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2019, volume 573, articles 7775

Publisher Correction: An actin-based viscoplastic lock ensures progressive body-axis elongation pp. E4-E4

Alicia Lardennois, Gabriella Pásti, Teresa Ferraro, Flora Llense, Pierre Mahou, Julien Pontabry, David Rodriguez, Samantha Kim, Shoichiro Ono, Emmanuel Beaurepaire, Christelle Gally and Michel Labouesse

Publisher Correction: Asymmetric lysosome inheritance predicts activation of haematopoietic stem cells pp. E5-E5

Dirk Loeffler, Arne Wehling, Florin Schneiter, Yang Zhang, Niklas Müller-Bötticher, Philipp S. Hoppe, Oliver Hilsenbeck, Konstantinos D. Kokkaliaris, Max Endele and Timm Schroeder

Digital health pp. S97-S97

Richard Hodson

Digital assistants aid disease diagnosis pp. S98-S99

Neil Savage

An AI boost for clinical trials pp. S100-S102

Marcus Woo

A fairer way forward for AI in health care pp. S103-S105

Linda Nordling

The emerging world of digital therapeutics pp. S106-S109

Simon Makin

Your robot surgeon will see you now pp. S110-S111

Elizabeth Svoboda

An operating system for the biology lab pp. S112-S113

Michael Segal

The future of electronic health records pp. S114-S116

Jeff Hecht

A journal club to fix science pp. 465-465

Amy Orben

Why young climate activists have captured the world’s attention pp. 471-472

Emma Marris

Scientists worldwide join strikes for climate change pp. 472-473

Quirin Schiermeier, Kate Atkinson, Emiliano Rodríguez Mega, T. V. Padma, Emma Stoye, Jeff Tollefson and Alexandra Witze

Trapped: why 300 scientists are locking themselves in Arctic ice pp. 473-474

Quirin Schiermeier

China’s tree-planting drive could falter in a warming world pp. 474-475

Mark Zastrow

First portrait of mysterious Denisovans drawn from DNA pp. 475-476

Ewen Callaway

The ecologist who wants to map everything pp. 478-481

Aisling Irwin

The potent effects of Japan’s stem-cell policies pp. 482-485

David Cyranoski

Discovery is always political pp. 487-490

David Kaiser

Make more digital twins pp. 490-491

Fei Tao and Qinglin Qi

Balance of power: The Economic Consequences of the Peace at 100 pp. 492-494

Ann Pettifor

Einstein in Britain, worlds on the ebb, and a new angle on climate engineering: Books in brief pp. 493-493

Barbara Kiser

Plastic wrap: journals, practise what you preach pp. 495-495

Philip Biggin

Plan S: take Latin America’s long experience on board pp. 495-495

Humberto Debat and Dominique Babini

Rare forecasted climate event under way in the Southern Hemisphere pp. 495-495

Harry H. Hendon, D. W. J. Thompson, Eun-Pa Lim, Amy H. Butler, Paul. A. Newman, Lawrence Coy, Adam Scaife, Inna Polichtchouk, Rene S. Garreaud, Theodore G. Shepherd and Hisashi Nakamura

Surge in applications to develop drones pp. 495-495

Norman Kerle and Francesco Nex

Avert collapse of research co-production systems pp. 495-495

Maria Kernecker, Maria Busse and Jana Zscheischler

Enigmatic origin of diamond-bearing rocks revealed pp. 498-499

Catherine Chauvel

Dangerous liaisons as tumour cells form synapses with neurons pp. 499-501

Andres Barria

Concerns that captive breeding affects the ability of monarch butterflies to migrate pp. 501-502

Karen S. Oberhauser

The structure of a T-cell mechanosensor pp. 502-504

Ellis L. Reinherz

X-rays glimpse solid hydrogen’s structure pp. 504-505

Bartomeu Monserrat and Chris J. Pickard

Graphene and two-dimensional materials for silicon technology pp. 507-518

Deji Akinwande, Cedric Huyghebaert, Ching-Hua Wang, Martha I. Serna, Stijn Goossens, Lain-Jong Li, H.-S. Philip Wong and Frank H. L. Koppens

Multivalent anions as universal latent electron donors pp. 519-525

Cindy G. Tang, Mazlan Nur Syafiqah, Qi-Mian Koh, Chao Zhao, Jamal Zaini, Qiu-Jing Seah, Michael J. Cass, Martin J. Humphries, Ilaria Grizzi, Jeremy H. Burroughes, Rui-Qi Png, Lay-Lay Chua and Peter K. H. Ho

Synaptic proximity enables NMDAR signalling to promote brain metastasis pp. 526-531

Qiqun Zeng, Iacovos P. Michael, Peng Zhang, Sadegh Saghafinia, Graham Knott, Wei Jiao, Brian D. McCabe, José A. Galván, Hugh P. C. Robinson, Inti Zlobec, Giovanni Ciriello and Douglas Hanahan

Glutamatergic synaptic input to glioma cells drives brain tumour progression pp. 532-538

Varun Venkataramani, Dimitar Ivanov Tanev, Christopher Strahle, Alexander Studier-Fischer, Laura Fankhauser, Tobias Kessler, Christoph Körber, Markus Kardorff, Miriam Ratliff, Ruifan Xie, Heinz Horstmann, Mirko Messer, Sang Peter Paik, Johannes Knabbe, Felix Sahm, Felix T. Kurz, Azer Aylin Acikgöz, Frank Herrmannsdörfer, Amit Agarwal, Dwight E. Bergles, Anthony Chalmers, Hrvoje Miletic, Sevin Turcan, Christian Mawrin, Daniel Hänggi, Hai-Kun Liu, Wolfgang Wick, Frank Winkler and Thomas Kuner

