Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection

Ran He, Shiyue Hou, Cheng Liu, Anli Zhang, Qiang Bai, Miao Han, Yu Yang, Gang Wei, Ting Shen, Xinxin Yang, Lifan Xu, Xiangyu Chen, Yaxing Hao, Pengcheng Wang, Chuhong Zhu, Juanjuan Ou, Houjie Liang, Ting Ni, Xiaoyan Zhang, Xinyuan Zhou, Kai Deng, Yaokai Chen, Yadong Luo, Jianqing Xu, Hai Qi (), Yuzhang Wu () and Lilin Ye ()
Additional contact information
Ran He: Institute of Immunology
Shiyue Hou: Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University
Cheng Liu: Institute of Immunology
Anli Zhang: Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University
Qiang Bai: Institute of Immunology
Miao Han: State Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University
Yu Yang: Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University
Gang Wei: State Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University
Ting Shen: State Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University
Xinxin Yang: Institute of Immunology
Lifan Xu: Institute of Immunology
Xiangyu Chen: Institute of Immunology
Yaxing Hao: Institute of Immunology
Pengcheng Wang: Institute of Immunology
Chuhong Zhu: School of Basic Medicine, Third Military Medical University
Juanjuan Ou: Southwestern Hospital, Third Military Medical University
Houjie Liang: Southwestern Hospital, Third Military Medical University
Ting Ni: State Key Laboratory of Genetic Engineering & MOE Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University
Xiaoyan Zhang: Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University
Xinyuan Zhou: Institute of Immunology
Kai Deng: Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University
Yaokai Chen: Chongqing Public Health Medical Center
Yadong Luo: Chongqing Public Health Medical Center
Jianqing Xu: Shanghai Public Health Clinical Center & Institutes of Biomedical Sciences, Fudan University
Hai Qi: Tsinghua-Peking Center for Life Sciences, Laboratory of Dynamic Immunobiology, School of Medicine, Tsinghua University
Yuzhang Wu: Institute of Immunology
Lilin Ye: Institute of Immunology

Nature, 2016, vol. 537, issue 7620, 412-416

Abstract: A population of partially exhausted CXCR5+ CD8+ T cells, induced by chronic virus infection and residing in B-cell follicles, is shown to control viral replication.

Date: 2016
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DOI: 10.1038/nature19317

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