, Emilie Beaudon, Ellen Mosley-Thompson, Newton Nguyen and Edward J. Brook

New-deal mortgage programmes benefited white borrowers disproportionately pp. 414-419

Katherine A. Thomas, Thomas B. Storrs, Wenfei Xu and Jacob W. Faber

Over 20,000 precolonial earthworks in the Southwest Amazonia pp. 420-425

Martti Pärssinen, Risto Kalliola, Alceu Ranzi, Eetu Puttonen, Rhuan Carlos Lopes, Pirjo Kristiina Virtanen, Francisco Apurinã, Kalle Ruokolainen, Juha Hyyppä, Antero Kukko, Mariana Campos, Fabio de Novaes, Markku Oinonen, Antonia D. Barbosa, Sanna Saunaluoma and Evandro Ferreira

The planktonic microbiome of the Great Barrier Reef pp. 426-435

Steven Robbins, Marko Terzin, Katherine Dougan, Julian Zaugg, Sara C. Bell, Patrick W. Laffy, J. Pamela Engelberts, Kim-Anh Lê Cao, Renee K. Gruber, Nicole S. Webster, David G. Bourne, Philip Hugenholtz and Yun Kit Yeoh

Uncovering the mechanism of female restitution in sugarcane hybrids pp. 436-442

Sihui Zhu, Haibao Tang, Tyler Jones, Nathan Fumia, Jing Zhou, Lingmin Cai, Wen Wang, Yanhong Zhou, Haoming Mao, Liping Zuo, Yutong Zheng, Yixing Zhang, Zhaoqian Ji, Huanhuan Tao, Jianling Pan, Yating Xu, Huiru Chen, Chifumi Nagai and Ray Ming

A vector-based strategy for olfactory navigation in Drosophila pp. 443-454

Andrew F. Siliciano, Sun Minni, Chad Morton, Charles K. Dowell, Noelle B. Eghbali, Silas E. Busch, Juliana Y. Rhee, L. F. Abbott and Vanessa Ruta

Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours pp. 455-468

Sara G. Pelaz, Katsukuni Mitsui, Natalia Kolosowska, Haley Fritch, Chiranjivi Neupane, Vanessa H. Casha, Marta Alonso-Gardón, Vijaya Pandey, Lizheng Wang, Riki Kawaguchi, James A. Wohlschlegel, Jiami Guo, Steven A. McCarroll, Sabina Berretta and Baljit S. Khakh

Late-life semaglutide treatment slows ageing and extends lifespan in female mice pp. 469-476

Yufan Feng, Marine Barthez, Yifei Wang, Yibing Chen, Huixian Qiu, Chih-Ling Wang, Kartoosh Heydari, Melaine Delcroix, Lene Juel Rasmussen, Vilhelm A. Bohr and Danica Chen

Glucose-responsive probiotics for glycaemic modulation in mice and monkeys pp. 477-486

Ningzi Guan, Deqiang Kong, Xianyun Gao, Lingxue Niu, Yang Zhou, Guiling Yu, Tian Gao, Mengyao Liu, Wenbo Ma, Yiyu Jin, Jianli Yin, Shangang Zhao and Haifeng Ye

The past and future impact of climate change on childhood malaria in Africa pp. 487-494

Colin J. Carlson, Tamma Carleton, Romaric C. Odoulami, Cullen D. Molitor and Christopher H. Trisos

GPC3-specific dnTGFβRII-armoured CAR T cells for hepatocellular carcinoma pp. 495-504

Qi Zhang, Qihan Fu, Yinan Shen, Wanyue Cao, Gaowei Jin, Yize Zhang, Jiangchao Wu, Cao Chen, Hongkan Wang, Xingyuan Xu, Ke Sun, Xing Xue, Attilio Bondanza, Daisy Cao, Nina Chu, Nick Durham, Mark Cobbold, Benedetto Farsaci, Maria Letizia Giardino Torchia, Yixin Hao, Yi Hong, Jiaqi Huang, Michael Humphries, Qijie Jian, Gordon Moody, John Stone, Lingyan Sun, Eric Tu, Fei Wang, Fuzhe Wang, Ye Yang, Yihong Yao, Andy Zou, Xueli Bai and Tingbo Liang

