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2014, volume 508, articles 7497

Iran needs to present a united front on science pp. 433-433

Elise Auerbach

Tamiflu report comes under fire pp. 439-440

Declan Butler

Chile quake defies expectations pp. 440-441

Alexandra Witze

Quantum communications leap out of the lab pp. 441-442

Jane Qiu

RNA interference rebooted pp. 443-443

Erika Check Hayden

Climate-change adaptation: Designer reefs pp. 444-446

Amanda Mascarelli

Renewable energy: Biofuels heat up pp. 448-449

Kim Krieger

Medical genomics: Gather and use genetic data in health care pp. 451-453

Geoffrey Ginsburg

Natural history: A scientist's eye pp. 454-455

Linda Lear

Medicine: The commodified body pp. 456-457

Scott Carney

Climate science: Stratospheric folly pp. 457-457

Tim Kruger

US sanctions put research at risk pp. 458-458

Konstantin Severinov

Ecology must seek universal principles pp. 458-458

John Harte

Mental health: More than neurobiology pp. 458-458

Eiko Fried, Francis Tuerlinckx and Denny Borsboom

Mental health: Drug search on risky path pp. 458-458

Douglas Kell

Restore public trust in care.data project pp. 458-458

Colin Mitchell, Linda Briceno Moraia and Jane Kaye

Catalysis at the boundaries pp. 460-461

Aaron M. Appel

Do you hear what I see? pp. 461-462

Ione Fine

Nibbled to death pp. 462-463

Nancy Guillén

The vital Y chromosome pp. 463-464

Andrew G. Clark

Sea levels from ancient seashells pp. 465-466

Ralph Schneider

Sperm protein finds its mate pp. 466-467

Paul M. Wassarman

Guidelines for investigating causality of sequence variants in human disease pp. 469-476

D. G. MacArthur, T. A. Manolio, D. P. Dimmock, H. L. Rehm, J. Shendure, G. R. Abecasis, D. R. Adams, R. B. Altman, S. E. Antonarakis, E. A. Ashley, J. C. Barrett, L. G. Biesecker, D. F. Conrad, G. M. Cooper, N. J. Cox, M. J. Daly, M. B. Gerstein, D. B. Goldstein, J. N. Hirschhorn, S. M. Leal, L. A. Pennacchio, J. A. Stamatoyannopoulos, S. R. Sunyaev, D. Valle, B. F. Voight, W. Winckler and C. Gunter

Sea-level and deep-sea-temperature variability over the past 5.3 million years pp. 477-482

E. J. Rohling, G. L. Foster, K. M. Grant, G. Marino, A. P. Roberts, M. E. Tamisiea and F. Williams

Juno is the egg Izumo receptor and is essential for mammalian fertilization pp. 483-487

Enrica Bianchi, Brendan Doe, David Goulding and Gavin J. Wright

Origins and functional evolution of Y chromosomes across mammals pp. 488-493

Diego Cortez, Ray Marin, Deborah Toledo-Flores, Laure Froidevaux, Angélica Liechti, Paul D. Waters, Frank Grützner and Henrik Kaessmann

Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators pp. 494-499

Daniel W. Bellott, Jennifer F. Hughes, Helen Skaletsky, Laura G. Brown, Tatyana Pyntikova, Ting-Jan Cho, Natalia Koutseva, Sara Zaghlul, Tina Graves, Susie Rock, Colin Kremitzki, Robert S. Fulton, Shannon Dugan, Yan Ding, Donna Morton, Ziad Khan, Lora Lewis, Christian Buhay, Qiaoyan Wang, Jennifer Watt, Michael Holder, Sandy Lee, Lynne Nazareth, Jessica Alföldi, Steve Rozen, Donna M. Muzny, Wesley C. Warren, Richard A. Gibbs, Richard K. Wilson and David C. Page

Superconducting quantum circuits at the surface code threshold for fault tolerance pp. 500-503

R. Barends, J. Kelly, A. Megrant, A. Veitia, D. Sank, E. Jeffrey, T. C. White, J. Mutus, A. G. Fowler, B. Campbell, Y. Chen, Z. Chen, B. Chiaro, A. Dunsworth, C. Neill, P. O’Malley, P. Roushan, A. Vainsencher, J. Wenner, A. N. Korotkov, A. N. Cleland and John M. Martinis

Electroreduction of carbon monoxide to liquid fuel on oxide-derived nanocrystalline copper pp. 504-507

Christina W. Li, Jim Ciston and Matthew W. Kanan

Hybrid shallow on-axis and deep off-axis hydrothermal circulation at fast-spreading ridges pp. 508-512

Jörg Hasenclever, Sonja Theissen-Krah, Lars H. Rüpke, Jason P. Morgan, Karthik Iyer, Sven Petersen and Colin W. Devey

Plate tectonics, damage and inheritance pp. 513-516

David Bercovici and Yanick Ricard

Herbivores and nutrients control grassland plant diversity via light limitation pp. 517-520

