Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid

Christian Schläger, Henrike Körner, Martin Krueger, Stefano Vidoli, Michael Haberl, Dorothee Mielke, Elke Brylla, Thomas Issekutz, Carlos Cabañas, Peter J. Nelson, Tjalf Ziemssen, Veit Rohde, Ingo Bechmann, Dmitri Lodygin, Francesca Odoardi and Alexander Flügel ()
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Christian Schläger: Institute of Neuroimmunology, Institute for Multiple Sclerosis Research, University Medical Centre Göttingen
Henrike Körner: Institute of Neuroimmunology, Institute for Multiple Sclerosis Research, University Medical Centre Göttingen
Martin Krueger: Institute of Anatomy, University of Leipzig
Stefano Vidoli: University of Rome La Sapienza
Michael Haberl: Institute of Neuroimmunology, Institute for Multiple Sclerosis Research, University Medical Centre Göttingen
Dorothee Mielke: University Medical Centre Göttingen
Elke Brylla: Institute of Anatomy, University of Leipzig
Thomas Issekutz: Division of Immunology, Department of Pediatrics Dalhousie University
Carlos Cabañas: Centro de Biología Molecular Severo Ochoa
Peter J. Nelson: Medical Clinic and Policlinic IV, Ludwig-Maximilians-University of Munich
Tjalf Ziemssen: University Hospital
Veit Rohde: University Medical Centre Göttingen
Ingo Bechmann: Institute of Anatomy, University of Leipzig
Dmitri Lodygin: Institute of Neuroimmunology, Institute for Multiple Sclerosis Research, University Medical Centre Göttingen
Francesca Odoardi: Institute of Neuroimmunology, Institute for Multiple Sclerosis Research, University Medical Centre Göttingen
Alexander Flügel: Institute of Neuroimmunology, Institute for Multiple Sclerosis Research, University Medical Centre Göttingen

Nature, 2016, vol. 530, issue 7590, 349-353

Abstract: By investigating trafficking of autoreactive T cells into the CSF during experimental autoimmune encephalitis, the authors find that T cells enter the CSF from the leptomeninges, and that commuting between the leptomeninges and the CSF is regulated by integrin adhesive forces triggered by T-cell activation and/or chemokines.

Date: 2016
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DOI: 10.1038/nature16939

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