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2026, volume 656, articles 8128

Artefacts in single-cell mtDNA analyses misinform phylogenies pp. E25-E31

Caleb A. Lareau, Michael Spencer Chapman, Livius Penter, Tal Nawy, Dana Pe’er and Leif S. Ludwig

Reply to: Artefacts in single-cell mtDNA analyses misinform phylogenies pp. E32-E38

Chen Weng, Jonathan S. Weissman and Vijay G. Sankaran

Author Correction: Sleep chart of biological ageing clocks in middle and late life pp. E39-E39

The MULTI Consortium, Cliodhna Kate O’Toole, Zhiyuan Song, Filippos Anagnostakis, Zhijian Yang, Ye Ella Tian, Michael R. Duggan, Chunrui Zou, Yue Leng, Yi Cai, Wenjia Bai, Cynthia H. Y. Fu, Michael S. Rafii, Paul Aisen, Gao Wang, Philip L. De Jager, Jian Zeng, Hamilton Se-Hwee Oh, Xia Zhou, Keenan A. Walker, Daniel W. Belsky, Andrew Zalesky, Eleanor M. Simonsick, Susan M. Resnick, Luigi Ferrucci, Christos Davatzikos and Junhao Wen

Author Correction: Cucurbituril-based anion-conducting membranes with supramolecular nanopores pp. E40-E40

Ziang Xu, Dongcheng Lin, Haoyu Yin, Qingqing Feng, Fabrizia Foglia, Yihan Zhen, Adam Morris, Quentin Berrod, Maobin Pang, Lida Huang, Jing Liu, Jiekang Tian, Xiaonan Wang, Chunming Yang, Xingchen Tang, Xi Zhang, Baoguo Wang, Haotian Wang and Kai Liu

Author Correction: Maturation and circuit integration of transplanted human cortical organoids pp. E41-E41

Omer Revah, Felicity Gore, Kevin W. Kelley, Jimena Andersen, Noriaki Sakai, Xiaoyu Chen, Min-Yin Li, Fikri Birey, Xiao Yang, Nay L. Saw, Samuel W. Baker, Neal D. Amin, Shravanti Kulkarni, Rachana Mudipalli, Bianxiao Cui, Seiji Nishino, Gerald A. Grant, Juliet K. Knowles, Mehrdad Shamloo, John R. Huguenard, Karl Deisseroth and Sergiu P. Paşca

Author Correction: Casdatifan shows durable response linked to HIF-2α biology in kidney cancer pp. E42-E42

Toni K. Choueiri, Jaime Merchán, Amita Patnaik, Alexandra Drakaki, Brian I. Rini, Sun Young Rha, Jae Lyun Lee, Moshe C. Ornstein, Rohit Kumar, Clara Hwang, Yusra Shao, Se Hoon Park, Pedro C. Barata, Bradley A. McGregor, Paul Foster, Jianfen Chen, Melissa Eisen, Hunter Cole, Ben Weeder, Yinghui Guan, Jaskirat Singh, Angelo Kaplan, Soonweng Cho, Richard Markus, Omar Kabbarah and Rana R. McKay

Publisher Correction: Progressive plasticity during colorectal cancer metastasis pp. E43-E43

Andrew Moorman, Elizabeth K. Benitez, Francesco Cambuli, Qingwen Jiang, Ahmed Mahmoud, Melissa Lumish, Saskia Hartner, Sasha Balkaran, Jonathan Bermeo, Simran Asawa, Canan Firat, Asha Saxena, Fan Wu, Anisha Luthra, Cassandra Burdziak, Yubin Xie, Valeria Sgambati, Kathleen Luckett, Yanyun Li, Zhifan Yi, Ignas Masilionis, Kevin Soares, Emmanouil Pappou, Rona Yaeger, T. Peter Kingham, William Jarnagin, Philip B. Paty, Martin R. Weiser, Linas Mazutis, Michael D’Angelica, Jinru Shia, Julio Garcia-Aguilar, Tal Nawy, Travis J. Hollmann, Ronan Chaligné, Francisco Sanchez-Vega, Roshan Sharma, Dana Pe’er and Karuna Ganesh

Editorial Expression of Concern: Tumour exosome integrins determine organotropic metastasis pp. E44-E44

Ayuko Hoshino, Bruno Costa-Silva, Tang-Long Shen, Goncalo Rodrigues, Ayako Hashimoto, Milica Tesic Mark, Henrik Molina, Shinji Kohsaka, Angela Di Giannatale, Sophia Ceder, Swarnima Singh, Caitlin Williams, Nadine Soplop, Kunihiro Uryu, Lindsay Pharmer, Tari King, Linda Bojmar, Alexander E. Davies, Yonathan Ararso, Tuo Zhang, Haiying Zhang, Jonathan Hernandez, Joshua M. Weiss, Vanessa D. Dumont-Cole, Kimberly Kramer, Leonard H. Wexler, Aru Narendran, Gary K. Schwartz, John H. Healey, Per Sandstrom, Knut Jørgen Labori, Elin H. Kure, Paul M. Grandgenett, Michael A. Hollingsworth, Maria de Sousa, Sukhwinder Kaur, Maneesh Jain, Kavita Mallya, Surinder K. Batra, William R. Jarnagin, Mary S. Brady, Oystein Fodstad, Volkmar Muller, Klaus Pantel, Andy J. Minn, Mina J. Bissell, Benjamin A. Garcia, Yibin Kang, Vinagolu K. Rajasekhar, Cyrus M. Ghajar, Irina Matei, Hector Peinado, Jacqueline Bromberg and David Lyden

Why China should reassess how it rewards young scientists pp. 540-540

Ming Li

Universities must stop protecting bullies — or more people will leave science pp. 541-541

Morteza Mahmoudi

Controversial White House plan to overhaul US science funding faces Senate opposition pp. 543-544

Dan Garisto

Ocean temperatures set to break all-time record: what’s next? pp. 544-545

James Dinneen

This AI tool claims to pick the top 1% of preprints. Should researchers trust it? pp. 546-546

Miryam Naddaf

A particle made of force: physicists say they’ve found mysterious ‘glueball’ pp. 547-547

Mohana Basu

Trump wants MMR vaccine split up: the science behind why it’s a bad idea pp. 548-549

Kaia Glickman and Max Kozlov

Scientists up in arms about cuts to UK physics and astronomy pp. 549-550

Elizabeth Gibney

Where are you ticklish? Researchers map the sensation across cultures pp. 550-550

Claire Ainsworth

Will you be wearing an exoskeleton in ten years? The tech that could change how we move pp. 552-553

Chris Stokel-Walker

Screening babies’ genomes could save lives. Here’s how it would work pp. 554-556

Uzma Rentia

Why AI systems are most useful as designers of new scientific tools pp. 557-558

James Evans

How the story of life and our planet unfolded — together pp. 559-561

Dianne K. Newman

The power of ignorance and peering into the Milky Way: Books in brief pp. 561-561

Andrew Robinson

Too hot to sleep? How heatwaves at night affect our health pp. 562-564

Pixin Gong, Li Lan, Ruiqi Guo, Shu Jiang, Zisheng Huang, Zhentao Wang, Yanbing Lin and Hui Xu

How the Middle East can become a hub for sustainable aviation fuels pp. 565-567

Ying Jiang and Samuel S. Mao

Activity of solar-driven polymer catalysts unleashed to produce a potential green fuel pp. 569-570

