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2014, volume 515, articles 7528

Haemophilia pp. S157-S157

Herb Brody

Born in the blood pp. S158-S159

Neil Savage

Gene therapy: Genie in a vector pp. S160-S161

Julie Gould

Clotting factors: Stretching time pp. S162-S164

Neil Savage

Perspective: The fix is in pp. S165-S165

Stephen Pemberton

Immunology: Oral solutions pp. S166-S167

Elie Dolgin

Thrombosis: Balancing act pp. S168-S169

Cassandra Willyard

Orthopaedics: Joint effort pp. S170-S171

Katharine Gammon

Animal models: Dogged pursuit pp. S172-S173

Emily Sohn

Open access is tiring out peer reviewers pp. 467-467

Martijn Arns

US–China climate deal raises hopes for Lima talks pp. 473-474

Jeff Tollefson

Ocean observatory project hits rough water pp. 474-475

Alexandra Witze

US regulators move on thought-controlled prosthetics pp. 476-476

Sara Reardon

Clinical-trial rules to improve access to results pp. 477-477

Sara Reardon

Confusion over publisher’s pioneering open-data rules pp. 478-478

Richard Van Noorden

Key Galapagos research station in trouble pp. 479-479

Aleszu Bajak

Publishing: The peer-review scam pp. 480-482

Cat Ferguson, Adam Marcus and Ivan Oransky

Nuclear power: Desperately seeking plutonium pp. 484-486

Alexandra Witze

Microscopy: Hasten high resolution pp. 487-488

Stephen J. Pennycook and Sergei V. Kalinin

Military science: Scientific spoils of war pp. 489-490

Ann Finkbeiner

Ornithology: Fowl domination pp. 490-491

Ewen Callaway

Climate science: A climate trance pp. 491-491

Richard Van Noorden

Ebola: models do more than forecast pp. 492-492

Caitlin Rivers

Ebola: the power of behaviour change pp. 492-492

Sebastian Funk, Gwenan M. Knight and Vincent A. A. Jansen

Can brain training boost cognition? pp. 492-492

David Moreau

Chinese universities: beware cronyism pp. 492-492

Hong-Wei Xiao

Chinese universities: gear up for Nobels pp. 492-492

Yi-Ping Chen, Yi-Shan Lin and Yi Zhang

Rename comet probe after Greek hero pp. 492-492

Len Fisher

El Niño's variable history pp. 494-495

Josephine R. Brown

A beast of the southern wild pp. 495-496

Anne Weil

Antitumour immunity gets a boost pp. 496-498

Jedd D. Wolchok and Timothy A. Chan

Cosmic triangles and black-hole masses pp. 498-499

Martin Elvis

Polarize to elongate pp. 499-501

Ulrich Tepass

Food choices for health and planet pp. 501-502

Elke Stehfest

Tolerance lies in the timing pp. 502-503

Nicholas R. J. Gascoigne

Belowground biodiversity and ecosystem functioning pp. 505-511

Richard D. Bardgett and Wim H. van der Putten

First cranial remains of a gondwanatherian mammal reveal remarkable mosaicism pp. 512-517

David W. Krause, Simone Hoffmann, John R. Wible, E. Christopher Kirk, Julia A. Schultz, Wighart von Koenigswald, Joseph R. Groenke, James B. Rossie, Patrick M. O’Connor, Erik R. Seiffert, Elizabeth R. Dumont, Waymon L. Holloway, Raymond R. Rogers, Lydia J. Rahantarisoa, Addison D. Kemp and Haingoson Andriamialison

Global diets link environmental sustainability and human health pp. 518-522

David Tilman and Michael Clark

A positional Toll receptor code directs convergent extension in Drosophila pp. 523-527

Adam C. Paré, Athea Vichas, Christopher T. Fincher, Zachary Mirman, Dene L. Farrell, Avantika Mainieri and Jennifer A. Zallen

A dust-parallax distance of 19 megaparsecs to the supermassive black hole in NGC 4151 pp. 528-530

Sebastian F. Hönig, Darach Watson, Makoto Kishimoto and Jens Hjorth

An impenetrable barrier to ultrarelativistic electrons in the Van Allen radiation belts pp. 531-534

D. N. Baker, A. N. Jaynes, V. C. Hoxie, R. M. Thorne, J. C. Foster, X. Li, J. F. Fennell, J. R. Wygant, S. G. Kanekal, P. J. Erickson, W. Kurth, W. Li, Q. Ma, Q. Schiller, L. Blum, D. M. Malaspina, A. Gerrard and L. J. Lanzerotti

Metallization of vanadium dioxide driven by large phonon entropy pp. 535-539

John D. Budai, Jiawang Hong, Michael E. Manley, Eliot D. Specht, Chen W. Li, Jonathan Z. Tischler, Douglas L. Abernathy, Ayman H. Said, Bogdan M. Leu, Lynn A. Boatner, Robert J. McQueeney and Olivier Delaire

Passive radiative cooling below ambient air temperature under direct sunlight pp. 540-544

Aaswath P. Raman, Marc Abou Anoma, Linxiao Zhu, Eden Rephaeli and Shanhui Fan

Design and fabrication of memory devices based on nanoscale polyoxometalate clusters pp. 545-549

Christoph Busche, Laia Vilà-Nadal, Jun Yan, Haralampos N. Miras, Long De-Liang, Vihar P. Georgiev, Asen Asenov, Rasmus H. Pedersen, Nikolaj Gadegaard, Muhammad M. Mirza, Douglas J. Paul, Josep M. Poblet and Leroy Cronin

Evolution and forcing mechanisms of El Niño over the past 21,000 years pp. 550-553

Zhengyu Liu, Zhengyao Lu, Xinyu Wen, B. L. Otto-Bliesner, A. Timmermann and K. M. Cobb

Multiplex single-molecule interaction profiling of DNA-barcoded proteins pp. 554-557