Elizabeth T. Borer, Eric W. Seabloom, Daniel S. Gruner, W. Stanley Harpole, Helmut Hillebrand, Eric M. Lind, Peter B. Adler, Juan Alberti, T. Michael Anderson, Jonathan D. Bakker, Lori Biederman, Dana Blumenthal, Cynthia S. Brown, Lars A. Brudvig, Yvonne M. Buckley, Marc Cadotte, Chengjin Chu, Elsa E. Cleland, Michael J. Crawley, Pedro Daleo, Ellen I. Damschen, Kendi F. Davies, Nicole M. DeCrappeo, Guozhen Du, Jennifer Firn, Yann Hautier, Robert W. Heckman, Andy Hector, Janneke HilleRisLambers, Oscar Iribarne, Julia A. Klein, Johannes M. H. Knops, Kimberly J. La Pierre, Andrew D. B. Leakey, Wei Li, Andrew S. MacDougall, Rebecca L. McCulley, Brett A. Melbourne, Charles E. Mitchell, Joslin L. Moore, Brent Mortensen, Lydia R. O'Halloran, John L. Orrock, Jesús Pascual, Suzanne M. Prober, David A. Pyke, Anita C. Risch, Martin Schuetz, Melinda D. Smith, Carly J. Stevens, Lauren L. Sullivan, Ryan J. Williams, Peter D. Wragg, Justin P. Wright and Louie H. Yang

Eutrophication weakens stabilizing effects of diversity in natural grasslands pp. 521-525

Yann Hautier, Eric W. Seabloom, Elizabeth T. Borer, Peter B. Adler, W. Stanley Harpole, Helmut Hillebrand, Eric M. Lind, Andrew S. MacDougall, Carly J. Stevens, Jonathan D. Bakker, Yvonne M. Buckley, Chengjin Chu, Scott L. Collins, Pedro Daleo, Ellen I. Damschen, Kendi F. Davies, Philip A. Fay, Jennifer Firn, Daniel S. Gruner, Virginia L. Jin, Julia A. Klein, Johannes M. H. Knops, Kimberly J. La Pierre, Wei Li, Rebecca L. McCulley, Brett A. Melbourne, Joslin L. Moore, Lydia R. O’Halloran, Suzanne M. Prober, Anita C. Risch, Mahesh Sankaran, Martin Schuetz and Andy Hector

Trogocytosis by Entamoeba histolytica contributes to cell killing and tissue invasion pp. 526-530

Katherine S. Ralston, Michael D. Solga, Nicole M. Mackey-Lawrence, Somlata, Alok Bhattacharya and William A. Petri

Inhibition of miR-25 improves cardiac contractility in the failing heart pp. 531-535

Christine Wahlquist, Dongtak Jeong, Agustin Rojas-Muñoz, Changwon Kho, Ahyoung Lee, Shinichi Mitsuyama, Alain van Mil, Woo Jin Park, Joost P. G. Sluijter, Pieter A. F. Doevendans, Roger J. Hajjar and Mark Mercola

Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation pp. 536-540

Yoshiki Omatsu, Masanari Seike, Tatsuki Sugiyama, Tsutomu Kume and Takashi Nagasawa

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus pp. 541-545

Pengda Liu, Michael Begley, Wojciech Michowski, Hiroyuki Inuzuka, Miriam Ginzberg, Daming Gao, Peiling Tsou, Wenjian Gan, Antonella Papa, Byeong Mo Kim, Lixin Wan, Amrik Singh, Bo Zhai, Min Yuan, Zhiwei Wang, Steven P. Gygi, Tae Ho Lee, Kun-Ping Lu, Alex Toker, Pier Paolo Pandolfi, John M. Asara, Marc W. Kirschner, Piotr Sicinski, Lewis Cantley and Wenyi Wei

Nectar secretion requires sucrose phosphate synthases and the sugar transporter SWEET9 pp. 546-549

I Winnie Lin, Davide Sosso, Li-Qing Chen, Klaus Gase, Sang-Gyu Kim, Danny Kessler, Peter M. Klinkenberg, Molly K. Gorder, Bi-Huei Hou, Xiao-Qing Qu, Clay J. Carter, Ian T. Baldwin and Wolf B. Frommer

Structure of a type IV secretion system pp. 550-553

Harry H. Low, Francesca Gubellini, Angel Rivera-Calzada, Nathalie Braun, Sarah Connery, Annick Dujeancourt, Fang Lu, Adam Redzej, Rémi Fronzes, Elena V. Orlova and Gabriel Waksman

Correction: Corrigendum: Rapid remobilization of magmatic crystals kept in cold storage pp. 554-554

Kari M. Cooper and Adam J. R. Kent

Correction: Corrigendum: C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma pp. 554-554

Matthew Parker, Kumarasamypet M. Mohankumar, Chandanamali Punchihewa, Ricardo Weinlich, James D. Dalton, Yongjin Li, Ryan Lee, Ruth G. Tatevossian, Timothy N. Phoenix, Radhika Thiruvenkatam, Elsie White, Bo Tang, Wilda Orisme, Kirti Gupta, Michael Rusch, Xiang Chen, Yuxin Li, Panduka Nagahawhatte, Erin Hedlund, David Finkelstein, Gang Wu, Sheila Shurtleff, John Easton, Kristy Boggs, Donald Yergeau, Bhavin Vadodaria, Heather L. Mulder, Jared Becksfort, Pankaj Gupta, Robert Huether, Jing Ma, Guangchun Song, Amar Gajjar, Thomas Merchant, Frederick Boop, Amy A. Smith, Li Ding, Charles Lu, Kerri Ochoa, David Zhao, Robert S. Fulton, Lucinda L. Fulton, Elaine R. Mardis, Richard K. Wilson, James R. Downing, Douglas R. Green, Jinghui Zhang, David W. Ellison and Richard J. Gilbertson