Diet–microbiome synergy underlies obesity-associated immunotherapy efficacy pp. 505-516

Lysanne Desharnais, Anikka Swaby, Meriem Messaoudene, Samuel Doré, Miranda W. Yu, Benoit Fiset, Valérie Breton, Mayra Ponce, Yongjia Hu, Liam Wilson, Mark Sorin, Ye Wang, Ken Dewar, Michael Pollak, Arielle Elkrief, Bertrand Routy, Logan A. Walsh and Daniela F. Quail

Rb-driven transcription limits its tumour-suppressive effects in breast cancer pp. 517-524

April C. Watt, Antonio Ahn, Catherine Blyth, Julia R. Dixon-Douglas, Krutika Ambani, Rhiannon Coulson, Michael Taylor, Keefe T. Chan, Catherine Dietrich, Brendan E. Russ, Susanne Ramm, Christabella A. Mahendra, Kun-Hui Lu, Nichelle Pires, Jesus Garcia-Sannicolas, Olivia Voulgaris, Sheena Nunag, Ching-Seng Ang, Mark A. Dawson, Elgene Lim, Monica Arnedos, Sarat Chandarlapaty, Fabrice André and Shom Goel

AI-redesigned starting points and outcomes enhance protein evolution pp. 525-538

Nicholas A. Krasnow, Joy A. Xu, Emily Zhang, Gandhar K. Mahadeshwar, Y. Allen Tao, Julia McCreary, Colin F. Hemez, Logan E. Brown, Wei Jiang and David R. Liu

Subnuclear genome compartmentalization controls bivalent chromatin activity pp. 539-548

Sajad Hamid Ahanger, Evan R. Semenza, Chujing Zhang, Eugene Gil, Mitchel A. Cole, Serena Huei-An Lu, Li Wang, Arnold R. Kriegstein and Daniel A. Lim

Primate-specific regulation of the human glycosphingolipid gatekeeper UGCG pp. 549-558

Canrong Wu, Sanshan Jin, Jiuyin Xu, James Jiqi Wang, Xiaoqi Guo, Yunhai Li, Zhenyu Cao, Mengting Jiang, Qingning Yuan, Wen Hu, Changyao Li, Youwei Xu, Ming-Wei Wang, Yi Jiang and H. Eric Xu

How to make your science business succeed when you’re a female founder pp. 559-561

Rachel Brazil

Probing the proteome at cellular scale pp. 562-564

Michael Eisenstein

Nepal disaster is a wake-up call to take compound climate risks seriously pp. 566-566

Ramit Debnath

Limit bets on clinical-trial outcomes being placed on prediction markets pp. 566-566

Thomas J. Hwang and Sarah M. E. Gabriele

Put patients at the centre of medical AI governance pp. 566-566

Yuan Shen and Linghua Yu

Sideline vested interests to reform China’s research pp. 566-566

Qilin Zhang

2026, volume 657, articles 8130

Author Correction: Structural mechanism of cGAS inhibition by the nucleosome pp. E1-E1

Ganesh R. Pathare, Alexiane Decout, Selene Glück, Simone Cavadini, Kristina Makasheva, Ruud Hovius, Georg Kempf, Joscha Weiss, Zuzanna Kozicka, Baptiste Guey, Pauline Melenec, Beat Fierz, Nicolas H. Thomä and Andrea Ablasser

Author Correction: Cretaceous bird from Brazil informs the evolution of the avian skull and brain pp. E2-E4

Luis M. Chiappe, Guillermo Navalón, Agustín G. Martinelli, Ismar de Souza Carvalho, Rodrigo Miloni Santucci, Yun-Hsin Wu and Daniel J. Field

Author Correction: Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP pp. E5-E5

Andrea Ablasser, Jonathan L. Schmid-Burgk, Inga Hemmerling, Gabor L. Horvath, Tobias Schmidt, Eicke Latz and Veit Hornung

Author Correction: Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer pp. E6-E6

