Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

Marco Sciacovelli, Emanuel Gonçalves, Timothy Isaac Johnson, Vincent Roberto Zecchini, Ana Sofia Henriques da Costa, Edoardo Gaude, Alizee Vercauteren Drubbel, Sebastian Julian Theobald, Sandra Riekje Abbo, Maxine Gia Binh Tran, Vinothini Rajeeve, Simone Cardaci, Sarah Foster, Haiyang Yun, Pedro Cutillas, Anne Warren, Vincent Gnanapragasam, Eyal Gottlieb, Kristian Franze, Brian Huntly, Eamonn Richard Maher, Patrick Henry Maxwell, Julio Saez-Rodriguez and Christian Frezza ()
Additional contact information
Marco Sciacovelli: Medical Research Council Cancer Unit, University of Cambridge
Emanuel Gonçalves: European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute (EBI)
Timothy Isaac Johnson: Medical Research Council Cancer Unit, University of Cambridge
Vincent Roberto Zecchini: Medical Research Council Cancer Unit, University of Cambridge
Ana Sofia Henriques da Costa: Medical Research Council Cancer Unit, University of Cambridge
Edoardo Gaude: Medical Research Council Cancer Unit, University of Cambridge
Alizee Vercauteren Drubbel: Medical Research Council Cancer Unit, University of Cambridge
Sebastian Julian Theobald: Medical Research Council Cancer Unit, University of Cambridge
Sandra Riekje Abbo: Medical Research Council Cancer Unit, University of Cambridge
Maxine Gia Binh Tran: Uro-Oncology Research Group, University of Cambridge
Vinothini Rajeeve: Integrative Cell Signalling and Proteomics, Centre for Haemato-Oncology, John Vane Science Centre, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square
Simone Cardaci: Cancer Research UK Beatson Institute
Sarah Foster: Development and Neuroscience, University of Cambridge
Haiyang Yun: Cambridge Institute for Medical Research and Addenbrooke’s Hospital, and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge
Pedro Cutillas: Integrative Cell Signalling and Proteomics, Centre for Haemato-Oncology, John Vane Science Centre, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square
Anne Warren: University of Cambridge
Vincent Gnanapragasam: Academic Urology Group, University of Cambridge
Eyal Gottlieb: Cancer Research UK Beatson Institute
Kristian Franze: Development and Neuroscience, University of Cambridge
Brian Huntly: Cambridge Institute for Medical Research and Addenbrooke’s Hospital, and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge
Eamonn Richard Maher: University of Cambridge
Patrick Henry Maxwell: Cambridge Institute for Medical Research, University of Cambridge
Julio Saez-Rodriguez: European Molecular Biology Laboratory (EMBL), European Bioinformatics Institute (EBI)
Christian Frezza: Medical Research Council Cancer Unit, University of Cambridge

Nature, 2016, vol. 537, issue 7621, 544-547

Abstract: Accumulation of fumarate resulting from mutations in fumarate hydratase,which are associated with renal and other cancers, is shown to induce epithelial-to-mesenchymal transition—a process associated with cancer initiation.

Date: 2016
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature19353 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:537:y:2016:i:7621:d:10.1038_nature19353

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature19353

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().