Grants: Funder storm pp. 555-556

Helen Shen

Turning point: Andrew Zwicker pp. 557-557

Virginia Gewin

Pop-ups pp. 560-560

Robert Dawson

2014, volume 508, articles 7496

Obesity pp. S49-S49

Tony Scully

Public health: Society at large pp. S50-S51

Tony Scully

Cell physiology: The changing colour of fat pp. S52-S53

Brian Owens

Treatment: Marginal gains pp. S54-S56

Emily Anthes

Perspective: Obesity is not a disease pp. S57-S57

D. L. Katz

Heritability: The family roots of obesity pp. S58-S60

Cassandra Willyard

Microbiome: A complicated relationship status pp. S61-S63

Sarah Deweerdt

Neuroscience: Dissecting appetite pp. S64-S65

Bijal P. Trivedi

Perspective: Tricks of the trade pp. S66-S66

Stephen J. Simpson and David Raubenheimer

Beware of backroom deals in the name of 'science' pp. 289-289

Colin Macilwain

Hepatitis C drugs not reaching poor pp. 295-296

Ewen Callaway

Sperm RNA carries marks of trauma pp. 296-297

Virginia Hughes

Panel homes in on sites for γ-ray detector pp. 297-297

Elizabeth Gibney

IPCC report under fire pp. 298-298

Quirin Schiermeier

Biologist defiant over stem-cell method pp. 299-299

David Cyranoski

Mini satellites prove their scientific power pp. 300-301

Nicola Jones

Power from the oceans: Blue energy pp. 302-304

Jeff Tollefson

Toxicology: The plastics puzzle pp. 306-308

Josie Glausiusz

Policy: Bring sustainable energy to the developing world pp. 309-311

Reid Detchon and Richenda Van Leeuwen

Publishing: Credit where credit is due pp. 312-313

Liz Allen, Jo Scott, Amy Brand, Marjorie Hlava and Micah Altman

Astronomy: Art of the eclipse pp. 314-315

Jay M. Pasachoff and Roberta J. M. Olson

Geology: Parsing eruptions pp. 316-317

Ted Nield

Animal behaviour: Nomads of necessity pp. 317-318

Joel Greenberg

Books in brief pp. 318-318

Barbara Kiser

China leads the way on renewables pp. 319-319

John A. Mathews and Hao Tan

Vanadium batteries will be cost-effective pp. 319-319

Huamin Zhang

A trading scheme to reduce false results pp. 319-319

Michael E. McCullough and David Kelly

Mouse already being charted gene by gene pp. 319-319

Steve Brown

Experimentation is science's lifeblood pp. 319-319

John Skoyles

Dating chimpanzees pp. 322-323

Michael Haslam

Up and down in Down's syndrome pp. 323-324

Benjamin D. Pope and David M. Gilbert

Catalysis marches on pp. 324-325

James P. Morken

Biocircuits in synchrony pp. 326-327

Ricard Solé and Javier Macía

The ugly duckling pp. 327-328

Joseph P. Heremans

The stressful influence of microbes pp. 328-329

Suzanne Wolff and Andrew Dillin

The ensemble nature of allostery pp. 331-339

Hesam N. Motlagh, James O. Wrabl, Jing Li and Vincent J. Hilser

Enantioselective construction of remote quaternary stereocentres pp. 340-344

Tian-Sheng Mei, Harshkumar H. Patel and Matthew S. Sigman

Domains of genome-wide gene expression dysregulation in Down’s syndrome pp. 345-350

Audrey Letourneau, Federico A. Santoni, Ximena Bonilla, M. Reza Sailani, David Gonzalez, Jop Kind, Claire Chevalier, Robert Thurman, Richard S. Sandstrom, Youssef Hibaoui, Marco Garieri, Konstantin Popadin, Emilie Falconnet, Maryline Gagnebin, Corinne Gehrig, Anne Vannier, Michel Guipponi, Laurent Farinelli, Daniel Robyr, Eugenia Migliavacca, Christelle Borel, Samuel Deutsch, Anis Feki, John A. Stamatoyannopoulos, Yann Herault, Bas van Steensel, Roderic Guigo and Stylianos E. Antonarakis

Brainstem nucleus MdV mediates skilled forelimb motor tasks pp. 351-356

Maria Soledad Esposito, Paolo Capelli and Silvia Arber

Skilled reaching relies on a V2a propriospinal internal copy circuit pp. 357-363

Eiman Azim, Juan Jiang, Bror Alstermark and Thomas M. Jessell

Isotopic links between atmospheric chemistry and the deep sulphur cycle on Mars pp. 364-368

Heather B. Franz, Sang-Tae Kim, James Farquhar, James M. D. Day, Rita C. Economos, Kevin D. McKeegan, Axel K. Schmitt, Anthony J. Irving, Joost Hoek and James Dottin