Giannicola Genovese, Alessandro Carugo, James Tepper, Frederick Scott Robinson, Liren Li, Maria Svelto, Luigi Nezi, Denise Corti, Rosalba Minelli, Piergiorgio Pettazzoni, Tony Gutschner, Chia-Chin Wu, Sahil Seth, Kadir Caner Akdemir, Elisabetta Leo, Samirkumar Amin, Marco Dal Molin, Haoqiang Ying, Lawrence N. Kwong, Simona Colla, Koichi Takahashi, Papia Ghosh, Virginia Giuliani, Florian Muller, Prasenjit Dey, Shan Jiang, Jill Garvey, Chang-Gong Liu, Jianhua Zhang, Timothy P. Heffernan, Carlo Toniatti, Jason B. Fleming, Michael G. Goggins, Laura D. Wood, Alessandro Sgambato, Abbas Agaimy, Anirban Maitra, Charles W. M. Roberts, Huamin Wang, Andrea Viale, Ronald A. DePinho, Giulio F. Draetta and Lynda Chin

Publisher Correction: Targeting cancer-specific mutations with RNA-triggered chromatin shredding pp. E7-E7

Jingkun Zeng, Zhiyuan Cheng, Huadong Chen, Zhaojun Wang, Jared Thompson, Kadin T. Crosby, Hesong Han, Arushi Singhal, Wayne Ngo, Chenglong Xia, Daniel Rosas-Rivera, Zeyuan Zhang, Min Hyung Kang, Ying Mao, Morgan E. Diolaiti, Giselle C. Lee, John F. X. Diffley, Yixuan Song, Longhui Qiu, Nathan M. Krah, Niren Murthy, Ryan N. Jackson, Yang Liu, Alan Ashworth and Jennifer A. Doudna

Women face bans on research underground — here’s how to modernize the system pp. 9-9

Linqi Huang

The Moderna cancer vaccine offers hope — now we must speed up personalized therapies pp. 10-10

Patrick A. Ott

Billion-dollar machine aims to set a fusion-energy record — and study nuclear weapons pp. 13-15

James Dinneen

These trees are making air quality in cities worse pp. 15-16

Mohana Basu

Moderna cancer vaccine stops melanoma returning: what’s next for personalized treatments? pp. 16-17

Rachel Fieldhouse and Mohana Basu

More than 18,000 questionable images found in antibody catalogues of 15 companies pp. 17-18

Dan Garisto

Exclusive: NSF set to issue lowest number of new grants in four decades pp. 18-19

Dan Garisto

Staggering 90% of biomedical papers now show signs of AI help pp. 20-20

Kaia Glickman

Bland new world: is AI making us all think the same? pp. 22-24

Matthew Hutson

When do infections lead to long COVID? Scientists close in on triggers and treatments for post-viral syndromes pp. 26-28

Simon Makin

Order from disorder: do we need a new law of physics? pp. 29-31

Graham Shields

Einstein the musician, AI prophets and more: Books in brief pp. 31-31

Andrew Robinson

Rudolph A. Marcus obituary: theoretical chemist who explained how electrons jump between molecules pp. 33-33

Garnet Kin-Lic Chan and Kenneth H. Marcus

Who is responsible when AI helps to write science? pp. 34-36

Robert Braun

Why are rich people so pessimistic? What the numbers say pp. 36-38

Florence Gaub

Self-driving cars make mistakes, and now users can see why pp. 39-40

Hyochang Kim and Hyunmin Kang

Intraspecific variation in tropical trees can drive resistance to drought pp. 40-42

Brendan Choat and Erick Calderón-Morales

Antimatter ‘tag’ used to detect elusive particle decay pp. 42-44

Matt Kenzie

Scale of snakebites estimated globally pp. 43-43

Mary Abraham

Skin cancer spreads between catfish in a freshwater lake pp. 44-45

Hannah Siddle

Designing physics experiments with artificial intelligence pp. 47-58

Jonathan Klimesch, Sören Arlt, Carlos Ruiz-Gonzalez, Carla Rodríguez, Xuemei Gu, Philipp Haslinger, Pietro Vischia, Christian Haack, Yehonathan Drori, Rana Adhikari, Markus Arndt, Michael Kagan, Lukas Heinrich and Mario Krenn

