Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala

Catherine A. Marcinkiewcz, Christopher M. Mazzone, Giuseppe D’Agostino, Lindsay R. Halladay, J. Andrew Hardaway, Jeffrey F. DiBerto, Montserrat Navarro, Nathan Burnham, Claudia Cristiano, Cayce E. Dorrier, Gregory J. Tipton, Charu Ramakrishnan, Tamas Kozicz, Karl Deisseroth, Todd E. Thiele, Zoe A. McElligott, Andrew Holmes, Lora K. Heisler and Thomas L. Kash ()
Additional contact information
Catherine A. Marcinkiewcz: Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill
Christopher M. Mazzone: Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill
Giuseppe D’Agostino: Rowett Institute of Nutrition and Health, University of Aberdeen
Lindsay R. Halladay: National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
J. Andrew Hardaway: Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill
Jeffrey F. DiBerto: Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill
Montserrat Navarro: College of Arts and Sciences, University of North Carolina at Chapel Hill
Nathan Burnham: College of Arts and Sciences, University of North Carolina at Chapel Hill
Claudia Cristiano: Rowett Institute of Nutrition and Health, University of Aberdeen
Cayce E. Dorrier: Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill
Gregory J. Tipton: Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill
Charu Ramakrishnan: Stanford University
Tamas Kozicz: Hayward Genetics Center, Tulane University
Karl Deisseroth: Stanford University
Todd E. Thiele: Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill
Zoe A. McElligott: Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill
Andrew Holmes: National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
Lora K. Heisler: Rowett Institute of Nutrition and Health, University of Aberdeen
Thomas L. Kash: Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill

Nature, 2016, vol. 537, issue 7618, 97-101

Abstract: A brain circuit is identified through which serotonin induces an anxiety-like state; this circuit also mediates the anxiety-like behaviour induced by acute administration of the selective serotonin reuptake inhibitor fluoxetine and may underlie the early adverse events that some patients with anxiety disorders have to these types of drugs.

Date: 2016
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DOI: 10.1038/nature19318

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