Adult restoration of Shank3 expression rescues selective autistic-like phenotypes

Yuan Mei, Patricia Monteiro, Yang Zhou, Jin-Ah Kim, Xian Gao, Zhanyan Fu and Guoping Feng ()
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Yuan Mei: McGovern Institute for Brain Research, Massachusetts Institute of Technology
Patricia Monteiro: McGovern Institute for Brain Research, Massachusetts Institute of Technology
Yang Zhou: McGovern Institute for Brain Research, Massachusetts Institute of Technology
Jin-Ah Kim: McGovern Institute for Brain Research, Massachusetts Institute of Technology
Xian Gao: McGovern Institute for Brain Research, Massachusetts Institute of Technology
Zhanyan Fu: McGovern Institute for Brain Research, Massachusetts Institute of Technology
Guoping Feng: McGovern Institute for Brain Research, Massachusetts Institute of Technology

Nature, 2016, vol. 530, issue 7591, 481-484

Abstract: Re-expression of the Shank3 gene in adult mice results in improvements in synaptic protein composition and spine density in the striatum; Shank3 also rescues autism-like features such as social interaction and grooming behaviour, and the results suggest that aspects of autism spectrum disorders may be reversible in adulthood.

Date: 2016
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DOI: 10.1038/nature16971

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