Electrical and synaptic integration of glioma into neural circuits pp. 539-545

Humsa S. Venkatesh, Wade Morishita, Anna C. Geraghty, Dana Silverbush, Shawn M. Gillespie, Marlene Arzt, Lydia T. Tam, Cedric Espenel, Anitha Ponnuswami, Lijun Ni, Pamelyn J. Woo, Kathryn R. Taylor, Amit Agarwal, Aviv Regev, David Brang, Hannes Vogel, Shawn Hervey-Jumper, Dwight E. Bergles, Mario L. Suvà, Robert C. Malenka and Michelle Monje

Structural basis of assembly of the human T cell receptor–CD3 complex pp. 546-552

Dong De, Lvqin Zheng, Jianquan Lin, Bailing Zhang, Yuwei Zhu, Ningning Li, Shuangyu Xie, Yuhang Wang, Ning Gao and Zhiwei Huang

Coherent spin-state transfer via Heisenberg exchange pp. 553-557

Yadav P. Kandel, Haifeng Qiao, Saeed Fallahi, Geoffrey C. Gardner, Michael J. Manfra and John M. Nichol

Ultrahigh-pressure isostructural electronic transitions in hydrogen pp. 558-562

Cheng Ji, Bing Li, Wenjun Liu, Jesse S. Smith, Arnab Majumdar, Wei Luo, Rajeev Ahuja, Jinfu Shu, Junyue Wang, Stanislav Sinogeikin, Yue Meng, Vitali B. Prakapenka, Eran Greenberg, Ruqing Xu, Xianrong Huang, Wenge Yang, Guoyin Shen, Wendy L. Mao and Ho-Kwang Mao

A 16-step synthesis of the isoryanodane diterpene (+)-perseanol pp. 563-567

Arthur Han, Yujia Tao and Sarah E. Reisman

Deep learning for multi-year ENSO forecasts pp. 568-572

Yoo-Geun Ham, Jeong-Hwan Kim and Jing-Jia Luo

Aridity is expressed in river topography globally pp. 573-577

Shiuan-An Chen, Katerina Michaelides, Stuart W. D. Grieve and Michael Bliss Singer

Kimberlites reveal 2.5-billion-year evolution of a deep, isolated mantle reservoir pp. 578-581

Jon Woodhead, Janet Hergt, Andrea Giuliani, Roland Maas, David Phillips, D. Graham Pearson and Geoff Nowell

Wilderness areas halve the extinction risk of terrestrial biodiversity pp. 582-585

Moreno Di Marco, Simon Ferrier, Tom D. Harwood, Andrew J. Hoskins and James E. M. Watson

A middle Cambrian arthropod with chelicerae and proto-book gills pp. 586-589

Cédric Aria and Jean-Bernard Caron

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome pp. 590-594

Parimal Samir, Sannula Kesavardhana, Deanna M. Patmore, Sebastien Gingras, R. K. Subbarao Malireddi, Rajendra Karki, Clifford S. Guy, Benoit Briard, David E. Place, Anannya Bhattacharya, Bhesh Raj Sharma, Amanda Nourse, Sharon V. King, Aaron Pitre, Amanda R. Burton, Stephane Pelletier, Richard J. Gilbertson and Thirumala-Devi Kanneganti

α-Ketoglutarate links p53 to cell fate during tumour suppression pp. 595-599

John P. Morris, Jossie J. Yashinskie, Richard Koche, Rohit Chandwani, Sha Tian, Chi-Chao Chen, Timour Baslan, Zoran S. Marinkovic, Francisco J. Sánchez-Rivera, Steven D. Leach, Carlos Carmona-Fontaine, Craig B. Thompson, Lydia W. S. Finley and Scott W. Lowe

The fundamental role of chromatin loop extrusion in physiological V(D)J recombination pp. 600-604

Yu Zhang, Xuefei Zhang, Zhaoqing Ba, Zhuoyi Liang, Edward W. Dring, Hongli Hu, Jiangman Lou, Nia Kyritsis, Jeffrey Zurita, Muhammad S. Shamim, Aviva Presser Aiden, Erez Lieberman Aiden and Frederick W. Alt

eIF5B gates the transition from translation initiation to elongation pp. 605-608

Jinfan Wang, Alex G. Johnson, Christopher P. Lapointe, Junhong Choi, Arjun Prabhakar, Dong-Hua Chen, Alexey N. Petrov and Joseph D. Puglisi

Low-barrier hydrogen bonds in enzyme cooperativity pp. 609-613

Shaobo Dai, Lisa-Marie Funk, Fabian Rabe Pappenheim, Viktor Sautner, Mirko Paulikat, Benjamin Schröder, Jon Uranga, Ricardo A. Mata and Kai Tittmann

Retraction Note: Quantification of ocean heat uptake from changes in atmospheric O2 and CO2 composition pp. 614-614

L. Resplandy, R. F. Keeling, Y. Eddebbar, M. K. Brooks, R. Wang, L. Bopp, M. C. Long, J. P. Dunne, W. Koeve and A. Oschlies

Microbial chemistry gains fresh focus pp. 615-616

Esther Landhuis

From academia to freelance curator pp. 617-618

Emily Scott-Dearing

reCAPTCHA all over again pp. 620-620

Aaron Moskalik

2019, volume 573, articles 7774

Influenza pp. S49-S49

Herb Brody

Towards a universal flu vaccine pp. S50-S52

Michael Eisenstein

Q&A: Keeping antivirals viable pp. S53-S53

Naomi Lubick

The push for better flu therapies pp. S54-S55

Neil Savage

A sticking point for rapid flu tests? pp. S56-S57

Elizabeth Svoboda

Real-time flu tracking pp. S58-S59

Charles Schmidt

Accelerating flu protection pp. S60-S61

Eric Bender

Flu on the farm pp. S62-S63

Cassandra Willyard

Why I welcome a climate emergency pp. 311-311

Paul Gilding

Meet the weather observers on climate change’s front lines pp. 317-318

Alexandra Witze

‘Ecological grief’ grips scientists witnessing Great Barrier Reef’s decline pp. 318-319