Filip Podjaski

HIV vaccines guide rare immune cells to make broadly neutralizing antibodies pp. 570-572

S. Gnanakaran and Cynthia A. Derdeyn

Can empty space interact with light — and even change its properties? pp. 572-573

Ekaterina Sokolova-Lapa and Joern Wilms

Intestinal stem cells count to eight divisions to maintain cell ratios pp. 574-575

Joaquín de Navascués

Safety and security of large language models in healthcare pp. 577-589

Jan Clusmann, Oscar Freyer, Max Ostermann, Dyke Ferber, Narmin Ghaffari Laleh, Lars Hilgers, Fiona R. Kolbinger, Carolin V. Schneider, Andrea Downing, Magdalena Katharina Wekenborg, Stephen Gilbert, Sebastian Foersch, Daniel Truhn, Isabella C. Wiest and Jakob Nikolas Kather

Vacuum birefringence and the polarized X-ray emission from a radio magnetar pp. 590-594

Rachael E. Stewart, Hoa Dinh Thi, George Younes, Marcus E. Lower, Matthew G. Baring, Michela Negro, Fernando Camilo, Joel B. Coley, Teruaki Enoto, Alice K. Harding, Wynn C. G. Ho, Chin-Ping Hu, Philip Kaaret, Paul Scholz, Alex Van Kooten and Zorawar Wadiasingh

Ubiquitous Kelvin–Helmholtz instabilities driving plasma mixing on the Sun pp. 595-601

David Kuridze, Friedrich Wöger, Michiel van Noort, Matthias Rempel, Robert Cameron, Thomas Rimmele, Sami K. Solanki, Sarah A. Jaeggli, Alexandra Tritschler, Han Uitenbroek, Damien Przybylski and David A. Boboltz

Pseudogap in a Fermi–Hubbard quantum simulator pp. 602-608

Lev Haldar Kendrick, Anant Kale, Youqi Gang, Alexander Dennisovich Deters, Martin Lebrat, Aaron W. Young and Markus Greiner

Superconducting 2D cuprate with a single CuO2 plane pp. 609-615

Hengsheng Luo, Dongjoon Song, Yijun Yu, Liguo Ma, Peng Cai, Ruidan Zhong, Yiwen Chen, Lin Zhao, Jian Shen, Dan Shahar, Xingjiang Zhou, Zhengyu Weng, Xian Hui Chen, Wei Ruan and Yuanbo Zhang

Perovskite–organic tandem solar cells with a photo-transformable stabilizer pp. 616-623

Ruihan Wu, Shucheng Qin, Tianwei Zou, Xin Jiang, Senyao Wang, Siyu Zhuang, Hongyu Li, Yiyang Wang, Siguang Li, Minchao Liu, Yishun Feng, Yufei Gong, Haozhe He, Peiwen Liao, Yu Chen, Jinyuan Zhang, Xiaojun Li, Lei Meng and Yongfang Li

Photocatalytic water splitting by 2D polymer with out-of-plane carrier flow pp. 624-629

Hangyu Zhuzhang, Zhiyang Yu, Xiaocong Liang, Lihua Lin, Xianzhi Fu, Kazunari Domen and Xinchen Wang

Selectivity emerges from indiscriminate photoreduction pp. 630-637

Joseph M. Edgecomb, Arindam Sau, Niket Manoj, Matthew D. Resmini, Alissia F. Meyer, Robert S. Paton, Niels H. Damrauer and Zachary K. Wickens

Cascading continental-scale floods across Europe in 1342–1343 pp. 638-645

Andrea Kiss, Alberto Viglione, Mariano Barriendos, Silvia Enzi, Martin Bauch, Kris Decker, Nicolas Maughan, Dag Retsö, Astrid Ogilvie, Miriam Bertola, Tim Soens, Libor Elleder, Rudolf Brázdil, Kathleen Pribyl, Juraj Parajka, Ioannis Telelis, Inês Amorim, Josep Barriendos, Oliver Böhm, Gerardo Benito, Chiara Bertolin, Dario Camuffo, Denis Coeur, Gaston Demarée, Radoslaw Doktor, Markus Dotterweich, Rüdiger Glaser, Jürgen Komma, Neil Macdonald, Hrvoje Petrić, Christian Rohr, Petra Schmocker-Fackel, Lothar Schulte, Willem H. J. Toonen, Oliver Wetter and Günter Blöschl

Intergenerational mobility fosters innovation in Europe pp. 646-652

Sarah McNamara, Guido Neidhöfer and Patrick Lehnert

Urokodia sheds light on the origin of chelicerae and book gills of Chelicerata pp. 653-658

Yu Liu, Lorenzo Lustri, Huijuan Mai, Mark Williams, Liming Liu, Yani Tang, Thomas H. P. Harvey and Xianguang Hou

Whole-genome duplication shaped cell-type evolution in the vertebrate brain pp. 659-669

Yuanzhen Zhu, Shuai Zhang, Jiankai Wei, Diego Dolgetta-Garcia, Katia Jindrich, Huimin Liu, Chenggang Shi, Rongrong Pan, Yuwei Chen, Yan Xu, Qiye Li, Günter P. Wagner, Peter W. H. Holland, Guang Li and Sebastian M. Shimeld

Analysis of 173,303 exomes and genomes in the Pakistan Genome Resource pp. 670-679

Christopher Koch, Shareef Khalid, Maleeha Zaman Khan, Shruthi Bandyadka, Brian Doyon, Daniel P. Denning, Muhammad Jahanzaib, Muhammad Rehan Mian, Wafa Gul, Muhammad Bilal Liaqat, Aneeqa Bano, Marium Dahar, Namra Saqib, Lubna Kamani, Nazish Butt, Anjum Jalal, Riffat Sultana, Shahid Abbas, Musfireh Siddiqeh, Muhammad Haroon, Asadullah Khan, Khalid Parvez Babar, Aflak Rasheed, Javed Iqbal, Faizan Aslam, Umar Usman, Muhammad Akram Bajwa, Ali Hyder, Muhammad Sadik Memon, Nauman Hashmani, Mohsin Iqbal Haroon, Ambreen Muddassir, Syed Asif Raza Zaidi, Mateen Akram, Muhammad Hussain, Saima Naz Mohsin, Samreen Bugti, Tariq Mehmood, Abdul Lateef Rodeni, Shahid Mukhtar, Tahir Rasool, Adil Mahmood, Muhammad Noor Wazir, Sheraz Jamal Khan, Muhammad Asghar Khan, Rahmat Ghaffar, Sanaullah Jan, Noor Ul Hadi, Roshina Anjum, Rehan Abdullah, Muhammad Usman Musharraf, Muhammad Tahir Bashir, Muhammad Ali, Irfan Majeed, Muhammad Haroon Bilal, Shahzad Ali Khan, Chihiro Hata, Ikuyo Kou, Makoto Asaumi, Wataru Morii, Katherine R. Smith, Kousik Kundu, Kieren Lythgow, Stewart MacArthur, Sebastian Wasilewski, Slavé Petrovski, Regeneron Genetics Center, Juan L. Rodriguez-Flores, Moeen Riaz, Manav Kapoor, Joshua D. Backman, Alan R. Shuldiner, James E. Bradner, Igor Splawski, Asif Rasheed, John E. Dominy, Allan M. Gurtan and Danish Saleheen