Liangcai Gu, Chao Li, John Aach, David E. Hill, Marc Vidal and George M. Church

MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer pp. 558-562

Thomas Powles, Joseph Paul Eder, Gregg D. Fine, Fadi S. Braiteh, Yohann Loriot, Cristina Cruz, Joaquim Bellmunt, Howard A. Burris, Daniel P. Petrylak, Siew-leng Teng, Xiaodong Shen, Zachary Boyd, Priti S. Hegde, Daniel S. Chen and Nicholas J. Vogelzang

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients pp. 563-567

Roy S. Herbst, Jean-Charles Soria, Marcin Kowanetz, Gregg D. Fine, Omid Hamid, Michael S. Gordon, Jeffery A. Sosman, David F. McDermott, John D. Powderly, Scott N. Gettinger, Holbrook E. K. Kohrt, Leora Horn, Donald P. Lawrence, Sandra Rost, Maya Leabman, Yuanyuan Xiao, Ahmad Mokatrin, Hartmut Koeppen, Priti S. Hegde, Ira Mellman, Daniel S. Chen and F. Stephen Hodi

PD-1 blockade induces responses by inhibiting adaptive immune resistance pp. 568-571

Paul C. Tumeh, Christina L. Harview, Jennifer H. Yearley, I. Peter Shintaku, Emma J. M. Taylor, Lidia Robert, Bartosz Chmielowski, Marko Spasic, Gina Henry, Voicu Ciobanu, Alisha N. West, Manuel Carmona, Christine Kivork, Elizabeth Seja, Grace Cherry, Antonio J. Gutierrez, Tristan R. Grogan, Christine Mateus, Gorana Tomasic, John A. Glaspy, Ryan O. Emerson, Harlan Robins, Robert H. Pierce, David A. Elashoff, Caroline Robert and Antoni Ribas

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing pp. 572-576

Mahesh Yadav, Suchit Jhunjhunwala, Qui T. Phung, Patrick Lupardus, Joshua Tanguay, Stephanie Bumbaca, Christian Franci, Tommy K. Cheung, Jens Fritsche, Toni Weinschenk, Zora Modrusan, Ira Mellman, Jennie R. Lill and Lélia Delamarre

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens pp. 577-581

Matthew M. Gubin, Xiuli Zhang, Heiko Schuster, Etienne Caron, Jeffrey P. Ward, Takuro Noguchi, Yulia Ivanova, Jasreet Hundal, Cora D. Arthur, Willem-Jan Krebber, Gwenn E. Mulder, Mireille Toebes, Matthew D. Vesely, Samuel S. K. Lam, Alan J. Korman, James P. Allison, Gordon J. Freeman, Arlene H. Sharpe, Erika L. Pearce, Ton N. Schumacher, Ruedi Aebersold, Hans-Georg Rammensee, Cornelis J. M. Melief, Elaine R. Mardis, William E. Gillanders, Maxim N. Artyomov and Robert D. Schreiber

Histone H2A.Z subunit exchange controls consolidation of recent and remote memory pp. 582-586

Iva B. Zovkic, Brynna S. Paulukaitis, Jeremy J. Day, Deepa M. Etikala and J. David Sweatt

Epigenetic reprogramming that prevents transgenerational inheritance of the vernalized state pp. 587-590

Pedro Crevillén, Hongchun Yang, Xia Cui, Christiaan Greeff, Martin Trick, Qi Qiu, Xiaofeng Cao and Caroline Dean

A structure-based mechanism for tRNA and retroviral RNA remodelling during primer annealing pp. 591-595

Sarah B. Miller, F. Zehra Yildiz, Jennifer A. Lo, Bo Wang and Victoria M. D’Souza

Diversity: Structural approach pp. 597-598

Leigh Krietsch Boerner

Ice and white roses pp. 600-600

Rebecca Birch

2014, volume 515, articles 7527

Melanoma pp. S109-S109

Brian Owens

The cancer that rises with the Sun pp. S110-S111

David Holmes

Risk factors: Riddle of the rays pp. S112-S113

Cassandra Willyard

Prevention: Lessons from a sunburnt country pp. S114-S116

Zoë Corbyn

Perspective: Catch melanoma early pp. S117-S117

Susan M. Swetter and Alan C. Geller

Drug development: A chance of survival pp. S118-S120

Hannah Hoag

Skin colour: No hiding in the dark pp. S121-S123

Sujata Gupta

Protection: The sunscreen pill pp. S124-S125

Erin Biba

Perspective: Protect the USA from UVA pp. S126-S126

Michael J. Werner

Openness in science is key to keeping public trust pp. 313-313

Mark Yarborough

Philae’s 64 hours of comet science yield rich data pp. 319-320

Elizabeth Gibney

Crisis mappers turn to citizen scientists pp. 321-321

Mark Zastrow

Green List promotes best conservation areas pp. 322-322

Natasha Gilbert

‘Platinum’ genome takes on disease pp. 323-323

Ewen Callaway

Joint effort nabs next wave of US supercomputers pp. 324-324

Alexandra Witze

Indirect costs: Keeping the lights on pp. 326-329

Heidi Ledford

Developing world: Far-flung physics pp. 330-333

Katia Moskvitch

Air pollution: Clean up our skies pp. 335-337

Julia Schmale, Drew Shindell, Erika von Schneidemesser, Ilan Chabay and Mark Lawrence

