Structure- and function-based design of Plasmodium-selective proteasome inhibitors

Hao Li, Anthony J. O’Donoghue, Wouter A. van der Linden, Stanley C. Xie, Euna Yoo, Ian T. Foe, Leann Tilley, Charles S. Craik, Paula C. A. da Fonseca () and Matthew Bogyo ()
Additional contact information
Hao Li: Stanford University School of Medicine
Anthony J. O’Donoghue: University of California San Francisco
Wouter A. van der Linden: Stanford University School of Medicine
Stanley C. Xie: Bio21 Institute, University of Melbourne
Euna Yoo: Stanford University School of Medicine
Ian T. Foe: Stanford University School of Medicine
Leann Tilley: Bio21 Institute, University of Melbourne
Charles S. Craik: University of California San Francisco
Paula C. A. da Fonseca: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus
Matthew Bogyo: Stanford University School of Medicine

Nature, 2016, vol. 530, issue 7589, 233-236

Abstract: Structural and functional characterizations show that the specificity of the Plasmodium falciparum proteasome is sufficiently unique from that of the human proteasome to allow selective targeting with inhibitors.

Date: 2016
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DOI: 10.1038/nature16936

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