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Catalytic enantioselective 1,6-conjugate additions of propargyl and allyl groups

Fanke Meng, Xiben Li, Sebastian Torker, Ying Shi, Xiao Shen and Amir H. Hoveyda ()
Additional contact information
Fanke Meng: Merkert Chemistry Center, Boston College
Xiben Li: Merkert Chemistry Center, Boston College
Sebastian Torker: Merkert Chemistry Center, Boston College
Ying Shi: Merkert Chemistry Center, Boston College
Xiao Shen: Merkert Chemistry Center, Boston College
Amir H. Hoveyda: Merkert Chemistry Center, Boston College

Nature, 2016, vol. 537, issue 7620, 387-393

Abstract: A difficult synthesis is described that uses an organocopper catalyst and commercially available starting materials to give high yield and the mechanics of the reaction are elucidated through density functional theory.

Date: 2016
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DOI: 10.1038/nature19063

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