Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

W. P. Vermeij, M. E. T. Dollé (), E. Reiling, D. Jaarsma, C. Payan-Gomez, C. R. Bombardieri, H. Wu, A. J. M. Roks, S. M. Botter, B. C. van der Eerden, S. A. Youssef, R. V. Kuiper, B. Nagarajah, C. T. van Oostrom, R. M. C. Brandt, S. Barnhoorn, S. Imholz, J. L. A. Pennings, A. de Bruin, Á. Gyenis, J. Pothof, J. Vijg, H. van Steeg and J. H. J. Hoeijmakers ()
Additional contact information
W. P. Vermeij: Erasmus University Medical Center Rotterdam
M. E. T. Dollé: Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), PO Box 1
E. Reiling: Erasmus University Medical Center Rotterdam
D. Jaarsma: Erasmus University Medical Center Rotterdam, PO Box 2040
C. Payan-Gomez: Erasmus University Medical Center Rotterdam
C. R. Bombardieri: Erasmus University Medical Center Rotterdam
H. Wu: Erasmus University Medical Center Rotterdam, PO Box 2040
A. J. M. Roks: Erasmus University Medical Center Rotterdam, PO Box 2040
S. M. Botter: Erasmus University Medical Center Rotterdam
B. C. van der Eerden: Erasmus University Medical Center Rotterdam, PO Box 2040
S. A. Youssef: Dutch Molecular Pathology Center, Faculty of Veterinary Medicine, Utrecht University, PO Box 80125
R. V. Kuiper: Dutch Molecular Pathology Center, Faculty of Veterinary Medicine, Utrecht University, PO Box 80125
B. Nagarajah: Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), PO Box 1
C. T. van Oostrom: Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), PO Box 1
R. M. C. Brandt: Erasmus University Medical Center Rotterdam
S. Barnhoorn: Erasmus University Medical Center Rotterdam
S. Imholz: Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), PO Box 1
J. L. A. Pennings: Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), PO Box 1
A. de Bruin: Dutch Molecular Pathology Center, Faculty of Veterinary Medicine, Utrecht University, PO Box 80125
Á. Gyenis: Erasmus University Medical Center Rotterdam
J. Pothof: Erasmus University Medical Center Rotterdam
J. Vijg: Albert Einstein College of Medicine
H. van Steeg: Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), PO Box 1
J. H. J. Hoeijmakers: Erasmus University Medical Center Rotterdam

Nature, 2016, vol. 537, issue 7620, 427-431

Abstract: A restricted diet extends the lives and improves the health of mice with accelerated ageing due to an inability to repair DNA damage.

Date: 2016
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DOI: 10.1038/nature19329

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