A PGC1α-mediated transcriptional axis suppresses melanoma metastasis

Chi Luo, Ji-Hong Lim, Yoonjin Lee, Scott R. Granter, Ajith Thomas, Francisca Vazquez, Hans R. Widlund and Pere Puigserver ()
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Chi Luo: Harvard Medical School
Ji-Hong Lim: Harvard Medical School
Yoonjin Lee: Harvard Medical School
Scott R. Granter: Brigham and Women’s Hospital, Harvard Medical School
Ajith Thomas: Harvard Medical School
Francisca Vazquez: Harvard Medical School
Hans R. Widlund: Brigham and Women’s Hospital, Harvard Medical School
Pere Puigserver: Harvard Medical School

Nature, 2016, vol. 537, issue 7620, 422-426

Abstract: PGC1α suppresses melanoma metastasis and promotes growth and survival in primary tumours, whilst inhibition of PGC1α induces increased invasion and metastasis.

Date: 2016
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DOI: 10.1038/nature19347

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