A mosaic of whole-body representations on the human precentral gyrus pp. 680-687

Darrel R. Deo, Elizaveta V. Okorokova, Anna L. Pritchard, Nick V. Hahn, Nicholas S. Card, Samuel R. Nason-Tomaszewski, Justin Jude, Thomas Hosman, Eun Young Choi, Deqiang Qiu, Yuguang Meng, Maitreyee Wairagkar, Claire Nicolas, Foram B. Kamdar, Carrina Iacobacci, Alexander Acosta, Leigh R. Hochberg, Sydney S. Cash, Ziv M. Williams, Daniel B. Rubin, David M. Brandman, Sergey D. Stavisky, Nicholas AuYong, Chethan Pandarinath, John E. Downey, Sliman J. Bensmaia, Jaimie M. Henderson and Francis R. Willett

Competing programs shape cortical sensorimotor–association axis development pp. 688-699

Jeremiah Tsyporin, Menglei Zhang, Cai Qi, Ashlea Segal, Xinyun Li, Hyojin Kim, Sang-Hun Choi, Ivan Pavlovic, Sara Bandiera, Thomas Finn, Suel-Kee Kim, Akemi Shibata, Takumi Nakamura, Kohei Onishi, Ziqin Zhang, Elijah Hammarlund, Graham Su, Nikkita Salla, Joy Kachko, Christi Hawley, Shuiyu Li, Daniel Z. Doyle, Xueyan Peng, Timothy Nottoli, Nuria Ruiz-Reig, Fadel Tissir, Yasushi Nakagawa, Erica Herzog, Shaojie Ma, Kevin Gobeske, Kartik Pattabiraman, Tomomi Shimogori, Alvaro Duque, Alex Fornito, Hao Huang, Mikihito Shibata, Bin Chen and Nenad Sestan

Virus reactivation in acute and long COVID-19 pp. 700-711

Cole Maguire, Jing Chen, Nadine Rouphael, Brinkley A. Morse, Annmarie Hoch, Harry Pickering, Hoang Van Phan, Abigail Glascock, Victoria Chu, Ravi Dandekar, Network Impacc, David Corry, Farrah Kheradmand, Lindsey R. Baden, Rafick-Pierre Sekaly, Grace A. McComsey, Elias K. Haddad, Charles B. Cairns, Bali Pulendran, Ana Fernandez-Sesma, Viviana Simon, Jordan P. Metcalf, Nelson I. Agudelo Higuita, William B. Messer, Mark M. Davis, Kari C. Nadeau, Monica Kraft, Chris Bime, Joanna Schaenman, David Erle, Carolyn S. Calfee, Mark A. Atkinson, Scott C. Brakenridge, Lauren I. R. Ehrlich, Ruth R. Montgomery, Albert Shaw, Catherine L. Hough, David Hafler, Alison D. Augustine, Patrice M. Becker, Bjoern Peters, Al Ozonoff, Seunghee Kim-Schulze, Florian Krammer, Steven E. Bosinger, Walter Eckalbar, Matthew C. Altman, Michael Wilson, Leying Guan, Steven H. Kleinstein, Kinga K. Smolen, Elaine F. Reed, Ofer Levy, Holden Maecker, Peter Hunt, Hanno Steen, Joann Diray-Arce, Charles R. Langelier and Esther Melamed

Enhanced B cell priming induces broadly neutralizing HIV-1 apex antibodies pp. 712-722

Lorie Marchitto, Kshitij Wagh, Ryan S. Roark, Severin Coleon, Hui Li, Ashwin N. Skelly, Michael P. Hogarty, Rumi Habib, Wenge Ding, Kasirajan Ayyanathan, Weimin Liu, Zizhang Sheng, Yicheng Guo, Joena Bal, Lena M. Smith, Laura L. Sutherland, Younghoon Park, Andrew J. Connell, Frederic Bibollet-Ruche, Emily Lewis, Samantha J. Plante, Macy J. Akeley, Jinery Lora, Chengyan Zhao, John W. Carey, Christian L. Martella, Yingying Li, Mary S. Campion, Melinda G. Lituchy, Rebecca A. Osbaldeston, Colette G. Gordon, Amie Albertus, Justin Su, Chiaki Noguchi, Ying K. Tam, Christopher Barbosa, Bo Liang, Khaled Amereh, Xuduo Li, Agnes A. Walsh, Darrell J. Irvine, Raiees Andrabi, Robert J. Edwards, Edward F. Kreider, Drew Weissman, Lawrence Shapiro, Peter D. Kwong, Bette T. Korber, Barton F. Haynes, Kevin O. Saunders, Beatrice H. Hahn and George M. Shaw

Vaccination elicits HIV broadly neutralizing antibodies in primates pp. 723-733

Jon M. Steichen, Patrick J. Madden, Claudia T. Flynn, Swastik Phulera, Monolina Shil, Oleksandr Kalyuzhniy, Alessia Liguori, Carolyne Kifude, Leigh M. Sewall, Christopher A. Cottrell, Krystal M. Ma, Sabyasachi Baboo, Jolene K. Diedrich, Katherine McKenney, Allan C. deCamp, Diane G. Carnathan, Ivy Phung, Parham Ramezani-Rad, Ester Marina-Zárate, Brian Freeman, Zhenfei Xie, Jeong Hyun Lee, Troy Sincomb, Nicole Phelps, Danny Lu, Diana Goodwin, Ryan Tingle, Yumiko Adachi, Nushin Alavi, Jenny Tran, Andy S. Tran, Alyne Nascimento, Catherine Sovie, Daniel L. V. Bader, Hannah Voic, Xiaoya Zhou, Grace Pixton, Agnes Walsh, Mariane B. Melo, Torben Schiffner, Facundo D. Batista, Dennis R. Burton, Darrell J. Irvine, James C. Paulson, John R. Yates, Gabriel Ozorowski, Andrew B. Ward, Guido Silvestri, Shane Crotty and William R. Schief

Casdatifan shows durable response linked to HIF-2α biology in kidney cancer pp. 734-741

Toni K. Choueiri, Jaime Merchán, Amita Patnaik, Alexandra Drakaki, Brian I. Rini, Sun Young Rha, Jae Lyun Lee, Moshe C. Ornstein, Rohit Kumar, Clara Hwang, Yusra Shao, Se Hoon Park, Pedro C. Barata, Bradley A. McGregor, Paul Foster, Jianfen Chen, Melissa Eisen, Hunter Cole, Ben Weeder, Yinghui Guan, Jaskirat Singh, Angelo Kaplan, Soonweng Cho, Richard Markus, Omar Kabbarah and Rana R. McKay

Intestinal stem cells count self-renewal divisions to switch multipotency pp. 742-751

Dong Tong, Anqi Li, Quanquan Jiang, Qili Yuan, Xiaozhao Liu, Ximiao He, Jiejunyi Liang, Yunyun Han and Zheng Guo

Chromatin landscape and epigenetic heterogeneity of acute myeloid leukaemia pp. 752-762