Coherent suppression of electromagnetic dissipation due to superconducting quasiparticles pp. 369-372

Ioan M. Pop, Kurtis Geerlings, Gianluigi Catelani, Robert J. Schoelkopf, Leonid I. Glazman and Michel H. Devoret

Ultralow thermal conductivity and high thermoelectric figure of merit in SnSe crystals pp. 373-377

Li-Dong Zhao, Shih-Han Lo, Yongsheng Zhang, Hui Sun, Gangjian Tan, Ctirad Uher, C. Wolverton, Vinayak P. Dravid and Mercouri G. Kanatzidis

Mid-latitude interhemispheric hydrologic seesaw over the past 550,000 years pp. 378-382

Kyoung-nam Jo, Kyung Sik Woo, Sangheon Yi, Dong Yoon Yang, Hyoun Soo Lim, Yongjin Wang, Hai Cheng and R. Lawrence Edwards

A new fossil species supports an early origin for toothed whale echolocation pp. 383-386

Jonathan H. Geisler, Matthew W. Colbert and James L. Carew

Rapid and tunable post-translational coupling of genetic circuits pp. 387-391

Arthur Prindle, Jangir Selimkhanov, Howard Li, Ivan Razinkov, Lev S. Tsimring and Jeff Hasty

Apical constriction drives tissue-scale hydrodynamic flow to mediate cell elongation pp. 392-396

Bing He, Konstantin Doubrovinski, Oleg Polyakov and Eric Wieschaus

A committed precursor to innate lymphoid cells pp. 397-401

Michael G. Constantinides, Benjamin D. McDonald, Philip A. Verhoef and Albert Bendelac

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430 pp. 402-405

Travis K. Warren, Jay Wells, Rekha G. Panchal, Kelly S. Stuthman, Nicole L. Garza, Sean A. Van Tongeren, Lian Dong, Cary J. Retterer, Brett P. Eaton, Gianluca Pegoraro, Shelley Honnold, Shanta Bantia, Pravin Kotian, Xilin Chen, Brian R. Taubenheim, Lisa S. Welch, Dena M. Minning, Yarlagadda S. Babu, William P. Sheridan and Sina Bavari

Caenorhabditis elegans pathways that surveil and defend mitochondria pp. 406-410

Ying Liu, Buck S. Samuel, Peter C. Breen and Gary Ruvkun

miRNAs trigger widespread epigenetically activated siRNAs from transposons in Arabidopsis pp. 411-415

Kate M. Creasey, Jixian Zhai, Filipe Borges, Frederic Van Ex, Michael Regulski, Blake C. Meyers and Robert A. Martienssen

Structural basis for translocation by AddAB helicase–nuclease and its arrest at χ sites pp. 416-419

Wojciech W. Krajewski, Xin Fu, Martin Wilkinson, Nora B. Cronin, Mark S. Dillingham and Dale B. Wigley

Correction: Corrigendum: Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling pp. 420-420

Wentian Yang, Jianguo Wang, Douglas C. Moore, Haipei Liang, Mark Dooner, Qian Wu, Richard Terek, Qian Chen, Michael G. Ehrlich, Peter J. Quesenberry and Benjamin G. Neel

Correction: Corrigendum: Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia pp. 420-420

Liran I. Shlush, Sasan Zandi, Amanda Mitchell, Weihsu Claire Chen, Joseph M. Brandwein, Vikas Gupta, James A. Kennedy, Aaron D. Schimmer, Andre C. Schuh, Karen W. Yee, Jessica L. McLeod, Monica Doedens, Jessie J. F. Medeiros, Rene Marke, Hyeoung Joon Kim, Kwon Lee, John D. McPherson, Thomas J. Hudson, The HALT Pan-Leukemia Gene Panel Consortium, Andrew M. K. Brown, Fouad Yousif, Quang M. Trinh, Lincoln D. Stein, Mark D. Minden, Jean C. Y. Wang and John E. Dick

Correction: Corrigendum: Regulatory evolution through divergence of a phosphoswitch in the transcription factor CEBPB pp. 420-420

Vincent J. Lynch, Gemma May and Günter P. Wagner

Tactical tenure manoeuvres pp. 421-423

Virginia Gewin

Turning point: Joel Elmquist pp. 423-423

Paul Smaglik

The vermilion market pp. 426-426

Preston Grassmann

2014, volume 508, articles 7495

Society needs more than wonder to respect science pp. 151-151

Susan Watts

NIH stem-cell programme closes pp. 157-157

Sara Reardon

Metabolic quirks yield tumour hope pp. 158-159

Heidi Ledford

E-cigarettes affect cells pp. 159-159

Daniel Cressey

Earth observation enters next phase pp. 160-161

Declan Butler

Funders punish open-access dodgers pp. 161-161

Richard Van Noorden

Western science severs ties with Russia pp. 162-162

Quirin Schiermeier

Time running out for rarest primate pp. 163-163

Daniel Cressey

Floods: Holding back the tide pp. 164-166

Quirin Schiermeier

Biomarkers and ageing: The clock-watcher pp. 168-170

W. Wayt Gibbs

Climate policy: Streamline IPCC reports pp. 171-173

David Griggs

Global warming: Improve economic models of climate change pp. 173-175

Richard L. Revesz, Peter H. Howard, Kenneth Arrow, Lawrence H. Goulder, Robert Kopp, Michael A. Livermore, Michael Oppenheimer and Thomas Sterner