Climate forecasting: Build high-resolution global climate models pp. 338-339

Tim Palmer

History of science: Pursuing the primordial pp. 340-341

Ted Nield

Books in brief pp. 341-341

Barbara Kiser

Evolution: students debate the debate pp. 343-343

Hope Klug

Evolution: viruses are key players pp. 343-343

Guenther Witzany and František Baluška

Evolution: networks and energy count pp. 343-343

Arturo Tozzi

Anti-vivisectionists respond pp. 343-343

Michelle Thew

Ice-bucket challenge should jolt funding pp. 343-343

Maria Teresa Carrì

Allison Doupe (1954–2014) pp. 344-344

Thomas R. Insel and Story Landis

Mice in the ENCODE spotlight pp. 346-347

Piero Carninci

RNA made in its own mirror image pp. 347-348

Sandip A. Shelke and Joseph A. Piccirilli

Reactive walls pp. 348-350

Philippe Ghosez and Jean-Marc Triscone

Succinate strikes pp. 350-351

Luke A. J. O'Neill

Agriculture and the global carbon cycle pp. 351-352

Natasha MacBean and Philippe Peylin

Leaf veins share the time of day pp. 352-353

María C. Martí and Alex A. R. Webb

A comparative encyclopedia of DNA elements in the mouse genome pp. 355-364

Feng Yue, Yong Cheng, Alessandra Breschi, Jeff Vierstra, Weisheng Wu, Tyrone Ryba, Richard Sandstrom, Zhihai Ma, Carrie Davis, Benjamin D. Pope, Yin Shen, Dmitri D. Pervouchine, Sarah Djebali, Robert E. Thurman, Rajinder Kaul, Eric Rynes, Anthony Kirilusha, Georgi K. Marinov, Brian A. Williams, Diane Trout, Henry Amrhein, Katherine Fisher-Aylor, Igor Antoshechkin, Gilberto DeSalvo, Lei-Hoon See, Meagan Fastuca, Jorg Drenkow, Chris Zaleski, Alex Dobin, Pablo Prieto, Julien Lagarde, Giovanni Bussotti, Andrea Tanzer, Olgert Denas, Kanwei Li, M. A. Bender, Miaohua Zhang, Rachel Byron, Mark T. Groudine, David McCleary, Long Pham, Zhen Ye, Samantha Kuan, Lee Edsall, Yi-Chieh Wu, Matthew D. Rasmussen, Mukul S. Bansal, Manolis Kellis, Cheryl A. Keller, Christapher S. Morrissey, Tejaswini Mishra, Deepti Jain, Nergiz Dogan, Robert S. Harris, Philip Cayting, Trupti Kawli, Alan P. Boyle, Ghia Euskirchen, Anshul Kundaje, Shin Lin, Yiing Lin, Camden Jansen, Venkat S. Malladi, Melissa S. Cline, Drew T. Erickson, Vanessa M. Kirkup, Katrina Learned, Cricket A. Sloan, Kate R. Rosenbloom, Beatriz Lacerda de Sousa, Kathryn Beal, Miguel Pignatelli, Paul Flicek, Jin Lian, Tamer Kahveci, Dongwon Lee, W. James Kent, Miguel Ramalho Santos, Javier Herrero, Cedric Notredame, Audra Johnson, Shinny Vong, Kristen Lee, Daniel Bates, Fidencio Neri, Morgan Diegel, Theresa Canfield, Peter J. Sabo, Matthew S. Wilken, Thomas A. Reh, Erika Giste, Anthony Shafer, Tanya Kutyavin, Eric Haugen, Douglas Dunn, Alex P. Reynolds, Shane Neph, Richard Humbert, R. Scott Hansen, Marella De Bruijn, Licia Selleri, Alexander Rudensky, Steven Josefowicz, Robert Samstein, Evan E. Eichler, Stuart H. Orkin, Dana Levasseur, Thalia Papayannopoulou, Kai-Hsin Chang, Arthur Skoultchi, Srikanta Gosh, Christine Disteche, Piper Treuting, Yanli Wang, Mitchell J. Weiss, Gerd A. Blobel, Xiaoyi Cao, Sheng Zhong, Ting Wang, Peter J. Good, Rebecca F. Lowdon, Leslie B. Adams, Xiao-Qiao Zhou, Michael J. Pazin, Elise A. Feingold, Barbara Wold, James Taylor, Ali Mortazavi, Sherman M. Weissman, John A. Stamatoyannopoulos, Michael P. Snyder, Roderic Guigo, Thomas R. Gingeras, David M. Gilbert, Ross C. Hardison, Michael A. Beer and Bing Ren

Conservation of trans-acting circuitry during mammalian regulatory evolution pp. 365-370

Andrew B. Stergachis, Shane Neph, Richard Sandstrom, Eric Haugen, Alex P. Reynolds, Miaohua Zhang, Rachel Byron, Theresa Canfield, Sandra Stelhing-Sun, Kristen Lee, Robert E. Thurman, Shinny Vong, Daniel Bates, Fidencio Neri, Morgan Diegel, Erika Giste, Douglas Dunn, Jeff Vierstra, R. Scott Hansen, Audra K. Johnson, Peter J. Sabo, Matthew S. Wilken, Thomas A. Reh, Piper M. Treuting, Rajinder Kaul, Mark Groudine, M. A. Bender, Elhanan Borenstein and John A. Stamatoyannopoulos

Principles of regulatory information conservation between mouse and human pp. 371-375

Yong Cheng, Zhihai Ma, Bong-Hyun Kim, Weisheng Wu, Philip Cayting, Alan P. Boyle, Vasavi Sundaram, Xiaoyun Xing, Nergiz Dogan, Jingjing Li, Ghia Euskirchen, Shin Lin, Yiing Lin, Axel Visel, Trupti Kawli, Xinqiong Yang, Dorrelyn Patacsil, Cheryl A. Keller, Belinda Giardine, The Mouse ENCODE Consortium, Anshul Kundaje, Ting Wang, Len A. Pennacchio, Zhiping Weng, Ross C. Hardison and Michael P. Snyder

The power of relativistic jets is larger than the luminosity of their accretion disks pp. 376-378

G. Ghisellini, F. Tavecchio, L. Maraschi, A. Celotti and T. Sbarrato

Artificial chemical and magnetic structure at the domain walls of an epitaxial oxide pp. 379-383