Yotaro Ochi, Markus Liew-Littorin, Yasuhito Nannya, Sofia Bengtzen, Benedicte Piauger, Stefan Deneberg, Martin Jädersten, Vladimir Lazarevic, Jörg Cammenga, Anna Robelius, Lovisa Wennström, Emma Ölander, Senji Kasahara, Nobuhiro Hiramoto, Nobuhiro Kanemura, Nobuo Sezaki, Maki Sakurada, Makoto Iwasaki, Junya Kanda, Yasunori Ueda, Satoshi Yoshihara, Tom Erkers, Nona Struyf, Yu Watanabe, Masanori Motomura, Masahiro M. Nakagawa, Ryunosuke Saiki, Hidehito Fukushima, Koji Okazaki, Suguru Morimoto, Akinori Yoda, Rurika Okuda, Shintaro Komatsu, Guoxiang Xie, Albin Österroos, Ayana Kon, Lanying Zhao, Yuichi Shiraishi, Takayuki Ishikawa, Satoru Miyano, Kotoe Katayama, Seiya Imoto, Shuichi Matsuda, Akifumi Takaori-Kondo, Hiroyuki Aburatani, Hiroshi I. Suzuki, Olli Kallioniemi, Gunnar Juliusson, Martin Höglund, Sören Lehmann and Seishi Ogawa

Targeted enzyme discovery using metal-coordination mining pp. 763-769

Ioannis Kipouros and Michelle C. Y. Chang

Small-molecule modulation of β-arrestins pp. 770-779

Alem W. Kahsai, Natalia Pakharukova, Henry Y. Kwon, Kunal S. Shah, Caroline T. del Real, Bowie N. Shreiber, Jason G. Liang-Lin, Paul J. Shim, Mason A. Lee, Ngo Van A., Allison M. Schwalb, Uyen Pham, Anand Chundi, Haoran Jiang, Emmanuel Flores-Espinoza, Samuel Liu, Preston C. Nibley, Dana K. Bassford, Hyunggu Hahn, Cal A. Kunzle, Brittany N. Thomas, Jihee Kim, Yang Zhou, Jialu Wang, Xingdong Zhang, Jeffrey S. Smith, Lindsay A. M. Rein, Alex R. B. Thomsen, Sudha K. Shenoy, Sudarshan Rajagopal, Lei Shi, Seungkirl Ahn, Howard A. Rockman, Ali Masoudi and Robert J. Lefkowitz

Retraction Note: NSD2 targeting reverses plasticity and drug resistance in prostate cancer pp. 780-780

Jia J. Li, Alessandro Vasciaveo, Dimitris Karagiannis, Zhen Sun, Kristjan H. Gretarsson, Xiao Chen, Ouathek Ouerfelli, Fabio Socciarelli, Ziv Frankenstein, Hanyang Dong, Min Zou, Wei Yuan, Guangli Yang, Gabriel M. Aizenman, Tania Pannellini, Xinjing Xu, Himisha Beltran, Yu Chen, Kevin Gardner, Brian D. Robinson, Johann de Bono, Or Gozani, Cory Abate-Shen, Mark A. Rubin, Massimo Loda, Charles L. Sawyers, Andrea Califano, Chao Lu and Michael M. Shen

Job insecurity is chipping away at me and my cohort. Is it us, or the state of the economy? pp. 781-782

Daniella Watson

Five ways 3D printing is improving lab work pp. 783-784

Neil Savage

Treat biological databases as infrastructure, not projects pp. 786-786

Neil Hall, Katja Röper, Valerie Wood and Paul Nurse

Asia’s longevity gains must be translated into better health pp. 786-786

Chiranjib Chakraborty

Heatwaves expose weak links in food systems pp. 786-786

Zongyin Zhao, Chengchao Zuo, Xinli Ke and Shuyu Yang

Europe must adapt to live with megafires pp. 786-786

Jorge Tobajas, Víctor Resco de Dios and Antoni Margalida

2026, volume 656, articles 8127

Pre-clinical data interpretation requires clinical context pp. E3-E4

R. Muirhead, G. G. Hanna, F. McDonald, D. Palma, S. Siva and A. Tree

Reply to: Pre-clinical data interpretation requires clinical context pp. E5-E6

Sean P. Pitroda and Ralph R. Weichselbaum

Dataset artefacts can partially drive the measured decline in disruption pp. E7-E13

Vincent Holst, Andres Algaba, Floriano Tori, Sylvia Wenmackers and Vincent Ginis

Reply to: Dataset artefacts can partially drive the measured decline in disruption pp. E14-E21

Michael Park, Erin Leahey and Russell J. Funk

Author Correction: Feature-specific threat coding in lateral septum guides defensive action pp. E22-E22

Dionnet Leandro Bhatti Mazo, Marc Z. C. Berger, Amanda Loren Pasqualini, Sherry Jingjing Wu, Christopher M. Reid, Salvador Ignacio Brito, Shenfeng Qiu, Pat Levitt, Corey C. Harwell, Todd Erryl Anthony and Gord Fishell

Author Correction: A ductile solid electrolyte interphase for solid-state batteries pp. E23-E23

Jinshuo Mi, Jun Yang, Likun Chen, Wenting Cui, Yuhang Li, Xufei An, Jiabin Ma, Ke Yang, Yaoshu Xie, Jie Biao, Yu Long, Huilin Ge, Bing Han, Ruohong Ke, Guanyou Xiao, Shendong Tan, Danfeng Zhang, Xing Cheng, Tingzheng Hou, Yan-Fei Huang, Ming Liu, Wei Lv, Lin Gan, Yan-Bing He, Quan-Hong Yang and Feiyu Kang

Editorial Expression of Concern: Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis pp. E24-E24

Sunhwa Kim, Hiroyuki Takahashi, Wan-Wan Lin, Pascal Descargues, Sergei Grivennikov, Youngjun Kim, Jun-Li Luo and Michael Karin

Why science must reinforce its social contract pp. 274-274

Peter Gluckman

I caught my students using AI to cheat in an exam — here’s what universities must do to stamp this out pp. 275-275

Roberto Serrano

Fires in Europe are breaking records: here’s what the future holds pp. 277-278

James Dinneen

AI agents are checking the scientific literature — and spotting decades-old errors pp. 278-279

Chris Stokel-Walker

Demand for lithium is surging: here’s how to make mining more sustainable pp. 279-280

Mohana Basu

Underdog ‘spin qubits’ leap forward in race to a useful quantum computer pp. 280-281

Dan Garisto

COVID can wake up a slew of dormant viruses inside you pp. 281-282

Max Kozlov

Tiny patch of Amazon probably holds 40,000 insect species — many new to science pp. 282-283

Mariana Lenharo

NSF rolls out ‘industry PhD’ programme — joining a global trend pp. 283-284

Jenna Ahart

A controversial Alzheimer’s surgery is said to reverse symptoms — here’s what scientists know pp. 286-289

Elie Dolgin

A ‘super’ El Niño could transform the Amazon. Is the world’s biggest rainforest doomed? pp. 290-291

Quentin Septer

Why environmental treaties must also address mental health pp. 292-296

Manasi Kumar, Tunde M. Ojo, Zeinab Hijazi, Cromwell Lukorito, James M. Hassell, Alkomiet Hasan, Jurjen J. Luykx and Lasse Brandt

Why scientists should lead the shift away from AI mega data centres pp. 296-298

Cassidy K. Buhler, Fernando Pérez and Carl Boettiger

Led by the nose: a queen’s scent shapes naked mole rat society pp. 299-300

Chris G. Faulkes

‘Little red dot’ gets its colour from gas — not dust pp. 301-302

Dominik Schleicher and Rodrigo Herrera-Camus

A high-fat, low-carbohydrate diet can feed intestinal tumours pp. 302-303

Souvik Patra and Evan C. Lien

AI identifies interactions in CRISPR complexes to improve specificity of DNA editing pp. 304-305