Molecular mechanisms and pathogenesis of MASH pp. 59-75

Suchira Gallage, Olivier Govaere, Quentin M. Anstee, Gerald I. Shulman, Frank Tacke and Mathias Heikenwalder

Current therapeutic landscape and future treatment perspectives of MASH pp. 76-91

Suchira Gallage, Olivier Govaere, Quentin M. Anstee, Gerald I. Shulman, Frank Tacke and Mathias Heikenwalder

Exploring baryon semileptonic decays through polarization and entanglement pp. 92-97

The BESIII Collaboration

Observation of conformal field theory spectra in a quantum simulator pp. 98-106

Xiangkai Sun, Yuan Le, Stephen Naus, Richard Bing-Shiun Tsai, Lewis R. B. Picard, Sara Murciano, Michael Knap, Jason Alicea and Manuel Endres

Atomic-scale double-slit interferometry with a focused electron probe pp. 107-113

Koudai Tabata, Takehito Seki, Toma Susi, Ryo Ishikawa and Naoya Shibata

Explainable deep learning improves human mental models of self-driving cars pp. 114-120

Eoin M. Kenny, Akshay Dharmavaram, Sang Uk Lee, Tung Phan-Minh, Shreyas Rajesh, Yunqing Hu, Laura Major, Momchil S. Tomov and Julie A. Shah

Phase-homogeneous mixed-halide perovskites for stable tandem photovoltaics pp. 121-126

Pengju Shi, Jiale Zhuang, Dayong Zhang, Chu Li, Stefan Zeiske, Jin Hou, Isaiah W. Gilley, Ilhan Yavuz, Ubaid Kazianga, Congqi Li, Yu Zhang, Kefu Huang, Teerapat Itsoponpan, Xin Jiang, Chiung-Han Chen, Chuying Huang, Yi Yang, Xianfu Zhang, Pronoy Nandi, Samantha A. Reitz, Antonio Facchetti, Keith P. White, Keenan W. Wyatt, Michael F. Toney, Mercouri G. Kanatzidis, Tobin J. Marks, Cheng Liu, Bin Chen and Edward H. Sargent

Luminescent-reaction-enabled super-resolution imaging pp. 127-134

Wenxin Zhu, Chi Zhang, Jiahui Gui, Yibo Yang, Yuxin Wan, Xin Wang, Liying Qu, Ao Guo, Ziqing Zhang, Zhenqian Han, Weisong Zhao and Jiandong Feng

Synthesis of pyrroles from isoxazoles by an O-to-C skeletal edit pp. 135-141

Abigail J. Bracken, Alexandra P. Lawrie, Isabella F. Romita and Mark D. Levin

Pyridoxal photoenzymes for asymmetric radical–radical cross-couplings pp. 142-149

Cole C. Sorensen, Suhao Wang, Yao Ouyang, Saim Waheed, Claire G. Page, Greg Mann, Simon Allmendinger and Todd K. Hyster

Critical zone processes limit alkalinity export from natural basaltic systems pp. 150-155

L. A. Derry, K. Maher and O. A. Chadwick

Food systems transformation would reshape global agriculture pp. 156-163

Matthew Gibson, Marina Sundiang, Daniel Mason-D’Croz, Thais Diniz Oliveira, Felicitas Beier, Lauren Benavidez, Astrid Bos, Maksym Chepeliev, Jonathan Doelman, Shahnila Dunston, Shinichiro Fujimori, Tomoko Hasegawa, Peter Havlik, Jordan Hristov, Jonas Jägermeyr, Marta Kozicka, Marijke Kuiper, Page Kyle, Thijs de Lange, Benjamin Leon Bodirsky, Hermann Lotze-Campen, Hermen Luchtenbelt, David Meng-Chuen Chen, Abhijeet Mishra, Christoph Müller, Gerald Nelson, Amanda Palazzo, Ignacio Perez Dominguez, Alexander Popp, Ronald Sands, Marco Springmann, Elke Stehfest, Timothy B. Sulser, Kiyoshi Takahashi, Gianmaria Tassinari, Ferike Thom, Philip Thornton, Kazuaki Tsuchiya, Willem-Jan van Zeist, Hans van Meijl, Dominique van der Mensbrugghe, Detlef Van Vuuren, Hannah H. E. van Zanten, Isabelle Weindl, Keith Wiebe, Xin Zhao and Mario Herrero

