Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

Se Jin Im, Masao Hashimoto, Michael Y. Gerner, Junghwa Lee, Haydn T. Kissick, Matheus C. Burger, Qiang Shan, J. Scott Hale, Judong Lee, Tahseen H. Nasti, Arlene H. Sharpe, Gordon J. Freeman, Ronald N. Germain, Helder I. Nakaya, Hai-Hui Xue and Rafi Ahmed ()
Additional contact information
Se Jin Im: Emory University School of Medicine
Masao Hashimoto: Emory University School of Medicine
Michael Y. Gerner: Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Junghwa Lee: Emory University School of Medicine
Haydn T. Kissick: Emory University School of Medicine
Matheus C. Burger: School of Pharmaceutical Sciences, University of São Paulo
Qiang Shan: Carver College of Medicine, University of Iowa
J. Scott Hale: Emory University School of Medicine
Judong Lee: Emory University School of Medicine
Tahseen H. Nasti: Emory University School of Medicine
Arlene H. Sharpe: Harvard Medical School
Gordon J. Freeman: Dana-Farber Cancer Institute, Harvard Medical School
Ronald N. Germain: Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Helder I. Nakaya: School of Pharmaceutical Sciences, University of São Paulo
Hai-Hui Xue: Carver College of Medicine, University of Iowa
Rafi Ahmed: Emory University School of Medicine

Nature, 2016, vol. 537, issue 7620, 417-421

Abstract: Chronic infection with lymphocytic choriomeningitis virus promotes the establishment of a population of stem-like PD-1+ CD8+ T cells that reside in lymphoid tissues and preferentially expand when the PD-1 inhibitory pathway is blocked.

Date: 2016
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DOI: 10.1038/nature19330

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