S. Farokhipoor, C. Magén, S. Venkatesan, J. Íñiguez, C. J. M. Daumont, D. Rubi, E. Snoeck, M. Mostovoy, C. de Graaf, A. Müller, M. Döblinger, C. Scheu and B. Noheda

Approaching disorder-free transport in high-mobility conjugated polymers pp. 384-388

Deepak Venkateshvaran, Mark Nikolka, Aditya Sadhanala, Vincent Lemaur, Mateusz Zelazny, Michal Kepa, Michael Hurhangee, Auke Jisk Kronemeijer, Vincenzo Pecunia, Iyad Nasrallah, Igor Romanov, Katharina Broch, Iain McCulloch, David Emin, Yoann Olivier, Jerome Cornil, David Beljonne and Henning Sirringhaus

Overcoming the limitations of directed C–H functionalizations of heterocycles pp. 389-393

Yue-Jin Liu, Hui Xu, Wei-Jun Kong, Ming Shang, Hui-Xiong Dai and Jin-Quan Yu

Agricultural Green Revolution as a driver of increasing atmospheric CO2 seasonal amplitude pp. 394-397

Ning Zeng, Fang Zhao, George J. Collatz, Eugenia Kalnay, Ross J. Salawitch, Tristram O. West and Luis Guanter

Direct human influence on atmospheric CO2 seasonality from increased cropland productivity pp. 398-401

Josh M. Gray, Steve Frolking, Eric A. Kort, Deepak K. Ray, Christopher J. Kucharik, Navin Ramankutty and Mark A. Friedl

Topologically associating domains are stable units of replication-timing regulation pp. 402-405

Benjamin D. Pope, Tyrone Ryba, Vishnu Dileep, Feng Yue, Weisheng Wu, Olgert Denas, Daniel L. Vera, Yanli Wang, R. Scott Hansen, Theresa K. Canfield, Robert E. Thurman, Yong Cheng, Günhan Gülsoy, Jonathan H. Dennis, Michael P. Snyder, John A. Stamatoyannopoulos, James Taylor, Ross C. Hardison, Tamer Kahveci, Bing Ren and David M. Gilbert

The drivers of tropical speciation pp. 406-409

Brian Tilston Smith, John E. McCormack, Andrés M. Cuervo, Michael. J. Hickerson, Alexandre Aleixo, Carlos Daniel Cadena, Jorge Pérez-Emán, Curtis W. Burney, Xiaoou Xie, Michael G. Harvey, Brant C. Faircloth, Travis C. Glenn, Elizabeth P. Derryberry, Jesse Prejean, Samantha Fields and Robb T. Brumfield

Individual improvements and selective mortality shape lifelong migratory performance pp. 410-413

Fabrizio Sergio, Alessandro Tanferna, Renaud De Stephanis, Lidia López Jiménez, Julio Blas, Giacomo Tavecchia, Damiano Preatoni and Fernando Hiraldo

Synaptic dysregulation in a human iPS cell model of mental disorders pp. 414-418

Zhexing Wen, Ha Nam Nguyen, Ziyuan Guo, Matthew A. Lalli, Xinyuan Wang, Yijing Su, Nam-Shik Kim, Ki-Jun Yoon, Jaehoon Shin, Ce Zhang, Georgia Makri, David Nauen, Huimei Yu, Elmer Guzman, Cheng-Hsuan Chiang, Nadine Yoritomo, Kozo Kaibuchi, Jizhong Zou, Kimberly M. Christian, Linzhao Cheng, Christopher A. Ross, Russell L. Margolis, Gong Chen, Kenneth S. Kosik, Hongjun Song and Guo-li Ming

Tissue-specific clocks in Arabidopsis show asymmetric coupling pp. 419-422

Motomu Endo, Hanako Shimizu, Maria A. Nohales, Takashi Araki and Steve A. Kay

Members of the human gut microbiota involved in recovery from Vibrio cholerae infection pp. 423-426

Ansel Hsiao, A. M. Shamsir Ahmed, Sathish Subramanian, Nicholas W. Griffin, Lisa L. Drewry, William A. Petri, Rashidul Haque, Tahmeed Ahmed and Jeffrey I. Gordon

Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies pp. 427-430

Katherine E. Wright, Kathryn A. Hjerrild, Jonathan Bartlett, Alexander D. Douglas, Jing Jin, Rebecca E. Brown, Joseph J. Illingworth, Rebecca Ashfield, Stine B. Clemmensen, Willem A. de Jongh, Simon J. Draper and Matthew K. Higgins

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS pp. 431-435

Edward T. Chouchani, Victoria R. Pell, Edoardo Gaude, Dunja Aksentijević, Stephanie Y. Sundier, Ellen L. Robb, Angela Logan, Sergiy M. Nadtochiy, Emily N. J. Ord, Anthony C. Smith, Filmon Eyassu, Rachel Shirley, Chou-Hui Hu, Anna J. Dare, Andrew M. James, Sebastian Rogatti, Richard C. Hartley, Simon Eaton, Ana S. H. Costa, Paul S. Brookes, Sean M. Davidson, Michael R. Duchen, Kourosh Saeb-Parsy, Michael J. Shattock, Alan J. Robinson, Lorraine M. Work, Christian Frezza, Thomas Krieg and Michael P. Murphy

Transcript-RNA-templated DNA recombination and repair pp. 436-439

Havva Keskin, Ying Shen, Fei Huang, Mikir Patel, Taehwan Yang, Katie Ashley, Alexander V. Mazin and Francesca Storici

A cross-chiral RNA polymerase ribozyme pp. 440-442

Jonathan T. Sczepanski and Gerald F. Joyce

Discovery and characterization of small molecules that target the GTPase Ral pp. 443-447