Hoi Yee Chu and Alan S. L. Wong

Shared principles of human and bacterial antiviral immunity pp. 307-319

Philip J. Kranzusch

Agentic profiles for effective AI governance pp. 320-328

Atoosa Kasirzadeh and Iason Gabriel

A gas-enshrouded and gas-reddened black hole at cosmic dawn pp. 329-333

Rohan P. Naidu, Jorryt Matthee, Harley Katz, Anna de Graaff, Pascal A. Oesch, Aaron Smith, Jenny E. Greene, Gabriel Brammer, Andrea Weibel, Raphael Hviding, John Chisholm, Ivo Labbé, Robert A. Simcoe, Callum Witten, Wendy Q. Sun, Hakim Atek, Josephine F. W. Baggen, Sirio Belli, Rachel Bezanson, Leindert A. Boogaard, Sownak Bose, Rychard J. Bouwens, Alba Covelo-Paz, Pratika Dayal, Yoshinobu Fudamoto, Lukas J. Furtak, Emma Giovinazzo, Andy Goulding, Max Gronke, Kasper E. Heintz, Michaela Hirschmann, Garth Illingworth, Akio K. Inoue, Benjamin D. Johnson, Joel Leja, Ecaterina Leonova, Ian McConachie, Michael V. Maseda, Priyamvada Natarajan, Erica Nelson, David J. Setton, Irene Shivaei, David Sobral, Mauro Stefanon, Sandro Tacchella, Sune Toft, Alberto Torralba, Pieter van Dokkum, Arjen van der Wel, Marta Volonteri, Fabian Walter, Bingjie Wang, Darach Watson and Katherine Whitaker

Numerous bow shocks in the outer Helix Nebula pp. 334-337

Pieter van Dokkum, Roberto Abraham, William P. Bowman, Seery Chen, Steven R. Janssens, Deborah M. Lokhorst, Imad Pasha and Carter Rhea

The piezochiral effect pp. 338-342

Z. Zeng, M. Först, M. Fechner, X. Deng, A. Cavalleri and P. G. Radaelli

Plasmonic metamaterial time crystal pp. 343-348

Tingwen Guo, Jules Sueiro, Gian Marcello Andolina, Artem Levchuk, Stefano Ponzoni, Romain Grasset, Donald Monthe, Ian Aupiais, Dmitri Daineka, Javier Briatico, Thales VAG de Oliveira, Alexey Ponomaryov, Atiqa Arshad, Arjun Karimbana-Kandy, Gulloo Lal Prajapati, Igor Ilyakov, Jan-Christoph Deinert, Sebastian F. Maehrlein, Luca Perfetti, Marco Schirò and Yannis Laplace

Encapsulation epitaxy of air-stable 2D superconductors for quantum circuits pp. 349-356

Xudong Zheng, Sameia Zaman, Kenan Zhang, Connor A. Occhialini, Haowei Xu, Zhien Wang, Xinyan Li, Fangyuan Liu, Luiz Gustavo Pimenta Martins, Sejoon Lim, Tianyi Zhang, Tilo H. Yang, Jiangtao Wang, Yunyue Zhu, Zachariah Hennighausen, Sein Park, Steven Vitale, Kevin Tibbetts, Stephen Margiotta, Phillip Kim, Cong Su, Yimo Han, Ju Li, Riccardo Comin, William D. Oliver, Joel Î-j. Wang and Jing Kong

Electrodeposited self-assembled molecules for perovskite photovoltaics pp. 357-363

Zhihui Xiong, Xuanang Luo, Fushen Tang, Bohan Wang, Sen Yin, Yu Li, Zhangyu Yuan, Chenxi Peng, Shaohua Tong, Jialin Wu, Xingwang Kang, Ganlin Liu, Ying Wang, Youran Lin, Mingke Li, Yulong Li, Yuanyuan Shu, Wei Meng, Ning Li and Lei Ying

Avalanche-like intercalation and intraparticle correlations in graphite pp. 364-369

Jiho Han, George S. Phillips, Alice J. Merryweather, Juhwan Lim, Christoph Schnedermann, Robert L. Jack, Clare P. Grey and Akshay Rao

Octahedral-coordinated Co3O4 for water electrolysis in acid pp. 370-375

Yue Wang, Yujin Ji, Jing Zhou, Jinxin Chen, Chenchen Li, Chendi Zhao, Jia Ke, Yutian Xiong, Sihui Pan, Wei-Hsiang Huang, Chih-Wen Pao, Chang-Yang Kuo, Chien-Te Chen, Youyong Li, Zhiwei Hu, Qi Shao and Xiaoqing Huang

Upcycling of polyvinyl chloride into polyalphaolefin lubricants pp. 376-382

Eric Munyaneza Nuwayo, Connor Thompson, Abby Civiello, Adrian DiMarco, Jingtao Zhang, Seungjoo Lee, Gugyeong Sung, Tridip Das, Yue Zhang, Clark Vu, Shelby Koshak, John B. Matson, Ali Erdemir, William A. Goddard, Xi Chen and Guoliang Liu

Food web complexity underlies biodiversity effects on ecosystem functioning pp. 383-389

Andrew D. Barnes, Ulrich Brose, Nico Eisenhauer, Emilio Berti, Mario Brauns, Susan L. Eggert, David Garcia-Callejas, Darren P. Giling, Robert O. Hall, Jes Hines, Malte Jochum, Daniil I. Korobushkin, Susanne Kortsch, Pavel Kratina, Marina Manca, Jordi-René Mor, Marie C. Nordström, Eoin J. O’Gorman, David Ott, Daniel M. Perkins, Benjamin Rosenbaum, Ruslan A. Saifutdinov, Victor S. Saito, Andrew J. Tanentzap, Catarina Vinagre and Benoit Gauzens

A queen odour mediates reproductive suppression in a eusocial mammal pp. 390-398

Mohammed A. Khallaf, Daniel W. Hart, Wenhan Luo, Firdevs Murad, Felipe Cybis Pereira, Daniel Mendez-Aranda, Nicole Hagenah, Alice Rossi, Valérie Bégay, Jan Okrouhlík, Dietmar Krautwurst, Mungo Kisinza Ngalameno, Andre Ganswindt, Alison J. Barker, Radim Šumbera, Markus Knaden, Sophie Pezet, Andrew Woehler, Bill S. Hansson, Nigel C. Bennett and Gary R. Lewin

Gene ancestries reveal diverse microbial associations during eukaryogenesis pp. 399-405

Moisès Bernabeu, Saioa Manzano-Morales, Marina Marcet-Houben and Toni Gabaldón

Centromeric footprints preserve telomere integrity in ALT cancers pp. 406-414

Ragini Bhargava, Megan A. Mahlke, Tobias T. Schmidt, Christoph Bartenhagen, Baylee A. Smith, Katherine L. Ramsey, Takoda T. Zuehlke, Ray W. Bowman, Michelle L. Lynskey, Anne R. Wondisford, Jean-Baptiste Ouriou, Sandra Schamus-Hayes, Michael J. Calderon, Simon C. Watkins, April E. Williams-Wehner, Jennifer M. Bone, Alok V. Joglekar, Matthias Fischer, Jan Karlseder, Yael Nechemia-Arbely and Roderick J. O’Sullivan