Gemma Conroy

African nations push UN to improve drought research pp. 319-319

T. V. Padma

Dramatic sea-ice melt caps tough Arctic summer pp. 320-321

Alexandra Witze

Giant ‘bubbles’ spotted around Milky Way’s black hole pp. 322-322

Davide Castelvecchi

The hard truths of climate change — by the numbers pp. 324-327

Jeff Tollefson

Where climate cash is flowing and why it’s not enough pp. 328-331

Sophie Yeo

Save reefs to rescue all ecosystems pp. 333-336

Tiffany H. Morrison, Terry P. Hughes, W. Neil Adger, Katrina Brown, Jon Barnett and Maria Carmen Lemos

Why I broke the law for climate change pp. 337-339

Farhana Yamin

Radical reform and the Green New Deal pp. 340-341

Michael E. Mann

Making the planetary personal: the roots of climate science pp. 341-343

Ruth A. Morgan

Climate and crisis: what survives pp. 343-344

Barbara Kiser

Computing a hard limit on growth pp. 344-345

Melanie Moses

Foster local expertise in Botswana’s elephant-hunting debate pp. 346-346

Masego J. Mokobela, Graham Kerley and Ryan J. Wasserman

China fortifies marine protection areas against climate change pp. 346-346

Yunzhou Li, Yiping Ren and Yong Chen

Cancer: more genetic BRCA testing for men pp. 346-346

Monica Marabelli, Mariarosaria Calvello and Bernardo Bonanni

Study what makes games addictive pp. 346-346

Daniel King, Ernst Koster and Joël Billieux

Debating the bedrock of climate-change mitigation scenarios pp. 348-349

Kevin Anderson and Jessica Jewell

Human embryo implantation modelled in microfluidic channels pp. 350-351

Amander T. Clark

Stochastic magnetic circuits rival quantum computing pp. 351-352

Dmitri E. Nikonov

Survival skills ensure that cancer spreads pp. 353-354

Roger R. Gomis

Spectacularly rapid and regular X-ray eruptions observed from an active galaxy pp. 354-355

Bożena Czerny

A key to unlocking chromatin revealed by complex structures pp. 355-356

Steven J. Gamblin and Jon R. Wilson

A new scenario logic for the Paris Agreement long-term temperature goal pp. 357-363

Joeri Rogelj, Daniel Huppmann, Volker Krey, Keywan Riahi, Leon Clarke, Matthew Gidden, Zebedee Nicholls and Malte Meinshausen

A national experiment reveals where a growth mindset improves achievement pp. 364-369

David S. Yeager, Paul Hanselman, Gregory M. Walton, Jared S. Murray, Robert Crosnoe, Chandra Muller, Elizabeth Tipton, Barbara Schneider, Chris S. Hulleman, Cintia P. Hinojosa, David Paunesku, Carissa Romero, Kate Flint, Alice Roberts, Jill Trott, Ronaldo Iachan, Jenny Buontempo, Sophia Man Yang, Carlos M. Carvalho, P. Richard Hahn, Maithreyi Gopalan, Pratik Mhatre, Ronald Ferguson, Angela L. Duckworth and Carol S. Dweck

Temporal plasticity of apical progenitors in the developing mouse neocortex pp. 370-374

Polina Oberst, Sabine Fièvre, Natalia Baumann, Cristina Concetti, Giorgia Bartolini and Denis Jabaudon

A unified mechanism for intron and exon definition and back-splicing pp. 375-380

Xueni Li, Shiheng Liu, Lingdi Zhang, Aaron Issaian, Ryan C. Hill, Sara Espinosa, Shasha Shi, Yanxiang Cui, Kalli Kappel, Rhiju Das, Kirk C. Hansen, Z. Hong Zhou and Rui Zhao

Nine-hour X-ray quasi-periodic eruptions from a low-mass black hole galactic nucleus pp. 381-384

G. Miniutti, R. D. Saxton, M. Giustini, K. D. Alexander, R. P. Fender, I. Heywood, I. Monageng, M. Coriat, A. K. Tzioumis, A. M. Read, C. Knigge, P. Gandhi, M. L. Pretorius and B. Agís-González

Quantum critical behaviour at the many-body localization transition pp. 385-389

Matthew Rispoli, Alexander Lukin, Robert Schittko, Sooshin Kim, M. Eric Tai, Julian Léonard and Markus Greiner

Integer factorization using stochastic magnetic tunnel junctions pp. 390-393

William A. Borders, Ahmed Z. Pervaiz, Shunsuke Fukami, Kerem Y. Camsari, Hideo Ohno and Supriyo Datta

Intrinsically stable organic solar cells under high-intensity illumination pp. 394-397

Quinn Burlingame, Xiaheng Huang, Xiao Liu, Changyeong Jeong, Caleb Coburn and Stephen R. Forrest

Hindered dialkyl ether synthesis with electrogenerated carbocations pp. 398-402

Jinbao Xiang, Ming Shang, Yu Kawamata, Helena Lundberg, Solomon H. Reisberg, Miao Chen, Pavel Mykhailiuk, Gregory Beutner, Michael R. Collins, Alyn Davies, Matthew Bel, Gary M. Gallego, Jillian E. Spangler, Jeremy Starr, Shouliang Yang, Donna G. Blackmond and Phil S. Baran

Rapid expansion of Greenland’s low-permeability ice slabs pp. 403-407

M. MacFerrin, H. Machguth, D. van As, C. Charalampidis, C. M. Stevens, A. Heilig, B. Vandecrux, P. L. Langen, R. Mottram, X. Fettweis, M. R. van den Broeke, W. T. Pfeffer, M. S. Moussavi and W. Abdalati

