Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor

Shin Isogai, Xavier Deupi, Christian Opitz, Franziska M. Heydenreich, Ching-Ju Tsai, Florian Brueckner, Gebhard F. X. Schertler (), Dmitry B. Veprintsev () and Stephan Grzesiek ()
Additional contact information
Shin Isogai: Focal Area Structural Biology and Biophysics, Biozentrum, University of Basel
Xavier Deupi: Paul Scherrer Institute
Christian Opitz: Focal Area Structural Biology and Biophysics, Biozentrum, University of Basel
Franziska M. Heydenreich: Paul Scherrer Institute
Ching-Ju Tsai: Paul Scherrer Institute
Florian Brueckner: Paul Scherrer Institute
Gebhard F. X. Schertler: Paul Scherrer Institute
Dmitry B. Veprintsev: Paul Scherrer Institute
Stephan Grzesiek: Focal Area Structural Biology and Biophysics, Biozentrum, University of Basel

Nature, 2016, vol. 530, issue 7589, 237-241

Abstract: Although several X-ray crystal structures of G protein-coupled receptors (GPCRs) have been reported, relatively little is known about the conformational dynamics of these important membrane proteins; here, the authors used NMR spectroscopy to monitor the conformational changes that occur in the turkey β1-adrenergic receptor in the presence of antagonists, partial agonists, and full agonists.

Date: 2016
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DOI: 10.1038/nature16577

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