Biotechnology: Recombinant gold pp. 176-177

Nathaniel Comfort

Ecology: Wilson in Africa pp. 178-179

Stuart Pimm

Climate Economics: A strained relationship pp. 179-180

Scott Barrett

Medicine: Outside the fold pp. 180-181

Giovanna Mallucci

Drugs: Gut response pp. 182-183

Maryn McKenna

Education: Digital lessons learned pp. 183-184

Robert A. Lue

New in paperback pp. 185-185

Emily Banham

Energy: The new oil era pp. 185-185

Chris Nelder

Growing time lag threatens Nobels pp. 186-186

Santo Fortunato

Livestock: tackle demand and yields pp. 186-186

Erasmus K. H. J. zu Ermgassen, David R. Williams and Andrew Balmford

Livestock: limit red meat consumption pp. 186-186

Brian Machovina and Kenneth J. Feeley

Zoo visits boost biodiversity literacy pp. 186-186

Andrew Moss, Eric Jensen and Markus Gusset

A protein that spells trouble pp. 186-186

David Boone

Alejandro Zaffaroni (1923–2014) pp. 187-187

Jane E. Shaw

Cracking up on asteroids pp. 190-191

Heather A. Viles

Damage prevention targeted pp. 191-192

Dan Dominissini and Chuan He

Africa's greenhouse-gas budget is in the red pp. 192-193

Cheikh Mbow

Targeting a fat-accumulation gene pp. 194-195

Charles Brenner

A strong hybrid couple pp. 195-196

Luming Duan

The purple heart of photosynthesis pp. 196-197

Richard J. Cogdell and Aleksander W. Roszak

Transcriptional landscape of the prenatal human brain pp. 199-206

Jeremy A. Miller, Song-Lin Ding, Susan M. Sunkin, Kimberly A. Smith, Lydia Ng, Aaron Szafer, Amanda Ebbert, Zackery L. Riley, Joshua J. Royall, Kaylynn Aiona, James M. Arnold, Crissa Bennet, Darren Bertagnolli, Krissy Brouner, Stephanie Butler, Shiella Caldejon, Anita Carey, Christine Cuhaciyan, Rachel A. Dalley, Nick Dee, Tim A. Dolbeare, Benjamin A. C. Facer, David Feng, Tim P. Fliss, Garrett Gee, Jeff Goldy, Lindsey Gourley, Benjamin W. Gregor, Guangyu Gu, Robert E. Howard, Jayson M. Jochim, Chihchau L. Kuan, Christopher Lau, Chang-Kyu Lee, Felix Lee, Tracy A. Lemon, Phil Lesnar, Bergen McMurray, Naveed Mastan, Nerick Mosqueda, Theresa Naluai-Cecchini, Nhan-Kiet Ngo, Julie Nyhus, Aaron Oldre, Eric Olson, Jody Parente, Patrick D. Parker, Sheana E. Parry, Allison Stevens, Mihovil Pletikos, Melissa Reding, Kate Roll, David Sandman, Melaine Sarreal, Sheila Shapouri, Nadiya V. Shapovalova, Elaine H. Shen, Nathan Sjoquist, Clifford R. Slaughterbeck, Michael Smith, Andy J. Sodt, Derric Williams, Lilla Zöllei, Bruce Fischl, Mark B. Gerstein, Daniel H. Geschwind, Ian A. Glass, Michael J. Hawrylycz, Robert F. Hevner, Hao Huang, Allan R. Jones, James A. Knowles, Pat Levitt, John W. Phillips, Nenad Šestan, Paul Wohnoutka, Chinh Dang, Amy Bernard, John G. Hohmann and Ed S. Lein

A mesoscale connectome of the mouse brain pp. 207-214

Seung Wook Oh, Julie A. Harris, Lydia Ng, Brent Winslow, Nicholas Cain, Stefan Mihalas, Quanxin Wang, Chris Lau, Leonard Kuan, Alex M. Henry, Marty T. Mortrud, Benjamin Ouellette, Thuc Nghi Nguyen, Staci A. Sorensen, Clifford R. Slaughterbeck, Wayne Wakeman, Yang Li, David Feng, Anh Ho, Eric Nicholas, Karla E. Hirokawa, Phillip Bohn, Kevin M. Joines, Hanchuan Peng, Michael J. Hawrylycz, John W. Phillips, John G. Hohmann, Paul Wohnoutka, Charles R. Gerfen, Christof Koch, Amy Bernard, Chinh Dang, Allan R. Jones and Hongkui Zeng