Climate and air-quality benefits of a realistic phase-out of fossil fuels pp. 408-411

Drew Shindell and Christopher J. Smith

Death march of a segmented and trilobate bilaterian elucidates early animal evolution pp. 412-415

Zhe Chen, Chuanming Zhou, Xunlai Yuan and Shuhai Xiao

Genome architecture and stability in the Saccharomyces cerevisiae knockout collection pp. 416-420

Fabio Puddu, Mareike Herzog, Alexandra Selivanova, Siyue Wang, Jin Zhu, Shir Klein-Lavi, Molly Gordon, Roi Meirman, Gonzalo Millan-Zambrano, Iñigo Ayestaran, Israel Salguero, Roded Sharan, Rong Li, Martin Kupiec and Stephen P. Jackson

Controlled modelling of human epiblast and amnion development using stem cells pp. 421-425

Yi Zheng, Xufeng Xue, Yue Shao, Sicong Wang, Sajedeh Nasr Esfahani, Zida Li, Jonathon M. Muncie, Johnathon N. Lakins, Valerie M. Weaver, Deborah L. Gumucio and Jianping Fu

Asymmetric lysosome inheritance predicts activation of haematopoietic stem cells pp. 426-429

Dirk Loeffler, Arne Wehling, Florin Schneiter, Yang Zhang, Niklas Müller-Bötticher, Philipp S. Hoppe, Oliver Hilsenbeck, Konstantinos D. Kokkaliaris, Max Endele and Timm Schroeder

Targeting cardiac fibrosis with engineered T cells pp. 430-433

Haig Aghajanian, Toru Kimura, Joel G. Rurik, Aidan S. Hancock, Michael S. Leibowitz, Li Li, John Scholler, James Monslow, Albert Lo, Wei Han, Tao Wang, Kenneth Bedi, Michael P. Morley, Ricardo A. Linares Saldana, Nikhita A. Bolar, Kendra McDaid, Charles-Antoine Assenmacher, Cheryl L. Smith, Dagmar Wirth, Carl H. June, Kenneth B. Margulies, Rajan Jain, Ellen Puré, Steven M. Albelda and Jonathan A. Epstein

SLC19A1 transports immunoreactive cyclic dinucleotides pp. 434-438

Rutger D. Luteijn, Shivam A. Zaver, Benjamin G. Gowen, Stacia K. Wyman, Nick E. Garelis, Liberty Onia, Sarah M. McWhirter, George E. Katibah, Jacob E. Corn, Joshua J. Woodward and David H. Raulet

E-cadherin is required for metastasis in multiple models of breast cancer pp. 439-444

Veena Padmanaban, Ilona Krol, Yasir Suhail, Barbara M. Szczerba, Nicola Aceto, Joel S. Bader and Andrew J. Ewald

Structural basis of nucleosome recognition and modification by MLL methyltransferases pp. 445-449

Han Xue, Tonghui Yao, Mi Cao, Guanjun Zhu, Yan Li, Guiyong Yuan, Yong Chen, Ming Lei and Jing Huang

Seven steps to make travel to scientific conferences more sustainable pp. 451-452

Olivier Hamant, Timothy Saunders and Virgile Viasnoff

Polar research should include Indigenous perspectives pp. 453-453

Virginia Gewin

The monster and the child pp. 456-456

Dolly Garland

2019, volume 573, articles 7773

Opioids pp. S1-S1

Herb Brody

Opioids by the numbers pp. S2-S3

Liam Drew

Author Correction: Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function pp. E2-E2

Will Bailis, Justin A. Shyer, Jun Zhao, Juan Carlos Garcia Canaveras, Fatimah J. Al Khazal, Rihao Qu, Holly R. Steach, Piotr Bielecki, Omair Khan, Ruaidhri Jackson, Yuval Kluger, Louis J. Maher, Joshua Rabinowitz, Joe Craft and Richard A. Flavell

Author Correction: Niche stiffness underlies the ageing of central nervous system progenitor cells pp. E3-E3

Michael Segel, Björn Neumann, Myfanwy F. E. Hill, Isabell P. Weber, Carlo Viscomi, Chao Zhao, Adam Young, Chibeza C. Agley, Amelia J. Thompson, Ginez A. Gonzalez, Amar Sharma, Staffan Holmqvist, David H. Rowitch, Kristian Franze, Robin J. M. Franklin and Kevin J. Chalut

Analgesia without opioids pp. S4-S6

Anthony King

Can cannabis help ease addiction? pp. S7-S7

Anna Nowogrodzki

Operating without opioids pp. S8-S9

Bianca Nogrady

Tracing the US opioid crisis to its roots pp. S10-S12

Sarah DeWeerdt

Treading the tightrope of opioid restrictions pp. S13-S15

Michael Eisenstein

The painful truth about pain pp. S16-S16

Travis N. Rieder

Mitigating opioids’ harm pp. S17-S19

Cassandra Willyard

Unravelling the mystery of opioid addiction pp. S20-S21

Lauren Gravitz

Research round-up pp. S22-S23

Neil Savage

Tackle the epidemic, not the opioids pp. 165-165

Judith Feinberg

Daring scientists extract ice from Earth’s highest tropical glacier pp. 171-172

Barbara Fraser

First hint that body’s ‘biological age’ can be reversed pp. 173-173

Alison Abbott

South Korea’s ‘Nobel prize project’ rocked by tough year pp. 174-175

Mark Zastrow

Elsevier investigates hundreds of peer reviewers for manipulating citations pp. 174-174