Chao Yan, Degang Liu, Liwei Li, Michael F. Wempe, Sunny Guin, May Khanna, Jeremy Meier, Brenton Hoffman, Charles Owens, Christina L. Wysoczynski, Matthew D. Nitz, William E. Knabe, Mansoor Ahmed, David L. Brautigan, Bryce M. Paschal, Martin A. Schwartz, David N. M. Jones, David Ross, Samy O. Meroueh and Dan Theodorescu

Structures of bacterial homologues of SWEET transporters in two distinct conformations pp. 448-452

Yan Xu, Yuyong Tao, Lily S. Cheung, Chao Fan, Li-Qing Chen, Sophia Xu, Kay Perry, Wolf B. Frommer and Liang Feng

Mentoring awards: Focus on people pp. 453-454

Philip Campbell

Turning point: Kate McAllister pp. 455-455

Virginia Gewin

When the music ends pp. 458-458

Philip Ball

2014, volume 515, articles 7526

Sickle-cell disease pp. S1-S1

Lauren Gravitz and Stephen Pincock

Epidemiology: A moving target pp. S2-S2

Simon Pleasants

Drug development: A complicated path pp. S4-S5

Courtney Humphries

Q&A: Healthy progress pp. S6-S7

Smriti Mallapaty

Neurobiology: Life beyond the pain pp. S8-S9

Bianca Nogrady

Perspective: We need a global solution pp. S10-S10

Isaac Odame

Gene therapy: Editorial control pp. S11-S13

Katharine Gammon

Stem cells: Creating a cure-all pp. S14-S15

Andrew R. Scott

Perspective: Thinking beyond survival pp. S16-S16

Michael R. DeBaun

Index 2014 Global pp. S49-S49

Nick Campbell and Michelle Grayson

Help luck along to find psychiatric medicines pp. 165-165

David Nutt

Italian seismologists cleared of manslaughter pp. 171-171

Alison Abbott and Nicola Nosengo

Landing on a comet: A guide to Rosetta’s perilous mission pp. 172-173

Elizabeth Gibney

Edits to ethics code rankle pp. 174-174

Heidi Ledford

Gut–brain link grabs neuroscientists pp. 175-177

Sara Reardon

Ethical dilemma for Ebola drug trials pp. 177-178

Erika Check Hayden

Mental health: A world of depression pp. 180-181

Kerri Smith

Medical research: If depression were cancer pp. 182-184

Heidi Ledford

Depression: A change of mind pp. 185-187

Emily Anthes

Mental health: Depression needs large human-genetics studies pp. 189-191

Steven Hyman

Infectious disease: Tough choices to reduce Ebola transmission pp. 192-194

Christopher J. M. Whitty, Jeremy Farrar, Neil Ferguson, W. John Edmunds, Peter Piot, Melissa Leach and Sally C. Davies

Film: Enigma variations pp. 195-196

Robert P. Crease

Q&A: Space-time visionary pp. 196-197

Zeeya Merali

Books in brief pp. 197-197

Barbara Kiser

Let poor countries into rich research pp. 198-198

Carl Lachat, Patrick Kolsteren and Dominique Roberfroid

Better modelling for the energy mix pp. 198-198

Alexander Q. Gilbert and Benjamin K. Sovacool

Funding plea for rural lab outreach pp. 198-198

André Ramos and Guilherme Razzera

Approximation aids handling of big data pp. 198-198

Thomas Heinis

EC grant applicants need fuller feedback pp. 198-198

Danuta Wasserman

The best way forward pp. 200-201

Lisa M. Monteggia, Robert C. Malenka and Karl Deisseroth

Magnetic fields without magnetic fields pp. 202-203

Jonathan Simon

Mystery of the horrible hands solved pp. 203-205

Thomas R. Holtz

Electron mirages in an iron salt pp. 205-206

Jan Zaanen

Building a bigger brain pp. 206-207

Forrest O. Gulden and Nenad Šestan

Towards unified vesicle endocytosis pp. 207-208

Vladan Lučić

Synaptic, transcriptional and chromatin genes disrupted in autism pp. 209-215

Silvia De Rubeis, Xin He, Arthur P. Goldberg, Christopher S. Poultney, Kaitlin Samocha, A. Ercument Cicek, Yan Kou, Li Liu, Menachem Fromer, Susan Walker, Tarjinder Singh, Lambertus Klei, Jack Kosmicki, Shih-Chen Fu, Branko Aleksic, Monica Biscaldi, Patrick F. Bolton, Jessica M. Brownfeld, Jinlu Cai, Nicholas G. Campbell, Angel Carracedo, Maria H. Chahrour, Andreas G. Chiocchetti, Hilary Coon, Emily L. Crawford, Lucy Crooks, Sarah R. Curran, Geraldine Dawson, Eftichia Duketis, Bridget A. Fernandez, Louise Gallagher, Evan Geller, Stephen J. Guter, R. Sean Hill, Iuliana Ionita-Laza, Patricia Jimenez Gonzalez, Helena Kilpinen, Sabine M. Klauck, Alexander Kolevzon, Irene Lee, Jing Lei, Terho Lehtimäki, Chiao-Feng Lin, Avi Ma’ayan, Christian R. Marshall, Alison L. McInnes, Benjamin Neale, Michael J. Owen, Norio Ozaki, Mara Parellada, Jeremy R. Parr, Shaun Purcell, Kaija Puura, Deepthi Rajagopalan, Karola Rehnström, Abraham Reichenberg, Aniko Sabo, Michael Sachse, Stephan J. Sanders, Chad Schafer, Martin Schulte-Rüther, David Skuse, Christine Stevens, Peter Szatmari, Kristiina Tammimies, Otto Valladares, Annette Voran, Li-San Wang, Lauren A. Weiss, A. Jeremy Willsey, Timothy W. Yu, Ryan K. C. Yuen, Edwin H. Cook, Christine M. Freitag, Michael Gill, Christina M. Hultman, Thomas Lehner, Aarno Palotie, Gerard D. Schellenberg, Pamela Sklar, Matthew W. State, James S. Sutcliffe, Christopher A. Walsh, Stephen W. Scherer, Michael E. Zwick, Jeffrey C. Barrett, David J. Cutler, Kathryn Roeder, Bernie Devlin, Mark J. Daly and Joseph D. Buxbaum

