Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling

Neil S. Dhawan, Alex P. Scopton and Arvin C. Dar ()
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Neil S. Dhawan: The Tisch Cancer Institute, The Icahn School of Medicine at Mount Sinai
Alex P. Scopton: The Tisch Cancer Institute, The Icahn School of Medicine at Mount Sinai
Arvin C. Dar: The Tisch Cancer Institute, The Icahn School of Medicine at Mount Sinai

Nature, 2016, vol. 537, issue 7618, 112-116

Abstract: A class of small molecules that stabilize a previously unrecognized inactive state of KSR is reported; the agonists synergize with MEK inhibitors to prevent growth of Ras mutant cell lines.

Date: 2016
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DOI: 10.1038/nature19327

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