NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

Yuan He, Melody Y. Zeng, Dahai Yang, Benny Motro and Gabriel Núñez ()
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Yuan He: University of Michigan Medical School
Melody Y. Zeng: University of Michigan Medical School
Dahai Yang: University of Michigan Medical School
Benny Motro: The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University
Gabriel Núñez: University of Michigan Medical School

Nature, 2016, vol. 530, issue 7590, 354-357

Abstract: NEK7, a member of the NIMA-related kinase family, is identified as a regulator of NLRP3 inflammasome oligomerization and activation; NEK7 functions downstream of potassium efflux in a manner that is independent of its kinase activity.

Date: 2016
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DOI: 10.1038/nature16959

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