CHD8 haploinsufficiency results in autistic-like phenotypes in mice

Yuta Katayama, Masaaki Nishiyama (), Hirotaka Shoji, Yasuyuki Ohkawa, Atsuki Kawamura, Tetsuya Sato, Mikita Suyama, Toru Takumi, Tsuyoshi Miyakawa and Keiichi I. Nakayama ()
Additional contact information
Yuta Katayama: Medical Institute of Bioregulation, Kyushu University
Masaaki Nishiyama: Medical Institute of Bioregulation, Kyushu University
Hirotaka Shoji: Institute for Comprehensive Medical Science, Fujita Health University
Yasuyuki Ohkawa: Medical Institute of Bioregulation, Kyushu University
Atsuki Kawamura: Medical Institute of Bioregulation, Kyushu University
Tetsuya Sato: Medical Institute of Bioregulation, Kyushu University
Mikita Suyama: Medical Institute of Bioregulation, Kyushu University
Toru Takumi: RIKEN Brain Science Institute
Tsuyoshi Miyakawa: Institute for Comprehensive Medical Science, Fujita Health University
Keiichi I. Nakayama: Medical Institute of Bioregulation, Kyushu University

Nature, 2016, vol. 537, issue 7622, 675-679

Abstract: Heterozygous Chd8 mutant mice display autistic-like behaviours and small but global changes in brain gene expression, which are associated with delays in neuronal development.

Date: 2016
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DOI: 10.1038/nature19357

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