Species intraspecific variation drives tropical forest drought resistance pp. 164-169

Chris M. Smith-Martin, Robert Muscarella, Timothy J. Brodribb and María Uriarte

Exceptional brain and ecological diversity in the earliest snakes pp. 170-178

Tiago R. Simões, Gabriela Sobral, Simone Macrì, Roy Ebel, Thiago S. Fachini, Agustín G. Martinelli, William R. Nava, Giovanna M. X. Paixão, Luis M. Chiappe, Nicolas Di-Poï and Annie S. Hsiou

An encyclopedia of human enhancer–gene regulatory interactions pp. 179-190

Andreas R. Gschwind, Kristy S. Mualim, Alireza Karbalayghareh, Maya U. Sheth, Kushal K. Dey, Evelyn Jagoda, Ramil N. Nurtdinov, Wang Xi, Anthony S. Tan, James Galante, Hank Jones, X. Rosa Ma, David Yao, Dulguun Amgalan, Judhajeet Ray, Chad J. Munger, Joseph Nasser, Žiga Avsec, Benjamin T. James, Muhammad S. Shamim, Neva C. Durand, Suhas S. P. Rao, Ragini Mahajan, Benjamin R. Doughty, Kalina Andreeva, Jacob C. Ulirsch, Kaili Fan, Elizabeth M. Perez, Tri C. Nguyen, David R. Kelley, Hilary K. Finucane, Jill E. Moore, Zhiping Weng, Manolis Kellis, Michael C. Bassik, Berk Ustun, Alkes L. Price, Michael A. Beer, Roderic Guigó, John A. Stamatoyannopoulos, Erez Lieberman Aiden, William J. Greenleaf, Christina S. Leslie, Lars M. Steinmetz, Anshul Kundaje and Jesse M. Engreitz

Cell-type signatures of Alzheimer’s disease shared across population groups pp. 191-201

Tain Luquez, Jonathan Algoo, Rebecca Chiu, Jason A. Mares, Archana Yadav, Matti Lam, Pallavi Gaur, Xiaoying Lai, Dylan I. Lee, Fahad Paryani, Rafe Batchelor, Irla Belli, Jordan Henry, Bat Hoter-Ishay, Courteney Mattison, Lindsey Starr, Tsering Lama, Berke Karaahmet, Wenqing Cao, Philip L. De Jager, Mariko Taga, Lisa L. Barnes, David X. Marquez, David A. Bennett, Ya Zhang and Vilas Menon

A global molecular code for birth order and neuronal identity in Drosophila pp. 202-212

Sebastian Cachero, Myrto Mitletton, Isabella R. Beckett, Elizabeth C. Marin, Laia Serratosa Capdevila, Marina Gkantia, Jelly H. M. Soffers, Haluk Lacin, Gregory S. X. E. Jefferis and Erika Donà

An intrinsic cytoskeletal oscillator establishes neuronal polarity pp. 213-225

Tien-chen Lin, Charlotte H. Coles, Eissa Alfadil, Florian Fäßler, Andreas Husch, Sebastian Dupraz, Thorben Pietralla, Akihiro Narita, Max Schelski, Kevin C. Flynn, Sina Stern, Christoph Möhl, Brett J. Hilton, Franz Vauti, Hans-Henning Arnold, Florian K. M. Schur and Frank Bradke

CRISPR–Cas regulates expression of embedded anti-phage defence systems pp. 226-235

Xian Shu, Rui Wang, Xufei Zhou, Feiyue Cheng, Jiayue Ma, Zhihua Li, Xin Li, Tuozhan Wu, Aici Wu, Qiong Xue, Chao Liu, Huiwei Zhao, Xifeng Cao, Lin Wang, Shouyue Zhang, Yan Zhang and Ming Li