Feature-specific threat coding in lateral septum guides defensive action pp. 415-424

Dionnet Leandro Bhatti Mazo, Marc Z. C. Berger, Amanda Loren Pasqualini, Sherry Jingjing Wu, Christopher M. Reid, Salvador Ignacio Brito, Shenfeng Qiu, Pat Levitt, Corey C. Harwell, Todd Erryl Anthony and Gord Fishell

Mapping the neuronal building blocks of human language with language models pp. 425-433

Jing Cai, Yoav Kfir, Mohsen Jamali, Hesen Huang, Young Joon Kim, Sydney S. Cash and Ziv M. Williams

Epiblast diversification and blood formation in a human pregastrula pp. 434-442

Zhenyu Xiao, Yandong Gong, Xiaolong Yang, Nannan He, Xinyuan Wang, Guoju You, Hanlin Zhu, Yingping Liang, Xinwei Xie, Baoqi Fang, Gaoke Liu, Bing Liu and Yu Lan

A secreted endosymbiont protein essential for colonizing host cells pp. 443-451

Gerald P. Maeda, Allen Z. Xue, Ethan W. Yu, Aadhunik Sundar, Derrick L. Kamp, J. Elijah Powell, Thomas E. Smith and Nancy A. Moran

Dietary cholesterol activates a Ral-dependent pathway driving LDLR turnover pp. 452-462

Xue Feng, Shuo Zhang, Yuqi Wang, Twisha Kurlagunda, Allyssa Sit, Priyadarshini Jaishankar, Pusu Yang, Sadatsugu Sakane, Se Yong Park, Churaibhon Wisessaowapak, Kaylee Nguyen, Jamie Yan, Himani Pothulu, Catherine Dinh, Felicia Chu, Yuyao Ren, Bichen Zhang, Patrick Secrest, Linmeng Han, Chao-Wei Hung, Preethi Veeragandham, Yuliya Skorobogatko, Tatiana Kisseleva, Philip L.S.M. Gordts, Adam R. Renslo, Peng Zhao, Amit R. Majithia and Alan R. Saltiel

Precise DNA base editing using AlphaFold3-based contact modelling pp. 463-473

Haowei Meng, Zhixin Lei, Yongchang Yan, Liren Wang, Sihan Zhang, Xichen Rao, Chuyun Shao, Xiaoting Zhang, Ke Chen, Lei Yang, Rongrong Liu, Gaohui Yang, Ruoyu Shen, Ruichu Gu, Xinyan Wang, Yiya Wang, Suiru Lu, Zhicong Lv, Bo He, Han Wen, Dali Li and Chengqi Yi

Ketogenic diet mediates intestinal tumorigenesis through lipids not ketones pp. 474-483

Jessica E. S. Shay, Fangtao Chi, Constantine N. Tzouanas, Shixun Han, Xiao Zhang, Johanna Ten Hoeve, Kevin J. Williams, Seda Neptun, Tolga Sever, Isabela Fuentes, Sangeeta N. Bhatia, Gizem Calibasi-Kocal, Matthew G. Vander Heiden, Alex K. Shalek and Ömer H. Yilmaz

CHPO coordinates chilling recovery and nitrogen use in rice pp. 484-492

Jie Cao, Yunyuan Xu, Zhitao Li, Jingdan Han, Qian Qian, Song Ge, Hong Wang, Wei Luo and Kang Chong

Replication-stress-induced chromatin loops protect fork stability pp. 493-505

Vincent Gaggioli, Kaustav Sengupta, Ashutosh Choudhury, Joanna Paulson, Raviprasad Kuthethur, Collin Bakker, Jialun Li, Calvin S. Y. Lo, Alex Whale, Jeroen van den Berg, Leire Asua Intxausti, Noelia Gil-Lanza, Iván Galván-Femenía, Eleni Maria Manolika, Sangavi Eswaran, Hina N. Khan, Estel Ferré, Gregorie Stik, Alexander van Oudenaarden, Argyris Papantonis, Jonathan Houseley, Sriram Sridharan, Arnab Ray Chaudhuri, Aleix Bayona-Feliu and Nitika Taneja

Alternate RNA decoding results in stable and abundant proteins in mammals pp. 506-515

Shira Tsour, Rainer Machné, Andrew Leduc, Simon Widmer, Eunice Koo, Jeremy Guez, Konrad J. Karczewski and Nikolai Slavov

Correcting congenital myasthenia-associated acetylcholine receptor defects pp. 516-524

Huanhuan Li, Nuriya Mukhtasimova, Jinfeng Teng, Elfie S. Cavalli, Xilin Gu, Jason K. Sello, Steven M. Sine and Ryan E. Hibbs

Despite global turmoil, Gen Z researchers are not giving up pp. 525-527

Meghie Rodrigues

Seven tips for a graceful lab exit pp. 528-529

Stephanie Melchor

The case for responsible scientific activism pp. 532-532

Stuart Capstick, Charlie Gardner and Abi Perrin

AI tools speed up analysis, but scientific truths must be grounded in reality pp. 532-532

Weishi Zhang, Ying Xu and Yitong Han

Will AI make our dreams all look the same? pp. 532-532

Claudio Nastruzzi

Funders should look beyond strict age criteria pp. 532-532

Xiaohui Xia

2026, volume 656, articles 8126

Author Correction: Authigenic mineral phases as a driver of the upper-ocean iron cycle pp. E1-E1

Alessandro Tagliabue, Kristen N. Buck, Laura E. Sofen, Benjamin S. Twining, Olivier Aumont, Philip W. Boyd, Salvatore Caprara, William B. Homoky, Rod Johnson, Daniela König, Daniel C. Ohnemus, Bettina Sohst and Peter Sedwick

Author Correction: OR7A10 GPCR engineering boosts CAR-NK therapy against solid tumours pp. E2-E2

Luojia Yang, Paul A. Renauer, Kaiyuan Tang, Josh Saskin, Liqun Zhou, Charles Zou, Seok-Hoon Lee, Madison Fox, Samuel Johnson-Noya, Benedict Weiss, Stephanie Deng, Paris Fang, Binfan Chen, Giacomo Sferruzza, Saba Fooladi, Kai Zhao, Daniel Park, Feifei Zhang, Jiayi Tu, Jing Chen, Jennifer Moliterno, Murat Gunel, Lei Peng and Sidi Chen

Why the need for the WHO has never been greater pp. 9-9

Tedros Adhanom Ghebreyesus

This El Niño is set to be the largest on record by a ‘mind-blowing margin’ pp. 11-12

James Dinneen

Humanity spoke thousands of languages at the dawn of farming — now many of them are lost pp. 12-13

Freda Kreier

First volunteer gets Ebola vaccine — three months after the outbreak began pp. 14-15

Dhruv Shenai

This AI Raygun can shrink and supersize proteins — opening the door to easy editing pp. 15-16

Gemma Conroy

Rising stars of mathematics awarded prestigious 2026 Fields Medal pp. 16-17

Davide Castelvecchi

White House rolls out AI funding — and signals a new era for US science pp. 17-18

