HER2 expression identifies dynamic functional states within circulating breast cancer cells

Nicole Vincent Jordan, Aditya Bardia, Ben S. Wittner, Cyril Benes, Matteo Ligorio, Yu Zheng, Min Yu, Tilak K. Sundaresan, Joseph A. Licausi, Rushil Desai, Ryan M. O’Keefe, Richard Y. Ebright, Myriam Boukhali, Srinjoy Sil, Maristela L. Onozato, Anthony J. Iafrate, Ravi Kapur, Dennis Sgroi, David T. Ting, Mehmet Toner, Sridhar Ramaswamy, Wilhelm Haas, Shyamala Maheswaran () and Daniel A. Haber ()
Additional contact information
Nicole Vincent Jordan: Massachusetts General Hospital Cancer Center, Harvard Medical School
Aditya Bardia: Massachusetts General Hospital Cancer Center, Harvard Medical School
Ben S. Wittner: Massachusetts General Hospital Cancer Center, Harvard Medical School
Cyril Benes: Massachusetts General Hospital Cancer Center, Harvard Medical School
Matteo Ligorio: Massachusetts General Hospital Cancer Center, Harvard Medical School
Yu Zheng: Massachusetts General Hospital Cancer Center, Harvard Medical School
Min Yu: Massachusetts General Hospital Cancer Center, Harvard Medical School
Tilak K. Sundaresan: Massachusetts General Hospital Cancer Center, Harvard Medical School
Joseph A. Licausi: Massachusetts General Hospital Cancer Center, Harvard Medical School
Rushil Desai: Massachusetts General Hospital Cancer Center, Harvard Medical School
Ryan M. O’Keefe: Massachusetts General Hospital Cancer Center, Harvard Medical School
Richard Y. Ebright: Massachusetts General Hospital Cancer Center, Harvard Medical School
Myriam Boukhali: Massachusetts General Hospital Cancer Center, Harvard Medical School
Srinjoy Sil: Massachusetts General Hospital Cancer Center, Harvard Medical School
Maristela L. Onozato: Massachusetts General Hospital Cancer Center, Harvard Medical School
Anthony J. Iafrate: Massachusetts General Hospital Cancer Center, Harvard Medical School
Ravi Kapur: Center for Bioengineering in Medicine and Shriners Hospital, Harvard Medical School
Dennis Sgroi: Massachusetts General Hospital Cancer Center, Harvard Medical School
David T. Ting: Massachusetts General Hospital Cancer Center, Harvard Medical School
Mehmet Toner: Harvard Medical School
Sridhar Ramaswamy: Massachusetts General Hospital Cancer Center, Harvard Medical School
Wilhelm Haas: Massachusetts General Hospital Cancer Center, Harvard Medical School
Shyamala Maheswaran: Massachusetts General Hospital Cancer Center, Harvard Medical School
Daniel A. Haber: Massachusetts General Hospital Cancer Center, Harvard Medical School

Nature, 2016, vol. 537, issue 7618, 102-106

Abstract: Patient-derived circulating tumour cells are used to characterize the dynamics and underlying plasticity of HER2 expression in non-HER2-amplified breast tumours.

Date: 2016
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DOI: 10.1038/nature19328

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