The contribution of de novo coding mutations to autism spectrum disorder pp. 216-221

Ivan Iossifov, Brian J. O’Roak, Stephan J. Sanders, Michael Ronemus, Niklas Krumm, Dan Levy, Holly A. Stessman, Kali T. Witherspoon, Laura Vives, Karynne E. Patterson, Joshua D. Smith, Bryan Paeper, Deborah A. Nickerson, Jeanselle Dea, Shan Dong, Luis E. Gonzalez, Jeffrey D. Mandell, Shrikant M. Mane, Michael T. Murtha, Catherine A. Sullivan, Michael F. Walker, Zainulabedin Waqar, Liping Wei, A. Jeremy Willsey, Boris Yamrom, Yoon-ha Lee, Ewa Grabowska, Ertugrul Dalkic, Zihua Wang, Steven Marks, Peter Andrews, Anthony Leotta, Jude Kendall, Inessa Hakker, Julie Rosenbaum, Beicong Ma, Linda Rodgers, Jennifer Troge, Giuseppe Narzisi, Seungtai Yoon, Michael C. Schatz, Kenny Ye, W. Richard McCombie, Jay Shendure, Evan E. Eichler, Matthew W. State and Michael Wigler

Evolution of mosquito preference for humans linked to an odorant receptor pp. 222-227

Carolyn S. McBride, Felix Baier, Aman B. Omondi, Sarabeth A. Spitzer, Joel Lutomiah, Rosemary Sang, Rickard Ignell and Leslie B. Vosshall

Clathrin regenerates synaptic vesicles from endosomes pp. 228-233

Shigeki Watanabe, Thorsten Trimbuch, Marcial Camacho-Pérez, Benjamin R. Rost, Bettina Brokowski, Berit Söhl-Kielczynski, Annegret Felies, M. Wayne Davis, Christian Rosenmund and Erik M. Jorgensen

The expanding fireball of Nova Delphini 2013 pp. 234-236

G. H. Schaefer, T. ten Brummelaar, D. R. Gies, C. D. Farrington, B. Kloppenborg, O. Chesneau, J. D. Monnier, S. T. Ridgway, N. Scott, I. Tallon-Bosc, H. A. McAlister, T. Boyajian, V. Maestro, D. Mourard, A. Meilland, N. Nardetto, P. Stee, J. Sturmann, N. Vargas, F. Baron, M. Ireland, E. K. Baines, X. Che, J. Jones, N. D. Richardson, R. M. Roettenbacher, L. Sturmann, N. H. Turner, P. Tuthill, G. van Belle, K. von Braun, R. T. Zavala, D. P. K. Banerjee, N. M. Ashok, V. Joshi, J. Becker and P. S. Muirhead

Experimental realization of the topological Haldane model with ultracold fermions pp. 237-240

Gregor Jotzu, Michael Messer, Rémi Desbuquois, Martin Lebrat, Thomas Uehlinger, Daniel Greif and Tilman Esslinger

Observation of topological transitions in interacting quantum circuits pp. 241-244

P. Roushan, C. Neill, Yu Chen, M. Kolodrubetz, C. Quintana, N. Leung, M. Fang, R. Barends, B. Campbell, Z. Chen, B. Chiaro, A. Dunsworth, E. Jeffrey, J. Kelly, A. Megrant, J. Mutus, P. J. J. O’Malley, D. Sank, A. Vainsencher, J. Wenner, T. White, A. Polkovnikov, A. N. Cleland and J. M. Martinis

Interfacial mode coupling as the origin of the enhancement of Tc in FeSe films on SrTiO3 pp. 245-248

J. J. Lee, F. T. Schmitt, R. G. Moore, S. Johnston, Y.-T. Cui, W. Li, M. Yi, Z. K. Liu, M. Hashimoto, Y. Zhang, D. H. Lu, T. P. Devereaux, D.-H. Lee and Z.-X. Shen

Formic-acid-induced depolymerization of oxidized lignin to aromatics pp. 249-252

Alireza Rahimi, Arne Ulbrich, Joshua J. Coon and Shannon S. Stahl

Subduction-driven recycling of continental margin lithosphere pp. 253-256

A. Levander, M. J. Bezada, F. Niu, E. D. Humphreys, I. Palomeras, S. M. Thurner, J. Masy, M. Schmitz, J. Gallart, R. Carbonell and M. S. Miller

Resolving the long-standing enigmas of a giant ornithomimosaur Deinocheirus mirificus pp. 257-260

Yuong-Nam Lee, Rinchen Barsbold, Philip J. Currie, Yoshitsugu Kobayashi, Hang-Jae Lee, Pascal Godefroit, François Escuillié and Tsogtbaatar Chinzorig

Comparative population genomics in animals uncovers the determinants of genetic diversity pp. 261-263

J. Romiguier, P. Gayral, M. Ballenghien, A. Bernard, V. Cahais, A. Chenuil, Y. Chiari, R. Dernat, L. Duret, N. Faivre, E. Loire, J. M. Lourenco, B. Nabholz, C. Roux, G. Tsagkogeorga, A. A.-T. Weber, L. A. Weinert, K. Belkhir, N. Bierne, S. Glémin and N. Galtier

Radial glia require PDGFD–PDGFRβ signalling in human but not mouse neocortex pp. 264-268

Jan H. Lui, Tomasz J. Nowakowski, Alex A. Pollen, Ashkan Javaherian, Arnold R. Kriegstein and Michael C. Oldham