Dalmeet Singh Chawla

Lost Denisovan bone reveals surprisingly human-like finger pp. 175-176

Ewen Callaway

Exclusive: Behind the front lines of the Ebola wars pp. 178-183

Amy Maxmen

How to banish manels and manferences from scientific meetings pp. 184-186

Holly Else

What’s next for Registered Reports? pp. 187-189

Chris Chambers

Keep quantum computing global and open pp. 190-191

Jacob D. Biamonte, Pavel Dorozhkin and Igor Zacharov

Danger and strangers: the trouble with face value pp. 192-193

Tim Radford

The enlightenment of age pp. 193-194

Toren Finkel

India’s journey to the red planet pp. 194-195

Subhra Priyadarshini

South African system tracks SDG research pp. 196-196

Willem Fourie, Isak van der Walt, Hannes Strydom and Christopher Marais

Bioethicists clarify mitochondrial-therapy ban pp. 196-196

Amy Gutmann and Jonathan D. Moreno

Colombia short on political will to protect pollinators pp. 196-196

Sofía López-Cubillos, Felipe Suárez-Castro, Eve McDonald-Madden, Duan Biggs, Guiomar Nates-Parra, Catalina Gutierrez-Chacón and Rebecca K. Runting

Not a first: identifying hominin fossils from their proteins pp. 196-196

Enrique G. Olivares

Scientists — make time for contemplation pp. 196-196

Stephen Webster

Electrochemical reactions drive morphing of materials pp. 198-199

Seung-Yeol Jeon and Sung Hoon Kang

A mechanism for touch pp. 199-200

Edwin W. McCleskey

Elusive cranium of early hominin found pp. 200-202

Fred Spoor

One tick closer to a nuclear clock pp. 202-203

Jason T. Burke

Strategies for combating online hate pp. 203-204

Noemi Derzsy

Electrochemically reconfigurable architected materials pp. 205-213

Xiaoxing Xia, Arman Afshar, Heng Yang, Carlos M. Portela, Dennis M. Kochmann, Claudio V. Di Leo and Julia R. Greer

A 3.8-million-year-old hominin cranium from Woranso-Mille, Ethiopia pp. 214-219

Yohannes Haile-Selassie, Stephanie M. Melillo, Antonino Vazzana, Stefano Benazzi and Timothy M. Ryan

Age and context of mid-Pliocene hominin cranium from Woranso-Mille, Ethiopia pp. 220-224

Beverly Z. Saylor, Luis Gibert, Alan Deino, Mulugeta Alene, Naomi E. Levin, Stephanie M. Melillo, Mark D. Peaple, Sarah J. Feakins, Benjamin Bourel, Doris Barboni, Alice Novello, Florence Sylvestre, Stanley A. Mertzman and Yohannes Haile-Selassie

Structure and mechanogating of the mammalian tactile channel PIEZO2 pp. 225-229

Li Wang, Heng Zhou, Mingmin Zhang, Wenhao Liu, Tuan Deng, Qiancheng Zhao, Yiran Li, Jianlin Lei, Xueming Li and Bailong Xiao

Force-induced conformational changes in PIEZO1 pp. 230-234

Yi-Chih Lin, Yusong R. Guo, Atsushi Miyagi, Jesper Levring, Roderick MacKinnon and Simon Scheuring

Inflation of 430-parsec bipolar radio bubbles in the Galactic Centre by an energetic event pp. 235-237

I. Heywood, F. Camilo, W. D. Cotton, F. Yusef-Zadeh, T. D. Abbott, R. M. Adam, M. A. Aldera, E. F. Bauermeister, R. S. Booth, A. G. Botha, D. H. Botha, L. R. S. Brederode, Z. B. Brits, S. J. Buchner, J. P. Burger, J. M. Chalmers, T. Cheetham, D. Villiers, M. A. Dikgale-Mahlakoana, L. J. Toit, S. W. P. Esterhuyse, B. L. Fanaroff, A. R. Foley, D. J. Fourie, R. R. G. Gamatham, S. Goedhart, S. Gounden, M. J. Hlakola, C. J. Hoek, A. Hokwana, D. M. Horn, J. M. G. Horrell, B. Hugo, A. R. Isaacson, J. L. Jonas, J. D. B. L. Jordaan, A. F. Joubert, G. I. G. Józsa, R. P. M. Julie, F. B. Kapp, J. S. Kenyon, P. P. A. Kotzé, H. Kriel, T. W. Kusel, R. Lehmensiek, D. Liebenberg, A. Loots, R. T. Lord, B. M. Lunsky, P. S. Macfarlane, L. G. Magnus, C. M. Magozore, O. Mahgoub, J. P. L. Main, J. A. Malan, R. D. Malgas, J. R. Manley, M. D. J. Maree, B. Merry, R. Millenaar, N. Mnyandu, I. P. T. Moeng, T. E. Monama, M. C. Mphego, W. S. New, B. Ngcebetsha, N. Oozeer, A. J. Otto, S. S. Passmoor, A. A. Patel, A. Peens-Hough, S. J. Perkins, S. M. Ratcliffe, R. Renil, A. Rust, S. Salie, L. C. Schwardt, M. Serylak, R. Siebrits, S. K. Sirothia, O. M. Smirnov, L. Sofeya, P. S. Swart, C. Tasse, D. T. Taylor, I. P. Theron, K. Thorat, A. J. Tiplady, S. Tshongweni, T. J. Balla, A. Byl, C. Merwe, C. L. Dyk, R. Rooyen, V. Tonder, R. Wyk, B. H. Wallace, M. G. Welz and L. P. Williams

