Single-cell analysis of mixed-lineage states leading to a binary cell fate choice

Andre Olsson, Meenakshi Venkatasubramanian, Viren K. Chaudhri, Bruce J. Aronow, Nathan Salomonis (), Harinder Singh () and H. Leighton Grimes ()
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Andre Olsson: Cincinnati Children’s Hospital Medical Center
Meenakshi Venkatasubramanian: Cincinnati Children’s Hospital Medical Center
Viren K. Chaudhri: Cincinnati Children’s Hospital Medical Center
Bruce J. Aronow: Cincinnati Children’s Hospital Medical Center
Nathan Salomonis: Cincinnati Children’s Hospital Medical Center
Harinder Singh: Cincinnati Children’s Hospital Medical Center
H. Leighton Grimes: Cincinnati Children’s Hospital Medical Center

Nature, 2016, vol. 537, issue 7622, 698-702

Abstract: Stem cells generate progenitors that transition through a series of dynamically unstable states with mixed-lineage gene expression, culminating in the specification of cell-fate.

Date: 2016
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DOI: 10.1038/nature19348

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