An essential receptor for adeno-associated virus infection

S. Pillay, N. L. Meyer, A. S. Puschnik, O. Davulcu, J. Diep, Y. Ishikawa, L. T. Jae, J. E. Wosen, C. M. Nagamine, M. S. Chapman () and J. E. Carette ()
Additional contact information
S. Pillay: Stanford University School of Medicine
N. L. Meyer: School of Medicine, Oregon Health & Science University
A. S. Puschnik: Stanford University School of Medicine
O. Davulcu: School of Medicine, Oregon Health & Science University
J. Diep: Stanford University School of Medicine
Y. Ishikawa: School of Medicine, Oregon Health & Science University
L. T. Jae: Netherlands Cancer Institute
J. E. Wosen: Stanford University School of Medicine
C. M. Nagamine: Stanford University School of Medicine
M. S. Chapman: School of Medicine, Oregon Health & Science University
J. E. Carette: Stanford University School of Medicine

Nature, 2016, vol. 530, issue 7588, 108-112

Abstract: An adeno-associated virus (AAV) receptor protein essential for AAV2 entry into cells is identified; AAV receptor binds directly to the virus, and its ablation renders a diverse range of mammalian cell types and mice resistant to infection by AAV of multiple serotypes.

Date: 2016
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DOI: 10.1038/nature16465

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