Locus coeruleus and dopaminergic consolidation of everyday memory

Tomonori Takeuchi, Adrian J. Duszkiewicz, Alex Sonneborn, Patrick A. Spooner, Miwako Yamasaki, Masahiko Watanabe, Caroline C. Smith, Guillén Fernández, Karl Deisseroth, Robert W. Greene () and Richard G. M. Morris ()
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Tomonori Takeuchi: Centre for Cognitive and Neural Systems, Edinburgh Neuroscience, The University of Edinburgh
Adrian J. Duszkiewicz: Centre for Cognitive and Neural Systems, Edinburgh Neuroscience, The University of Edinburgh
Alex Sonneborn: University of Texas Southwestern Medical Center
Patrick A. Spooner: Centre for Cognitive and Neural Systems, Edinburgh Neuroscience, The University of Edinburgh
Miwako Yamasaki: Hokkaido University Graduate School of Medicine
Masahiko Watanabe: Hokkaido University Graduate School of Medicine
Caroline C. Smith: University of Texas Southwestern Medical Center
Guillén Fernández: Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Centre
Karl Deisseroth: Stanford University
Robert W. Greene: University of Texas Southwestern Medical Center
Richard G. M. Morris: Centre for Cognitive and Neural Systems, Edinburgh Neuroscience, The University of Edinburgh

Nature, 2016, vol. 537, issue 7620, 357-362

Abstract: Abstract The retention of episodic-like memory is enhanced, in humans and animals, when something novel happens shortly before or after encoding. Using an everyday memory task in mice, we sought the neurons mediating this dopamine-dependent novelty effect, previously thought to originate exclusively from the tyrosine-hydroxylase-expressing (TH+) neurons in the ventral tegmental area. Here we report that neuronal firing in the locus coeruleus is especially sensitive to environmental novelty, locus coeruleus TH+ neurons project more profusely than ventral tegmental area TH+ neurons to the hippocampus, optogenetic activation of locus coeruleus TH+ neurons mimics the novelty effect, and this novelty-associated memory enhancement is unaffected by ventral tegmental area inactivation. Surprisingly, two effects of locus coeruleus TH+ photoactivation are sensitive to hippocampal D1/D5 receptor blockade and resistant to adrenoceptor blockade: memory enhancement and long-lasting potentiation of synaptic transmission in CA1 ex vivo. Thus, locus coeruleus TH+ neurons can mediate post-encoding memory enhancement in a manner consistent with possible co-release of dopamine in the hippocampus.

Date: 2016
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DOI: 10.1038/nature19325

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