X-ray pumping of the 229Th nuclear clock isomer pp. 238-242

Takahiko Masuda, Akihiro Yoshimi, Akira Fujieda, Hiroyuki Fujimoto, Hiromitsu Haba, Hideaki Hara, Takahiro Hiraki, Hiroyuki Kaino, Yoshitaka Kasamatsu, Shinji Kitao, Kenji Konashi, Yuki Miyamoto, Koichi Okai, Sho Okubo, Noboru Sasao, Makoto Seto, Thorsten Schumm, Yudai Shigekawa, Kenta Suzuki, Simon Stellmer, Kenji Tamasaku, Satoshi Uetake, Makoto Watanabe, Tsukasa Watanabe, Yuki Yasuda, Atsushi Yamaguchi, Yoshitaka Yoda, Takuya Yokokita, Motohiko Yoshimura and Koji Yoshimura

Energy of the 229Th nuclear clock transition pp. 243-246

Benedict Seiferle, Lars Wense, Pavlo V. Bilous, Ines Amersdorffer, Christoph Lemell, Florian Libisch, Simon Stellmer, Thorsten Schumm, Christoph E. Düllmann, Adriana Pálffy and Peter G. Thirolf

Position and momentum mapping of vibrations in graphene nanostructures pp. 247-250

Ryosuke Senga, Kazu Suenaga, Paolo Barone, Shigeyuki Morishita, Francesco Mauri and Thomas Pichler

Anthropogenic biases in chemical reaction data hinder exploratory inorganic synthesis pp. 251-255

Xiwen Jia, Allyson Lynch, Yuheng Huang, Matthew Danielson, Immaculate Lang’at, Alexander Milder, Aaron E. Ruby, Hao Wang, Sorelle A. Friedler, Alexander J. Norquist and Joshua Schrier

Mediterranean winter rainfall in phase with African monsoons during the past 1.36 million years pp. 256-260

Bernd Wagner, Hendrik Vogel, Alexander Francke, Tobias Friedrich, Timme Donders, Jack H. Lacey, Melanie J. Leng, Eleonora Regattieri, Laura Sadori, Thomas Wilke, Giovanni Zanchetta, Christian Albrecht, Adele Bertini, Nathalie Combourieu-Nebout, Aleksandra Cvetkoska, Biagio Giaccio, Andon Grazhdani, Torsten Hauffe, Jens Holtvoeth, Sebastien Joannin, Elena Jovanovska, Janna Just, Katerina Kouli, Ilias Kousis, Andreas Koutsodendris, Sebastian Krastel, Markus Lagos, Niklas Leicher, Zlatko Levkov, Katja Lindhorst, Alessia Masi, Martin Melles, Anna M. Mercuri, Sebastien Nomade, Norbert Nowaczyk, Konstantinos Panagiotopoulos, Odile Peyron, Jane M. Reed, Leonardo Sagnotti, Gaia Sinopoli, Björn Stelbrink, Roberto Sulpizio, Axel Timmermann, Slavica Tofilovska, Paola Torri, Friederike Wagner-Cremer, Thomas Wonik and Xiaosen Zhang

Hidden resilience and adaptive dynamics of the global online hate ecology pp. 261-265

N. F. Johnson, R. Leahy, N. Johnson Restrepo, N. Velasquez, M. Zheng, P. Manrique, P. Devkota and S. Wuchty

An actin-based viscoplastic lock ensures progressive body-axis elongation pp. 266-270

Alicia Lardennois, Gabriella Pásti, Teresa Ferraro, Flora Llense, Pierre Mahou, Julien Pontabry, David Rodriguez, Samantha Kim, Shoichiro Ono, Emmanuel Beaurepaire, Christelle Gally and Michel Labouesse

Maternal vitamin C regulates reprogramming of DNA methylation and germline development pp. 271-275

Stephanie P. DiTroia, Michelle Percharde, Marie-Justine Guerquin, Estelle Wall, Evelyne Collignon, Kevin T. Ebata, Kathryn Mesh, Swetha Mahesula, Michalis Agathocleous, Diana J. Laird, Gabriel Livera and Miguel Ramalho-Santos

Salmonella persisters promote the spread of antibiotic resistance plasmids in the gut pp. 276-280

Erik Bakkeren, Jana S. Huisman, Stefan A. Fattinger, Annika Hausmann, Markus Furter, Adrian Egli, Emma Slack, Mikael E. Sellin, Sebastian Bonhoeffer, Roland R. Regoes, Médéric Diard and Wolf-Dietrich Hardt

The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape pp. 281-286

Daniel N. Weinberg, Simon Papillon-Cavanagh, Haifen Chen, Yuan Yue, Xiao Chen, Kartik N. Rajagopalan, Cynthia Horth, John T. McGuire, Xinjing Xu, Hamid Nikbakht, Agata E. Lemiesz, Dylan M. Marchione, Matthew R. Marunde, Matthew J. Meiners, Marcus A. Cheek, Michael-Christopher Keogh, Eric Bareke, Anissa Djedid, Ashot S. Harutyunyan, Nada Jabado, Benjamin A. Garcia, Haitao Li, C. David Allis, Jacek Majewski and Chao Lu

Structures of influenza A virus RNA polymerase offer insight into viral genome replication pp. 287-290

Haitian Fan, Alexander P. Walker, Loïc Carrique, Jeremy R. Keown, Itziar Serna Martin, Dimple Karia, Jane Sharps, Narin Hengrung, Els Pardon, Jan Steyaert, Jonathan M. Grimes and Ervin Fodor

Structure and mechanism of mitochondrial proton-translocating transhydrogenase pp. 291-295

Domen Kampjut and Leonid A. Sazanov

Animal registries aim to reduce bias pp. 297-298

Monya Baker

Make science PhDs more than just a training path for academia pp. 299-300

Sarah Anderson

Developing cancer drugs from African plants pp. 300-300

Abdullahi Tsanni

Hello, Hello pp. 302-302

Jeff Hecht

2019, volume 573, articles 7772

Author Correction: Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment pp. E1-E1