The participation of cortical amygdala in innate, odour-driven behaviour pp. 269-273

Cory M. Root, Christine A. Denny, René Hen and Richard Axel

A three-dimensional human neural cell culture model of Alzheimer’s disease pp. 274-278

Se Hoon Choi, Young Hye Kim, Matthias Hebisch, Christopher Sliwinski, Seungkyu Lee, Carla D’Avanzo, Hechao Chen, Basavaraj Hooli, Caroline Asselin, Julien Muffat, Justin B. Klee, Can Zhang, Brian J. Wainger, Michael Peitz, Dora M. Kovacs, Clifford J. Woolf, Steven L. Wagner, Rudolph E. Tanzi and Doo Yeon Kim

Piezo1 integration of vascular architecture with physiological force pp. 279-282

Jing Li, Bing Hou, Sarka Tumova, Katsuhiko Muraki, Alexander Bruns, Melanie J. Ludlow, Alicia Sedo, Adam J. Hyman, Lynn McKeown, Richard S. Young, Nadira Y. Yuldasheva, Yasser Majeed, Lesley A. Wilson, Baptiste Rode, Marc A. Bailey, Hyejeong R. Kim, Zhaojun Fu, Deborah A. L. Carter, Jan Bilton, Helen Imrie, Paul Ajuh, T. Neil Dear, Richard M. Cubbon, Mark T. Kearney, K. Raj Prasad, Paul C. Evans, Justin F. X. Ainscough and David J. Beech

The complete structure of the large subunit of the mammalian mitochondrial ribosome pp. 283-286

Basil J. Greber, Daniel Boehringer, Marc Leibundgut, Philipp Bieri, Alexander Leitner, Nikolaus Schmitz, Ruedi Aebersold and Nenad Ban

Structural basis for the assembly of the Sxl–Unr translation regulatory complex pp. 287-290

Janosch Hennig, Cristina Militti, Grzegorz M. Popowicz, Iren Wang, Miriam Sonntag, Arie Geerlof, Frank Gabel, Fátima Gebauer and Michael Sattler

A deep look at synaptic dynamics pp. 293-297

Vivien Marx

Neurodegenerative disease: Brain windfall pp. 299-300

Katharine Gammon

Turning point: Morris Birnbaum pp. 301-301

Virginia Gewin

Möbius pp. 304-304

J. W. Alden

2014, volume 515, articles 7525

Metascience could rescue the ‘replication crisis’ pp. 9-9

Jonathan W. Schooler

Fledgling space industry resolute after fatal crash pp. 15-16

Alexandra Witze

Future of Great Barrier Reef divides scientists pp. 16-17

Daniel Cressey

Ministers promise basket of gifts for German science pp. 17-17

Quirin Schiermeier

Models overestimate Ebola cases pp. 18-18

Declan Butler

Lobbying sways NIH grants pp. 19-19

Sara Reardon

University sued after firing creationist fossil hunter pp. 20-20

Christopher Kemp

After the Berlin Wall: Central Europe up close pp. 22-25

Alison Abbott and Quirin Schiermeier

Working together: A call for inclusive conservation pp. 27-28

Heather Tallis and Jane Lubchenco

Economics: Account for depreciation of natural capital pp. 32-33

Edward Barbier

History of science: Chemists behaving badly pp. 34-35

Theodore Gray

Books in brief pp. 35-35

Barbara Kiser

Chemistry: A life in science and literature pp. 36-36

Alison Abbott

Reap the benefits of the Nagoya Protocol pp. 37-37

David E. Schindel and Pierre du Plessis

Endangered species damned by dams pp. 37-37

Pankaj Barah and Kaveri Bhuyan

Navigation Nobel: Soviet pioneer pp. 37-37

Mihai Nadin

Navigation Nobel: Ways to help the lost pp. 37-37

Raza M. Naqvi

Surf's up at SLAC pp. 40-41

Mike Downer and Rafal Zgadzaj

Cells unite by trapping a signal pp. 41-42

James Sharpe

Monster star found hiding in plain sight pp. 42-43

Donald F. Figer

Diversity breeds complementarity pp. 44-45

David Tilman and Emilie C. Snell-Rood

Shape control in reactions with light pp. 45-46

Kazimer L. Skubi and Tehshik P. Yoon

Metastasis risk after anti-macrophage therapy pp. 46-47

Ioanna Keklikoglou and Michele De Palma

Sustainable ecosystems and society pp. 49-49

Patrick Goymer

Implications of agricultural transitions and urbanization for ecosystem services pp. 50-57

Graeme S. Cumming, Andreas Buerkert, Ellen M. Hoffmann, Eva Schlecht, Stephan von Cramon-Taubadel and Teja Tscharntke

Learning to coexist with wildfire pp. 58-66

Max A. Moritz, Enric Batllori, Ross A. Bradstock, A. Malcolm Gill, John Handmer, Paul F. Hessburg, Justin Leonard, Sarah McCaffrey, Dennis C. Odion, Tania Schoennagel and Alexandra D. Syphard

The performance and potential of protected areas pp. 67-73

James E. M. Watson, Nigel Dudley, Daniel B. Segan and Marc Hockings

Life cycles, fitness decoupling and the evolution of multicellularity pp. 75-79

Katrin Hammerschmidt, Caroline J. Rose, Benjamin Kerr and Paul B. Rainey

Architecture of mammalian respiratory complex I pp. 80-84

Kutti R. Vinothkumar, Jiapeng Zhu and Judy Hirst

Turbulent heating in galaxy clusters brightest in X-rays pp. 85-87

I. Zhuravleva, E. Churazov, A. A. Schekochihin, S. W. Allen, P. Arévalo, A. C. Fabian, W. R. Forman, J. S. Sanders, A. Simionescu, R. Sunyaev, A. Vikhlinin and N. Werner