Dan Garisto and Kaia Glickman

Exclusive: the science papers that patents cite the most pp. 19-23

Richard Van Noorden, Heidi Ledford and Edward Chen

Could mending damaged DNA prolong life? pp. 24-26

Elizabeth Quill

The secret relationships that govern life on Earth pp. 28-30

Richard Schiffman

Why pain hurts more when we’re lonely, and the myth of original sin: Books in brief pp. 30-30

Andrew Robinson

Obituary: Susumu Tonegawa, Japan’s first Nobel prizewinner in physiology or medicine pp. 31-31

Adrian Hayday

Plans for nuclear-powered merchant ships must confront risks pp. 33-36

Jihong Chen and Zheng Wan

Europe can become a bioengineering powerhouse with these three changes pp. 36-38

Vasilis Ntziachristos, Thomas Schwarz-Romond and Fiona M. Watt

Artificial algal blooms could remove atmospheric carbon — but can they be used responsibly? pp. 39-40

Sara Nawaz

Judicious use of LLMs could speed up progress in the social sciences pp. 40-41

James N. Druckman

Venus’s rift valleys could be its secret to staying active pp. 42-42

Katherine Skipper

Privacy risks from medical AI tools are not shared equally pp. 42-44

Haoran Zhang and Marzyeh Ghassemi

Electric dipoles go sideways in thin ferroelectric film pp. 44-45

Elzbieta Gradauskaite

DNA-shredding CRISPR enzyme takes aim at cancer cells pp. 45-46

Mehran Takallo and Raymond H. J. Staals

An entangling gate for dual-rail erasure qubits pp. 47-53

D-Wave Quantum Inc.

Imaging of nanoscale polar textures in quantum paraelectric SrTiO3 pp. 54-59

Yang Zhang, Suk Hyun Sung, Nishkarsh Agarwal, Maya Gates, Cong Li, Pu Yu, Robert Hovden and Ismail El Baggari

Family of magnetic field-boosted superconductors in rhombohedral graphene pp. 60-66

Junseok Seo, Armel A. Cotten, Shenyong Ye, Mingchi Xu, Omid Sharifi Sedeh, Henok Weldeyesus, Tonghang Han, Zhengguang Lu, Zhenghan Wu, Wei Xu, Jixiang Yang, Emily Aitken, Prayoga P. Liong, Phatthanon Pattanakanvijit, Zach Hadjri, Rasul Gazizulin, Kenji Watanabe, Takashi Taniguchi, Mingda Li, Dominik M. Zumbühl and Long Ju

Perpendicular switching of polarization in layered ferroelectrics pp. 67-72

Pushpendra Gupta, Sergio Puebla, Fernando Gómez-Ortiz, Xinyan Li, Sajid Husain, Ting-Ran Liu, Peter Meisenheimer, Vishantak Srikrishna, Dmitri Nikonov, Matthew Chen, Yogesh Kumar, Ashish Omar, Koushik Das, Barat Achinuq, Sujoy Roy, Yu-Tsun Shao, Yimo Han, Sayeef Salahuddin, Amrita Mathuriya, Sasikanth Manipatruni, Philippe Ghosez, Javier Junquera and Ramamoorthy Ramesh

Insulator-free topological photonic multi-lane highways pp. 73-79

Xiaohan Cui, Ruo-Yang Zhang, Mudi Wang, Zi-Xuan Gao, Xiao-Dong Chen, Zhao-Qing Zhang, Yun Lai and C. T. Chan

Non-epitaxial perovskite polariton laser diode operating under direct current pp. 80-85

Anatoly P. Pushkarev, Daria Khmelevskaia, Ivan A. Matchenya, Stepan A. Baryshev, Denis A. Sannikov, Alexey A. Ekgardt, Eduard I. Moiseev, Natalia V. Kryzhanovskaya, Alexey E. Zhukov, Dmitry V. Krasnikov, Alexandr A. Marunchenko, Alexey V. Yulin, Albert G. Nasibulin and Pavlos G. Lagoudakis

Semiconducting and magnetic lanthanide MXenes from intercalated halides pp. 86-91

Qian Fang, Liming Wang, Kai Chang, Hongxin Yang, Pu Yan, Kecheng Cao, Mian Li, Jianming Xue, Xiaoping Ouyang, Zhifang Chai and Qing Huang

Alternating CO2 and bicycloalkane copolymerization to circular polyesters pp. 92-97

Min Zhu, Xavier Westworth, Yingluo Zhao, Gaurav S. Deshmukh, Deepak K. Barange, Tao Zhang, Ravikumar R. Gowda, Linda J. Broadbelt and Eugene Y.-X. Chen

Ligand-enabled distal desaturative lactonization of aliphatic acids pp. 98-105

Tanay Pal, Md Saimuddin Sk, Yazhinimuthu C M, Somnath Kar, Animesh Ghosh and Debabrata Maiti

Climate benefit and ecological cost trade-offs for ocean iron fertilization pp. 106-114

Jun Yu, J. Keith Moore, Francois W. Primeau, Anthony F. Michaels, Amy G. Nuno, Kristen M. Krumhardt, Michael N. Levy, Keith Lindsay, Hui Wang, James T. Randerson and Adam C. Martiny

Large language models can predict the results of social science experiments pp. 115-122

Ashwini Ashokkumar, Luke Hewitt, Isaias Ghezae and Robb Willer

High-fidelity modular skeletons authenticate a Cambrian origin for Bryozoa pp. 123-128

Baopeng Song, Zhifei Zhang, Luke C. Strotz, Timothy P. Topper, Andrej Ernst, Junye Ma, Zhiliang Zhang, Mei Luo, Lars E. Holmer, Yue Liang, Yazhou Hu, Caibin Zhang, Yanlong Chen and Glenn A. Brock

Cell-type-resolved genetic variation shapes inflammatory bowel disease risk pp. 129-139

Tobi Alegbe, Bradley T. Harris, Laura Fachal, Lucia Ramirez-Navarro, Marcus Tutert, Monika Krzak, Mennatallah Ghouraba, Michelle Strickland, Matiss Ozols, Celeste E. Cohen, Saniya Khullar, Eleonora Khabirova, Nikolaos I. Panousis, David Ochoa, Noor Wana, May Xueqi Hu, Jason Skelton, Jasmin Ostermayer, Kimberly Ai Xian Cheam, D. Leland Taylor, Yong Gu, Claire Dawson, Tina Thompson, Kenneth Arestang, Nilanga Nishad, Biljana Brezina, Charry Queen Caballes, Wendy Garri, Steven Leonard, Vivek Iyer, Miles Parkes, Chris Wallace, Rebecca E. McIntyre, Cristina Cotobal Martin, Gareth-Rhys Jones, Tim Raine and Carl A. Anderson

Mechanism of age-related accumulation of mtDNA mutations in human blood pp. 140-148

Rahul Gupta, Timothy J. Durham, Grant Chau, Masahiro Kanai, Md Mesbah Uddin, Wenhan Lu, M. Austin Argentieri, Konrad J. Karczewski, Daniel Howrigan, Pradeep Natarajan, Wei Zhou, Benjamin M. Neale and Vamsi K. Mootha

A thalamus–brainstem attractor network drives history-biased decisions pp. 149-158

Shan Zhao, Heying Shan, Xiao Liu, Yu Qian, Jingyao Huang, Yi-Ran Liu, Zhenfei Jiao, Lichen Ye, Lin Cong, Xiaoou Wang, Zhi-Yuan Wang, Danyang Li, Ming-Quan Chen, Kai Wang, Ling Fu, Xu-Fei Du, Si Wu and Yu Mu