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool pp. 215-221

Helge Gad, Tobias Koolmeister, Ann-Sofie Jemth, Saeed Eshtad, Sylvain A. Jacques, Cecilia E. Ström, Linda M. Svensson, Niklas Schultz, Thomas Lundbäck, Berglind Osk Einarsdottir, Aljona Saleh, Camilla Göktürk, Pawel Baranczewski, Richard Svensson, Ronnie P.-A. Berntsson, Robert Gustafsson, Kia Strömberg, Kumar Sanjiv, Marie-Caroline Jacques-Cordonnier, Matthieu Desroses, Anna-Lena Gustavsson, Roger Olofsson, Fredrik Johansson, Evert J. Homan, Olga Loseva, Lars Bräutigam, Lars Johansson, Andreas Höglund, Anna Hagenkort, Therese Pham, Mikael Altun, Fabienne Z. Gaugaz, Svante Vikingsson, Bastiaan Evers, Martin Henriksson, Karl S. A. Vallin, Olov A. Wallner, Lars G. J. Hammarström, Elisee Wiita, Ingrid Almlöf, Christina Kalderén, Hanna Axelsson, Tatjana Djureinovic, Jordi Carreras Puigvert, Maria Häggblad, Fredrik Jeppsson, Ulf Martens, Cecilia Lundin, Bo Lundgren, Ingrid Granelli, Annika Jenmalm Jensen, Per Artursson, Jonas A. Nilsson, Pål Stenmark, Martin Scobie, Ulrika Warpman Berglund and Thomas Helleday

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy pp. 222-227

Kilian V. M. Huber, Eidarus Salah, Branka Radic, Manuela Gridling, Jonathan M. Elkins, Alexey Stukalov, Ann-Sofie Jemth, Camilla Göktürk, Kumar Sanjiv, Kia Strömberg, Therese Pham, Ulrika Warpman Berglund, Jacques Colinge, Keiryn L. Bennett, Joanna I. Loizou, Thomas Helleday, Stefan Knapp and Giulio Superti-Furga

Structure of the LH1–RC complex from Thermochromatium tepidum at 3.0 Å pp. 228-232

Satomi Niwa, Long-Jiang Yu, Kazuki Takeda, Yu Hirano, Tomoaki Kawakami, Zheng-Yu Wang-Otomo and Kunio Miki

Thermal fatigue as the origin of regolith on small asteroids pp. 233-236

Marco Delbo, Guy Libourel, Justin Wilkerson, Naomi Murdoch, Patrick Michel, K. T. Ramesh, Clément Ganino, Chrystele Verati and Simone Marchi

A quantum gate between a flying optical photon and a single trapped atom pp. 237-240

Andreas Reiserer, Norbert Kalb, Gerhard Rempe and Stephan Ritter

Nanophotonic quantum phase switch with a single atom pp. 241-244

T. G. Tiecke, J. D. Thompson, N. P. de Leon, L. R. Liu, V. Vuletić and M. D. Lukin

Dynamics of continental accretion pp. 245-248

L. Moresi, P. G. Betts, M. S. Miller and R. A. Cayley

RETRACTED ARTICLE: Detection and replication of epistasis influencing transcription in humans pp. 249-253

Gibran Hemani, Konstantin Shakhbazov, Harm-Jan Westra, Tonu Esko, Anjali K. Henders, Allan F. McRae, Jian Yang, Greg Gibson, Nicholas G. Martin, Andres Metspalu, Lude Franke, Grant W. Montgomery, Peter M. Visscher and Joseph E. Powell

A synchronized global sweep of the internal genes of modern avian influenza virus pp. 254-257

Michael Worobey, Guan-Zhu Han and Andrew Rambaut

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity pp. 258-262

Daniel Kraus, Qin Yang, Dong Kong, Alexander S. Banks, Lin Zhang, Joseph T. Rodgers, Eija Pirinen, Thomas C. Pulinilkunnil, Fengying Gong, Ya-chin Wang, Yana Cen, Anthony A. Sauve, John M. Asara, Odile D. Peroni, Brett P. Monia, Sanjay Bhanot, Leena Alhonen, Pere Puigserver and Barbara B. Kahn

ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression pp. 263-268

Hong Wen, Yuanyuan Li, Yuanxin Xi, Shiming Jiang, Sabrina Stratton, Danni Peng, Kaori Tanaka, Yongfeng Ren, Zheng Xia, Jun Wu, Bing Li, Michelle C. Barton, Wei Li, Haitao Li and Xiaobing Shi

Direct measurement of local oxygen concentration in the bone marrow of live animals pp. 269-273

Joel A. Spencer, Francesca Ferraro, Emmanuel Roussakis, Alyssa Klein, Juwell Wu, Judith M. Runnels, Walid Zaher, Luke J. Mortensen, Clemens Alt, Raphaël Turcotte, Rushdia Yusuf, Daniel Côté, Sergei A. Vinogradov, David T. Scadden and Charles P. Lin

Correction: Corrigendum: Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice pp. 274-274

Maya Saleh, John C. Mathison, Melissa K. Wolinski, Steve J. Bensinger, Patrick Fitzgerald, Nathalie Droin, Richard J. Ulevitch, Douglas R. Green and Donald W. Nicholson

Retraction Note: CLASP-mediated cortical microtubule organization guides PIN polarization axis pp. 274-274

