Tumour-specific proline vulnerability uncovered by differential ribosome codon reading

Fabricio Loayza-Puch, Koos Rooijers, Levi C. M. Buil, Jelle Zijlstra, Joachim F. Oude Vrielink, Rui Lopes, Alejandro Pineiro Ugalde, Pieter van Breugel, Ingrid Hofland, Jelle Wesseling, Olaf van Tellingen, Axel Bex and Reuven Agami ()
Additional contact information
Fabricio Loayza-Puch: The Netherlands Cancer Institute
Koos Rooijers: The Netherlands Cancer Institute
Levi C. M. Buil: The Netherlands Cancer Institute
Jelle Zijlstra: The Netherlands Cancer Institute
Joachim F. Oude Vrielink: The Netherlands Cancer Institute
Rui Lopes: The Netherlands Cancer Institute
Alejandro Pineiro Ugalde: The Netherlands Cancer Institute
Pieter van Breugel: The Netherlands Cancer Institute
Ingrid Hofland: Core Facility Molecular Pathology and Biobanking, The Netherlands Cancer Institute
Jelle Wesseling: Molecular Pathology, The Netherlands Cancer Institute
Olaf van Tellingen: The Netherlands Cancer Institute
Axel Bex: Division of Surgical Oncology, Department of Urology The Netherlands Cancer Institute
Reuven Agami: The Netherlands Cancer Institute

Nature, 2016, vol. 530, issue 7591, 490-494

Abstract: Tumours can require certain amino acids for their proliferation, and the diricore method described here helps to identify such restrictive amino acids; using this method in kidney cancer tissue and breast carcinoma cells, the authors observe an association between proline deficiency and upregulation of PYCR1, an enzyme required for proline synthesis.

Date: 2016
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature16982 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:530:y:2016:i:7591:d:10.1038_nature16982

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature16982

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().