Cortical development dynamics across autism spectrum disorder mouse models pp. 159-172

Lena A. Schwarz, Christoph P. Dotter, Sergey Isaev, Michela Lisi, Daniel Malzl, Christoph Büschl, Sabrina Ladstätter, Bárbara Oliveira, Matteo Barel, Bernadette Basilico, Chaitanya Chintaluri, Sarah Gorkiewicz, Mohammad Goudarzi, Tereza Belinova, Stephan Reichl, Gintarė Sendžikaitė, Satish Arcot Jayaram, Peter Koppensteiner, Christoph Sommer, Tim P. Vogels, Jörg Menche, Igor Adameyko, Peter V. Kharchenko, Christoph Bock and Gaia Novarino

Cold-induced peptide signalling secures pollen resilience and crop yield pp. 173-182

Shudong Chen, Yupan Zou, Huanshuo Cui, Qingfeng Dong, Dandan Yang, Xiaozhen Huang, Shujing Cheng, Peiyong Xin, Jinfang Chu, Wen Song and Cao Xu

Universal cell embedding provides a foundation model for cell biology pp. 183-191

Yanay Rosen, Yusuf Roohani, Ayush Agrawal, Leon Samotorčan, Tabula Sapiens Consortium, Stephen R. Quake and Jure Leskovec

Disparate privacy risks from medical AI pp. 192-198

Moritz A. Knolle, Martin J. Menten, Friederike Jungmann, Felix Meissen, Ben Glocker, Daniel Rueckert and Georgios Kaissis

Targeting cancer-specific mutations with RNA-triggered chromatin shredding pp. 199-206

Jingkun Zeng, Zhiyuan Cheng, Huadong Chen, Zhaojun Wang, Jared Thompson, Kadin T. Crosby, Hesong Han, Arushi Singhal, Wayne Ngo, Chenglong Xia, Daniel Rosas-Rivera, Zeyuan Zhang, Min Hyung Kang, Ying Mao, Morgan E. Diolaiti, Giselle C. Lee, John F. X. Diffley, Yixuan Song, Longhui Qiu, Nathan M. Krah, Niren Murthy, Ryan N. Jackson, Yang Liu, Alan Ashworth and Jennifer A. Doudna

Steatosis shapes prognosis-defining liver metastasis heterogeneity in CRC pp. 207-215

Yiming Peng-Winkler, Xiao-Zheng Liu, Sanne M. L. Verheul, Charlotte Girondel, Sebastian Igelmann, Sara Marie Rotter, Michail Doukas, Ming Liu, Anke Vandekeere, Mélanie Planque, Juan Fernández-García, Sébastien Tabariès, Marta Buetas-Arcas, Sandra Martínez-Martín, Florian Döbbe, Margherita Demicco, Ines Vermeire, Janine Theile, Johannes Ceuppens, Jonas Haesevoets, Emma Tobarra-López, Dorien Broekaert, Johannes Georg Bode, Tom Luedde, Peter Vermeulen, Daniele V. F. Tauriello, Raquel Perez-Lopez, Steve Stegen, Laura Soucek, Tiago De Oliveira, Lena-Christin Conradi, Peter M. Siegel, Cornelis Verhoef and Sarah-Maria Fendt

LASER couples damage sensing to ESCRT assembly for lysosome repair pp. 216-226

Claire S. Goul, Aakriti Jain, Samira Yitiz, Zahra E. Soltani, Serim Yang, Simon Rapp, Martina Spacci, Scot Federman, James Sacco, Huinan Li, Lauren D. Enriquez, Nalan Liv, Laralynne Przybyla and Roberto Zoncu

Spatial distribution of the proteome in the human body and in cancers pp. 227-236

Liang Yue, Wenhao Jiang, Sainan Li, Meng Luo, Ning Fan, Xiaolu Zhan, Rui Sun, Honghan Cheng, Zhangzhi Xue, Tong Liu, Qianhe Zhou, Kexin Chen, Tian Lu, Fang Guo, Dongwei Li, Weigang Ge, Zongxiang Nie, Mengge Lyu, Jun A, Yingrui Wang, Yingdan Chen, Zhenhai Fu, Nan Xiang, Lu Li, Fengchao Yu, Guo Ci Teo, Alexey I. Nesvizhskii, Meng Wang, Michael P. Snyder, Ben C. Collins, Qi Xiao, Ruedi Aebersold, Fei Xu, Hui Yang, Sijia Zhang, Yi Han, Yi Zhu, Yong Ji, Yan Li and Tiannan Guo

Zero-shot design of drug-binding proteins via neural iterative selection−expansion pp. 237-249

Benjamin Fry, Kaia Slaw and Nicholas F. Polizzi

Diverse binding poses of agonistic neurotoxins on human Nav1.6 pp. 250-259

Xiao Fan, Jian Huang, Lin Yang, Jiaofeng Chen, Huan Wang, Xiaoshuang Huang, Jinli Geng, Qinglin Wu, Yuzhen Xie, Fangzhou Lu, Qinmeng Guo, Zilin Shen, Xueqin Jin and Nieng Yan

Retraction Note: Sub-second periodicity in a fast radio burst pp. 260-260

The CHIME/FRB Collaboration, Bridget C. Andersen, Kevin Bandura, Mohit Bhardwaj, P. J. Boyle, Charanjot Brar, Daniela Breitman, Tomas Cassanelli, Shami Chatterjee, Pragya Chawla, Jean-François Cliche, Davor Cubranic, Alice P. Curtin, Meiling Deng, Matt Dobbs, Fengqiu Adam Dong, Emmanuel Fonseca, B. M. Gaensler, Utkarsh Giri, Deborah C. Good, Alex S. Hill, Alexander Josephy, J. F. Kaczmarek, Zarif Kader, Joseph Kania, Victoria M. Kaspi, Calvin Leung, D. Z. Li, Hsiu-Hsien Lin, Kiyoshi W. Masui, Ryan Mckinven, Juan Mena-Parra, Marcus Merryfield, B. W. Meyers, D. Michilli, Arun Naidu, Laura Newburgh, C. Ng, Anna Ordog, Chitrang Patel, Aaron B. Pearlman, Ue-Li Pen, Emily Petroff, Ziggy Pleunis, Masoud Rafiei-Ravandi, Mubdi Rahman, Scott Ransom, Andre Renard, Pranav Sanghavi, Paul Scholz, J. Richard Shaw, Kaitlyn Shin, Seth R. Siegel, Saurabh Singh, Kendrick Smith, Ingrid Stairs, Chia Min Tan, Shriharsh P. Tendulkar, Keith Vanderlinde, D. V. Wiebe, Dallas Wulf and Andrew Zwaniga

Science-backed tips on how to avoid distractions pp. 261-263

Nikki Forrester

Scientists don’t need more trust, they need public allies pp. 266-266

Anandita C. Sabherwal and Gregg Sparkman

How scientists can tackle the paradox of political polarization pp. 266-266

Peter Calow

Put health systems at the centre of European heatwave plans pp. 266-266

Chirantan Chatterjee, Indrajit Adhikari and Benjamin K. Sovacool

Lab leaders should follow football’s lead and have coaching qualifications pp. 266-266

Pat Casey