Klementina Kakar, Hongtao Zhang, Ben Scheres and Pankaj Dhonukshe

A guide for the innovator pp. 275-276

Peter Fiske

Turning point: Tracey Holloway pp. 277-277

Virginia Gewin

How Kameron Layas rode out the crash pp. 280-280

Rahul Kanakia

2014, volume 508, articles 7494

Interneuron subtypes and orientation tuning pp. E1-E2

Seung-Hee Lee, Alex C. Kwan and Yang Dan

Schizophrenia pp. S1-S1

Herb Brody

Aetiology: Searching for schizophrenia's roots pp. S2-S3

Emily Elert

El-Boustani et al. reply pp. E3-E4

Sami El-Boustani, Nathan R. Wilson, Caroline A. Runyan and Mriganka Sur

Atallah et al. reply pp. E3-E3

Bassam V. Atallah, Massimo Scanziani and Matteo Carandini

Language: Lost in translation pp. S4-S5

David Noonan

Genetics: Unravelling complexity pp. S6-S7

Jessica Wright

Drug development: The modelling challenge pp. S8-S9

Alla Katsnelson

Political borders should not hamper wildlife pp. 9-9

Aaron M. Ellison

Therapeutics: Negative feedback pp. S10-S11

Elie Dolgin

Prevention: Before the break pp. S12-S13

Michele Solis

Developing countries: The outcomes paradox pp. S14-S15

T. V. Padma

Ukraine’s science in turmoil pp. 15-16

Alison Abbott

Regulators adopt more orphan drugs pp. 16-17

Sara Reardon

Ageing: Live faster, die younger pp. S16-S17

Emily Anthes

Perspective: Retreat from the radical pp. S18-S18

Stephen R. Marder

ExoMars scientists narrow down landing sites pp. 19-20

Elizabeth Gibney

Perspective: Revealing molecular secrets pp. S20-S20

Steven E. Hyman

El Niño tests forecasters pp. 20-21

Jeff Tollefson

Epigenomics starts to make its mark pp. 22-22

Ewen Callaway

Cancer treatment: The killer within pp. 24-26

Heidi Ledford

Cosmology: Polar star pp. 28-30

Ron Cowen

Human evolution: Fifty years after Homo habilis pp. 31-33

Bernard Wood

Development: Mobilize citizens to track sustainability pp. 33-35

Angel Hsu, Omar Malik, Laura Johnson and Daniel C Esty

Policy: Free Indian science pp. 36-38

Mathai Joseph and Andrew Robinson

Tudor technology: Shakespeare and science pp. 39-40

Jennifer Rampling

Earth systems: No place like home pp. 41-42

Tim Lenton

Psychology: The clamorous mind pp. 42-43

Susanne Ahmari

Books in brief pp. 43-43

Barbara Kiser

ArXiv screens spot fake papers pp. 44-44

Paul Ginsparg

Free up systems for funding and advice pp. 44-44

Nicola Gaston

Journals must boost data sharing pp. 44-44

Timothy H. Vines

Projects powered by free computing grid pp. 44-44

Juan Hindo

Disabling defences in the brain pp. 46-47

Janine T. Erler

A is for immunity pp. 47-48

Gérard Eberl

Ring in the new pp. 48-49

Joseph A. Burns

Brain vessels squeezed to death pp. 50-51

Daniel M. Greif and Anne Eichmann

A chronometer for Earth's age pp. 51-52

John Chambers

Clonal cooperation pp. 52-53

Kornelia Polyak and Andriy Marusyk

Capillary pericytes regulate cerebral blood flow in health and disease pp. 55-60

Catherine N. Hall, Clare Reynell, Bodil Gesslein, Nicola B. Hamilton, Anusha Mishra, Brad A. Sutherland, Fergus M. O’Farrell, Alastair M. Buchan, Martin Lauritzen and David Attwell

Mechanism of Tc toxin action revealed in molecular detail pp. 61-65

Dominic Meusch, Christos Gatsogiannis, Rouslan G. Efremov, Alexander E. Lang, Oliver Hofnagel, Ingrid R. Vetter, Klaus Aktories and Stefan Raunser

Poly(A)-tail profiling reveals an embryonic switch in translational control pp. 66-71

Alexander O. Subtelny, Stephen W. Eichhorn, Grace R. Chen, Hazel Sive and David P. Bartel

A ring system detected around the Centaur (10199) Chariklo pp. 72-75

F. Braga-Ribas, B. Sicardy, J. L. Ortiz, C. Snodgrass, F. Roques, R. Vieira-Martins, J. I. B. Camargo, M. Assafin, R. Duffard, E. Jehin, J. Pollock, R. Leiva, M. Emilio, D. I. Machado, C. Colazo, E. Lellouch, J. Skottfelt, M. Gillon, N. Ligier, L. Maquet, G. Benedetti-Rossi, A. Ramos Gomes, P. Kervella, H. Monteiro, R. Sfair, M. El Moutamid, G. Tancredi, J. Spagnotto, A. Maury, N. Morales, R. Gil-Hutton, S. Roland, A. Ceretta, S.-h. Gu, X.-b. Wang, K. Harpsøe, M. Rabus, J. Manfroid, C. Opitom, L. Vanzi, L. Mehret, L. Lorenzini, E. M. Schneiter, R. Melia, J. Lecacheux, F. Colas, F. Vachier, T. Widemann, L. Almenares, R. G. Sandness, F. Char, V. Perez, P. Lemos, N. Martinez, U. G. Jørgensen, M. Dominik, F. Roig, D. E. Reichart, A. P. LaCluyze, J. B. Haislip, K. M. Ivarsen, J. P. Moore, N. R. Frank and D. G. Lambas

