Ionic immune suppression within the tumour microenvironment limits T cell effector function

Robert Eil (), Suman K. Vodnala, David Clever, Christopher A. Klebanoff, Madhusudhanan Sukumar, Jenny H. Pan, Douglas C. Palmer, Alena Gros, Tori N. Yamamoto, Shashank J. Patel, Geoffrey C. Guittard, Zhiya Yu, Valentina Carbonaro, Klaus Okkenhaug, David S. Schrump, W. Marston Linehan, Rahul Roychoudhuri and Nicholas P. Restifo ()
Additional contact information
Robert Eil: National Cancer Institute, National Institutes of Health (NIH)
Suman K. Vodnala: National Cancer Institute, National Institutes of Health (NIH)
David Clever: National Cancer Institute, National Institutes of Health (NIH)
Christopher A. Klebanoff: National Cancer Institute, National Institutes of Health (NIH)
Madhusudhanan Sukumar: National Cancer Institute, National Institutes of Health (NIH)
Jenny H. Pan: National Cancer Institute, National Institutes of Health (NIH)
Douglas C. Palmer: National Cancer Institute, National Institutes of Health (NIH)
Alena Gros: National Cancer Institute, National Institutes of Health (NIH)
Tori N. Yamamoto: National Cancer Institute, National Institutes of Health (NIH)
Shashank J. Patel: National Cancer Institute, National Institutes of Health (NIH)
Geoffrey C. Guittard: National Cancer Institute, National Institutes of Health (NIH)
Zhiya Yu: National Cancer Institute, National Institutes of Health (NIH)
Valentina Carbonaro: Laboratory of Lymphocyte Signalling and Development, The Babraham Institute
Klaus Okkenhaug: Laboratory of Lymphocyte Signalling and Development, The Babraham Institute
David S. Schrump: National Cancer Institute, National Institutes of Health (NIH)
W. Marston Linehan: National Cancer Institute, National Institutes of Health (NIH)
Rahul Roychoudhuri: Laboratory of Lymphocyte Signalling and Development, The Babraham Institute
Nicholas P. Restifo: National Cancer Institute, National Institutes of Health (NIH)

Nature, 2016, vol. 537, issue 7621, 539-543

Abstract: Potassium ions released by necrotic cells in tumours impair T cell function by increasing the intracellular potassium concentration in vitro and in vivo.

Date: 2016
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DOI: 10.1038/nature19364

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