Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

Shilpi Khare, Advait S. Nagle, Agnes Biggart, Yin H. Lai, Fang Liang, Lauren C. Davis, S. Whitney Barnes, Casey J. N. Mathison, Elmarie Myburgh, Mu-Yun Gao, J. Robert Gillespie, Xianzhong Liu, Jocelyn L. Tan, Monique Stinson, Ianne C. Rivera, Jaime Ballard, Vince Yeh, Todd Groessl, Glenn Federe, Hazel X. Y. Koh, John D. Venable, Badry Bursulaya, Michael Shapiro, Pranab K. Mishra, Glen Spraggon, Ansgar Brock, Jeremy C. Mottram, Frederick S. Buckner, Srinivasa P. S. Rao, Ben G. Wen, John R. Walker, Tove Tuntland, Valentina Molteni, Richard J. Glynne and Frantisek Supek ()
Additional contact information
Shilpi Khare: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Advait S. Nagle: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Agnes Biggart: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Yin H. Lai: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Fang Liang: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Lauren C. Davis: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
S. Whitney Barnes: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Casey J. N. Mathison: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Elmarie Myburgh: Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow
Mu-Yun Gao: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
J. Robert Gillespie: University of Washington
Xianzhong Liu: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Jocelyn L. Tan: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Monique Stinson: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Ianne C. Rivera: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Jaime Ballard: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Vince Yeh: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Todd Groessl: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Glenn Federe: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Hazel X. Y. Koh: Novartis Institute for Tropical Diseases
John D. Venable: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Badry Bursulaya: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Michael Shapiro: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Pranab K. Mishra: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Glen Spraggon: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Ansgar Brock: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Jeremy C. Mottram: Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow
Frederick S. Buckner: University of Washington
Srinivasa P. S. Rao: Novartis Institute for Tropical Diseases
Ben G. Wen: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
John R. Walker: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Tove Tuntland: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Valentina Molteni: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Richard J. Glynne: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive
Frantisek Supek: Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive

Nature, 2016, vol. 537, issue 7619, 229-233

Abstract: A selective inhibitor of the kinetoplastid proteasome (GNF6702) is identified that is highly efficacious in vivo, clearing the parasites that cause leishmaniasis, Chagas disease and sleeping sickness from mice, highlighting the possibility of developing a single class of drugs for these neglected diseases.

Date: 2016
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DOI: 10.1038/nature19339

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