Efficient rotational cooling of Coulomb-crystallized molecular ions by a helium buffer gas pp. 76-79

A. K. Hansen, O. O. Versolato, Ł. Kłosowski, S. B. Kristensen, A. Gingell, M. Schwarz, A. Windberger, J. Ullrich, J. R. Crespo López-Urrutia and M. Drewsen

Coherent control of the waveforms of recoilless γ-ray photons pp. 80-83

Farit Vagizov, Vladimir Antonov, Y. V. Radeonychev, R. N. Shakhmuratov and Olga Kocharovskaya

Highly siderophile elements in Earth’s mantle as a clock for the Moon-forming impact pp. 84-87

Seth A. Jacobson, Alessandro Morbidelli, Sean N. Raymond, David P. O'Brien, Kevin J. Walsh and David C. Rubie

The hippocampal CA2 region is essential for social memory pp. 88-92

Frederick L. Hitti and Steven A. Siegelbaum

Mouse liver repopulation with hepatocytes generated from human fibroblasts pp. 93-97

Saiyong Zhu, Milad Rezvani, Jack Harbell, Aras N. Mattis, Alan R. Wolfe, Leslie Z. Benet, Holger Willenbring and Sheng Ding

Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia pp. 98-102

Yilong Li, Claire Schwab, Sarra L. Ryan, Elli Papaemmanuil, Hazel M. Robinson, Patricia Jacobs, Anthony V. Moorman, Sara Dyer, Julian Borrow, Mike Griffiths, Nyla A. Heerema, Andrew J. Carroll, Polly Talley, Nick Bown, Nick Telford, Fiona M. Ross, Lorraine Gaunt, Richard J. Q. McNally, Bryan D. Young, Paul Sinclair, Vikki Rand, Manuel R. Teixeira, Olivia Joseph, Ben Robinson, Mark Maddison, Nicole Dastugue, Peter Vandenberghe, Claudia Haferlach, Philip J. Stephens, Jiqiu Cheng, Peter Van Loo, Michael R. Stratton, Peter J. Campbell and Christine J. Harrison

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway pp. 103-107

Xi Chen, Dimitrios Iliopoulos, Qing Zhang, Qianzi Tang, Matthew B. Greenblatt, Maria Hatziapostolou, Elgene Lim, Wai Leong Tam, Min Ni, Yiwen Chen, Junhua Mai, Haifa Shen, Dorothy Z. Hu, Stanley Adoro, Bella Hu, Minkyung Song, Chen Tan, Melissa D. Landis, Mauro Ferrari, Sandra J. Shin, Myles Brown, Jenny C. Chang, X. Shirley Liu and Laurie H. Glimcher

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides pp. 108-112

Kıvanç Birsoy, Richard Possemato, Franziska K. Lorbeer, Erol C. Bayraktar, Prathapan Thiru, Burcu Yucel, Tim Wang, Walter W. Chen, Clary B. Clish and David M. Sabatini

Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers pp. 113-117

Allison S. Cleary, Travis L. Leonard, Shelley A. Gestl and Edward J. Gunther

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma pp. 118-122

Chong Sun, Liqin Wang, Sidong Huang, Guus J. J. E. Heynen, Anirudh Prahallad, Caroline Robert, John Haanen, Christian Blank, Jelle Wesseling, Stefan M. Willems, Davide Zecchin, Sebastijan Hobor, Prashanth K. Bajpe, Cor Lieftink, Christina Mateus, Stephan Vagner, Wipawadee Grernrum, Ingrid Hofland, Andreas Schlicker, Lodewyk F. A. Wessels, Roderick L. Beijersbergen, Alberto Bardelli, Federica Di Nicolantonio, Alexander M. M. Eggermont and Rene Bernards

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity pp. 123-127

Serge A. van de Pavert, Manuela Ferreira, Rita G. Domingues, Hélder Ribeiro, Rosalie Molenaar, Lara Moreira-Santos, Francisca F. Almeida, Sales Ibiza, Inês Barbosa, Gera Goverse, Carlos Labão-Almeida, Cristina Godinho-Silva, Tanja Konijn, Dennis Schooneman, Tom O’Toole, Mark R. Mizee, Yasmin Habani, Esther Haak, Fabio R. Santori, Dan R. Littman, Stefan Schulte-Merker, Elaine Dzierzak, J. Pedro Simas, Reina E. Mebius and Henrique Veiga-Fernandes

Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans pp. 128-132

En-Zhi Shen, Chun-Qing Song, Yuan Lin, Wen-Hong Zhang, Pei-Fang Su, Wen-Yuan Liu, Pan Zhang, Jiejia Xu, Na Lin, Cheng Zhan, Xianhua Wang, Yu Shyr, Heping Cheng and Meng-Qiu Dong

Sharp shooters pp. 133-138

Vivien Marx

Translational research: Cancer killers pp. 139-140

Rachel Bernstein

Turning point: Liping Qin pp. 141-141

Virginia Gewin