Suppression of cooling by strong magnetic fields in white dwarf stars pp. 88-91

G. Valyavin, D. Shulyak, G. A. Wade, K. Antonyuk, S. V. Zharikov, G. A. Galazutdinov, S. Plachinda, S. Bagnulo, L. Fox Machado, M. Alvarez, D. M. Clark, J. M. Lopez, D. Hiriart, Inwoo Han, Young-Beom Jeon, C. Zurita, R. Mujica, T. Burlakova, T. Szeifert and A. Burenkov

High-efficiency acceleration of an electron beam in a plasma wakefield accelerator pp. 92-95

M. Litos, E. Adli, W. An, C. I. Clarke, C. E. Clayton, S. Corde, J. P. Delahaye, R. J. England, A. S. Fisher, J. Frederico, S. Gessner, S. Z. Green, M. J. Hogan, C. Joshi, W. Lu, K. A. Marsh, W. B. Mori, P. Muggli, N. Vafaei-Najafabadi, D. Walz, G. White, Z. Wu, V. Yakimenko and G. Yocky

Solution-processed, high-performance light-emitting diodes based on quantum dots pp. 96-99

Xingliang Dai, Zhenxing Zhang, Yizheng Jin, Yuan Niu, Hujia Cao, Xiaoyong Liang, Liwei Chen, Jianpu Wang and Xiaogang Peng

Asymmetric photoredox transition-metal catalysis activated by visible light pp. 100-103

Haohua Huo, Xiaodong Shen, Chuanyong Wang, Lilu Zhang, Philipp Röse, Liang-An Chen, Klaus Harms, Michael Marsch, Gerhard Hilt and Eric Meggers

Recent Northern Hemisphere stratospheric HCl increase due to atmospheric circulation changes pp. 104-107

E. Mahieu, M. P. Chipperfield, J. Notholt, T. Reddmann, J. Anderson, P. F. Bernath, T. Blumenstock, M. T. Coffey, S. S. Dhomse, W. Feng, B. Franco, L. Froidevaux, D. W. T. Griffith, J. W. Hannigan, F. Hase, R. Hossaini, N. B. Jones, I. Morino, I. Murata, H. Nakajima, M. Palm, C. Paton-Walsh, J. M. Russell, M. Schneider, C. Servais, D. Smale and K. A. Walker

Selection for niche differentiation in plant communities increases biodiversity effects pp. 108-111

Debra Zuppinger-Dingley, Bernhard Schmid, Jana S. Petermann, Varuna Yadav, Gerlinde B. De Deyn and Dan F. B. Flynn

Nodal signalling determines biradial asymmetry in Hydra pp. 112-115

Hiroshi Watanabe, Heiko A. Schmidt, Anne Kuhn, Stefanie K. Höger, Yigit Kocagöz, Nico Laumann-Lipp, Suat Özbek and Thomas W. Holstein

Sensory-evoked LTP driven by dendritic plateau potentials in vivo pp. 116-119

Frédéric Gambino, Stéphane Pagès, Vassilis Kehayas, Daniela Baptista, Roberta Tatti, Alan Carleton and Anthony Holtmaat

Luminal signalling links cell communication to tissue architecture during organogenesis pp. 120-124

Sevi Durdu, Murat Iskar, Celine Revenu, Nicole Schieber, Andreas Kunze, Peer Bork, Yannick Schwab and Darren Gilmour

PLETHORA gradient formation mechanism separates auxin responses pp. 125-129

Ari Pekka Mähönen, Kirsten ten Tusscher, Riccardo Siligato, Ondřej Smetana, Sara Díaz-Triviño, Jarkko Salojärvi, Guy Wachsman, Kalika Prasad, Renze Heidstra and Ben Scheres

Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis pp. 130-133

Laura Bonapace, Marie-May Coissieux, Jeffrey Wyckoff, Kirsten D. Mertz, Zsuzsanna Varga, Tobias Junt and Mohamed Bentires-Alj

Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer pp. 134-137

Diletta Di Mitri, Alberto Toso, Jing Jing Chen, Manuela Sarti, Sandra Pinton, Tanja Rezzonico Jost, Rocco D’Antuono, Erica Montani, Ramon Garcia-Escudero, Ilaria Guccini, Sabela Da Silva-Alvarez, Manuel Collado, Mario Eisenberger, Zhe Zhang, Carlo Catapano, Fabio Grassi and Andrea Alimonti

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface pp. 138-142

Jinghe Huang, Byong H. Kang, Marie Pancera, Jeong Hyun Lee, Tommy Tong, Yu Feng, Hiromi Imamichi, Ivelin S. Georgiev, Gwo-Yu Chuang, Aliaksandr Druz, Nicole A. Doria-Rose, Leo Laub, Kwinten Sliepen, Marit J. van Gils, Alba Torrents de la Peña, Ronald Derking, Per-Johan Klasse, Stephen A. Migueles, Robert T. Bailer, Munir Alam, Pavel Pugach, Barton F. Haynes, Richard T. Wyatt, Rogier W. Sanders, James M. Binley, Andrew B. Ward, John R. Mascola, Peter D. Kwong and Mark Connors

Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells pp. 143-146

Thomas M. Carlile, Maria F. Rojas-Duran, Boris Zinshteyn, Hakyung Shin, Kristen M. Bartoli and Wendy V. Gilbert

Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli pp. 147-150

Hongtu Zhao, Gang Sheng, Jiuyu Wang, Min Wang, Gabor Bunkoczi, Weimin Gong, Zhiyi Wei and Yanli Wang

Interactive notebooks: Sharing the code pp. 151-152

Helen Shen

Interactive notebooks: Sharing the code pp. 152-152

Helen Shen

It takes time and a team to win grants pp. 153-154

Ingrid Eisenstadter

Boundary waters pp. 156-156

Marissa Lingen