In vivo feasibility study of humanoid robots in surgery pp. 236-244

Zekai Liang, Nikita Thareja, Peihan Zhang, Calvin Joyce, Soofiyan Atar, Florian Richter, Garth Jacobsen, Shanglei Liu, Ryan Broderick and Michael Yip

Brown bullhead catfish melanoma represents a novel transmissible cancer pp. 245-251

Emily E. Curd, Samuel F. M. Hart, James Lubkowitz, Kirsten M. Tracy, Lucas Milazzo, Matthew Bodnar, Tom Jones, Mark J. Henderson, Peter Emerson and Julie A. Dragon

Modular in vivo antibody–ADC click to reverse drug resistance in tumours pp. 252-261

Cristina Simó, Alexander C. Vanover, Ricardo D’Oliveira Albanus, Sandeep Surendra Panikar, Shayla Shmuel, Alex Benton, Jader Giraldo-Guzman, José M. Luna, Yifei Xu, Na-Keysha Berry, Nai Keltee, Jingxia Liu, Farrokh Dehdashti and Patrícia M. R. Pereira

Non-genotoxic transplantation and in vivo selection through epitope editing pp. 262-274

Gabriele Casirati, Andrea Cosentino, Marta Freschi, Jing Zeng, Adele Mucci, Sébastien Levesque, Nola Neri, Enrico Drago, Viola Carzaniga, Francesco Romano, Varun Katta, Azusa Matsubara, Yichao Li, Mohammed S. Mahmoud, Moisés Chávez-Navarro, Christian Brendel, John P. Manis, Shengdar Tsai, Danilo Pellin, Daniel Bauer and Pietro Genovese

An expanded codebook of human transcription factor DNA-binding specificity pp. 275-283

Arttu Jolma, Kaitlin U. Laverty, Ali Fathi, Ally W. H. Yang, Isaac Yellan, Ilya E. Vorontsov, Antoni J. Gralak, Judith F. Kribelbauer-Swietek, Sachi Inukai, Rozita Razavi, Mihai Albu, Alexander Brechalov, Zain M. Patel, Vladimir Nozdrin, Georgy Meshcheryakov, Andrey Buyan, Ivan Kozin, Sergey Abramov, Alexandr Boytsov, The Codebook Consortium, Quaid Morris, Matthew T. Weirauch, Oriol Fornes, Vsevolod J. Makeev, Jan Grau, Ivo Grosse, Philipp Bucher, Bart Deplancke, Ivan V. Kulakovskiy and Timothy R. Hughes

Efficient and precise programmable DNA knock-in without double-strand breaks pp. 284-294

Yanmin Gao, Yu Ma, Kexin Yu, Yintian Liu, Buming Gu, Hao Tang, Wenjie Yan, Shuangshuang Yang, Jingran Su, Xindong Wang, Xin Ma, Xinming Wang, Fang Wang, Qingyang Li, Mengying Liu and Haifeng Wang

Enzymatic glycosylation and amidation reshapes polyene bioactivity pp. 295-303

Saadia N. Mirza, Alberto Carella, Joseph W. Thompson, Deepanjan Panda, Anna R. I. McDonald, Matthew D. Crossley, Wei Li Thong, Katherine J. Robins, Sarah. A. Shepherd, Matthew J. Cliff, Clara Valero, Andrew Thom, Michael Bromley and Jason Micklefield

Researcher, heal thyself: meet the scientists studying their own diseases pp. 305-307

Josie Glausiusz

AI models are being used to track zoonotic diseases. Will they prevent the next pandemic? pp. 308-310

Heather Richardson

When AI does science, who is accountable for mistakes? pp. 312-312

Chiranjib Chakraborty

Europe should adapt, not copy, China’s practical PhD pp. 312-312

Alan Żukowski and Martyna Stępień

China’s regulatory innovation for new biomedical technologies pp. 312-312

Yuan Fang, Siying Guo, Jun Du and Ning Li

The global plastics treaty must account for conflict-driven energy insecurity pp. 312-312

Wei Wu and Farooq Shah