Pulin Li, Jamie L. Lahvic, Vera Binder, Emily K. Pugach, Elizabeth B. Riley, Owen J. Tamplin, Dipak Panigrahy, Teresa V. Bowman, Francesca G. Barrett, Garrett C. Heffner, Shannon McKinney-Freeman, Thorsten M. Schlaeger, George Q. Daley, Darryl C. Zeldin and Leonard I. Zon

Eliminating malaria should not be the end of vigilance pp. 7-7

Kamini Mendis

‘The most terrifying moments’: India counts down to risky Moon landing pp. 13-14

T.V. Padma

No ‘gay gene’: Massive study homes in on genetic basis of human sexuality pp. 14-15

Jonathan Lambert

Ancient worm fossil rolls back origins of animal life pp. 15-15

Colin Barras

India–Pakistan nuclear escalation: where could it lead? pp. 16-17

Priyanka Pulla

Ocean drilling revolutionized Earth science — now geologists want to plumb new depths pp. 17-18

Alexandra Witze

A land without water: the scramble to stop Jordan from running dry pp. 20-23

Elizabeth Whitman

What the data say about police shootings pp. 24-26

Lynne Peeples

Restrict use of riot-control chemicals pp. 27-29

Dan Kaszeta

The bizarre logic of the many-worlds theory pp. 30-32

Robert P. Crease

Synthetic meat, racism at the poles, and the long road to the opioid crisis: Books in Brief pp. 31-31

Barbara Kiser

Deciphering dark matter: the remarkable life of Fritz Zwicky pp. 32-33

Jaco de Swart

Germline evo-devo — a history in two steps pp. 34-34

Neil Blackstone, Diane Bridge, Paulyn Cartwright, Heike Hadrys and Bernd Schierwater

Is Japan’s commercial whaling doomed? pp. 34-34

Shunsuke Managi

Sand governance: include artisanal miners’ voices pp. 34-34

Daniel M. Franks

Promoting science in India’s minority languages pp. 34-34

Sameen Ahmed Khan

Embrace data anonymity, not ‘digital consent’ pp. 34-34

Neil Seeman

A recipe book for cell types in the human brain pp. 36-37

Matthew G. Keefe and Tomasz J. Nowakowski

Fluorinated compounds present opportunities for drug discovery pp. 37-38

Jonathan Clayden

Inhibitory protein puts a lid on an epigenetic marker pp. 38-39

Sergi Aranda and Luciano Di Croce

Information gerrymandering in social networks skews collective decision-making pp. 40-41

Carl T. Bergstrom and Joseph B. Bak-Coleman

Pressure regulates immune-cell function pp. 41-42

Sarah R. Walmsley

Small and large earthquakes can have similar starts pp. 42-43

Rachel E. Abercrombie

Organization and regulation of gene transcription pp. 45-54

Patrick Cramer

Magnitude of urban heat islands largely explained by climate and population pp. 55-60

Gabriele Manoli, Simone Fatichi, Markus Schläpfer, Kailiang Yu, Thomas W. Crowther, Naika Meili, Paolo Burlando, Gabriel G. Katul and Elie Bou-Zeid

Conserved cell types with divergent features in human versus mouse cortex pp. 61-68

Rebecca D. Hodge, Trygve E. Bakken, Jeremy A. Miller, Kimberly A. Smith, Eliza R. Barkan, Lucas T. Graybuck, Jennie L. Close, Brian Long, Nelson Johansen, Osnat Penn, Zizhen Yao, Jeroen Eggermont, Thomas Höllt, Boaz P. Levi, Soraya I. Shehata, Brian Aevermann, Allison Beller, Darren Bertagnolli, Krissy Brouner, Tamara Casper, Charles Cobbs, Rachel Dalley, Nick Dee, Song-Lin Ding, Richard G. Ellenbogen, Olivia Fong, Emma Garren, Jeff Goldy, Ryder P. Gwinn, Daniel Hirschstein, C. Dirk Keene, Mohamed Keshk, Andrew L. Ko, Kanan Lathia, Ahmed Mahfouz, Zoe Maltzer, Medea McGraw, Thuc Nghi Nguyen, Julie Nyhus, Jeffrey G. Ojemann, Aaron Oldre, Sheana Parry, Shannon Reynolds, Christine Rimorin, Nadiya V. Shapovalova, Saroja Somasundaram, Aaron Szafer, Elliot R. Thomsen, Michael Tieu, Gerald Quon, Richard H. Scheuermann, Rafael Yuste, Susan M. Sunkin, Boudewijn Lelieveldt, David Feng, Lydia Ng, Amy Bernard, Michael Hawrylycz, John W. Phillips, Bosiljka Tasic, Hongkui Zeng, Allan R. Jones, Christof Koch and Ed S. Lein

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity pp. 69-74

Angel G. Solis, Piotr Bielecki, Holly R. Steach, Lokesh Sharma, Christian C. D. Harman, Sanguk Yun, Marcel R. Zoete, James N. Warnock, S. D. Filip To, Autumn G. York, Matthias Mack, Martin A. Schwartz, Charles. S. Cruz, Noah W. Palm, Ruaidhrí Jackson and Richard A. Flavell

Neuronal vulnerability and multilineage diversity in multiple sclerosis pp. 75-82

Lucas Schirmer, Dmitry Velmeshev, Staffan Holmqvist, Max Kaufmann, Sebastian Werneburg, Diane Jung, Stephanie Vistnes, John H. Stockley, Adam Young, Maike Steindel, Brian Tung, Nitasha Goyal, Aparna Bhaduri, Simone Mayer, Jan Broder Engler, Omer A. Bayraktar, Robin J. M. Franklin, Maximilian Haeussler, Richard Reynolds, Dorothy P. Schafer, Manuel A. Friese, Lawrence R. Shiow, Arnold R. Kriegstein and David H. Rowitch

