Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche

James Y. Chen, Masanori Miyanishi (), Sean K. Wang, Satoshi Yamazaki, Rahul Sinha, Kevin S. Kao, Jun Seita, Debashis Sahoo, Hiromitsu Nakauchi and Irving L. Weissman ()
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James Y. Chen: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Masanori Miyanishi: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Sean K. Wang: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Satoshi Yamazaki: Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo
Rahul Sinha: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Kevin S. Kao: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Jun Seita: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Debashis Sahoo: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Hiromitsu Nakauchi: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Irving L. Weissman: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine

Nature, 2016, vol. 530, issue 7589, 223-227

Abstract: Until recently, complex multi-parameters were required for the isolation and identification of haematopoietic stem cells, complicating study of their biology in situ; here the authors have found that expression of a single gene, Hoxb5, defines haematopoietic stem cells with long-term reconstitution capacity, and that these cells are mainly found in direct contact with endothelial cells.

Date: 2016
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DOI: 10.1038/nature16943

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