Fast inflows as the adjacent fuel of supermassive black hole accretion disks in quasars pp. 83-86

Hongyan Zhou, Xiheng Shi, Weimin Yuan, Lei Hao, Xiangjun Chen, Jian Ge, Tuo Ji, Peng Jiang, Ge Li, Bifang Liu, Guilin Liu, Wenjuan Liu, Honglin Lu, Xiang Pan, Juntai Shen, Xinwen Shu, Luming Sun, Qiguo Tian, Huiyuan Wang, Tinggui Wang, Shengmiao Wu, Chenwei Yang, Shaohua Zhang and Zhihao Zhong

Absence of a thick atmosphere on the terrestrial exoplanet LHS 3844b pp. 87-90

Laura Kreidberg, Daniel D. B. Koll, Caroline Morley, Renyu Hu, Laura Schaefer, Drake Deming, Kevin B. Stevenson, Jason Dittmann, Andrew Vanderburg, David Berardo, Xueying Guo, Keivan Stassun, Ian Crossfield, David Charbonneau, David W. Latham, Abraham Loeb, George Ricker, Sara Seager and Roland Vanderspek

Charge order and broken rotational symmetry in magic-angle twisted bilayer graphene pp. 91-95

Yuhang Jiang, Xinyuan Lai, Kenji Watanabe, Takashi Taniguchi, Kristjan Haule, Jinhai Mao and Eva Y. Andrei

Emergence of tissue-like mechanics from fibrous networks confined by close-packed cells pp. 96-101

Anne S. G. Oosten, Xingyu Chen, LiKang Chin, Katrina Cruz, Alison E. Patteson, Katarzyna Pogoda, Vivek B. Shenoy and Paul A. Janmey

Straightforward access to N-trifluoromethyl amides, carbamates, thiocarbamates and ureas pp. 102-107

Thomas Scattolin, Samir Bouayad-Gervais and Franziska Schoenebeck

Changing climate both increases and decreases European river floods pp. 108-111

Günter Blöschl, Julia Hall, Alberto Viglione, Rui A. P. Perdigão, Juraj Parajka, Bruno Merz, David Lun, Berit Arheimer, Giuseppe T. Aronica, Ardian Bilibashi, Miloň Boháč, Ognjen Bonacci, Marco Borga, Ivan Čanjevac, Attilio Castellarin, Giovanni B. Chirico, Pierluigi Claps, Natalia Frolova, Daniele Ganora, Liudmyla Gorbachova, Ali Gül, Jamie Hannaford, Shaun Harrigan, Maria Kireeva, Andrea Kiss, Thomas R. Kjeldsen, Silvia Kohnová, Jarkko J. Koskela, Ondrej Ledvinka, Neil Macdonald, Maria Mavrova-Guirguinova, Luis Mediero, Ralf Merz, Peter Molnar, Alberto Montanari, Conor Murphy, Marzena Osuch, Valeryia Ovcharuk, Ivan Radevski, José L. Salinas, Eric Sauquet, Mojca Šraj, Jan Szolgay, Elena Volpi, Donna Wilson, Klodian Zaimi and Nenad Živković

Frequent observations of identical onsets of large and small earthquakes pp. 112-116

Satoshi Ide

Information gerrymandering and undemocratic decisions pp. 117-121

Alexander J. Stewart, Mohsen Mosleh, Marina Diakonova, Antonio A. Arechar, David G. Rand and Joshua B. Plotkin

Fossil insect eyes shed light on trilobite optics and the arthropod pigment screen pp. 122-125

Johan Lindgren, Dan-Eric Nilsson, Peter Sjövall, Martin Jarenmark, Shosuke Ito, Kazumasa Wakamatsu, Benjamin P. Kear, Bo Pagh Schultz, René Lyng Sylvestersen, Henrik Madsen, James R. LaFountain, Carl Alwmark, Mats E. Eriksson, Stephen A. Hall, Paula Lindgren, Irene Rodríguez-Meizoso and Per Ahlberg

Natural selection on the Arabidopsis thaliana genome in present and future climates pp. 126-129

Moises Exposito-Alonso, Hernán A. Burbano, Oliver Bossdorf, Rasmus Nielsen and Detlef Weigel

Niche stiffness underlies the ageing of central nervous system progenitor cells pp. 130-134

Michael Segel, Björn Neumann, Myfanwy F. E. Hill, Isabell P. Weber, Carlo Viscomi, Chao Zhao, Adam Young, Chibeza C. Agley, Amelia J. Thompson, Ginez A. Gonzalez, Amar Sharma, Staffan Holmqvist, David H. Rowitch, Kristian Franze, Robin J. M. Franklin and Kevin J. Chalut

The flight response impairs cytoprotective mechanisms by activating the insulin pathway pp. 135-138

María José De Rosa, Tania Veuthey, Jeremy Florman, Jeff Grant, María Gabriela Blanco, Natalia Andersen, Jamie Donnelly, Diego Rayes and Mark J. Alkema

Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation pp. 139-143

Jixiao Niu, Yang Sun, Baoen Chen, Baohui Zheng, Gopala K. Jarugumilli, Sarah R. Walker, Aaron N. Hata, Mari Mino-Kenudson, David A. Frank and Xu Wu

DEAD-box ATPases are global regulators of phase-separated organelles pp. 144-148

Maria Hondele, Ruchika Sachdev, Stephanie Heinrich, Juan Wang, Pascal Vallotton, Beatriz M. A. Fontoura and Karsten Weis

Workflow systems turn raw data into scientific knowledge pp. 149-150

Jeffrey M. Perkel

A project-management tool from the tech industry could benefit your lab pp. 151-153

David Adam

Six project-management tips for your PhD pp. 153-153

Angel Santiago-Lopez

What must remain pp. 156-156

Thomas Broderick